DE102004001267A1 - Improving oxygen supply to hair follicles to promote hair growth, especially for combating alopecia, using preparation containing emulsified phytohemoglobin and/or perfluorocarbon as oxygen carrier - Google Patents

Abstract

The use of cosmetic and/or dermatological preparations (A) is claimed for improving the oxygen supply to hair follicles, where (A) contains oxygen carrier(s) (I) selected from phytohemoglobins (PHG's) and/or synthetic perfluorocarbon compounds (PFC's), emulsified and stabilized with lecithin and other lipids. ACTIVITY : Metabolic. MECHANISM OF ACTION : Oxygen source.

Description

The The present invention relates to hair care preparations which are characterized by an invigorating effect on the individual hair follicle. In particular, it relates to such preparations containing a content of have free oxygen and allow this in for growth of the single hair useful way physiologically usable. In particular, oxygen is used for this purpose storing substances used.

in the human body the oxygen transport takes place except by ordinary solution especially by oxygen transport proteins. Such are the hemoglobin (900 g per adult) and myoglobin (40 g per adult).

hemoglobin is a tetrameric protein with heme, an iron complex as a prosthetic group. The binding of oxygen takes place at one of the coordination points of the iron, over or below the level of the heme molecule. The tetramer can bind a total of 4 oxygen molecules. The inclusion of a molecule Oxygen in the association of a Hb molecule causes a conformational change of the macromolecule (Allostery), characterized by contact interactions of one Subunit propagates to the other, so that the following Oxygen molecules easier to connect to the relevant Hb molecule. This Effect is called cooperativity designated.

at The oxygen release also affects the presence of carbon dioxide and lactic acid (low pH value) in the blood (so-called Bohr effect).

Beginning The 1970s made perfluorinated compounds as blood substitutes talking about themselves, e.g. Fluorohydrocarbons, perfluorinated ethers and amines, optionally emulsified with polyethers, since oxygen solves very well in them. It was launched in 1973, even a separate journal, this the subject, the Artificial Cells, Blood Substitutes and Biotechnology.

perfluorocarbons (PFC) have long been considered reliable synthetic blood replacement solutions and have since the beginning of the eighties also in the experimental Heart surgery taken foot. Carbon-fluorine bonds in molecules have the highest in the organic chemistry known binding energies. Thereby are Perfluorocarbons chemically extremely stable. They are therefore physiological inert. Because PFC does not dissolve in water are, must they are brought into the bloodstream in emulsified form. she have a high transport capacity for oxygen. So far only applications in emergency medicine become known.

Efficient oxygen transport proteins are also known from the plant kingdom. For example, the symbiotic leghemoglobin homologous to the hemoglobins of animal cells is capable of binding enough O ₂ and transporting the oxygen through the dense tissue of leguminous nodules where it is necessary for the nitrogen fixation reaction, even at low oxygen partial pressure (Yocum et al., 1964 ). This mechanism is comparable to the transport of oxygen into the muscle fibers of human tissue by myoglobin or in blood by hemoglobin (Wittenberg et al., 1970). The amino acid sequences of leghemoglobin and hemoglobins of animal cells are similar, the tertiary structures are largely identical. Leghemoglobin not only binds the oxygen efficiently but also ensures its exchange in the tissue. Thus, it could be shown that with increasing concentration of O2-loaded leghemoglobin oxygen-dependent nitrogen fixation in intact soy bean nodules increased (Bergersen et al., 1973, Appleby, 1992). In addition to the symbiotic hemoglobins of the root nodules, other plant and bacterial non-symbiotic hemoglobins, such as phytoglobins and flavohemoglobins, are known. The occurrence of phytoglobins is distributed throughout the plant kingdom. The oxygen binding capacity of phytoglobins is similar to that of human myoglobin (Duft et al., 1997).

To create a hair shaft, the hair follicle must produce and differentiate large epithelial cell masses. The necessary biosynthetic services, in particular the protein biosynthesis of the structuring hair keratins, are very energy-consuming. With increasing age, defects accumulate in the oxygen-dependent energy metabolism (Linnane AW, Zhang C, Baumer A, Nagley P (1992): Mitochondrial DNA mutation and the aging process: bioenergy and pharmacological intervention (Mutat Res 275: 195-208)) Contribute to the impairment of follicular biosynthesis. In this context, age-related deficits in hair formation are known (Courtois M, Loussouarn G, Hourseau C, Grollier JF (1995): Aging and hair cycles, British Journal of Dermatology 132: 86-93). These can be attributed to a reduced O 2 supply due to the deterioration in age of the formation of perifollicular capillaries and the capillary loop of the dermal papilla. In addition, was Significantly reduced O2 partial pressure has been found in scalp areas where hair formation is impaired (Goldman BE, Fisher DM, Ringler SI (1996): Transcutaneous PO2 of the scalp in Male Pattern Baldness: Plast Reconstr Surg 97 (6): 1109-16). According to the prevailing opinion, the hair follicle also "gasses" when it comes to oxygen access due to lactic acid fermentation, so it would be desirable to develop cosmetic ingredients that improve hair formation by preventing O2 supply while preventing this fermentation.

additional to the scientific background of this topic can be found in the publication by Dinkelmann S, Northoff H: Life Support by Artificial Oxygen carrier. In: Sames K, Medical Regeneration and Tissue Engineering. ecomed Verlagsgesellschaft, Landsberg a.L., 2000, and literature cited therein.

The font US 5885564 discloses oxygen-containing preparations containing phospholipids and oxygenated fluorocarbons, which necessarily contain phosphatidylcholine and cell extracts, for example yeast extracts.

The font US 5393513 discloses PFC-containing emulsions and a process for their preparation. However, such emulsions must be heat sterilized.

The font US 5830444 discloses various decorative cosmetic products containing fluorinated hydrocarbons. These are not perfluorinated.

The font EP 379765 discloses an oxygen-containing cosmetic preparation to be stored under pressure.

The font US 5851544 discloses O / W emulsions containing carbon dioxide loaded PFC, sunscreens, and cationic conditioning agents.

Alles This indicates no way to preparations that slow the growth of the hair promote, by revitalizing the hair follicle by supplying oxygen. Based on this, the task was to provide preparations, which have this effect.

It has not been foreseeably for the skilled person that the use of cosmetic and / or dermatological preparations containing oxygen carriers selected from the group of phytohemoglobins (oxygen carriers of plant origin) and / or synthetic perfluorocarbon compounds (PFC) as oxygen carriers, with lecithin and other lipids emulsified and stabilized, to improve the oxygen supply of the hair follicle, particularly preferably to improve the oxygen supply and the energy metabolism of the hair follicle, the disadvantages of the prior art remedies. Due to the improved O ₂ supply of O ₂ -dependent improves energy metabolism, the respiratory chain and the formation of ATP by oxidative phosphorylation of the cells of the hair follicle. This counteracts a deterioration of hair formation, especially age-related or androgenetic alopecia.

there it is preferred if the phytohemoglobins are chosen from the group of soybean leghemoglobins, hemoglobins from rice, barley and / or Parasponia, as well as the Arabidopsis hemoglobins Hb1, Hb2 and / or Hb3. Likewise, it is preferred if the synthetic Perfluorocarbon selected are selected from the group perfluorodecalin, perfluorotributylamine, perfluorooctylbromide, Perfluorotripropylamine, perfluorohexylethene, perfluorobutylethene, fluoromethylcyclohexylpiperidine, Fluoromethyldecahydroisoquinoline, fluoromethyladamantane and / or perfluorodichlorooctane. In particular, the PFC (perfluorodecalin, perfluorotributylamine, perfluorodichlorooctane etc.) provide oxygen carriers which is applied topically to the scalp due to their topical application high lipophilicity easily into the lipophilic environment of the hair follicle can penetrate and thus to an improvement in the energy metabolism important O2 supply directly in the affected tissue lead. It's special in all of this preferred when the oxygen carrier in a concentration of 0.001 to 15% by weight, in particular from 0.01 to 5% by weight and most preferably in one Concentration of 0.1 to 2% by weight, based on the total weight the preparation are used. Furthermore, it is preferred if in the preparation in addition lipophilic antioxidants, more preferably tocopherol or its Derivatives, such as, for example, 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (Trolox, CAS-No. 53188-07-1, 2,6-di-tert-butyl-4-methylphenol (BHT)), gamma-oryzanol, flavonoids are included.

