DE102005051035A1 - Arrangement for the proof of cerebral disinfections in vivo by electroencephalogram and laser fluorescence-energy metabolic measurement, comprises a needle shaped cylindrical measuring probe exhibiting a thin metallic outer casing - Google Patents

Arrangement for the proof of cerebral disinfections in vivo by electroencephalogram and laser fluorescence-energy metabolic measurement, comprises a needle shaped cylindrical measuring probe exhibiting a thin metallic outer casing Download PDF

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DE102005051035A1
DE102005051035A1 DE102005051035A DE102005051035A DE102005051035A1 DE 102005051035 A1 DE102005051035 A1 DE 102005051035A1 DE 102005051035 A DE102005051035 A DE 102005051035A DE 102005051035 A DE102005051035 A DE 102005051035A DE 102005051035 A1 DE102005051035 A1 DE 102005051035A1
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measuring probe
optical fibers
measurement
outer casing
center
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DE102005051035B4 (en
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Bernd Dr. Lecher
Werner Dr. Schramm
Simone Maurer
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Mfd Diagnostics GmbH
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A61B5/14553—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases specially adapted for cerebral tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/369—Electroencephalography [EEG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A61B5/14556—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases by fluorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof

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Abstract

The arrangement for the proof of cerebral disinfections in vivo by electroencephalogram (EEG) and laser fluorescence-energy metabolic measurement, comprises a needle shaped cylindrical measuring probe (2) exhibiting a thin metallic outer casing. The cylindrical measuring probe is brought in contact or implanted at a defined point of the brain surface and has even frontal surface. The metallic outer casing encloses a grouping of optical fibers in such a manner that a bundle of UV-permeable optical fibers, is surrounded at the center of a concentric ring and an outer ring. The arrangement for the proof of cerebral disinfections in vivo by electroencephalogram (EEG) and laser fluorescence-energy metabolic measurement, comprises a needle shaped cylindrical measuring probe (2) exhibiting a thin metallic outer casing. The cylindrical measuring probe is brought in contact or implanted at a defined point of the brain surface and has even frontal surface. The metallic outer casing encloses a grouping of optical fibers in such a manner that a bundle of UV-permeable optical fibers, is surrounded at the center of a concentric ring and an outer ring from fibers visible light permeable optical fibers. Into the grouping of optical fibers, two thin metal wires are inserted, which act as metal electrodes at the frontal side and which are respectively arranged on a diameter line at the distance (a) from the center of the measuring probe. The measuring probe is locked by a hand piece (3), which is formed with a larger diameter in such a manner that it houses an electronic amplifier and which is connected with a flexible cable (4) from optical fibers. Electrical lines are connected by a detachable plug-in connector (5) with an equipment module, which contains component group for the measurement of the EEG- and the laser fluorescence signal and microcomputer for the storage and evaluation of the optical- and electrical measuring signal. A monitor for the representation of the results, is attached to the equipment module. The center of the concentric ring consists a fiber or a mixture of UV-permeable- and UV-impermeable optical fiber. The metal electrodes are arranged at a distance (a) of 0.5 mm, project from the front surface by a distance (d) of 0.2 mm and are closed with the frontal surface. The measuring probe is designed in straight or curved manner and is suited to the anatomy of the test objects. From the frontal side and at a short straight section with a length (l), a ring-shaped piece joins itself, which possesses a radius of curvature (r) and extends itself over the angle of curvature. The length, the radius of curvature and the angle of curvature are adaptable to the test objects.

Description

Die Erfindung betrifft eine Anordnung zum Nachweis von zerebralen Dysfunktionen in vivo. Sie ist für die gleichzeitige Messung der lokalen elektrophysiologischen Funktionszustände und der biochemischen Prozesse des Energiestoffwechsels der beteiligten Zellen in Echtzeit anwendbar.The The invention relates to an arrangement for the detection of cerebral dysfunctions in vivo. She is for the simultaneous measurement of local electrophysiological functional states and the biochemical processes of the energy metabolism of the involved Cells applicable in real time.

