DE1016251B - Process for the preparation of monomagnesium dicalcium citrate for the treatment of pulmonary tuberculosis - Google Patents

Process for the preparation of monomagnesium dicalcium citrate for the treatment of pulmonary tuberculosis

Info

Publication number
DE1016251B
DE1016251B DEO4076A DEO0004076A DE1016251B DE 1016251 B DE1016251 B DE 1016251B DE O4076 A DEO4076 A DE O4076A DE O0004076 A DEO0004076 A DE O0004076A DE 1016251 B DE1016251 B DE 1016251B
Authority
DE
Germany
Prior art keywords
citrate
monomagnesium
treatment
pulmonary tuberculosis
magnesium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DEO4076A
Other languages
German (de)
Inventor
Dipl-Chem Adolf Chri Opfermann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADOLF CHRISTIAN JOSEF OPFERMAN
Original Assignee
ADOLF CHRISTIAN JOSEF OPFERMAN
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADOLF CHRISTIAN JOSEF OPFERMAN filed Critical ADOLF CHRISTIAN JOSEF OPFERMAN
Priority to DEO4076A priority Critical patent/DE1016251B/en
Publication of DE1016251B publication Critical patent/DE1016251B/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/418—Preparation of metal complexes containing carboxylic acid moieties

Description

Verfahren zur Herstellung von zur Behandlung der Lungentuberkulose dienendem Monomagnesiumdicalciumcitrat Die Erfindung betrifft die Herstellung von Monomagncsium-dicalciumcitrat der Zusammensetzung Ca2 Mg (C6 H5 07)2.Process for the preparation of for the treatment of pulmonary tuberculosis Serving Monomagnesium Dicalcium Citrate The invention relates to the production of Monomagncsium dicalcium citrate with the composition Ca2 Mg (C6 H5 07) 2.

Es wurde gefunden, daß das bisher nicht beschriebeine Monomagnesium-dicalciumcitrat eine günstige Wirkung bei der Behandlung der Lungentuberkulose besitzt. Dies Produkt fördert in besonders guter Weise den Verkalkungsprozeß bzw. die Verkapselung bei der Lungentuberkulose. Der Krankheitsverlauf wird dadurch in vielen Fällen günstig beeinflußt. It has been found that the hitherto not described is a monomagnesium dicalcium citrate has a beneficial effect in the treatment of pulmonary tuberculosis. This product promotes the calcification process or encapsulation in a particularly good way pulmonary tuberculosis. The course of the disease is thereby favorable in many cases influenced.

Die neue Verbindung kann erhalten werden, indem Citrenensäure mit für die Bildung des Monomagnesium - dicalciumcitrates berechneten Mengen von zur Bildung des Salzes befähigten Magnesium- und Calcium-Ausgangsprodukten umgesetzt wird. Die Umsetzung erfolgt zweckmäßig in wäßriger Lösung. Als Magnesium-Ausgangsprodukte können Magnesiummetall oder Magnesiumverbindungen, wie Magnesiumhydroxyd, -citrat, -carbonat, -formiat, -acetat, -lactat, verwendet werden. Entsprechendes gilt für die Calcium-Ausgangsprodukte. Auf 2 Mol Citronensäure ist bzw. sind 1-Grammatom Magnesium oder 1 Mol des Magnesium- und 2 Mol des Calcium-Ausgangsproduktes einzusetzen. The new compound can be obtained by using citrenic acid for the formation of the monomagnesium - dicalcium citrates calculated amounts of for Formation of the salt enabled magnesium and calcium starting products implemented will. The reaction is expediently carried out in aqueous solution. As magnesium raw materials magnesium metal or magnesium compounds such as magnesium hydroxide, citrate, carbonate, formate, acetate, lactate can be used. The same applies to the calcium starting products. There is or are 1 gram atom per 2 moles of citric acid Magnesium or 1 mol of the magnesium and 2 mol of the calcium starting product to be used.

Beispiel 1 2 Mol Citronensäure oder ein Vielfaches davon werden bzw. wird in etwa 1500 ccm Wasser gelöst. Example 1 2 moles of citric acid or a multiple thereof are or is dissolved in about 1500 ccm of water.

Nunmehr wird 1 Grammatom Magnesium in der Lösung aufgelöst. Hierbei scheidet sich saures Magnesiumcitrat ab. Durch Umsetzung mit 2 Mol Calciumcarbonat wird unter Kohlensäureentwicklung das Monomagnesium-dicalciumcitrat gebildet. Das Wasser wird durch Erhitzen bis auf 2000 abdestilliert, wonach ein trockenes Kristallpulver zurückbleibt. Die Ausbeute an Ca2Mg(C6H5O7)2 beträgt 95 0/o der Theorie.1 gram atom of magnesium is now dissolved in the solution. Here acidic magnesium citrate is deposited. By reaction with 2 moles of calcium carbonate Monomagnesium dicalcium citrate is formed with the evolution of carbonic acid. That Water is distilled off by heating up to 2000, after which a dry crystal powder remains behind. The yield of Ca2Mg (C6H5O7) 2 is 95% of theory.

Analyse Berechnet . . C 29,81 0/o, H 2,07 O/o; Gefunden . . C 29,50%, H 2,130/o.Analysis calculated. . C 29.81 O / o, H 2.07 O / o; Found . . C 29.50%, H 2.130 / o.

