DE10122342A1 - Use of isoflavones in cosmetic or dermatological preparations - Google Patents

Abstract

The use of substances selected from the following group: ipriflavone (7 -isopropoxy-isoflavone), formononetin (7 -hydroxy-4'-hethoxyisoflavonr) ononin (formononetin-7-O- beta -D-glucopyranoside) 4'-isopropyl-isoflavone, mono-hydroxy-isoflavone, mono-hydroxy-dihydro-isoflavone, mono-hydroxy- tetrahydro-isoflavone, O-desmethylangolensin, dihydro-daidzein (dihydro-7,4'- dihydroxy-isoflavone), tetrahy dro-daidzein (tetrahydro- 7,4'-dihydroxy-isoflavone), dihydro-genistein (dihydro-5,7,4'-trihydroxy-isoflavone), 2-dehydro-O-desmethyl-angolensin, dehydroequol, 4-hydroxy-7-glucose-isoflavone and 5-hydroy-7,4'-dimethoxy-isoflavone, in cosmetic or dermatological preparations in the treatment and prophylaxis of symptoms of inflammatory or itchy skin conditions in sensible skin and in modificiations of DNS synthesis and/or DNS repair in skin.

Description

The present invention relates to the use of specific isoflavonoids in kosmeti or dermatological preparations for the prophylaxis and treatment of sensitive skin, itching and changes in DNA synthesis and / or DNA Repair performance in the skin.

In particular, the present invention relates to cosmetic preparations with a additional, effective protection against harmful oxidation processes in the skin, however also for additional protection of cosmetic preparations themselves or to addi protection of the constituents of cosmetic preparations against harmful oxidation processes.

Under cosmetic skincare is to be understood in the first place that the natural radio the skin as a barrier against environmental influences (eg dirt, chemicals, microorgan organisms) and against the loss of endogenous substances (eg water, natural Fats, electrolytes) is strengthened or restored.

If this function is disturbed, it can lead to increased absorption of toxic or allergenic Substances or infestation of microorganisms and as a result to toxic or allergi skin reactions.

It is also the goal of skin care to reduce the fat and thinning caused by daily washing To compensate for water loss of the skin. This is important when the natural regenerative capacity is insufficient. In addition, skin care products are intended  Environmental influences, especially against sun and wind, protect and skin aging delay.

The chronological skin aging is z. B. caused by endogenous, genetically determined factors. In epidermis and dermis it comes due to aging z. B. to fol lowing structural damage and dysfunction, which may also fall under the term "senile xerosis":

• a) dryness, roughness and formation of dryness wrinkles,
• b) itching and
• c) diminished fatty acid regeneration (eg after washing).

Exogenous factors such as UV light and chemical noxae can be cumulatively effective. In epidermis and dermis it comes in particular by exogenous factors z. B. to fol lowing structural damage and dysfunction in the skin:

• a) increased susceptibility to mechanical stress (eg cracking).

Products for the care of sensitive, itchy and / or dry skin or products Treatment or prophylaxis of DNA damage is known per se. all However, their effectiveness is limited.

The damaging effect of the ultraviolet part of solar radiation on the skin is well known. While rays with a wavelength smaller than 290 nm (the so-called UVC range), absorbed by the ozone layer in the earth's atmosphere be, cause rays in the range between 290 nm and 320 nm, the soge called UVB, erythema, simple sunburn or even more or less severe burns.

As a maximum of the erythema efficiency of sunlight becomes the narrower area indicated at 308 nm.

For protection against UVB radiation, numerous compounds are known in which it derivatives of 3-benzylidene camphor, 4-aminobenzoic acid, cinnamic acid,  salicylic acid, benzophenone and 2-phenylbenzimidazole.

Also for the range between about 320 nm and about 400 nm, the so-called UVA Area, it is important to have filter substances available as its rays Can cause reactions in photosensitive skin. It has been proven that UVA Radiation damage the elastic and collagen fibers of the connective tissue What leads the skin to prematurely age, and that it is the cause of numerous photo toxic and photoallergic reactions can be seen. The damaging influence of UVB radiation can be amplified by UVA radiation.

