DE10193213T1 - analytical tool - Google Patents

analytical tool Download PDF

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Publication number
DE10193213T1
DE10193213T1 DE10193213T DE10193213T DE10193213T1 DE 10193213 T1 DE10193213 T1 DE 10193213T1 DE 10193213 T DE10193213 T DE 10193213T DE 10193213 T DE10193213 T DE 10193213T DE 10193213 T1 DE10193213 T1 DE 10193213T1
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instrument according
analytical instrument
capillary
substrate
sample chamber
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Granted
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DE10193213T
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German (de)
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DE10193213T8 (en
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wird später genannt werden Erfinder
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Arkray Inc
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Arkray Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/150022—Source of blood for capillary blood or interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150053—Details for enhanced collection of blood or interstitial fluid at the sample site, e.g. by applying compression, heat, vibration, ultrasound, suction or vacuum to tissue; for reduction of pain or discomfort; Skin piercing elements, e.g. blades, needles, lancets or canulas, with adjustable piercing speed
    • A61B5/150061—Means for enhancing collection
    • A61B5/150099—Means for enhancing collection by negative pressure, other than vacuum extraction into a syringe by pulling on the piston rod or into pre-evacuated tubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150221—Valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150358—Strips for collecting blood, e.g. absorbent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15101—Details
    • A61B5/15115—Driving means for propelling the piercing element to pierce the skin, e.g. comprising mechanisms based on shape memory alloys, magnetism, solenoids, piezoelectric effect, biased elements, resilient elements, vacuum or compressed fluids
    • A61B5/15117—Driving means for propelling the piercing element to pierce the skin, e.g. comprising mechanisms based on shape memory alloys, magnetism, solenoids, piezoelectric effect, biased elements, resilient elements, vacuum or compressed fluids comprising biased elements, resilient elements or a spring, e.g. a helical spring, leaf spring, or elastic strap
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15101—Details
    • A61B5/15115—Driving means for propelling the piercing element to pierce the skin, e.g. comprising mechanisms based on shape memory alloys, magnetism, solenoids, piezoelectric effect, biased elements, resilient elements, vacuum or compressed fluids
    • A61B5/15123—Driving means for propelling the piercing element to pierce the skin, e.g. comprising mechanisms based on shape memory alloys, magnetism, solenoids, piezoelectric effect, biased elements, resilient elements, vacuum or compressed fluids comprising magnets or solenoids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15186—Devices loaded with a single lancet, i.e. a single lancet with or without a casing is loaded into a reusable drive device and then discarded after use; drive devices reloadable for multiple use
    • A61B5/15188—Constructional features of reusable driving devices
    • A61B5/1519—Constructional features of reusable driving devices comprising driving means, e.g. a spring, for propelling the piercing unit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15186—Devices loaded with a single lancet, i.e. a single lancet with or without a casing is loaded into a reusable drive device and then discarded after use; drive devices reloadable for multiple use
    • A61B5/15188—Constructional features of reusable driving devices
    • A61B5/15192—Constructional features of reusable driving devices comprising driving means, e.g. a spring, for retracting the lancet unit into the driving device housing
    • A61B5/15194—Constructional features of reusable driving devices comprising driving means, e.g. a spring, for retracting the lancet unit into the driving device housing fully automatically retracted, i.e. the retraction does not require a deliberate action by the user, e.g. by terminating the contact with the patient's skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/157—Devices characterised by integrated means for measuring characteristics of blood
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0825—Test strips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/10—Means to control humidity and/or other gases
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3272—Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Optics & Photonics (AREA)
  • Manufacturing & Machinery (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

Analyseinstrument, mit: einem Substrat (1); einer Vielzahl von Elektroden (11, 12, 13) auf dem Substrat; einer Abdeckung (2); Abstandsmitteln (3), die zwischen dem Substrat und der Abdeckung angeordnet sind, wobei die Abstandsmittel (3) untereinander beabstandete Abschnitte aufweisen; und einer Probenkammer (4, 5), die oben und unten zwischen der Abdeckung (2) und dem Substrat (1) und seitlich zwischen den untereinander beabstandeten Abschnitten der Abstandsmittel (3) definiert ist; wobei die Probenkammer (4, 5) eine Kapillare (5) und einen Flüssigkeitssammelabschnitt (4) mit gekrümmten Seitenwänden aufweist, der mit der Kapillare (5) in Verbindung ist und einen Abschnitt aufweist, der breiter als die Kapillare (5) ist.Analytical instrument, comprising: a substrate (1); a plurality of electrodes (11, 12, 13) on the substrate; a cover (2); Spacer means (3) disposed between the substrate and the cover, the spacer means (3) having spaced apart portions; and a sample chamber (4, 5) defined above and below between the cover (2) and the substrate (1) and laterally between the spaced-apart portions of the spacer means (3); the sample chamber (4, 5) having a capillary (5) and a liquid collecting section (4) with curved side walls communicating with the capillary (5) and having a portion which is wider than the capillary (5).

