DE102004023522A1 - Substituierte Cyclohexyl-1,4-diamin-Derivate - Google Patents

Substituierte Cyclohexyl-1,4-diamin-Derivate Download PDF

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Publication number
DE102004023522A1
DE102004023522A1 DE102004023522A DE102004023522A DE102004023522A1 DE 102004023522 A1 DE102004023522 A1 DE 102004023522A1 DE 102004023522 A DE102004023522 A DE 102004023522A DE 102004023522 A DE102004023522 A DE 102004023522A DE 102004023522 A1 DE102004023522 A1 DE 102004023522A1
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Germany
Prior art keywords
benzyl
dimethylamino
cyclohexyl
succinamide
chloro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE102004023522A
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German (de)
English (en)
Inventor
Bernd Dr. Sundermann
Corinna Dr. Sundermann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruenenthal GmbH
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Gruenenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal GmbH filed Critical Gruenenthal GmbH
Priority to DE102004023522A priority Critical patent/DE102004023522A1/de
Priority to AT05739598T priority patent/ATE438617T1/de
Priority to PCT/EP2005/004913 priority patent/WO2005110974A1/de
Priority to EP05739598A priority patent/EP1745010B1/de
Priority to CA2566297A priority patent/CA2566297C/en
Priority to PT05739598T priority patent/PT1745010E/pt
Priority to SI200530825T priority patent/SI1745010T1/sl
Priority to DE502005007850T priority patent/DE502005007850D1/de
Priority to US11/594,963 priority patent/US8088763B2/en
Priority to JP2007512033A priority patent/JP5037337B2/ja
Priority to PL05739598T priority patent/PL1745010T3/pl
Priority to DK05739598T priority patent/DK1745010T3/da
Priority to ES05739598T priority patent/ES2333026T3/es
Publication of DE102004023522A1 publication Critical patent/DE102004023522A1/de
Priority to CY20091101145T priority patent/CY1109569T1/el
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/41—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
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    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
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    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids

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  • Health & Medical Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Dermatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE102004023522A 2004-05-10 2004-05-10 Substituierte Cyclohexyl-1,4-diamin-Derivate Withdrawn DE102004023522A1 (de)

Priority Applications (14)

Application Number Priority Date Filing Date Title
DE102004023522A DE102004023522A1 (de) 2004-05-10 2004-05-10 Substituierte Cyclohexyl-1,4-diamin-Derivate
DE502005007850T DE502005007850D1 (de) 2004-05-10 2005-05-06 Substituierte cyclohexyl-1,4-diamin-derivate
US11/594,963 US8088763B2 (en) 2004-05-10 2005-05-06 Cyclohexyl-1, 4-diamine compounds
EP05739598A EP1745010B1 (de) 2004-05-10 2005-05-06 Substituierte cyclohexyl-1,4-diamin-derivate
CA2566297A CA2566297C (en) 2004-05-10 2005-05-06 Substituted cyclohexyl-1,4-diamine derivatives
PT05739598T PT1745010E (pt) 2004-05-10 2005-05-06 Derivados de ciclo-hexil-1,4-diamina substituídos
SI200530825T SI1745010T1 (sl) 2004-05-10 2005-05-06 Substituirani cikloheksil-1,4-diaminski derivati
AT05739598T ATE438617T1 (de) 2004-05-10 2005-05-06 Substituierte cyclohexyl-1,4-diamin-derivate
PCT/EP2005/004913 WO2005110974A1 (de) 2004-05-10 2005-05-06 Substituierte cyclohexyl-1,4-diamin-derivate
JP2007512033A JP5037337B2 (ja) 2004-05-10 2005-05-06 置換されたシクロヘキシル−１，４−ジアミンの酸誘導体
PL05739598T PL1745010T3 (pl) 2004-05-10 2005-05-06 Podstawione pochodne cykloheksylo-1,4-diaminy
DK05739598T DK1745010T3 (da) 2004-05-10 2005-05-06 Substituerede cyklohexyl-1,4-diaminderivater
ES05739598T ES2333026T3 (es) 2004-05-10 2005-05-06 Derivados de ciclohexil-1,4-diamina sustituidos.
CY20091101145T CY1109569T1 (el) 2004-05-10 2009-11-05 Υποκατεστημενα παραγωγα κυκλοεξανο-1,4-διαμινης

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102004023522A DE102004023522A1 (de) 2004-05-10 2004-05-10 Substituierte Cyclohexyl-1,4-diamin-Derivate

Publications (1)

Publication Number Publication Date
DE102004023522A1 true DE102004023522A1 (de) 2005-12-01

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ID=34967002

Family Applications (2)

