DE10158286B4 - Active substance storage layer material - Google Patents

Abstract

Agent-storing layer material, consisting of multilayer flexible film material with a honeycomb layer (3) whose lower honeycomb openings (6) are closed by a base layer (2) and the upper honeycomb openings (7) through a cover layer (4) with the formation of honeycomb chambers (9) .
characterized in that
the honeycomb chambers (9) contain active substance compositions in the form of liquids, gases, gels or powders, optionally in combination with fillers,
the cover layer (4) is permeable to substances of the active substance composition and
the base layer (2) is made of a material which is impermeable to liquids and gases.

Description

The The invention relates to a drug-storing layer material according to the generic term of claim 1.

layer materials are known in different compositions. Preferably become layered Materials such as e.g. Foils with different properties combined to have special effects regarding the exchange of air and also steaming to achieve. The known layered materials in use have However, no saving effect, with it, for example possible would be, certain Substances or substance composition targeted to a site of action transport or deliver there.

Of the The invention is therefore based on the object, a layer material to offer that multifunctional properties associated with a Has metered delivery of drugs. If necessary, this should Layer material also pressure-damping Own properties.

The solution The object is achieved with the features of claim 1.

After that is the drug-storing layer material consisting of multilayer flexible film material with a honeycomb layer, the lower honeycomb openings through a base layer and its upper honeycomb openings through a cover layer closed under the formation of honeycomb chambers, thereby characterized in that the honeycomb chambers are active ingredient compositions in the form of liquids, Gases, gels or powders, optionally in combination with fillers, Contain the topcoat for Substances of the active ingredient composition is permeable and the base coat Made of a material that is impermeable to liquids and gases.

advantageous Further developments are specified in the subclaims.

The Layer material according to the invention consists of a honeycomb layer, the lower honeycomb openings through a base layer and its upper honeycomb openings through a cover layer are sealed under the formation of honeycomb chambers. The layer material according to the invention allows it, as needed continuously or specifically z. As liquids leave or absorb into individual honeycomb chambers. Preferably, the honeycomb shape is chosen here for better pressure resistance to reach. However, there are other forms of education these chambers conceivable. The individual layers of the layer material according to the invention are arranged so that they are superimposed in layers. Depending on the effect to be achieved and the materials used the structure must be strong or thicker.

It is provided in the honeycomb chambers active ingredient compositions, possibly connected with fillers, contribute. The honeycomb chambers consist of a special elastic membrane. These adapt to the volume of the filling material, creating a permanent Contact with the side walls and a vapor or liquid exchange the chambers allows each other becomes. By this material arrangement is a drying individual Prevents honeycomb chambers and a better distribution when shooting or dispensing liquids guaranteed. A solids exchange between the honeycomb chambers is not or only possible to a small extent.

One Advantage of the system of honeycomb chambers is that a uniform drug delivery or fluid intake on the entire surface allows becomes. Even if only certain areas of the surface are pressed or to be used. The chambers adapt to the volume of the filling material on and allows a vapor or liquid exchange the chambers with each other. This will give a uniform distribution of fluids allows even if only parts of the surface are used.

The Active substance storing filling material consists of e.g. from a swellable Polysaccharide or a natural, semisynthetic or synthetic polymer. Products with these Properties are u.a. from BASF under the trade name HySorb offered. After ingestion of liquid, these materials swell within a short time by a factor of 8 to 125.

The Layer material according to the invention can industrially manufactured by the meter. In a melting Welding process, causing the margins can be firmly interconnected, the most diverse Molds are made. The storage material is e.g. as granules already embedded in the meterware. The amount is to be measured that too after feed of the active substance, taking into account a swelling action of the granules, is sufficient space in the chambers.

It is possible, the chambers after consumption of the drug again with an active ingredient to mist. But it is questionable whether this increased workload worth. By a cost-effective mass production is it more economical replace the used product with a new one.

The Layer material according to the invention is suitable for the following application areas:

Decontamination and disinfection of surfaces:

Of the most important transmission route pathogens of all kinds are the hands; about 80% of all infections are transmitted in this way. The decontamination and disinfection or even a reduction the pathogen on commonly used surfaces is desirable this transmission chain to interrupt or at least slow down.

One Scope is e.g. a cover for: door handles, Light switch, push buttons inter alia, depending on the active ingredient, the development may decontaminate after each contact, or the transfer of Reduce germs.