Die Messung der elektrophysiologischen Funktionszustände am Gehirn mittels EEG, wobei Elektroden zur Aufnahme von Hirnströmen an definierten Stellen aufgesetzt werden, ist seit langem bekannt (siehe Beschreibung in DE 19725214 ). Nachteilig ist dabei, dass größere Areale pro Elektrode erfasst werden, so dass eine genaue lokale Zuordnung auf Einzelpunkte nicht möglich ist. Deshalb wurde bereits vorgeschlagen (Anmeldung 10 2005 031 737.5), lokale EEG-Messungen mittels einer abgeschirmten Doppelelektrodenanordnung durchzuführen.The measurement of the electrophysiological functional states on the brain by means of EEG, in which electrodes for receiving brain waves are applied at defined locations, has long been known (see description in FIG DE 19725214 ). The disadvantage here is that larger areas are detected per electrode, so that an accurate local assignment to individual points is not possible. Therefore, it has already been proposed (Application 10 2005 031 737.5) to perform local EEG measurements by means of a shielded double electrode arrangement.

Es ist ebenfalls seit langem bekannt, fluoreszenzspektroskopisch den Energiestoffwechsel von Zellen und Geweben zu erfassen (DE-OS 3210593). Für die Messung am Gehirn wurde bereits ein Verfahren und eine Anordnung vorgeschlagen (Anmeldung 10 2005 021 205.0-41), das eine Messung des zeitlichen Verlaufs des Energiestoffwechsels gestattet.It has also long been known fluorescence spectroscopy the To detect energy metabolism of cells and tissues (DE-OS 3210593). For the Measurement on the brain has already been a procedure and an arrangement proposed (Application 10 2005 021 205.0-41), which is a measurement of the temporal Course of the energy metabolism allowed.

Nachteilig für den Einsatz dieser Methoden in der Praxis ist jedoch, dass die Messsonde für das EEG und die Messsonde zur Erfassung des Energiestoffwechsels nicht gleichzeitig, sondern nacheinander an der gleichen Stelle des Gehirns aufgesetzt werden müssen, was neben einer Ungenauigkeit des Messortes auch einen unerwünschten Zeitverzug bedeutet.adversely for the However, use of these methods in practice is that the measuring probe for the EEG and the measuring probe to detect the energy metabolism not simultaneously, but one after the other at the same place of the brain have to be set up What next to an inaccuracy of the site also an undesirable Time delay means.

Es gibt bisher keine Anordnung zur gleichzeitigen Erfassung beider Messgrößen, obwohl seit langem bekannt ist, dass ein pathologisches EEG-Signal in den meisten Fällen mit Störungen im zellulären Energiestoffwechsel in Beziehung steht.It So far there is no arrangement for the simultaneous detection of both Measurements, though It has long been known that a pathological EEG signal in the most cases with disturbances in the cellular Energy metabolism is related.

Aufgabe der Erfindung ist es deshalb, eine Anordnung zu schaffen, mit der gleichzeitig an einem Messpunkt das lokale EEG und der dazugehörige Energiestoffwechsel in situ gemessen und in einem zugeordneten Mikrocomputer die Korrelationen zwischen beiden ausgewertet und auf einem angeschlossenen Monitor dargestellt werden können.task The invention is therefore to provide an arrangement with the simultaneously at one measuring point the local EEG and the associated energy metabolism measured in situ and in an associated microcomputer the correlations evaluated between the two and displayed on a connected monitor can be.

Die Auggabe wird mit der Anordnung gemäß Patentanspruch 1 gelöst. Zweckmäßige Ausgestaltungen sind Gegenstand weiterer Unteransprüche.The Auggabe is solved with the arrangement according to claim 1. Appropriate embodiments are Subject of further subclaims.

Die Erfindung wird anhand von Ausführungsbeispielen erläutert.The Invention is based on embodiments explained.

Dabei zeigt:there shows:

1 eine schematische Darstellung der Messanordnung 1 a schematic representation of the measuring arrangement

2 den Querschnitt der Messsonde an der Stirnseite 2 the cross-section of the probe on the front side

3 die Seitenansicht der Messsondenspitze 3 the side view of the probe tip

4 eine Anpassung der nadelförmigen Messsonde an die Anatomie des Messobjekts 4 an adaptation of the needle-shaped probe to the anatomy of the measurement object