By combination with lipophilic antioxidants such as tocopherol, the phytohemoglobin or PFC-mediated O2 transport can be stabilized. This results in a better product effect on penetration into the skin.

All it is particularly preferred if the water content of the preparation is more than 70% by weight and additionally Cyclodextrins are included. This allows their application as well with cosmetic products that have a more hydrophilic environment, such as hydrogels or shampoos. The generally apolar PFCs or the phytohemoglobins store themselves in the lipophilic cavern of outwardly polar cyclodextrins which creates a depot effect and also the release and distribution of O2-loaded PFCs or phytohemoglobins in the aqueous and / or polar environment in the tissue (skin, subcutaneous tissue, hair follicles) and in the cells themselves is improved. Further benefits of phytohemoglobins or the PFC are compared to hemoglobin linear and pH-independent oxygen solution behavior as well as their biocompatibility and lack of awareness.

The Omitting a single ingredient interferes with the unique properties the overall composition. Therefore, all specified ingredients the preparations according to the invention necessarily to carry out the invention.

The cosmetic preparations according to the invention can contain cosmetic excipients, such as those commonly used in such preparations can be used, e.g. Preservatives, bactericides, deodorising active substances, antiperspirants, insect repellents, vitamins, Means for preventing foaming, Dyes, pigments with coloring Effect, thickener, softening substances, moisturizing and / or moisturizing substances, fats, oils, waxes or other common ingredients a cosmetic formulation such as alcohols, polyols, polymers, Foam stabilizers, electrolytes, organic solvents or silicone derivatives.

Advantageous can Preparations according to the invention Furthermore Contain substances that absorb UV radiation in the UVB range, the total amount of filter substances being e.g. 0.1% by weight to 30 Wt .-%, preferably 0.5 to 10 wt .-%, in particular 1.0 to 6.0 Wt .-%, based on the total weight of the preparations to cosmetic Preparations available to put the hair or the skin in front of the entire area protect the ultraviolet radiation. You can also as a sunscreen for To serve hair.

• – 3-Benzylidencampher-Derivate, vorzugsweise 3-(4-Methylbenzyliden)campher, 3-Benzylidencampher;
• – 4-Aminobenzoesäure-Derivate, vorzugsweise 4-(Dimethylamino)-benzoesäure(2-ethylhexyl)ester, 4-(Dimethylamino)benzoesäureamylester;
• – Ester der Zimtsäure, vorzugsweise 4-Methoxyzimtsäure(2-ethylhexyl)ester, 4-Methoxyzimtsäureisopentylester;
• – Ester der Salicylsäure, vorzugsweise Salicylsäure(2-ethylhexyl)ester, Salicylsäure(4-isopropylbenzyl)ester, Salicylsäurehomomenthylester,
• – Derivate des Benzophenons, vorzugsweise 2-Hydroxy-4-methoxybenzophenon, 2-Hydroxy-4-methoxy-4'-methylbenzophenon, 2,2'-Dihydroxy-4-methoxybenzophenon;
• – Ester der Benzalmalonsäure, vorzugsweise 4-Methoxybenzalmalonsäuredi(2-ethylhexyl)ester,
• – 2,4,6-Trianilino-(p-carbo-2'-ethyl-1'-hexyloxy)-1,3,5-triazin.

If the preparations according to the invention contain UVB filter substances, these may be oil-soluble or water-soluble. Oil-soluble UVB filters which are advantageous according to the invention are, for example:

• 3-benzylidene camphor derivatives, preferably 3- (4-methylbenzylidene) camphor, 3-benzylidene camphor;
• 4-aminobenzoic acid derivatives, preferably 2-ethylhexyl 4- (dimethylamino) benzoate, 4- (dimethylamino) benzoic acid amyl ester;
• Esters of cinnamic acid, preferably 4-methoxycinnamic acid (2-ethylhexyl) ester, 4-methoxycinnamic acid isopentyl ester;
• Esters of salicylic acid, preferably 2-ethylhexyl salicylate, 4-isopropylbenzyl salicylate, homomenthyl salicylate,
• Derivatives of benzophenone, preferably 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone;
• Esters of benzalmalonic acid, preferably di-2-ethylhexyl 4-methoxybenzalmalonate,
• 2,4,6-trianilino (p-carbo-2'-ethyl-1'-hexyloxy) -1,3,5-triazine.

• – Salze der 2-Phenylbenzimidazol-5-sulfonsäure wie ihr Natrium-, Kalium- oder ihr Triethanolammonium-Salz, sowie die Sulfonsäure selbst;
• – Sulfonsäure-Derivate von Benzophenonen, vorzugsweise 2-Hydroxy-4-methoxybenzophenon-5-sulfonsäure und ihre Salze;
• – Sulfonsäure-Derivate des 3-Benzylidencamphers, wie z.B. 4-(2-Oxo-3-bornylidenmethyl)benzolsulfonsäure, 2-Methyl-5-(2-oxo-3-bornylidenmethyl)sulfonsäure und ihre Salze sowie das 1,4-di(2-oxo-10-Sulfo-3-bornylidenmethyl)-Benzol und dessen Salze (die entsprechenden 10-Sulfato-verbindungen, beispielsweise das entsprechende Natrium-, Kalium- oder Triethanolammonium-Salz), auch als Benzol-1,4-di(2-oxo-3-bornylidenmethyl-10-Sulfonsäure bezeichnet

Advantageous water-soluble UVB filters are, for example:

• Salts of 2-phenylbenzimidazole-5-sulphonic acid, such as its sodium, potassium or triethanolammonium salt, and the sulphonic acid itself;
• Sulfonic acid derivatives of benzophenones, preferably 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid and its salts;
• - Sulfonic acid derivatives of 3-Benzylidencamphers, such as 4- (2-oxo-3-bomylidenemethyl) benzenesulfonic acid, 2-methyl-5- (2-oxo-3-bomylidenemethyl) sulfonic acid and its salts, and the 1,4-di (2-oxo-10-sulfo-3-bomylidenemethyl) benzene and its salts (the corresponding 10-sulfato compounds, for example the corresponding sodium, potassium or triethanolammonium salt), also as benzene-1,4-di (2-oxo-3-bornylidenemethyl-10-sulfonic acid

The List of said UVB filters used according to the invention can, should of course not limiting.

