DE102004063794A1 - implant - Google Patents
implant Download PDFInfo
- Publication number
- DE102004063794A1 DE102004063794A1 DE102004063794A DE102004063794A DE102004063794A1 DE 102004063794 A1 DE102004063794 A1 DE 102004063794A1 DE 102004063794 A DE102004063794 A DE 102004063794A DE 102004063794 A DE102004063794 A DE 102004063794A DE 102004063794 A1 DE102004063794 A1 DE 102004063794A1
- Authority
- DE
- Germany
- Prior art keywords
- coating
- implant according
- implant
- bone
- core
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000007943 implant Substances 0.000 title claims abstract description 64
- 210000000988 bone and bone Anatomy 0.000 claims abstract description 46
- 239000011248 coating agent Substances 0.000 claims abstract description 44
- 238000000576 coating method Methods 0.000 claims abstract description 44
- 239000000316 bone substitute Substances 0.000 claims abstract description 35
- 229920000747 poly(lactic acid) Polymers 0.000 claims abstract description 15
- 229920001577 copolymer Polymers 0.000 claims abstract description 6
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 10
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 5
- 229920000642 polymer Polymers 0.000 claims description 5
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 229910052751 metal Inorganic materials 0.000 claims description 4
- 239000002184 metal Substances 0.000 claims description 4
- 239000010936 titanium Substances 0.000 claims description 4
- 229910052719 titanium Inorganic materials 0.000 claims description 4
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 3
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 3
- 102000008186 Collagen Human genes 0.000 claims description 2
- 108010035532 Collagen Proteins 0.000 claims description 2
- 229910001069 Ti alloy Inorganic materials 0.000 claims description 2
- 229920001436 collagen Polymers 0.000 claims description 2
- 239000002131 composite material Substances 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 229910021645 metal ion Inorganic materials 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 229940124597 therapeutic agent Drugs 0.000 claims description 2
- 229920006237 degradable polymer Polymers 0.000 claims 1
- JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical compound C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 208000010392 Bone Fractures Diseases 0.000 description 3
- 230000006978 adaptation Effects 0.000 description 3
- 239000001506 calcium phosphate Substances 0.000 description 3
- 229910000389 calcium phosphate Inorganic materials 0.000 description 3
- 235000011010 calcium phosphates Nutrition 0.000 description 3
- 230000035876 healing Effects 0.000 description 3
- 238000002513 implantation Methods 0.000 description 3
- 230000010354 integration Effects 0.000 description 3
- 239000004626 polylactic acid Substances 0.000 description 3
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 2
- 229920001519 homopolymer Polymers 0.000 description 2
- 230000000278 osteoconductive effect Effects 0.000 description 2
- 230000002138 osteoinductive effect Effects 0.000 description 2
- 229910014497 Ca10(PO4)6(OH)2 Inorganic materials 0.000 description 1
- JVTAAEKCZFNVCJ-UWTATZPHSA-N D-lactic acid Chemical compound C[C@@H](O)C(O)=O JVTAAEKCZFNVCJ-UWTATZPHSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000000560 biocompatible material Substances 0.000 description 1
- 229920000249 biocompatible polymer Polymers 0.000 description 1
- 239000004568 cement Substances 0.000 description 1
- 238000005336 cracking Methods 0.000 description 1
- 229940022769 d- lactic acid Drugs 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 229920001432 poly(L-lactide) Polymers 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000011218 segmentation Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000004018 waxing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/30—Inorganic materials
- A61L27/32—Phosphorus-containing materials, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/80—Cortical plates, i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
- A61L27/06—Titanium or titanium alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/30—Inorganic materials
- A61L27/306—Other specific inorganic materials not covered by A61L27/303 - A61L27/32
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/80—Cortical plates, i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates
- A61B17/8085—Cortical plates, i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates with pliable or malleable elements or having a mesh-like structure, e.g. small strips
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/84—Fasteners therefor or fasteners being internal fixation devices
- A61B17/842—Flexible wires, bands or straps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00004—(bio)absorbable, (bio)resorbable or resorptive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00831—Material properties
- A61B2017/00862—Material properties elastic or resilient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Inorganic Chemistry (AREA)
- Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
Abstract
Es wird ein Implantat mit einem nicht resorbierbaren, vorzugsweise metallischen Kern vorgeschlagen, der mit einer vollständigen oder teilweisen Beschichtung aus mindestens einem Knochenersatzstoff versehen ist. Um eine universelle Einsetzbarkeit und gute Verbindung des Implantats mit Knochen bzw. Knochengewebe zu ermöglichen, wird vorgeschlagen, daß das Implantat oder zumindest dessen Beschichtung elastisch und/oder inelastisch verformbar ausgebildet ist, daß die Beschichtung mehrschichtig ausgebildet ist und/oder daß der Knochenersatzstoff Polylactid oder ein Copolymer davon enthält.It is proposed an implant with a non-absorbable, preferably metallic core, which is provided with a complete or partial coating of at least one bone substitute. In order to enable a universal applicability and good connection of the implant with bone or bone tissue, it is proposed that the implant or at least its coating is elastically and / or inelastically deformable, that the coating is multi-layered and / or that the bone substitute polylactide or contains a copolymer thereof.