In 1 ist die Anordnung zum Nachweis zerebraler Dysfunktionen dargestellt. Auf die Gehirnoberfläche 1 ist die Stirnseite 2a einer nadelförmigen Messsonde 2 aufgesetzt, die in ein zylinderförmiges Handstück 3 übergeht. Letzteres ist mit einem flexiblen Kabel 4 über einen lösbaren Steckverbinder 5 mit einem Gerätemodul 6 verbunden. Dieser enthält als Funktionsgruppe eine EEG-Mess- und Auswerteeinheit 6a, eine Laserfluoreszenzmess- und Auswerteeinheit 6b und einen Mikrocomputer 6c. Der Gerätemodul 6 ist mit einem Anzeigegerät 7, wie z.B. einem Monitor, verbunden.In 1 the arrangement for the detection of cerebral dysfunctions is shown. On the brain surface 1 is the front side 2a a needle-shaped probe 2 placed in a cylindrical handpiece 3 passes. The latter is with a flexible cable 4 via a detachable connector 5 with a device module 6 connected. This contains as a functional group an EEG measuring and evaluation unit 6a , a laser fluorescence measuring and evaluation unit 6b and a microcomputer 6c , The device module 6 is with a display device 7 , such as a monitor, connected.

In 2 ist die Stirnseite 2a der Messsonde 2 im Querschnitt dargestellt. Dabei umschließt ein metallischer Außenmantel 8 eine Gruppierung von Lichtleitfasern 9, in die zwei Metallelektroden 10 eingelagert sind, welche sich auf einer Durchmesserlinie im Abstand a vom Mittelpunkt befinden. Der Abstand a beträgt bei Messsondendurchmessern von 2 mm beispielsweise 0,5 mm.In 2 is the front side 2a the measuring probe 2 shown in cross section. This encloses a metallic outer jacket 8th a grouping of optical fibers 9 , into the two metal electrodes 10 are embedded, which are located on a diameter line at a distance a from the center. The distance a is for measuring probe diameters of 2 mm, for example, 0.5 mm.

Die Gruppierung von Lichtleitfasern 9 besitzt ein Zentrum 9a von UV-durchlässigen Lichtleitfasern, um das ein konzentrischer Ring 9b aus einer Mischung von Lichtleitfasern angeordnet ist, die für UV-Licht (vorzugsweise 340 nm) bzw. sichtbares Licht (vorzugsweise ab 440 nm) durchlässig sind, sowie ein Außenring 9c aus Lichtleitfasern für sichtbares Licht. Im konzentrischer Ring 9b sollte das Mischungsverhältnis von Lichtleitfasern für das sichtbare Licht zu Lichtleitfasern für das UV-Licht etwa so sein, dass das Querschnittsverhältnis etwa 1 zu 10 beträgt.The grouping of optical fibers 9 has a center 9a of UV-transparent optical fibers around which a concentric ring 9b is arranged from a mixture of optical fibers which are transparent to UV light (preferably 340 nm) or visible light (preferably from 440 nm), as well as an outer ring 9c made of optical fibers for visible light. In the concentric ring 9b For example, the mixing ratio of visible light optical fibers to ultraviolet light optical fibers should be about such that the aspect ratio is about 1 to 10.

Für einfache Anordnungen ist es auch denkbar, dass das Zentrum 9a und der Außenring 9c nur mindestens eine Lichtleitfaser aufweist.For simple arrangements, it is also conceivable that the center 9a and the outer ring 9c only has at least one optical fiber.

3 zeigt eine Seitenansicht des distalen Endes der Messsonde 2. Dabei ist skizziert, dass die Metallelektroden 10, die im Abstand 2a voneinander angeordnet sind, um das Maß d, das z.B. 0,2 mm betragen kann, aus der Stirnseite 2a herausragen. 3 shows a side view of the distal end of the probe 2 , It is sketched that the metal electrodes 10 in the distance 2a are arranged from one another to the dimension d, which may be for example 0.2 mm, from the front side 2a protrude.

In 4 ist skizziert, wie die Form der nadelförmigen Messsonde 2 an die Anatomie des Messobjektes angepasst sein kann, wenn sie beispielsweise für das Aufsetzen im Ventrikel des Gehirns bestimmt ist.In 4 is outlined as the shape of the needle-shaped probe 2 can be adapted to the anatomy of the measurement object, if it is intended, for example, for placement in the ventricle of the brain.

Dabei schließt sich von der Stirnseite 2a der Messsonde 2 her gesehen an ein kurzes gerades Stück 11 ein Kreisbogenstück 12 an, das durch den Radius r und die Bogenlänge bestimmt ist, die durch den Bogenwinkel 13 definiert ist, wonach die Sonde über ein weiteres gerades Stück 14 in das Handstück 3 übergeht.This concludes from the front page 2a the measuring probe 2 seen from a short straight piece 11 a circular arc piece 12 , which is determined by the radius r and the arc length, by the arc angle 13 is defined, after which the probe over another straight piece 14 in the handpiece 3 passes.