It may also be advantageous to use UVA filters, which are usually contained in cosmetic preparations. For these substances they are preferably derivatives of dibenzoylmethane, in particular 1- (4'-tert-butylphenyl) -3- (4'-methoxyphenyl) propane-1,3-dione and 1-phenyl-3- (4'-isopropylphenyl) propane-1,3-dione. It can the for the amounts used in the UVB combination are used.

According to the invention, cosmetic and dermatological preparations advantageously also contain inorganic pigments based on metal oxides and / or other sparingly soluble or insoluble metal compounds, in particular the oxides of titanium (TiO ₂ ), zinc (ZnO), iron (eg Fe ₂ O ₃ ), zirconium (ZrO ₂ ), silicon (SiO ₂ ), manganese (eg MnO), aluminum (Al ₂ O ₃ ), cerium (eg Ce ₂ O ₃ ), mixed oxides of the corresponding metals and mixtures of such oxides. Particular preference is given to pigments based on TiO ₂ .

According to the invention in the preparations containing the oxygen carriers, the usual antioxidants be used.

Advantageous the antioxidants are chosen from the group consisting of amino acids (e.g., glycine, histidine, Tyrosine, tryptophan) and their derivatives, imidazoles (e.g., urocanic acid) and their derivatives, peptides such as D, L-carnosine, D-carnosine, L-carnosine and their derivatives (e.g., anserine), carotenoids, carotenes (e.g., α-carotene, β-carotene, Lycopene) and their derivatives, aurothioglucose, propylthiouracil and other thiols (e.g., thioredoxin, glutathione, cysteine, cystine, cystamine and their glycosyl, N-acetyl, methyl, ethyl, propyl, amyl, Butyl and lauryl, palmitoyl, oleyl, γ-linoleyl, cholesteryl and Glyceryl esters) and their salts, dilauryl thiodipropionate, distearyl thiodipropionate, thiodipropionic and their derivatives (esters, ethers, peptides, lipids, nucleotides, nucleosides and salts) in very low tolerated dosages (e.g., pmol to μmol / kg), further (metal) chelators (e.g., α-hydroxy fatty acids, palmitic acid, phytic acid, lactoferrin), α-hydroxy acids (e.g. citric acid, Lactic acid, Malic acid) humic acid, Bile acid Bile extracts, bilirubin, biliverdin, unsaturated fatty acids and their derivatives (e.g., γ-linolenic acid, linoleic acid, oleic acid), folic acid and their derivatives, alaninediacetic acid, Flavonoids, polyphenols, catechins, vitamin C and derivatives (e.g. Ascorbyl palmitate, Mg ascorbyl phosphate, ascorbyl acetate), tocopherols and derivatives (e.g., vitamin E acetate), as well as coniferyl benzoate of Benzoin resin, rutinic acid and their derivatives, ferulic acid and their derivatives, butylhydroxytoluene, butylhydroxyanisole, nordihydroguaiacetic acid, nordihydroguiaretic acid, trihydroxybutyrophenone, uric acid and their derivatives, mannose and its derivatives, selenium and its Derivatives (e.g., selenium methionine), stilbenes and their derivatives (e.g. Stilbene oxide, trans-stilbene oxide) and the present invention suitable Derivatives (salts, esters, ethers, sugars, nucleotides, nucleosides, peptides and lipids) of these drugs.

The Amount of antioxidants (one or more compounds) in the Preparations is preferably from 0.001 to 10% by weight, particularly preferably from 0.025 to 2.0% by weight, especially 0.05 - 1.0 Wt .-%, based on the total weight of the preparation.

Provided Vitamin A or vitamin A derivatives, or carotenes or their derivatives the one or more antioxidants are advantageous, their respective Concentrations from the range of 0.001 to 10 wt .-%, based on the total weight of the formulation to choose.

Provided Vitamin E and / or derivatives thereof are the antioxidant (s), is advantageous, their respective concentrations from the field from 0.001 to 10% by weight, based on the total weight of the formulation, to choose.

Further advantageous active ingredients in the context of the present invention natural Active ingredients and / or their derivatives, such as. Alpha-lipoic acid, phytoene, D-biotin, coenzyme Q10, alpha-glucosylrutin, carnitine, carnosine, natural and / or synthetic isoflavonoids, creatine, taurine and / or β-alanine.

It is particularly advantageous in the context of the present invention, although not mandatory if the inorganic pigments are in hydrophobic form that is superficial Water-repellent treatment. This surface treatment can consist of that the pigments according to known methods with a thin hydrophobic Layer be provided.

One such method is, for example, that the hydrophobic surface layer according to a reaction according to n TiO ₂ + m (RO) ₃ Si-R '→ n TiO ₂ (surface) is produced. n and m are stoichiometric parameters to be used as desired, R and R 'are the desired organic radicals. For example, in analogy to DE-OS 33 14 742 illustrated hydrophobized pigments are advantageous.

Advantageous TiO ₂ pigments are available, for example, under the trade names MT 100 T from TAYCA, furthermore M 160 from Kemira and T 805 from Degussa.

preparations according to the invention can, especially when crystalline or microcrystalline solids, for example inorganic micropigments incorporated into the preparations according to the invention are also anionic, nonionic and / or amphoteric Containing surfactants. Surfactants are amphiphilic substances that are organic, Dissolve nonpolar substances in water can.

• • anionische Tenside,
• • kationische Tenside,
• • amphotere Tenside und
• • nichtionische Tenside.

The hydrophilic portions of a surfactant molecule are usually polar functional groups, for example -COO ^- , -OSO ₃ ^2- , -SO ₃ ^- , while the hydrophobic parts are usually nonpolar hydrocarbon radicals. Surfactants are generally classified according to the nature and charge of the hydrophilic part of the molecule. Here four groups can be distinguished:

• Anionic surfactants,
• Cationic surfactants,
• • amphoteric surfactants and
• • nonionic surfactants.

Anionic surfactants generally have carboxylate, sulfate or sulfonate groups as functional groups. In aqueous solution, they form negatively charged organic ions in an acidic or neutral medium. Cationic surfactants are almost exclusively characterized by the presence of a quaternary ammonium group. In aqueous solution they form positively charged organic ions in an acidic or neutral environment. Amphoteric surfactants contain both anionic and cationic groups and behave accordingly in aqueous solution depending on the pH as anionic or cationic surfactants. They have a positive charge in a strongly acidic environment and a negative charge in an alkaline environment. In the neutral pH range, however, they are zwitterionic, as the following example is intended to illustrate:

Typical for non-ionic Surfactants are polyether chains. Nonionic surfactants form in aqueous medium no ions.