Beispiel 2 2 Mol Citronensäure oder ein Vielfaches davon werden bzw. wird in etwa 1500 ccm destilliertem Wasser gelöst. Nunmehr wird 1 Mol Magnesiumhydroxyd in der Lösung aufgelöst. Es bildet sich saures Magnesiumcitrat. Hierauf wird die Lösung mit 2 Mol Calciumcarbonat versetzt, wobei sich unter Kohlensäureentwicklung Monomagnesium- dicalciumcitrat bildet. Example 2 2 moles of citric acid or a multiple thereof are or are is dissolved in about 1500 cc of distilled water. Now 1 mole of magnesium hydroxide becomes dissolved in the solution. Acid magnesium citrate is formed. Then the Solution mixed with 2 mol of calcium carbonate, with evolution of carbonic acid Forms monomagnesium dicalcium citrate.

Das Wasser wird durch Erhitzen bis auf 2000 abdestilliert, wonach ein trockenes Kristallpulver zurückbleibt. Die Ausbeute an Ca2 Mg (C6 H5 07)2 beträgt 95% der Theorie.The water is distilled off by heating up to 2000, after which a dry crystal powder remains. The yield of Ca2 Mg (C6 H5 07) 2 is 95% of theory.

Analyse Berechnet.. C 29,81 0/0, H 2,07 0/o; Gefunden .. C 29,40O/o, H 1,990/o.Analysis Calculated. C 29.81%, H 2.07%; Found .. C 29.40O / o, H 1.990 / o.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung von zur Behandlung der Lungentuberkulose dienendem Monomagnesium-dicalciumcitrat, dadurch gekennzeichnet, daß man 2 Mol Citronensäure mit 1 Grammatom Magnesium oder 1 Mol einer zur Bildung des Citrates befähigten Magnesiumverbindung und 2 Grammatomen Calcium oder 2 Mol einer zur Bildung des Citrates befähigten Calciumverbindung in wäßriger Lösung umsetzt. PATENT CLAIM: Process for the production of for the treatment of Monomagnesium dicalcium citrate serving for pulmonary tuberculosis, characterized in that that you add 2 moles of citric acid with 1 gram atom of magnesium or 1 mole of one to form of the citrate capable magnesium compound and 2 gram atoms of calcium or 2 moles converts a calcium compound capable of forming the citrate in aqueous solution. In Betracht gezogene Druckschriften: Deutsche Patentschriften Nr. 857 363, 869 485, 874 305, 882 699. Considered publications: German Patent Specifications No. 857 363, 869 485, 874 305, 882 699.
DEO4076A 1955-01-22 1955-01-22 Process for the preparation of monomagnesium dicalcium citrate for the treatment of pulmonary tuberculosis Pending DE1016251B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DEO4076A DE1016251B (en) 1955-01-22 1955-01-22 Process for the preparation of monomagnesium dicalcium citrate for the treatment of pulmonary tuberculosis

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEO4076A DE1016251B (en) 1955-01-22 1955-01-22 Process for the preparation of monomagnesium dicalcium citrate for the treatment of pulmonary tuberculosis

Publications (1)

Publication Number Publication Date
DE1016251B true DE1016251B (en) 1957-09-26

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
DEO4076A Pending DE1016251B (en) 1955-01-22 1955-01-22 Process for the preparation of monomagnesium dicalcium citrate for the treatment of pulmonary tuberculosis

Country Status (1)

Country Link
DE (1) DE1016251B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2394513A1 (en) * 1977-06-16 1979-01-12 Madaus & Co Dr NEW ALKALINE ACID CITRATE, PROCESS FOR ITS PREPARATION AND USE AS A MEDICINAL PRODUCT
EP0380829A1 (en) * 1988-01-05 1990-08-08 Mission Pharmacal Company, Inc. Magnesium potassium citrate

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE857363C (en) * 1949-09-13 1952-11-27 Johann G W Opfermann & Sohn Process for the production of ferrocalcium citrate
DE869485C (en) * 1942-12-29 1953-03-05 Basf Ag Process for the production of aliphatic alcohols with more than 2 carbon atoms or their sulfuric acid esters
DE874305C (en) * 1950-11-22 1953-04-23 Johann G W Opfermann & Sohn Process for the production of ferrocalcium citrate
DE882699C (en) * 1950-04-09 1953-07-09 Wilhelm Theopold Dr Med Process for the production of calcium-citric acid complex compounds or their aqueous solutions

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE869485C (en) * 1942-12-29 1953-03-05 Basf Ag Process for the production of aliphatic alcohols with more than 2 carbon atoms or their sulfuric acid esters
DE857363C (en) * 1949-09-13 1952-11-27 Johann G W Opfermann & Sohn Process for the production of ferrocalcium citrate
DE882699C (en) * 1950-04-09 1953-07-09 Wilhelm Theopold Dr Med Process for the production of calcium-citric acid complex compounds or their aqueous solutions
DE874305C (en) * 1950-11-22 1953-04-23 Johann G W Opfermann & Sohn Process for the production of ferrocalcium citrate

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2394513A1 (en) * 1977-06-16 1979-01-12 Madaus & Co Dr NEW ALKALINE ACID CITRATE, PROCESS FOR ITS PREPARATION AND USE AS A MEDICINAL PRODUCT
EP0380829A1 (en) * 1988-01-05 1990-08-08 Mission Pharmacal Company, Inc. Magnesium potassium citrate

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