In der nachfolgenden Tabelle sind zweckmäßige Bemessungen für unterschiedliche Messobjekte, wie das Gehirn von Maus, Ratte und von Primaten angegeben

Figure 00030001
The following table gives appropriate measurements for different objects to be measured, such as the mouse, rat and primate brain
Figure 00030001

11
Gehirnoberflächebrain surface
22
Messsondeprobe
2a2a
Stirnseitefront
33
Handstückhandpiece
3a3a
elektronischer Verstärkerelectronic amplifier
44
flexibles Kabelflexible electric wire
55
lösbarer Steckverbinderreleasable connector
66
Gerätemodulequipment module
6a6a
EEG-Mess- und AuswerteeinheitEEG measurement and evaluation unit
6b6b
Laserfluoreszenzmess- und AuswerteeinheitLaserfluoreszenzmess- and evaluation unit
6c6c
Mikrocomputermicrocomputer
77
Anzeigegerätdisplay
88th
metallischer Außenmantelmetallic outer sheath
99
Gruppierung von Lichtleitfaserngrouping of optical fibers
9a9a
Zentrumcenter
9b9b
konzentrischer Ringconcentric ring
9c9c
Außenringouter ring
1010
Metallelektrodenmetal electrodes
1111
gerades Stück am distalen Messsondenendestraight Piece on distal probe end
1212
KreisbogenstückArc piece
1313
Winkel des Bogenstücksangle of the bow piece
1414
gerades Stück zwischen Kreisbogenstück und Handstückstraight Piece between Arc piece and handpiece

Claims (5)