A. Anionic surfactants

• 1. Acylglutamate, beispielsweise Natriumacylglutamat, Di-TEA-palmitoylaspartat und Natrium Caprylic/Capric Glutamat,
• 2. Acylpeptide, beispielsweise Palmitoyl-hydrolysiertes Milchprotein, Natrium Cocoyl-hydrolysiertes Soja Protein und Natrium-/Kalium Cocoyl-hydrolysiertes Kollagen,
• 3. Sarcosinate, beispielsweise Myristoyl Sarcosin, TEA-lauroyl Sarcosinat, Natriumlauroylsarcosinat und Natriumcocoylsarkosinat,
• 4. Taurate, beispielsweise Natriumlauroyltaurat und Natriummethylcocoyltaurat,
• 5. AcylLactylate, lauroyllactylat, Caproyllactylat
• 6. Alaninate

Carbonsäuren und Derivate, wie

• 1. Carbonsäuren, beispielsweise Laurinsäure, Aluminiumstearat, Magnesiumalkanolat und Zinkundecylenat,
• 2. Ester-Carbonsäuren, beispielsweise Calciumstearoyllactylat, Laureth-6 Citrat und Natrium PEG-4 Lauramidcarboxylat,
• 3. Ether-Carbonsäuren, beispielsweise Natriumlaureth-13 Carboxylat und Natrium PEG-6 Cocamide Carboxylat,

Phosphorsäureester und Salze, wie beispielsweise DEA-Oleth-10-Phosphat und Dilaureth-4 Phosphat,
Sulfonsäuren und Salze, wie

• 1. Acyl-isethionate, z.B. Natrium-/Ammoniumcocoyl-isethionat,
• 2. Alkylarylsulfonate,
• 3. Alkylsulfonate, beispielsweise Natriumcocosmonoglyceridsulfat, Natrium C_12-14 Olefin-sulfonat, Natriumlaurylsulfoacetat und Magnesium PEG-3 Cocamidsulfat,
• 4. Sulfosuccinate, beispielsweise Dioctylnatriumsulfosuccinat, Dinatriumlaurethsulfosuccinat, Dinatriumlaurylsulfosuccinat und Dinatriumundecylenamido MEA-Sulfosuccinat

sowie
Schwefelsäureester, wie

• 1. Alkylethersulfat, beispielsweise Natrium-, Ammonium-, Magnesium-, MIPA-, TIPA-Laurethsulfat, Natriummyrethsulfat und Natrium C_12-13 Parethsulfat,
• 2. Alkylsulfate, beispielsweise Natrium-, Ammonium- und TEA-Laurylsulfat.

Advantageously used anionic surfactants are
Acylamino acids (and their salts), such as

• 1. acylglutamates, for example sodium acylglutamate, di-TEA-palmitoylaspartate and sodium caprylic / capric glutamate,
• 2. acyl peptides, for example palmitoyl-hydrolyzed milk protein, sodium cocoyl-hydrolyzed soy protein and sodium / potassium cocoyl-hydrolyzed collagen,
• 3. sarcosinates, for example myristoyl sarcosine, TEA lauroyl sarcosinate, sodium lauroyl sarcosinate and sodium cocoyl sarcosinate,
• 4. taurates, for example sodium lauroyl taurate and sodium methyl cocoyl taurate,
• 5. acyl lactylate, lauroyl lactylate, caproyl lactylate
• 6. Alaninates

Carboxylic acids and derivatives, such as

• 1. carboxylic acids, for example lauric acid, aluminum stearate, magnesium alkoxide and zinc undecylenate,
• 2. Ester carboxylic acids, for example calcium stearoyl lactylate, laureth-6 citrate and sodium PEG-4 lauramide carboxylate,
• 3. Ether carboxylic acids, for example sodium laureth-13 carboxylate and sodium PEG-6 cocamide carboxylate,

Phosphoric acid esters and salts such as DEA-oleth-10-phosphate and dilaureth-4-phosphate,
Sulfonic acids and salts, such as

• 1. acyl isethionates, eg sodium / ammonium cocoyl isethionate,
• 2. alkylaryl sulphonates,
• 3. alkyl sulfonates, for example sodium coconut monoglyceride sulfate, sodium C _12-14 olefin sulfonate, sodium lauryl sulfoacetate and magnesium PEG-3 cocamide sulfate,
• 4. Sulfosuccinates, for example dioctyl sodium sulfosuccinate, disodium laureth sulfosuccinate, disodium lauryl sulfosuccinate and disodium undecylenamido MEA sulfosuccinate

such as
Sulfuric acid esters, such as

• 1. alkyl ether sulfate, for example sodium, ammonium, magnesium, MIPA, TIPA laureth sulfate, sodium myreth sulfate and sodium C _12-13 pareth sulfate,
• 2. Alkyl sulfates, for example sodium, ammonium and TEA lauryl sulfate.

B. Cationic surfactants

• 1. Alkylamine,
• 2. Alkylimidazole,
• 3. Ethoxylierte Amine und
• 4. Quaternäre Tenside.
• 5. Esterquats

Advantageously to use cationic surfactants

• 1. alkylamines,
• 2. alkylimidazoles,
• 3. Ethoxylated amines and
• 4. Quaternary surfactants.
• 5. Esterquats

Quaternary surfactants contain at least one N-atom containing 4 alkyl or aryl groups covalently linked. This leads to, independently from pH, to a positive charge. Advantageous are alkyl betaine, Alkylamidopropyl betaine and alkyl amidopropyl hydroxysulfine. The used according to the invention cationic surfactants can furthermore preferably chosen are selected from the group of quaternary ammonium compounds, in particular Benzyltrialkylammoniumchloride or bromides, such as Benzyldimethylstearylammonium chloride, further alkyltrialkylammonium salts, for example, for example, cetyltrimethylammonium chloride or bromide, alkyldimethylhydroxyethylammonium chlorides or bromides, Dialkyldimethylammonium chlorides or bromides, Alkylamidethyltrimethylammoniumethersulfate, Alkylpyridinium salts, for example lauryl or cetylpyrimidinium chloride, Imidazoline derivatives and cationic compounds such as amine oxides, for example, alkyldimethylamine oxides or alkylaminoethyldimethylamine oxides. Cetyltrimethylammonium salts are particularly advantageous to use.

C. Amphoteric surfactants

• 1. Acyl-/dialkylethylendiamin, beispielsweise Natriumacylamphoacetat, Dinatriumacylamphodipropionat, Dinatriumalkylamphodiacetat, Natriumacylamphohydroxypropylsulfonat, Dinatriumacylamphodiacetat und Natriumacylamphopropionat,
• 2. N-Alkylaminosäuren, beispielsweise Aminopropylalkylglutamid, Alkylaminopropionsäure, Natriumalkylimidodipropionat und Lauroamphocarboxyglycinat.

Advantageously used amphoteric surfactants

• 1. acyl / dialkylethylenediamine, for example sodium acylamphoacetate, disodium acylamphodipropionate, disodium alkylamphodiacetate, sodium acylamphohydroxypropylsulfonate, disodium acylamphodiacetate and sodium acylamphopropionate,
• 2. N-alkylamino acids, for example aminopropylalkylglutamide, alkylaminopropionic acid, sodium alkylimidodipropionate and lauroamphocarboxyglycinate.

D. Nonionic surfactants

• 1. Alkohole,
• 2. Alkanolamide, wie Cocamide MEA/DEA/MIPA,
• 3. Aminoxide, wie Cocoamidopropylaminoxid,
• 4. Ester, die durch Veresterung von Carbonsäuren mit Ethylenoxid, Glycerin, Sorbitan oder anderen Alkoholen entstehen,
• 5. Ether, beispielsweise ethoxylierte/propoxylierte Alkohole, ethoxylierte/propoxylierte Ester, ethoxylierte/propoxylierte Glycerinester, ethoxylierte/propoxylierte Cholesterine, ethoxylierte/propoxylierte Triglyceridester, ethoxyliertes propoxyliertes Lanolin, ethoxylierte/propoxylierte Polysiloxane, propoxylierte POE-Ether und Alkylpolyglycoside wie Laurylglucosid, Decylglycosid und Cocoglycosid.
• 6. Sucroseester, -Ether
• 7 Polyglycerinester, Diglycerinester, Monoglycerinester
• 8. Methylglucosester, Ester von Hydroxysäuren

Advantageously used nonionic surfactants are

• 1. Alcohols,
• 2. alkanolamides, such as cocamide MEA / DEA / MIPA,
• 3. amine oxides, such as cocoamidopropylamine oxide,
• 4. Esters formed by esterification of carboxylic acids with ethylene oxide, glycerol, sorbitan or other alcohols,
• 5. Ethers, for example ethoxylated / propoxylated alcohols, ethoxylated / propoxylated esters, ethoxylated / propoxylated glycerol esters, ethoxylated / propoxylated cholesterols, ethoxylated / propoxylated triglyceride esters, ethoxylated propoxylated lanolin, ethoxylated / propoxylated polysiloxanes, propoxylated POE ethers and alkyl polyglycosides such as lauryl glucoside, decyl glycoside and cocoglycoside.
• 6. sucrose ester, ether
• 7 polyglycerol esters, diglycerol esters, monoglycerol esters
• 8. Methyl glucose esters, esters of hydroxy acids

Advantageous is also the use of a combination of anionic and / or amphoteric surfactants with one or more non-ionic surfactants.