A affordable Production of the invention in a variety of forms and variations possible. An application of the invention with a disinfecting agent appears in all facilities where the transmission risk of germs especially is great such as in schools, kindergartens, catering establishments, hospitals Telephone booths, public Transportation, Offices, Medical practices etc. useful.

If through frequent or long use the volume in the chambers decreased enough has and thus the effect wears off, can this be previously e.g. blue colored Storage material (filler) no longer through the above lying layers seem. Another possibility is that Storage material with a dye to offset the color changed at a drug or moisture loss. So the user can recognize whether the desired effect is still sufficient or when a change to a fresh area becomes necessary.

For the before described application is proposed, these interchangeable surfaces also as an advertising medium to use.

Targeted delivery of active ingredients in the application areas of medicine or in body care:

A Cover layer in film form which is an "automatic" drug delivery allows is being proposed.

The following application options may be useful:
Wound dressings that deliver a healing-promoting substance, patches for supporting wound treatment, or relieving pressure points with pain-reducing or cooling substances, shoe insoles against athlete's foot and other foot diseases or odors, floor mats with drugs against disease germs this is particularly interesting for use in public swimming pools Etc.

Collars the were fogged with agents against ectoparasites, for example against a flea infestation in pets.

Targeted intake of liquids in the application areas of medicine or in body care:

In the production of tampons, where the invention for the purpose of better Moisture absorption with simultaneous use of active substance could find. Wound dressings the fluids and at the same time can release active ingredients.

Targeted delivery of active ingredients or moisture in the application areas of botany:

A automatic delivery of fertilizers. By applying the invention, it is possible for many months nutrients to give off to plants, so as to frequent re-fertilizing prevent. Possible is also the introduction of the invention into the soil of potted plants, to store moisture better.

Targeted delivery of active ingredients in the application areas of the food and beverage industry:

The Invention is e.g. also useful in the storage of tobacco products, when it comes to maintaining a consistent humidity in containers too produce.

Targeted intake of dampen and liquids in the application areas of the food and beverage industry:

The Development is also useful in the storage of powders, when it comes to avoid clumping. She could to Example introduced into the inside of a screw cap of storage jars be, this would have the advantage of having a better tightness with a simultaneous Moisture absorption would be achieved.

Pressure reducing layer in mattresses:

A several centimeters thick layer material of the invention is incorporated over the entire surface or partially in a mattress. Whether lying on your stomach, back or side, rolled up or stretched out - the layer material on the mattress will conform to the body line, supportive or relieving and so it meets the orthopedic requirements. Similar to a waterbed, but without its annoying wave movements.

Pressure reducing layer in prostheses:

A Location of the layer material according to the invention is attached so that it is between the human body and a prosthesis lies. With this method the formation of pressure points or Circulatory disorders prevented, but at least diminished.

Pressure reducing layer in safety helmets:

The Layer material is attached so that it is between the head and the helmet lies. This prevents the formation of pressure points or circulatory disorders and so the wearing comfort significantly increased.

Impact and pressure damping Layer in shoes:

The Layer material according to the invention is placed in certain sole areas, e.g. in the heel area, introduced and enable there is a shock absorption. The individual chambers of the layer material allow a selective damping. Depending on the membrane size in the Chamber side walls can the steaming Effect be responsive or sluggish. The impact-absorbing Layer can for an even greater wearing comfort over the entire sole be extended.

meaningful the incorporation of the development as pressure-damping also appears Layer in the clamping area, because this zone is the most Shoe manufacturers only half-heartedly with a padding considered. A Lining shoes with the layer construction would have one higher Comfort and a better fit.

Seating comfort enhancing layer for seating:

A several centimeters thick layer of the invention is over the the whole area the seat cushion on e.g. Bicycle saddles, car seats or office chairs incorporated. Through this layer, the seating comfort is essential elevated.

The The invention is explained in more detail below with reference to drawings:

It demonstrate

1 a schematic sectional view of unconnected, individual layers,

2 a schematic representation of the layer material in section,

3 a honeycomb chamber in perspective,

4 a honeycomb chamber system in plan view,

5 the unconnected layers of a layer material with fleece layer,

6 a layer material with fleece layer,

7 a sole for the heel area, formed in two parts, in plan view and

8th the sole in the heel area in section.