Description
Die vorliegende Erfindung betrifft ein Implantat gemäß dem Oberbegriff des Anspruchs 1.The The present invention relates to an implant according to the preamble of the claim 1.
Die vorliegende Erfindung betrifft insbesondere ein Implantat zur permanenten Verbindung mit Knochen bzw. Knochengewebe im menschlichen oder tierischen Körper. Das Implantat weist mindestens einen Knochenersatzstoff auf, so daß ein unmittelbares Anwachsen bzw. Verwachsen mit Knochen oder Knochengewebe ermöglicht wird. Durch den Einsatz von Knochenersatzstoff wird also insbesondere ein zementfreies Einsetzen bzw. Implantieren des Implantats und Verbinden mit Knochen bzw. Knochengewebe ermöglicht. Unter dem Begriff "Knochenersatzstoff" ist daher ein Material oder eine davon gebildete Oberfläche zu verstehen, so daß durch insbesondere osteokonduktive und/oder osteoinduktive Wirkung eine knöcherne Integration, also ein Einwachsen oder Anwachsen, ermöglicht wird. Nach dem An- bzw. Einwachsen wird eine zumindest für längere Zeit haltbare oder gar dauerhafte unmittelbare Verbindung des Implantats mit Knochen bzw. Knochengewebe erreicht, so daß eine sonstige mechanische Verbindung, wie eine Schraubverbindung, Klemmverbindung oder dgl., zwischen dem Implantat und dem Knochen entsprechend entlastet wird.The The present invention particularly relates to an implant for permanent use Connection with bone or bone tissue in human or animal Body. The implant has at least one bone substitute, so the existence immediate growth or ingrowth with bone or bone tissue allows becomes. The use of bone substitute is therefore in particular a cementless insertion or implantation of the implant and Connecting with bone or bone tissue allows. The term "bone substitute" is therefore a material or a surface formed thereof to be understood, so that in particular osteoconductive and / or osteoinductive effect bony integration, thus ingrowth or growth is made possible. After the arrival or Waxing is one for at least a long time durable or even permanent immediate connection of the implant achieved with bone or bone tissue, so that some other mechanical Connection, such as a screw connection, clamp connection or the like., between the implant and the bone is relieved accordingly.
Die WO 98/48862 A1, die den Ausgangspunkt der vorliegenden Erfindung bildet, offenbart ein nicht verformbares Implantat aus Titan mit einer Calcium-Phosphat-Beschichtung. Calcium-Phosphat stellt einen Knochenersatzstoff dar. Calcium-Phosphat ist sehr spröde, so daß die Beschichtung leicht reißen oder sich gar ablösen kann.The WO 98/48862 A1, which is the starting point of the present invention discloses a non-deformable titanium implant a calcium phosphate coating. Calcium phosphate provides one Bone substitute. Calcium phosphate is very brittle, so the coating tear easily or even peel off can.