The surfactants Substance can in a concentration between 1 and 95 wt .-% in the inventive preparations present, based on the total weight of the preparations.

• – Mineralöle, Mineralwachse
• – Öle, wie Triglyceride der Caprin- oder der Caprylsäure, ferner natürliche Öle wie z.B. Rizinusöl;
• – Fette, Wachse und andere natürliche und synthetische Fettkörper, vorzugsweise Ester von Fettsäuren mit Alkoholen niedriger C-Zahl, z.B. mit Isopropanol, Propylenglykol oder Glycerin, oder Ester von Fettalkoholen mit Alkansäuren niedriger C-Zahl oder mit Fettsäuren;
• – Alkylbenzoate;
• – Silikonöle wie Dimethylpolysiloxane, Diethylpolysiloxane, Diphenylpolysiloxane sowie Mischformen daraus.

The lipid phase of the cosmetic or dermatological emulsions according to the invention can advantageously be selected from the following substance group:

• - mineral oils, mineral waxes
• - Oils such as triglycerides of capric or caprylic acid, further natural oils such as castor oil;
• Fats, waxes and other natural and synthetic fatty substances, preferably esters of fatty acids with lower C-number alcohols, for example with isopropanol, propylene glycol or glycerol, or esters of fatty alcohols with lower C-number alkanoic acids or with fatty acids;
• - alkyl benzoates;
• - Silicone oils such as dimethylpolysiloxanes, diethylpolysiloxanes, diphenylpolysiloxanes and mixed forms thereof.

The oil phase of Emulsions according to the present invention Invention is chosen advantageously from the group of saturated esters and / or unsaturated, branched and / or unbranched alkanecarboxylic acids of a chain length of 3 to 30 carbon atoms and saturated and / or unsaturated, branched and / or unbranched alcohols of a chain length of 3 to 30 carbon atoms, from the group of esters of aromatic carboxylic acids and saturated and / or unsaturated, branched and / or unbranched alcohols of a chain length of 3 to 30 carbon atoms. Such ester oils can then chosen advantageous are from the group isopropyl myristate, isopropyl palmitate, isopropyl stearate, Isopropyl oleate, n-butyl stearate, n-hexyl laurate, n-decyl oleate, isooctyl stearate, isononyl stearate, Isononyl isononanoate, 2-ethylhexyl palmitate, 2-ethylhexyl laurate, 2-hexyldecyl stearate, 2-octyl dodecyl palmitate, oleyl oleate, oleyl erucate, erucyl oleate, erucyl erucate as well as synthetic, semi-synthetic and natural mixtures of such esters, e.g. Jojoba oil.

Further can the oil phase chosen favorably are from the group of branched and unbranched hydrocarbons and waxes, the silicone oils, the dialkyl ether, the group of saturated or unsaturated, branched or unbranched alcohols, as well as the fatty acid triglycerides, namely the triglycerol esters of saturated and / or unsaturated branched and / or unbranched alkanecarboxylic acids of a chain length of 8 to 24, in particular 12 to 18 C-atoms. The fatty acid triglycerides can for example, advantageously chosen are selected from the group of synthetic, semi-synthetic and natural oils, e.g. Olive oil, Sunflower oil, Soybean oil, Peanut oil, Rapeseed oil, Almond oil, Palm oil, Coconut oil, Palm kernel oil and more.

Also any mixtures of such oil and wax components are advantageous in the sense of the present Use invention. It may also be advantageous if Waxes, for example cetyl palmitate, as the sole lipid component the oil phase use.

The oil phase is advantageously selected from the group 2-ethylhexyl isostearate, octyldodecanol, isotridecyl isononanoate, isoeicosane, 2-ethylhexyl cocoate, C _12-15 -alkyl benzoate, caprylic-capric triglyceride, dicaprylyl ether.

Particularly advantageous are mixtures of C _12-15 -alkyl benzoate and 2-ethylhexyl isostearate, mixtures of C _12-15 -alkyl benzoate and isotridecyl isononanoate and mixtures of C _12-15 -alkyl benzoate, 2-ethylhexyl isostearate and isotridecyl isononanoate.

From The hydrocarbons are paraffin oil, squalane and squalene advantageous to be used in the sense of the present invention.

Advantageously, the oil phase may further comprise a content of cyclic or linear silicone oils or consist entirely of such oils, although it is preferred to use an additional content of other oil phase components in addition to the silicone oil or silicone oils. Such silicones or silicone oils may be present as monomers, which are typically characterized by structural elements, as follows:

wobei die Siliciumatome mit gleichen oder unterschiedlichen Alkylresten und/oder Arylresten substituiert werden können, welche hier verallgemeinernd durch die Reste R₁ – R₄ dargestellt sind (will sagen, dass die Anzahl der unterschiedlichen Reste nicht notwendig auf bis zu 4 beschränkt ist). m kann dabei Werte von 2 – 200.000 annehmen.As linear silicones having several siloxy units which are advantageously used according to the invention, they are generally characterized by structural elements as follows:

wherein the silicon atoms can be substituted with identical or different alkyl radicals and / or aryl radicals, which are here generalized by the radicals R ₁ - R ₄ (to say that the number of different radicals is not necessarily limited to 4). m can assume values of 2 - 200,000.

wobei die Siliciumatome mit gleichen oder unterschiedlichen Alkylresten und/oder Arylresten substituiert werden können, welche hier verallgemeinernd durch die Reste R₁ – R₄ dargestellt sind (will sagen, dass die Anzahl der unterschiedlichen Reste nicht notwendig auf bis zu 4 beschränkt ist). n kann dabei Werte von 3/2 bis 20 annehmen. Gebrochene Werte für n berücksichtigen, dass ungeradzahlige Anzahlen von Siloxylgruppen im Zyklus vorhanden sein können.Cyclic silicones which are advantageously used in accordance with the invention are generally characterized by structural elements as follows

wherein the silicon atoms can be substituted with identical or different alkyl radicals and / or aryl radicals, which are here generalized by the radicals R ₁ - R ₄ (to say that the number of different radicals is not necessarily limited to 4). n can assume values of 3/2 to 20. Broken values for n take into account that odd numbers of siloxyl groups may be present in the cycle.

Advantageous For example, cyclomethicone (e.g., decamethylcyclopentasiloxane) is to be used in accordance with the present invention silicone oil used. But other silicone oils are beneficial in the sense of the present invention, for example undecamethylcyclotrisiloxane, Polydimethylsiloxane, poly (methylphenylsiloxane), cetyl dimethicone, Behenoxydimethicone.