According to 1 If the layer material according to the invention consists of an adhesive layer 1 , a base layer 2 , a honeycomb layer 3 and a cover layer 4 ,

As in 2 are shown, the said layers are firmly bonded together in the layer material according to the invention. The bonding of the individual layers can be done by gluing, but also by welding.

3 shows a honeycomb chamber 9 passing through a chamber wall 8th is limited with a lower honeycomb opening 6 and an upper honeycomb opening 7 , This honeycomb chamber 9 is part of the honeycomb layer 3 , The base layer 2 and the topcoat 4 close the lower honeycomb opening 6 and the upper honeycomb opening 7 , The honeycomb chamber 9 Contains the active ingredient composition with or without fillers.

4 shows a detail of a system of honeycomb chambers, which is a part of the honeycomb layer 3 is.

In 5 are in a development of the invention, the non-bonded adhesive layer 1 , Base layer 2 , Honeycomb layer 3 , Cover layer 4 and a nonwoven layer 5 shown, wherein the nonwoven layer 5 a grid-shaped distribution of pimples 10 having.

In 6 All these layers are shown interconnected.

7 shows a sole for the heel area of a shoe in two-piece design.

Combined with 8th is on the adhesive layer 1 the topcoat 2 and then the honeycomb layer 3 arranged. The honeycomb layer 3 gets through the topcoat 4 closed at the top. The bipartite sole for the heel area makes it possible to achieve advantageously a different pressure sensitivity in individual areas of the heel.

The adhesive layer 1 consists of adhesive, Velcro, magnetic film or other materials, which make it possible to attach the layer material according to the invention on or on a variety of surfaces and also easy to remove after use. Rubber or plastic film or a material with similar properties are especially for the base layer 2 suitable. It serves as a carrier material for the adhesive layer 1 , It is possible the base layer 2 to stain with a contrasting dye to aid in an indicator effect when the contents in the honeycomb chambers 9 has decreased.

The material composition of the honeycomb chambers 9 is designed to adapt to the height and width of their contents and a mass transfer between the honeycomb chambers 9 is possible. This can be achieved, inter alia, by perforating the chamber wall 8th the honeycomb chamber 9 is introduced. The honeycomb layer 3 is on the base layer 2 glued or bonded by thermal fusion.

The honeycomb chambers 9 are filled with a colored liquid, a powder or a gel. The coloring of the filler can also be used as an indicator, with which it can be seen whether there is enough active ingredient composition in the layer structure. The less the dye is present, the smaller is the filling volume and thus the duration of action. Should the content of the active ingredient composition in the honeycomb chambers 9 completely consumed, so would the color impression through the transparent cover layer 4 have changed.

The exchange or transport of the active ingredient in the active ingredient composition takes place through the chamber walls B. The size of the honeycomb chamber 9 is chosen according to the required volume of active ingredient composition. In order to allow a controlled escape of the contents from the honeycomb chambers, these are bonded to a perforated or special membrane film or with a material having similar properties, or connected by thermal fusion with the side walls. This as a topcoat 4 used film should be transparent to allow the already described indicator effect by color changes.

By sticking the cover layer 4 on the chamber walls 8th Adhesive sites have arisen that can no longer be saturated with the active ingredients. This has the consequence that, for example, a disinfecting effect can not be guaranteed without gaps over the entire surface. For this reason, a nonwoven layer 5 on the topcoat 4 applied. The fleece layer 5 supports the skin-friendly properties of the coating material. Furthermore, this also ensures a tactile softness of the surface. It is held in place by the welded side walls of the layer structure. When using the coating material, for example when used as a disinfecting coating on door handles, light switches, etc., this non-woven layer slips and so wets with the underlying drug. To avoid wetting when not in use, are on the bottom of the nonwoven layer 5 individual, grid-like arranged knobs 10 applied as a spacer. These can be printed, for example, by means of a special screen printing technique. The pimples 10 consist of a liquid-impermeable material, for example, from a specially developed for this process hot melt adhesive (hotmelt) as by hot melt adhesive with the name Lunatac D014Bg2 or BD4 from Fuller. Also suitable is a commercially available ethylene / vinyl acetate polymer dispersion. It makes sense to have a nub diameter of 0.6 mm and a number of 120 nubs per cm ² . Due to the grid-like arrangement of the knobs 10 remain areas where the open fiber structure of the nonwoven layer 5 preserved. The between the pimples 10 areas that are thus forming passage areas for an active ingredient outlet.