Aus
der
Der vorliegenden Erfindung liegt die Aufgabe zugrunde, ein Implantat für die permanente Verbindung mit Knochen bzw. Knochengewebe anzugeben, wobei das Implantat universell – insbesondere zum Schienen von Knochenbrüchen oder dgl. – verwendbar ist und eine gute bzw. hoch belastbare Verbindung zum Knochen bzw. Knochengewebe ermöglicht.Of the The present invention is based on the object, an implant for the indicate permanent connection with bone or bone tissue, wherein the implant universal - especially for splints of bone fractures or the like - usable is and a good or highly resilient connection to the bone or Bone tissue allows.
Die obige Aufgabe wird durch ein Implantat gemäß Anspruch 1 gelöst. Vorteilhafte Weiterbildungen sind Gegenstand der Unteransprüche.The The above object is achieved by an implant according to claim 1. advantageous Further developments are the subject of the dependent claims.
Das vorschlagsgemäße Implantat weist einen nicht resorbierbaren Kern, insbesondere aus Titan oder dgl., auf, der vollständig oder teilweise mit Knochenersatzstoff beschichtet ist, wobei das Implantat oder zumindest die Beschichtung elastisch und/oder inelastisch verformbar ausgebildet ist. Die verformbare, insbesondere elastische Ausbildung des Knochenersatzstoffes bzw. der Beschichtung führt dazu, daß gegenüber dem Stand der Technik eine wesentlich bessere bzw. höher belastbare Verbindung mit Knochen bzw. Knochengewebe erreichbar ist, auch wenn der mit dem Knochen bzw. Knochengewebe permanent zu verbindende Kern eine vergleichbare oder höhere Steifigkeit als der zugeordnete Knochen bzw. das zugeordnete Knochengewebe aufweist.The Proposed implant has a non-absorbable core, in particular titanium or Like., On, the complete or partially coated with bone substitute, wherein the Implant or at least the coating elastic and / or inelastic is formed deformable. The deformable, especially elastic Training of the bone substitute or the coating leads to that against the State of the art a much better or more reliable connection with Bone or bone tissue is achievable, even if with the Bone or bone tissue permanently connected core a comparable or higher Stiffness as the associated bone or associated bone tissue having.
Ein weiterer, auch unabhängig realisierbarer Aspekt liegt darin, daß die Beschichtung mehrschichtig ausgebildet ist, insbesondere wobei die äußere Schicht elastischer, flexibler und/oder schneller resorbierbar als eine darunterliegende Schicht ausgebildet ist. Dies gestattet eine schrittweise bzw. stufenweise Anpassung der mechanischen Eigenschaften ausgehend vom Knochen bzw. Knochengewebe zum demgegenüber insbesondere steiferen Kern des Implantats hin. Dies ist im an- bzw. eingewachsenen Zustand einer guten und dauerhaften, hoch belastbaren Verbindung des Implantats mit dem Knochen bzw. Knochengewebe zuträglich.One further, also independent realizable aspect is that the coating is multi-layered is formed, in particular wherein the outer layer elastic, flexible and / or faster absorbable than an underlying layer is trained. This allows a stepwise or stepwise Adaptation of the mechanical properties starting from the bone or Bone tissue on the other hand especially stiffer core of the implant. This is in the or ingrown state of a good and permanent, highly resilient Connection of the implant with the bone or bone tissue conducive.
Gemäß einem weiteren, bedarfsweise auch unabhängig realisierbaren Aspekt der vorliegenden Erfindung ist Polylactid oder ein Copolymer davon als Knochenersatzstoff auf einem nicht resorbierbaren, insbesondere metallischen Kern, vorgesehen. So können die günstigen mechanischen Eigenschaften des Kerns – insbesondere dessen Steifigkeit, Verformbarkeit, Belastbarkeit auch gegenüber Wechselbeanspruchungen und dgl. – mit den eine knöcherne Integration fördernden Eigenschaften von Polylactid oder dgl. in idealer Weise kombiniert werden. Überraschenderweise hat sich herausgestellt, daß Polylactid zur Bildung einer Beschichtung sehr gut geeignet ist und daß auch eine sehr gute Verbindung mit einem insbesondere metallischen Kern möglich ist, so daß eine unerwünschte Rißbildung oder gar ein Ablösen bzw. Segmentieren der Beschichtung auch bei starker Belastung – beispielsweise beim Schienen von Knochenbrüchen – nicht auftritt bzw. auftreten.According to one another, if necessary, independently realizable aspect The present invention is polylactide or a copolymer thereof as a bone substitute on a non-absorbable, in particular metallic core, provided. Thus, the favorable mechanical properties of the Kerns - in particular its rigidity, deformability, load capacity also against alternating stresses and the like - with a bony integration promoting Properties of polylactide or the like. Combined in an ideal way become. Surprisingly it has been found that polylactide is very well suited for the formation of a coating and that also a very good connection with a particular metallic core is possible, so that one undesirable cracking or even a detachment or segmentation of the coating even under heavy load - for example when splints fractured - not occurs or occur.