Advantageous are also mixtures of cyclomethicone and isotridecyl isononanoate, and those of cyclomethicone and 2-ethylhexyl isostearate.

It but is also beneficial, silicone oils similar constitution as the to select compounds referred to above, the organic side chains derivatized, for example polyethoxylated and / or polypropoxylated are. These include For example, polysiloxane-polyalkyl-polyether copolymers such as Cetyl Dimethicone Copolyol Cetyl Dimethicone Copolyol (and) Polyglyceryl-4-isostearate (and) hexyl laurate)

Especially also advantageous are mixtures of cyclomethicone and isotridecyl isononanoate, from cyclomethicone and 2-ethylhexyl isostearate.

The aqueous Phase of the preparations according to the invention contains optionally advantageous alcohols, diols or polyols lower C number, and their ethers, preferably ethanol, isopropanol, propylene glycol, Glycerol, ethylene glycol, ethylene glycol monoethyl or monobutyl ether, Propylene glycol monomethyl, monoethyl or monobutyl ether, diethylene glycol monomethyl or monoethyl ether and analogous products, furthermore lower alcohols C number, e.g. Ethanol, isopropanol, 1,2-propanediol, glycerin as well in particular one or more thickening agents, which or which chosen favorably can be from the group silicon dioxide, aluminum silicates.

In accordance with the invention, preparations present as emulsions contain, in particular, advantageously or more hydrocolloids. These hydrocolloids can be advantageously selected from the group of gums, polysaccharides, cellulose derivatives, phyllosilicates, polyacrylates and / or other polymers.

Included in the invention as hydrogels present preparations one or more hydrocolloids. These hydrocolloids can advantageously be selected from the aforementioned group.

To counting the gums you plant or tree juices, which harden in the air and resins or extracts from aquatic plants. From this group can be selected advantageously in the context of the present invention for example gum arabic, locust bean gum, tragacanth, karaya, Guar gum, pectin, gellan gum, carrageenan, agar, algine, chondrus, Xanthan gum.

Also advantageous is the use of derivatized gums such as hydroxypropyl guar ( ^Jaguar® HP 8).

Under the polysaccharides and derivatives are e.g. Hyaluronic acid, chitin and chitosan, chondroitin sulfates, starch and starch derivatives.

Under the cellulose derivatives are e.g. Methylcellulose, carboxymethylcellulose, Hydroxyethylcellulose, hydroxypropylmethylcellulose.

The phyllosilicates include naturally occurring and synthetic clays such as montmorillonite, bentonite, hectorite, laponite, magnesium aluminum silicates such as Veegum ^®. These can be used as such or in modified form, such as stearylalkonium hectorites.

Farther can also advantageous silica gel be used.

Under the polyacrylates are e.g. Carbopol types of the company Goodrich (Carbopol 980, 981, 1382, 5984, 2984, EDT 2001 or Pemulen TR2).

Under the polymers are e.g. Polyacrylamide (Seppigel 305), Polyvinyl alcohols, PVP, PVP / VA copolymers, polyglycols.

Included in the invention emulsions present as emulsions one or more emulsifiers. These emulsifiers can chosen favorably are from the group of nonionic, anionic, cationic or amphoteric emulsifiers.

• a) Partialfettsäureester und Fettsäureester mehrwertiger Alkohole und deren ethoxylierte Derivate (z. B. Glycerylmonostearate, Sorbitanstearate, Glycerylstearylcitrate, Sucrosestearate)
• b) ethoxylierte Fettalkohole und Fettsäuren
• c) ethoxylierte Fettamine, Fettsäureamide, Fettsäurealkanolamide
• d) Alkylphenolpolyglycolether (z.B. Triton X)

Among the nonionic emulsifiers are

• a) Partial fatty acid esters and fatty acid esters of polyhydric alcohols and their ethoxylated derivatives (eg glyceryl monostearates, sorbitan stearates, glyceryl stearyl citrates, sucrose stearates)
• b) ethoxylated fatty alcohols and fatty acids
• c) ethoxylated fatty amines, fatty acid amides, fatty acid alkanolamides
• d) alkylphenol polyglycol ethers (eg Triton X)

• a) Seifen (z. B. Natriumstearat)
• b) Fettalkoholsulfate
• c) Mono-, Di- und Trialkylphosphosäureester und deren Ethoxylate

Among the anionic emulsifiers are

• a) soaps (eg sodium stearate)
• b) fatty alcohol sulfates
• c) mono-, di- and Trialkylphosphosäureester and their ethoxylates

• a) quaternäre Ammoniumverbindungen mit einem langkettigen aliphatischen Rest z.B. Distearyldimonium Chloride

Among the cationic emulsifiers are

• a) quaternary ammonium compounds with a long-chain aliphatic radical, for example distearyl dimonium chlorides

• a) Alkylamininoalkancarbonsäuren
• b) Betaine, Sulfobetaine
• c) Imidazolinderivate

Among the amphoteric emulsifiers are

• a) Alkylamininoalkanecarboxylic acids
• b) betaines, sulfobetaines
• c) imidazoline derivatives

Farther there are of course occurring emulsifiers, which include beeswax, wool wax, lecithin and Sterols belong.

• – der Fettalkoholethoxylate
• – der ethoxylierten Wollwachsalkohole,
• – der Polyethylenglycolether der allgemeinen Formel R-O-(-CH₂-CH₂-O-)_n-R',
• – der Fettsäureethoxylate der allgemeinen Formel R-COO-(-CH₂-CH₂-O-)_n-H,
• – der veretherten Fettsäureethoxylate der allgemeinen Formel R-COO-(-CH₂-CH₂-O-)_n-R',
• – der veresterten Fettsäureethoxylate der allgemeinen Formel R-COO-(-CH₂-CH₂-O-)_n-C(O)-R',
• – der Polyethylenglycolglycerinfettsäureester
• – der ethoxylierten Sorbitanester
• – der Cholesterinethoxylate
• – der ethoxylierten Triglyceride
• – der Alkylethercarbonsäuren der allgemeinen Formel R-O-(-CH₂-CH₂-O-)_n-CH₂-COOH nd n eine Zahl von 5 bis 30 darstellen,
• – der Polyoxyethylensorbitolfettsäureester,
• – der Alkylethersulfate der allgemeinen Formel R-O-(-CH₂-CH₂-O-)_n-SO₃-H
• – der Fettalkoholpropoxylate der allgemeinen Formel R-O-(-CH₂-CH(CH₃)-O-)_n-H,
• – der Polypropylenglycolether der allgemeinen Formel R-O-(-CH₂-CH(CH₃)-O-)_n-R',
• – der propoxylierten Wollwachsalkohole,
• – der veretherten Fettsäurepropoxylate R-COO-(-CH₂-CH(CH₃)-O-)_n-R',
• – der veresterten Fettsäurepropoxylate der allgemeinen Formel R-COO-(-CH₂-CH(CH₃)-O-)_n-C(O)-R',
• – der Fettsäurepropoxylate der allgemeinen Formel R-COO-(-CH₂-CH(CH₃)-O-)_n-H,
• – der Polypropylenglycolglycerinfettsäureester
• – der propoxylierten Sorbitanester
• – der Cholesterinpropoxylate
• – der propoxylierten Triglyceride
• – der Alkylethercarbonsäuren der allgemeinen Formel R-O-(-CH₂-CH(CH₃)O-)_n-CH₂-COOH
• – der Alkylethersulfate bzw. die diesen Sulfaten zugrunde liegenden Säuren der allgemeinen Formel R-O-(-CH₂-CH(CH₃)-O-)_n-SO₃-H
• – der Fettalkoholethoxylate/propoxylate der allgemeinen Formel R-O-X_n-Y_m-H,
• – der Polypropylenglycolether der allgemeinen Formel R-O-X_n-Y_m-R',
• – der veretherten Fettsäurepropoxylate der allgemeinen Formel R-COO-X_n-Y_m-R',
• – der Fettsäureethoxylate/propoxylate der allgemeinen Formel R-COO-X_n-Y_m-H,.