Claims (23)

Analyseinstrument, mit: einem Substrat (1); einer Vielzahl von Elektroden (11, 12, 13) auf dem Substrat; einer Abdeckung (2); Abstandsmitteln (3), die zwischen dem Substrat und der Abdeckung angeordnet sind, wobei die Abstandsmittel (3) untereinander beabstandete Abschnitte aufweisen; und einer Probenkammer (4, 5), die oben und unten zwischen der Abdeckung (2) und dem Substrat (1) und seitlich zwischen den untereinander beabstandeten Abschnitten der Abstandsmittel (3) definiert ist; wobei die Probenkammer (4, 5) eine Kapillare (5) und einen Flüssigkeitssammelabschnitt (4) mit gekrümmten Seitenwänden aufweist, der mit der Kapillare (5) in Verbindung ist und einen Abschnitt aufweist, der breiter als die Kapillare (5) ist.Analytical instrument, comprising: a substrate ( 1 ); a plurality of electrodes ( 11 . 12 . 13 ) on the substrate; a cover ( 2 ); Distance means ( 3 ), which are arranged between the substrate and the cover, wherein the spacing means ( 3 ) have mutually spaced sections; and a sample chamber ( 4 . 5 ), the top and bottom between the cover ( 2 ) and the substrate ( 1 ) and laterally between the spaced-apart portions of the spacer means (FIG. 3 ) is defined; the sample chamber ( 4 . 5 ) a capillary ( 5 ) and a liquid collecting section ( 4 ) having curved sidewalls which communicates with the capillary ( 5 ) and has a portion which is wider than the capillary ( 5 ). Analyseinstrument nach Anspruch 1, bei dem das Substrat (1) oder die Abdeckung (2) mit einer Aussparung ausgebildet ist, die eine Öffnung für den Flüssigkeitssammelabschnitt (4) der Probenkammer definiert.Analytical instrument according to Claim 1, in which the substrate ( 1 ) or the cover ( 2 ) is formed with a recess which has an opening for the liquid collecting section (FIG. 4 ) of the sample chamber defined. Analyseinstrument nach Anspruch 1 oder 2, bei dem die gekrümmten Seitenwände des Flüssigkeitssammelabschnitts durch das Abstandsmittel definiert sind.Analytical instrument according to claim 1 or 2, wherein the curved side walls of the liquid collecting portion are defined by the spacer means. Analyseinstrument nach Anspruch 2 oder Anspruch 3, wenn abhängig von Anspruch 2, bei dem die gekrümmten Seitenwände des Flüssigkeitssammelabschnitts entlang der Aussparung gekrümmt sind.Analytical instrument according to claim 2 or claim 3, when dependent on claim 2, wherein the curved side walls of the liquid collecting section are curved along the recess. Analyseinstrument nach einem der Ansprüche 1 bis 4, bei dem sich die gekrümmten Seitenwände des Flüssigkeitssammelabschnitts (4) von der Kapillare (5) auf eine konkave Weise erstrecken, um den Abschnitt zu definieren, der breiter als die Kapillare ist.Analytical instrument according to one of claims 1 to 4, wherein the curved side walls of the liquid collecting portion ( 4 ) from the capillary ( 5 ) in a concave manner to define the portion that is wider than the capillary. Analyseinstrument nach einem der Ansprüche 1 bis 5, bei dem eine Breite der Probenkammer in dem Flüssigkeitssammelabschnitt (4) abnimmt und in der Kapillare (5) im Wesentlichen unverändert ist.Analytical instrument according to one of claims 1 to 5, wherein a width of the sample chamber in the liquid collecting section ( 4 ) and in the capillary ( 5 ) is essentially unchanged. Analyseinstrument nach einem der Ansprüche 1 bis 6, bei dem die Probenkammer (4, 5) bei einer Überschneidung des Flüssigkeitssammelabschnitts (4) und der Kapillare (5) einen winkligen Übergangsabschnitt aufweist.Analytical instrument according to one of Claims 1 to 6, in which the sample chamber ( 4 . 5 ) at an intersection of the liquid collecting section ( 4 ) and the capillary ( 5 ) has an angled transition section. Analyseinstrument nach einem der vorstehenden Ansprüche, bei dem die Abdeckung (2) einen transparenten oder lichtdurchlässigen Abschnitt aufweist.Analysis instrument according to one of the preceding claims, in which the cover ( 2 ) has a transparent or translucent portion. Analyseinstrument nach einem der vorstehenden Ansprüche, bei dem mindestens eine der Flächen des Substrats oder der Abdeckung, die den Flüssigkeitssammelabschnitt (4) definieren, eine Benetzbarkeit von nicht weniger als 57 mN/m aufweisen.Analytical instrument according to one of the preceding claims, in which at least one of the surfaces of the substrate or the cover covering the liquid collecting section ( 4 ) have a wettability of not less than 57 mN / m. Analyseinstrument nach einem der vorstehenden Ansprüche, bei dem die Kapillare (5) der Probenkammer eine Belüftung aufweist.Analytical instrument according to one of the preceding claims, in which the capillary ( 5 ) of the sample chamber has a ventilation. Analyseinstrument nach einem der vorstehenden Ansprüche, bei dem die Abmessungen der Probenkammer (4, 5) für in die Kapillare (5) durch Kapillarwirkung einzuziehendes Blut geeignet sind.Analytical instrument according to one of the preceding claims, in which the dimensions of the sample chamber ( 4 . 