Weitere Vorteile, Merkmale, Eigenschaften und Aspekte der vorliegenden Erfindung ergeben sich aus der nachfolgenden Beschreibung eines bevorzugten Ausführungsbeispiels anhand der Zeichnung. Es zeigt:Further Advantages, features, characteristics and aspects of the present invention will be apparent from the following description of a preferred embodiment based on the drawing. It shows:
Das
Implantat
Bedarfsweise
kann der Kern
Der
Kern
Die
Beschichtung
Die
Beschichtung
Beim
Darstellungsbeispiel sind die erste Schicht
Unter dem Begriff "resorbierbar" ist ein Auflösen im implantierten Zustand im Körper zu verstehen.Under The term "resorbable" is a dissolution in the implanted Condition in the body to understand.
Die
erste Schicht
Die
zweite Schicht
Das
Implantat
Vorzugsweise
entspricht die Beschichtung
Die
Beschichtung
Gemäß einer
Ausführungsvariante
ist die Beschichtung
Vorzugsweise
ist die zweite Schicht
Die
Beschichtung
Die
Beschichtung
Die
Beschichtung
Das
vorschlagsgemäße Implantat
Ein
Knochen
Je
nach Art der mechanischen Anbringung des Implantats
Das
Implantat
Die
insbesondere vorgesehene Bildung der Beschichtung
Das
vorschlagsgemäße Implantat
Claims (18)
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102004063794A DE102004063794A1 (en) | 2004-12-30 | 2004-12-30 | implant |
PCT/EP2005/014125 WO2006072451A1 (en) | 2004-12-30 | 2005-12-30 | Implant |
DE202005020490U DE202005020490U1 (en) | 2004-12-30 | 2005-12-30 | implant |
EP05850376A EP1830899A1 (en) | 2004-12-30 | 2005-12-30 | Implant |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102004063794A DE102004063794A1 (en) | 2004-12-30 | 2004-12-30 | implant |
Publications (1)
Publication Number | Publication Date |
---|---|
DE102004063794A1 true DE102004063794A1 (en) | 2006-07-13 |
Family
ID=36354119
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE102004063794A Withdrawn DE102004063794A1 (en) | 2004-12-30 | 2004-12-30 | implant |
DE202005020490U Expired - Lifetime DE202005020490U1 (en) | 2004-12-30 | 2005-12-30 | implant |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE202005020490U Expired - Lifetime DE202005020490U1 (en) | 2004-12-30 | 2005-12-30 | implant |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP1830899A1 (en) |
DE (2) | DE102004063794A1 (en) |
WO (1) | WO2006072451A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102009024616A1 (en) | 2009-06-08 | 2010-12-23 | Telos Gmbh | Sterilizable coating used for complete or partial treatment of surfaces of implantable materials for use as implants or hard tissue replacement materials in medical and dental field, comprises osteogenic protein and ionic polysaccharide |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102012006454A1 (en) * | 2012-03-30 | 2013-10-02 | Heraeus Medical Gmbh | Anti-infective spacer for osteosynthesis plates |
EP2945555B1 (en) | 2013-04-12 | 2018-03-14 | Zimmer GmbH | Orthopedic plate |
Citations (12)
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DE4435652A1 (en) * | 1993-10-07 | 1996-04-11 | Stemberger Axel Dr | Coating for bio-material to be used e.g. as sutures |
DE19723287A1 (en) * | 1997-06-04 | 1998-12-10 | Castolin Sa | Implant for use in living beings, method for producing the implant and its use |
WO1999045979A1 (en) * | 1998-03-11 | 1999-09-16 | Johnson & Johnson Professional, Inc. | Bioactive ceramic coating and method |