For example, O / W emulsifiers can be advantageously selected from the group of polyethoxylated or polypropoxylated or polyethoxylated and polypropoxylated products, for example:

• - the fatty alcohol ethoxylates
• - the ethoxylated wool wax alcohols,
• The polyethylene glycol ether of the general formula RO - (- CH ₂ -CH ₂ -O-) _n -R ',
• The fatty acid ethoxylates of the general formula R-COO - (- CH ₂ -CH ₂ -O-) _n -H,
• The etherified fatty acid ethoxylates of the general formula R-COO - (- CH ₂ -CH ₂ -O-) _n -R ',
• - the esterified fatty acid ethoxylates of the general formula R-COO - (- CH ₂ -CH ₂ -O-) _n -C (O) -R ',
• - The Polyethylenglycolglycerinfettsäureester
• - the ethoxylated sorbitan ester
• - the cholesterol ethoxylates
• - the ethoxylated triglycerides
• The alkyl ether carboxylic acids of the general formula RO - (- CH ₂ -CH ₂ -O-) _n -CH ₂ -COOH nd n represent a number from 5 to 30,
• The polyoxyethylene sorbitol fatty acid ester,
• The alkyl ether sulfates of the general formula RO - (- CH ₂ -CH ₂ -O-) _n -SO ₃ -H
• The fatty alcohol propoxylates of the general formula RO - (- CH ₂ -CH (CH ₃ ) -O-) _n -H,
• The polypropylene glycol ether of the general formula RO - (- CH ₂ -CH (CH ₃ ) -O-) _n -R ',
• The propoxylated wool wax alcohols,
• - the etherified fatty acid propoxylates R-COO - (- CH ₂ -CH (CH ₃ ) -O-) _n -R ',
• - the esterified fatty acid propoxylates of the general formula R-COO - (- CH ₂ -CH (CH ₃ ) -O-) _n -C (O) -R ',
• The fatty acid propoxylates of the general formula R-COO - (- CH ₂ -CH (CH ₃ ) -O-) _n -H,
• The polypropylene glycol glycerin fatty acid ester
• - the propoxylated sorbitan ester
• - the cholesterol propoxylates
• - the propoxylated triglycerides
• - The alkyl ether carboxylic acids of the general formula RO - (- CH ₂ -CH (CH ₃ ) O-) _n -CH ₂ -COOH
• - The alkyl ether sulfates or these sulfates underlying acids of the general formula RO - (- CH ₂ -CH (CH ₃ ) -O-) _n -SO ₃ -H
• The fatty alcohol ethoxylates / propoxylates of the general formula ROX _n -Y _m -H,
• The polypropylene glycol ether of the general formula ROX _n -Y _m -R ',
• - etherified fatty acid propoxylates of the general formula R-COO-X _n -Y _m -R ',
• - The fatty acid ethoxylates / propoxylates of the general formula R-COO-X _n -Y _m -H ,.

Particularly according to the invention The polyethoxylated or polypropoxylated used are advantageous or polyethoxylated and polypropoxylated O / W / emulsifiers selected from the group of substances with HLB values of 11-18, very particularly advantageous with HLB values of 14.5-15.5, provided that the O / W emulsifiers saturated Radicals R and R 'have. Do the O / W emulsifiers have unsaturated Radicals R and / or R ', or are Isoalkylderivate, so the preferred HLB value such emulsifiers are also lower or higher.

It is advantageous to choose the fatty alcohol ethoxylates from the group of ethoxylated stearyl alcohols, cetyl alcohols, cetylstearyl alcohols (cetearyl alcohols). Particularly preferred are:
Polyethylene glycol (13) stearyl ether (steareth-13), polyethylene glycol (14) stearyl ether (steareth-14), polyethylene glycol (15) stearyl ether (steareth-15), polyethylene glycol (16) stearyl ether (steareth-16), polyethylene glycol (17) stearyl ether ( Steareth-17), polyethylene glycol (18) stearyl ether (steareth-18), polyethylene glycol (19) stearyl ether (steareth-19-), polyethylene glycol (20) stearyl ether (steareth-20),
Polyethylene glycol (12) isostearyl ether (isosteareth-12), polyethylene glycol (13) isostearyl ether (isosteareth-13), polyethylene glycol (14) isostearyl ether (isosteareth-14), polyethylene glycol (15) isostearyl ether (isosteareth-15), polyethylene glycol (16) isostearyl ether ( Isosteareth-16), polyethylene glycol (17) isostearyl ether (isosteareth-17), polyethylene glycol (18) isostearyl ether (isosteareth-18), polyethylene glycol (19) isostearyl ether (isosteareth-19), polyethylene glycol (20) isostearyl ether (isosteareth-20),
Polyethylene glycol (13) Cetyl ether (Ceteth-13), Polyethylene glycol (14) Cetyl ether (Ceteth-14), Polyethylene glycol (15) Cetyl ether (Ceteth-15), Polyethylene glycol (16) Cetyl ether (Ceteth-16), Polyethylene glycol (17) Cetyl ether ( Ceteth-17), polyethylene glycol (18) cetyl ether (ceteth-18), polyethylene glycol (19) cetyl ether (ceteth-19), polyethylene glycol (20) cetyl ether (ceteth-20),
Polyethylene glycol (13) isocetyl ether (isoceteth-13), polyethylene glycol (14) isocetyl ether (isoceteth-14), polyethylene glycol (15) isocetyl ether (isoceteth-15), polyethylene glycol (16) isocetyl ether (isoceteth-16), polyethylene glycol (17) isocetyl ether ( Isoceteth-17), polyethylene glycol (18) isocetyl ether (isoceteth-18), polyethylene glycol (19) isocetyl ether (isoceteth-19), polyethylene glycol (20) isocetyl ether (isoceteth-20),
Polyethylene glycol (12) oleyl ether (Oleth-12), polyethylene glycol (13) oleyl ether (Oleth-13), polyethylene glycol (14) oleyl ether (Oleth-14), polyethylene glycol (15) oleyl ether (Oleth-15),
Polyethylene glycol (12) lauryl ether (Laureth-12), polyethylene glycol (12) isolauryl ether (Isolaureth-12).
Polyethylene glycol (13) cetyl stearyl ether (ceteareth-13), polyethylene glycol (14) cetyl stearyl ether (ceteareth-14), polyethylene glycol (15) cetyl stearyl ether (ceteareth-15), polyethylene glycol (16) cetyl stearyl ether (ceteareth-16), polyethylene glycol (17) cetyl stearyl ether ( Ceteareth-17), polyethylene glycol (18) cetyl stearyl ether (ceteareth-18), polyethylene glycol (19) cetyl stearyl ether (ceteareth-19), polyethylene glycol (20) cetyl stearyl ether (ceteareth-20),