5 ) for into the capillary ( 5 ) are suitable for use by capillary action. Analyseinstrument nach einem der vorstehenden Ansprüche, bei dem die Innenfläche des Substrats (1) oder der Abdeckung (2) im Wesentlichen glatt ist.Analytical instrument according to one of the preceding claims, in which the inner surface of the substrate ( 1 ) or the cover ( 2 ) is substantially smooth. Analyseinstrument nach Anspruch 12, bei dem die Innenflächen des Substrats (1), der Abdeckung (2) und des Abstandsmittels (3) im Wesentlichen glatt sind.Analytical instrument according to Claim 12, in which the inner surfaces of the substrate ( 1 ), the cover ( 2 ) and the spacing agent ( 3 ) are substantially smooth. Analyseinstrument nach einem der vorstehenden Ansprüche, bei dem eine Öffnung an der Kante der Probenkammer (4, 5) als eine Probeneinführöffnung dient.Analytical instrument according to one of the preceding claims, wherein an opening at the edge of the sample chamber ( 4 . 5 ) serves as a sample introduction port. Analyseinstrument nach einem der vorstehenden Ansprüche, bei dem die Kanten des Substrats (1) und der Abdeckung (2) angrenzend an eine Öffnung der Kammer (4, 5) im Wesentlichen zueinander ausgerichtet sind.Analysis instrument according to one of the preceding claims, in which the edges of the substrate ( 1 ) and the cover ( 2 ) adjacent to an opening of the chamber ( 4 . 5 ) are substantially aligned with each other. Analyseinstrument nach einem der vorstehenden Ansprüche, bei dem die Abdeckung (2), das Substrat (1) und die Abstandsmittel (3) jeweils im Wesentlichen flach ist.Analysis instrument according to one of the preceding claims, in which the cover ( 2 ), the substrate ( 1 ) and the spacing means ( 3 ) is each substantially flat. Analyseinstrument nach einem der vorstehenden Ansprüche, bei dem die Elektroden (11, 12) ein gabelförmiges Muster aufweisen.Analytical instrument according to one of the preceding claims, in which the electrodes ( 11 . 12 ) have a fork-shaped pattern. Analyseinstrument nach einem der vorstehenden Ansprüche, bei dem die Elektroden (11, 12) angrenzend an die Kapillare auf dem Substrat angeordnet sind.Analytical instrument according to one of the preceding claims, in which the electrodes ( 11 . 12 ) are arranged adjacent to the capillary on the substrate. Analyseinstrument nach einem der vorstehenden Ansprüche, das eine Reagenzschicht (13) aufweist, die in der Kapillare angeordnet ist.Analytical instrument according to one of the preceding claims, comprising a reagent layer ( 13 ), which is arranged in the capillary. Analyseinstrument nach einem der vorstehenden Ansprüche, bei dem eine Öffnung der Probenkammer (4, 5) eine Breite von weniger als in etwa 5 mm aufweist.Analytical instrument according to one of the preceding claims, in which an opening of the sample chamber ( 4 . 5 ) has a width of less than about 5 mm. Analyseinstrument nach Anspruch 20, bei dem eine Öffnung der Probenkammer (4, 5) eine Breite von weniger als in etwa 3 mm aufweist. Analytical instrument according to claim 20, in which an opening of the sample chamber ( 4 . 5 ) has a width of less than about 3 mm. Analyseinstrument nach einem der vorstehenden Ansprüche, bei dem eine Öffnung der Probenkammer (4, 5) eine Höhe von weniger als in etwa 200 μm aufweist.Analytical instrument according to one of the preceding claims, in which an opening of the sample chamber ( 4 . 5 ) has a height of less than about 200 microns. Analyseinstrument nach einem der vorstehenden Ansprüche, bei dem eine Öffnung der Probenkammer (4, 5) eine Höhe von größer als in etwa 50 μm aufweist.Analytical instrument according to one of the preceding claims, in which an opening of the sample chamber ( 4 . 5 ) has a height of greater than about 50 microns.
DE10193213T 2001-07-27 2002-07-26 analytical tool Active DE10193213T8 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2001227777 2001-07-27
JP2001227777 2001-07-27
JP2001242486 2001-08-09
JP2001242486 2001-08-09
EP10193213.5A EP2290358B1 (en) 2001-07-27 2002-07-26 Analyzing instrument

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DE10193213T1 true DE10193213T1 (en) 2013-01-31
DE10193213T8 DE10193213T8 (en) 2013-04-25

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US (2) US7824616B2 (en)
EP (2) EP2290358B1 (en)
JP (1) JP4282477B2 (en)
CN (1) CN1300578C (en)
DE (1) DE10193213T8 (en)
WO (1) WO2003010530A1 (en)

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