DE19781971T1 (en) * | 1996-08-19 | 1999-09-30 | Korea Inst Sci & Tech | Process for coating surfaces of metal implants |
US6451373B1 (en) * | 2000-08-04 | 2002-09-17 | Advanced Cardiovascular Systems, Inc. | Method of forming a therapeutic coating onto a surface of an implantable prosthesis |
DE10237572A1 (en) * | 2002-08-13 | 2004-02-26 | Biotronik Meß- und Therapiegeräte GmbH & Co. Ingenieurbüro Berlin | Stent with a polymer coating |
DE10254215A1 (en) * | 2002-11-20 | 2004-06-09 | Ethicon Gmbh | Surgical implant |
DE69821510T2 (en) * | 1997-04-24 | 2004-06-24 | Takeda Chemical Industries, Ltd. | FIXED COMPOSITION COATED WITH APATIT |
EP1440699A1 (en) * | 2003-01-24 | 2004-07-28 | Medtronic Vascular, Inc. | Stent with epoxy primer coating |
US20040147998A1 (en) * | 2003-01-24 | 2004-07-29 | Nolting John E. | Differentially coated stent |
EP1477192A1 (en) * | 2003-05-13 | 2004-11-17 | Bmg Incorporated | Bone-adherent implant with shock-absorbing property and manufacturing method thereof |
DE10323676A1 (en) * | 2003-05-15 | 2004-12-02 | Aesculap Ag & Co. Kg | Implant with long-term antibiotic effect |
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US5947893A (en) * | 1994-04-27 | 1999-09-07 | Board Of Regents, The University Of Texas System | Method of making a porous prothesis with biodegradable coatings |
FI19991852A (en) * | 1999-09-01 | 2001-03-01 | Yli Urpo Antti | New multilayer material with a biologically active agent, and its preparation |
US6518328B2 (en) * | 2000-12-15 | 2003-02-11 | Biomet, Inc. | Coated resorbable polymer and method of making the same |
EP1591133A1 (en) * | 2004-04-30 | 2005-11-02 | Synthes | Biologically active implants |
-
2004
- 2004-12-30 DE DE102004063794A patent/DE102004063794A1/en not_active Withdrawn
-
2005
- 2005-12-30 DE DE202005020490U patent/DE202005020490U1/en not_active Expired - Lifetime
- 2005-12-30 EP EP05850376A patent/EP1830899A1/en not_active Withdrawn
- 2005-12-30 WO PCT/EP2005/014125 patent/WO2006072451A1/en active Application Filing
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DE4334272C2 (en) * | 1993-10-07 | 1996-07-18 | Stemberger Axel Dr | Coating for biomaterial and its use |
DE4435652A1 (en) * | 1993-10-07 | 1996-04-11 | Stemberger Axel Dr | Coating for bio-material to be used e.g. as sutures |
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EP1440699A1 (en) * | 2003-01-24 | 2004-07-28 | Medtronic Vascular, Inc. | Stent with epoxy primer coating |
US20040147998A1 (en) * | 2003-01-24 | 2004-07-29 | Nolting John E. | Differentially coated stent |
EP1477192A1 (en) * | 2003-05-13 | 2004-11-17 | Bmg Incorporated | Bone-adherent implant with shock-absorbing property and manufacturing method thereof |
DE10323676A1 (en) * | 2003-05-15 | 2004-12-02 | Aesculap Ag & Co. Kg | Implant with long-term antibiotic effect |
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DE102009024616A1 (en) | 2009-06-08 | 2010-12-23 | Telos Gmbh | Sterilizable coating used for complete or partial treatment of surfaces of implantable materials for use as implants or hard tissue replacement materials in medical and dental field, comprises osteogenic protein and ionic polysaccharide |
Also Published As
Publication number | Publication date |
---|---|
EP1830899A1 (en) | 2007-09-12 |
WO2006072451A1 (en) | 2006-07-13 |
DE202005020490U1 (en) | 2006-03-02 |
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