It is also advantageous to choose the fatty acid ethoxylates from the following group:
Polyethylene glycol (20) stearate, polyethylene glycol (21) stearate, polyethylene glycol (22) stearate, polyethylene glycol (23) stearate, polyethylene glycol (24) stearate, polyethylene glycol (25) stearate,
Polyethylene glycol (12) isostearate, polyethylene glycol (13) isostearate, polyethylene glycol (14) isostearate, polyethylene glycol (15) isostearate, polyethylene glycol (16) isostearate, polyethylene glycol (17) isostearate, polyethylene glycol (18) isostearate, polyethylene glycol (19) isostearate, polyethylene glycol (20) isostearate, polyethylene glycol (21) isostearate, polyethylene glycol (22) isostearate, polyethylene glycol (23) isostearate, polyethylene glycol (24) isostearate, polyethylene glycol (25) isostearate,
Polyethylene glycol (12) oleate, polyethylene glycol (13) oleate, polyethylene glycol (14) oleate, polyethylene glycol (15) oleate, polyethylene glycol (16) oleate, polyethylene glycol (17) oleate, polyethylene glycol (18) oleate, polyethylene glycol (19) oleate, polyethylene glycol ( 20) oleate

When ethoxylated alkyl ether carboxylic acid or its salt may advantageously be the sodium laureth-11-carboxylate be used.

When Alkyl ether sulfate can be advantageously used sodium laureth 1-4 sulfate become.

When Ethoxylated cholesterol derivative may advantageously be polyethylene glycol (30) cholesteryl ether be used. Also, polyethylene glycol (25) sojasterol has become proven.

When ethoxylated triglycerides can Advantageously, the Polyethylene Glycol (60) Evening Primrose Glycerides is used become (Evening Primrose = evening primrose)

Farther is advantageous, the Polyethylenglycolglycerinfettsäureester from the group polyethylene glycol (20) glyceryl laurate, polyethylene glycol (21) glyceryl laurate, Polyethylene glycol (22) glyceryl laurate, polyethylene glycol (23) glyceryl laurate, Polyethylene glycol (6) glyceryl caprate / caprinate, polyethylene glycol (20) glyceryl oleate, Polyethylene glycol (20) glyceryl isostearate, polyethylene glycol (18) glyceryl oleate / cocoate to choose.

It is also cheap the sorbitan esters from the group polyethylene glycol (20) sorbitan monolaurate, polyethylene glycol (20) sorbitan monostearate, Polyethylene glycol (20) sorbitan monoisostearate, polyethylene glycol (20) sorbitan monopalmitate, Polyethylene glycol (20) to choose sorbitan monooleate.

When advantageous W / O emulsifiers can be used: fatty alcohols having 8 to 30 carbon atoms, Monoglycerol ester saturated and / or unsaturated, branched and / or unbranched alkanecarboxylic acids of a chain length of 8 to 24, in particular 12 to 18 C atoms, diglycerol esters saturated and / or unsaturated, branched and / or unbranched alkanecarboxylic acids of a chain length of 8 to 24, in particular 12 to 18 C atoms, monoglycerol ether saturated and / or unsaturated, branched and / or unbranched alcohols of a chain length of 8 to 24, in particular 12 to 18 C atoms, diglycerol ether saturated and / or unsaturated, branched and / or unbranched alcohols of a chain length of 8 to 24, especially 12 - 18 C atoms, propylene glycol esters of saturated and / or unsaturated, branched and / or unbranched alkanecarboxylic acids of a chain length of 8 to 24, in particular 12 to 18 C atoms and saturated sorbitan esters and / or unsaturated, branched and / or unbranched alkanecarboxylic acids of a chain length of 8 to 24, in particular 12 to 18 C-atoms.

Especially advantageous W / O emulsifiers are glyceryl monostearate, glyceryl monoisostearate, Glyceryl monomyristate, glyceryl monooleate, diglyceryl monostearate, Diglyceryl monoisostearate, propylene glycol monostearate, propylene glycol monoisostearate, Propylene glycol monocaprylate, propylene glycol monolaurate, sorbitan monoisostearate, Sorbitan monolaurate, sorbitan monocaprylate, sorbitan monoisooleate, Sucrose distearate, cetyl alcohol, stearyl alcohol, arachidyl alcohol, Behenyl alcohol, isobehenyl alcohol, selachyl alcohol, chimyl alcohol, Polyethylene glycol (2) stearyl ether (steareth-2), glyceryl monolaurate, Glyceryl monocaprinate, glyceryl monocaprylate.

It is in all this possible in individual cases that the aforementioned Concentration data slightly over- or be fallen below and still be obtained according to the invention preparations. This comes in the face of the wide variety of suitable Components of such preparations are not unexpected to the person skilled in the art, so he knows that such over- or underruns the soil of the present invention is not will leave.

The The following examples are intended to illustrate the present invention, without restricting it. The Numerical values in the examples mean percentages by weight on the total weight of the respective preparations.

Examples:

When leghaemoglobin was recombinantly produced soybean leghemoglobin a (Lba) was used (manufacturing instructions, s. Hargrove et al., 1997), as hemoglobin from rice the recombinant Hb1 molecule was used (manufacturing instructions s. Arredondo-Peter et al., 1997). The Perfluorcarbonverbindungen Perfluordecalin (CAS number 306-94-5) and perfluorotributylamine (CAS number 101182-89-2) are about To obtain Sigma (Seelze, Germany).

hair treatments

hair conditioners

Spray Conditioner

Leave-on conditioner

Conditioner shampoo with pearlescent

• The pH is adjusted to 6.

Clear conditioner shampoo

• The pH is adjusted to 6.

Clear light shampoo with volume effect

• The pH is adjusted to 5.5.

hair lotions

Claims (7)

Use of cosmetic and / or dermatological Preparations containing oxygen carriers selected from the group of phytohemoglobins and / or synthetic perfluorocarbon compounds (PFC) as oxygen carriers, the are emulsified and stabilized with lecithin and other lipids to improve the oxygenation of the hair follicle. Use according to claim 1 for improvement the oxygen supply and the energy metabolism of the hair follicle. Use according to at least one of the preceding claims characterized in that the phytohemoglobins are chosen from the group of soybean leghemoglobins, hemoglobins from rice, barley and / or Parasponia, as well as the Arabidopsis hemoglobins Hb1, Hb2 and / or Hb3. Use according to at least one of the preceding claims characterized in that the synthetic perfluorocarbon compounds chosen are selected from the group perfluorodecalin, perfluorotributylamine, perfluorooctylbromide, Perfluorotripropylamine, perfluorohexylethene, perfluorobutylethene, fluoromethylcyclohexylpiperidine, Fluoromethyldecahydroisoquinoline, fluoromethyladamantane and / or perfluorodichlorooctane. Use according to at least one of the preceding claims characterized in that the oxygen carriers in a concentration from 0.001 to 15% by weight, especially from 0.01 to 5% by weight and most preferably in a concentration of 0.1 to 2% by weight, be used based on the total weight of the preparation. Use according to at least one of the preceding claims characterized in that the preparation additionally contains lipophilic antioxidants, particularly preferably tocopherol or its derivatives, such as, for example, 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid, 2,6-di-tert-butyl-4-methylphenol, gamma-oryzanol, flavonoids are included. Use according to at least one of the preceding claims characterized in that the water content of the preparation more is 70% by weight and additionally Cyclodextrins are included.