The use of the nonwoven layer 5 is not necessary for all applications.

The active ingredient composition, in the form of liquids, powders, gels or vapors in the honeycomb chambers 9 can be combined with swellable polysaccharides or natural, semisynthetic or synthetic polymers. It is important that there is a constant contact of the active ingredient composition with the chamber walls 8th consists.

The layer material according to the invention and also the individual layers can be produced in a wide variety of forms. The control of the amount or rate of drug delivery from the honeycomb chambers 9 is achieved by targeted selection of the material.

The layer material according to the invention is outstandingly suitable as an advertising medium. It can be made in a wide variety of colors. Also here exemplified as honeycomb Chambers can also be formed from other shapes. The honeycomb layer 3 also contains inlets and outlets or a valve system.

Also in the formation of a pressure-sensitive layer material according to the invention, honeycomb chambers should preferably be used 9 in the honeycomb layer 3 be provided to achieve better pressure resistance. Also here are how out 7 and 8th it can be seen, the layers one above the other.

The use of the pressure-sensitive material according to the invention is limited not only to shoe soles but also as Druckdämpfschichten in prostheses, mattress pads, eg in the treatment of decubitus. The pressure-damping layer structure consists of a very stable and elastic material, which should have similar properties as rubber, eg polyurethane. Will the coating material in certain areas of the honeycomb layer 3 compressed, for example, the gel-like filling material only sluggishly through the chamber walls 8th escape. This material behavior enables a uniform damping effect on the entire surface. The cushioning effect of the layer material according to the invention can also be generated by the fact that also from the outside into the system of honeycomb chambers 9 Gas, moisture or steam are introduced via a valve system, whereby a targeted control of the internal pressure is made possible. This structure of the layer material coupled with a valve system is suitable, inter alia, for use as a cushioning mattress pad for the treatment of various complaints.

1

adhesive layer

2

base layer

3

honeycomb layer

4

topcoat

5

fleece layer

6

lower honeycomb opening

7

upper honeycomb opening

8th

chamber wall

9

honeycomb chamber

10

burl

Claims (14)

Active substance storage layer material consisting of multilayer flexible film material with a honeycomb layer ( 3 ), whose lower honeycomb openings ( 6 ) by a base layer ( 2 ) and their upper honeycomb openings ( 7 ) by a cover layer ( 4 ) under the formation of honeycomb chambers ( 9 ), characterized in that the honeycomb chambers ( 9 ) Active substance compositions in the form of liquids, gases, gels or powders, optionally in combination with fillers, containing the top layer ( 4 ) is permeable to substances of the active substance composition and the base layer ( 2 ) is made of a material that is impermeable to liquids and gases. Layer material according to claim 1, characterized in that the cover layer ( 4 ) Has perforations. Layer material according to claim 1 or 2, characterized in that below the base layer ( 2 ) an adhesive layer ( 1 ) is arranged. Layer material according to one of claims 1 to 3, characterized in that above the cover layer ( 4 ) a nonwoven layer ( 5 ) is arranged. Layer material according to one of claims 1 to 4, characterized in that the adhesive layer ( 1 ) on its outer side adhesion-promoting functional elements, such as adhesive layers, hook and loop fasteners, magnetic films having. Layer material according to one of claims 1 to 5, characterized in that the base layer ( 2 ) made of rubber or a flexible plastic. Layer material according to one of claims 1 to 6, characterized in that the base layer ( 2 ) has a contrast coloration. Layer material according to one of claims 1 to 7, characterized in that the active ingredient composition a counterstain having. Layer material according to one of claims 1 to 8, characterized in that the cover layer ( 4 ) is transparent. Layer material according to one of claims 1 to 9, characterized in that the chamber walls ( 8th ) of the honeycomb chambers ( 9 ) is permeable to substances of the active ingredient composition. Layer material according to claim 10, characterized in that the chamber walls ( 8th ) of the honeycomb chambers ( 9 ) Have perforations. Layer material according to one of claims 4 to 11, characterized in that the nonwoven layer ( 5 ) on its underside a grid-shaped arrangement of pimples ( 10 ) having. Layer material according to one of claims 1 to 12, characterized in that the system the honeycomb chambers ( 9 ) Have inflows and outlets and possibly valves. Layer material according to one of claims 1 to 13, characterized in that the honeycomb layer ( 3 ) a valve system for controlling the pressure in the honeycomb chambers ( 9 ) having.