Application Number Title Priority Date Filing Date
DE102004023522A Withdrawn DE102004023522A1 (de) 2004-05-10 2004-05-10 Substituierte Cyclohexyl-1,4-diamin-Derivate
DE502005007850T Expired - Lifetime DE502005007850D1 (de) 2004-05-10 2005-05-06 Substituierte cyclohexyl-1,4-diamin-derivate

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE502005007850T Expired - Lifetime DE502005007850D1 (de) 2004-05-10 2005-05-06 Substituierte cyclohexyl-1,4-diamin-derivate

Country Status (13)

Country Link
US (1) US8088763B2 (https=)
EP (1) EP1745010B1 (https=)
JP (1) JP5037337B2 (https=)
AT (1) ATE438617T1 (https=)
CA (1) CA2566297C (https=)
CY (1) CY1109569T1 (https=)
DE (2) DE102004023522A1 (https=)
DK (1) DK1745010T3 (https=)
ES (1) ES2333026T3 (https=)
PL (1) PL1745010T3 (https=)
PT (1) PT1745010E (https=)
SI (1) SI1745010T1 (https=)
WO (1) WO2005110974A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004023501A1 (de) * 2004-05-10 2005-12-01 Grünenthal GmbH Oxosubstituierte Cyclohexyl-1,4-diamin-Derivate
MX2009004314A (es) * 2006-11-13 2009-05-05 Pfizer Prod Inc Diaril, dipiridinil y arilpiridinilderivados y usos de los mismos.
AU2009228647B2 (en) 2008-03-27 2013-07-04 Grunenthal Gmbh Substituted spirocyclic cyclohexane derivatives
JP5529843B2 (ja) 2008-03-27 2014-06-25 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 置換シクロヘキシルジアミン
EP2280941B1 (de) 2008-03-27 2015-05-06 Grünenthal GmbH (hetero-)aryl-cyclohexan-derivate
ES2375543T3 (es) 2008-03-27 2012-03-01 Grünenthal GmbH Derivados de espiro(5.5)undecano.
ES2464102T3 (es) 2008-03-27 2014-05-30 Grünenthal GmbH Derivados de 4-aminociclohexano sustituidos
CN102046591B (zh) * 2008-03-27 2014-12-03 格吕伦塔尔有限公司 羟甲基环己胺
CN116554127B (zh) * 2022-01-28 2025-03-21 成都麻沸散医药科技有限公司 哌嗪取代苯酚类衍生物及其用途
CN117430522A (zh) * 2022-07-14 2024-01-23 浙江友宁生物医药科技有限公司 一种gpr139受体激动剂及其制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002090317A1 (de) * 2001-05-09 2002-11-14 Grünenthal GmbH Substituierte cyclohexan-1,4-diaminderivate
US20030229119A1 (en) * 2002-02-22 2003-12-11 Kym Philip R. Antagonists of melanin concentrating hormone effects on the melanin concetrating hormone receptor

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2373855A1 (en) * 1999-05-12 2000-11-23 Solvay Pharmaceuticals B.V. Method of treating psychotic disorders
ES2188344B1 (es) * 2000-11-29 2004-09-16 Laboratorios Vita, S.A. Compuestos derivados de benzotiofeno, su procedimiento de obtencion y utilizacion de los mismos.
EP1458704A1 (en) * 2001-12-21 2004-09-22 H. Lundbeck A/S Aminoindane derivatives as serotonin and norepinephrine uptake inhibitors
DE10252650A1 (de) * 2002-11-11 2004-05-27 Grünenthal GmbH Cyclohexyl-Harnstoff-Derivate
DE10252666A1 (de) * 2002-11-11 2004-08-05 Grünenthal GmbH N-Piperidyl-cyclohexan-Derivate

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002090317A1 (de) * 2001-05-09 2002-11-14 Grünenthal GmbH Substituierte cyclohexan-1,4-diaminderivate
US20030229119A1 (en) * 2002-02-22 2003-12-11 Kym Philip R. Antagonists of melanin concentrating hormone effects on the melanin concetrating hormone receptor

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PL1745010T3 (pl) 2010-01-29
EP1745010A1 (de) 2007-01-24
US20070112007A1 (en) 2007-05-17
SI1745010T1 (sl) 2010-01-29
DK1745010T3 (da) 2009-12-07
ES2333026T3 (es) 2010-02-16
DE502005007850D1 (de) 2009-09-17
JP5037337B2 (ja) 2012-09-26
CA2566297C (en) 2012-10-30
US8088763B2 (en) 2012-01-03
CY1109569T1 (el) 2014-08-13
CA2566297A1 (en) 2005-11-24
EP1745010B1 (de) 2009-08-05
JP2007536323A (ja) 2007-12-13

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