Anordnung zum Nachweis von zerebralen Dysfunktionen in vivo mittels EEG- und Laserfluoreszenz-Energiestoffwechselmessung, dadurch gekennzeichnet, dass eine nadelförmige zylindrische Messsonde (2), die an definierten Stellen der Gehirnoberfläche (1) in Kontakt gebracht bzw. in diese implantiert wird, eine im wesentlichen ebene Stirnfläche besitzt, wobei die Sonde einen dünnen metallischen Außenmantel (8) aufweist, der eine Gruppierung von optischen Lichtleitfasern (9) derart umschließt, dass ein Bündel von UV-durchlässigen Lichtleitfasern im Zentrum (9a) von einem konzentrischen Ring (9b) aus einer Mischung von Lichtleitfasern aus UV-durchlässigen und UV-nichtdurchlässigen Lichtleitfaser und einem Außenring (9c) aus für sichtbares Licht durchlässigen Fasern umgeben ist, während in die Gruppierung von Lichtleitfasern (9) zwei dünne Metalldrähte eingefügt sind, die an der Stirnseite als Metallelektroden (10) zutage treten und auf einer Durchmesserlinie jeweils im Abstand a vom Mittelpunkt der Messsonde (2) angeordnet sind, und die nadelförmige Messsonde (2) mit einem Handstück (3) abschließt, das mit einem größeren Durchmesser so ausgebildet ist, dass ein elektronischer Verstärker (3a) Platz findet, wobei das Handstück (3) mit einem flexiblen Kabel (4) aus Lichtleitfasern und elektrischen Leitungen über einen lösbaren Steckverbinder (5) mit einem Gerätemodul (6) verbunden ist, der die Baugruppe (6a) für die Messung der EEG-Signale und die Baugruppe (6b) für die Messung der Laserfluoreszenzsignale sowie den Mikrocomputer (6c) für die Speicherung und Auswertung der optischen und elektrischen Messsignale enthält und an den ein Monitor (7) für die Darstellung der Ergebnisse angeschlossen ist.Arrangement for the detection of cerebral dysfunctions in vivo by means of EEG and laser fluorescence energy metabolism measurement, characterized in that a needle-shaped cylindrical measuring probe ( 2 ) at defined sites of the brain surface ( 1 ) is brought into contact with or implanted in, has a substantially flat end face, wherein the probe has a thin metallic outer shell ( 8th ) comprising a grouping of optical fibers ( 9 ) in such a way that a bundle of UV-transparent optical fibers in the center ( 9a ) of a concentric ring ( 9b ) of a mixture of optical fibers made of UV-transparent and UV-non-transparent optical fiber and an outer ring ( 9c ) is surrounded by visible-light-transmitting fibers, while in the grouping of optical fibers ( 9 ) two thin metal wires are inserted, which at the front side as metal electrodes ( 10 ) and on a diameter line in each case at a distance a from the center of the measuring probe ( 2 ), and the needle-shaped measuring probe ( 2 ) with a handpiece ( 3 ), which is formed with a larger diameter so that an electronic amplifier ( 3a ), The handpiece ( 3 ) with a flexible cable ( 4 ) of optical fibers and electrical cables via a detachable connector ( 5 ) with a device module ( 6 ) that connects the module ( 6a ) for the measurement of EEG signals and the assembly ( 6b ) for the measurement of the laser fluorescence signals and the microcomputer ( 6c ) for storing and evaluating the optical and electrical measuring signals and to which a monitor ( 7 ) is connected to the presentation of the results. Anordnung nach Anspruch 1, dadurch gekennzeichnet, dass die Metallelektroden (10) im Abstand a = 0,5 mm angeordnet sind und aus der Stirnfläche (2a) um d = 0,2 mm herausragen.Arrangement according to claim 1, characterized in that the metal electrodes ( 10 ) are arranged at a distance a = 0.5 mm and from the end face ( 2a ) protrude by d = 0.2 mm. Anordnung nach Anspruch 1, dadurch gekennzeichnet, dass die Metallelektroden (10) im Abstand a = 0,5 mm angeordnet sind und mit der Stirnfläche (2a) bündig abschließen.Arrangement according to claim 1, characterized in that the metal electrodes ( 10 ) are arranged at a distance a = 0.5 mm and with the end face ( 2a ) finish flush. Anordnung nach Anspruch 1, dadurch gekennzeichnet, dass die nadelförmige Messsonde (2) gerade oder in Anpassung an die Anatomie der Messobjekte gebogen ausgebildet ist, wobei sich von der Stirnseite (2a) her an einen kurzen geraden Abschnitt 11 mit der Länge l ein Kreisbogenstück 12 anschließt, das einen Krümmungsradius r besitzt und sich über den Bogenwinkel 13 erstreckt, wobei die Länge l und der Radius r sowie der Bogenwinkel an die Messobjekte anpassbar sind.Arrangement according to claim 1, characterized in that the needle-shaped measuring probe ( 2 ) is formed bent straight or in adaptation to the anatomy of the measurement objects, wherein from the end face ( 2a ) to a short straight section 11 with the length l a circular arc piece 12 connects, which has a radius of curvature r and over the arc angle 13 extends, wherein the length l and the radius r and the arc angle are adaptable to the measurement objects. Anordnung nach Anspruch 1, dadurch gekennzeichnet, dass das Zentrum (9a) wie auch der Außenring (9c) aus mindestens einer Faser besteht.Arrangement according to claim 1, characterized in that the center ( 9a ) as well as the outer ring ( 9c ) consists of at least one fiber.
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US20040030258A1 (en) * 2000-10-09 2004-02-12 Williams Christopher Edward Sensor assembly for monitoring an infant brain

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD283218A5 (en) * 1989-05-16 1990-10-03 Akad Wissenschaften Ddr METHOD AND DEVICE FOR NONINVASIVELY DETERMINING THE OXIDATIVE METABOLIC CONDITION OF A CHILD BEFORE AND DURING THE BIRTH
DE19631577C2 (en) * 1996-07-26 1999-05-27 Werner Dr Schramm Arrangement for monitoring a fetus during childbirth
US20040030258A1 (en) * 2000-10-09 2004-02-12 Williams Christopher Edward Sensor assembly for monitoring an infant brain

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220015640A1 (en) * 2018-11-01 2022-01-20 Leibniz-Institut für Neurobiologie Magdeburg Image-capturing device, system and method for capturing images

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Inventor name: LOEFFLER, ANDRAS, 79189 BAD KROZINGEN, DE

Inventor name: LECHER, BERND, DR., 55131 MAINZ, DE

Inventor name: MAURER, SIMONE, 55606 LIMBACH, DE

Inventor name: SCHRAMM, WERNER, DR., 15370 FREDERSDORF, DE

8181 Inventor (new situation)

Inventor name: MAURER, SIMONE, 55606 LIMBACH, DE

Inventor name: LECHER, BERND, DR., 55131 MAINZ, DE

Inventor name: LOEFFLER, ANDREAS, 79189 BAD KROZINGEN, DE

Inventor name: SCHRAMM, WERNER, DR., 15370 FREDERSDORF, DE

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