For protection against the rays of the UVA range, therefore, certain derivatives of the Dibenzoylmethane, whose photostability (Int J. Cosm. Science 10, 53 (1988)), is not given sufficiently.

The UV radiation can also lead to photochemical reactions, in which case the photochemical reaction products interfere with the skin metabolism.

Predominantly, such photochemical reaction products are ra dicalic compounds, for example hydroxy radicals. Also undefined radical Photoproducts, which develop in the skin itself, can due to their high Reactivity uncontrolled subsequent reactions to the day. But also Singulettsauer substance, a non-radical excited state of the oxygen molecule can be Irradiation occur, as are short-lived epoxides and many others. singlet For example, is distinguished from the normally existing Triplettsau erstoff (radical ground state) by increased reactivity. However, there exists also excited, reactive (radical) triplet states of the oxygen molecule.

Furthermore, UV radiation counts as ionizing radiation. So there is a risk that also arise ionic species on UV exposure, which in turn oxidative in to be able to intervene in the biochemical processes.

To prevent these reactions, the cosmetic or dermatological Formulations additional antioxidants and / or radical scavengers are incorporated.  

It has already been suggested vitamin E, a substance with known antioxida tive effect in sunscreen formulations, but still remains here scored far behind the hoped for effect.

The object of the invention was, therefore, cosmetic, dermatological and pharmi to provide active substances and preparations as well as sunscreen formulations which for the prophylaxis and treatment of photosensitive skin, especially photoderms matose, preferably the polymorphic light dermatosis serve.

Other terms for polymorphic photodermatosis include PLD, PLE, Mallorcan Acne and a variety of other names, as described in the literature (eg. Voelckel et al. Zentralblatt skin and venereal diseases (1989), 156, p. 2) give.

Mainly antioxidants are used as protective substances against the spoilage of them used preparations containing. Nevertheless, it is known that in menschli Skin and animal skin undesirable oxidation processes can occur.

In the article "Skin Diseases Associated with Oxidative Injury" in "Oxidative Stress in the Matology, p. 323 et seq. (Marcel Decker Inc., New York, Basel, Hong Kong, publisher: Jürgen Fuchs, Frankfurt, and Lester Packer, Berkeley, California), become oxidative Damage to the skin and its nearer causes listed.

Also, to prevent such reactions, cosmetic or cosmetic dermatological formulations additionally antioxidants and / or radical scavengers be incorporated.

Although some antioxidants and radical scavengers are known. So is already in the US Pa pending 4,144,325 and 4,248,861 and from numerous other documents been beaten, vitamin E, a substance with known antioxidant activity in Nevertheless, the effect achieved here also remains here far behind the hoped for.

Another object of the present invention was therefore to overcome the disadvantages of the prior art  to avoid the technology and in particular those caused by environmental noxae Damage permanently, sustainably and without the risk of side effects remedy or to prevent them.

It has surprisingly been found that the use of substances selected from the group:
Ipriflavone (7-isopropoxy-isoflavone), formononetin (7-hydroxy-4'-methoxyisoflavone), ononine (formononetin-7-O-.beta.-D-glucopyranoside), 4'-isopropyl-isoflavone, mono-hydroxy-isoflavones , Mono-hydroxy-dihydro-isoflavones, mono-hydroxy-tetrahydro-isoflavones, O-desmethylangolensin, dihydro-daidzein (dihydro-7,4'-dihydroxy-isoflavone), tetrahydro-daidzein (tetrahydro-7,4'-dihydroxy Isoflavone), dihydro-genistein (dihydro-5,7,4'-trihydroxy-isoflavone), 2-dehydro-O-desmethyl-angolensin, dehydroequol, 4-hydroxy-7-glucose isoflavone and 5-hydroxy-7, 4'-dimethoxy-isoflavone
in cosmetic or dermatological preparations for the treatment, care and prophylaxis of sensitive skin and / or for the treatment and prophylaxis of the symptoms of a negative change in the physiological homeostasis of the healthy skin.
the disadvantages of the prior art helps.

Cosmetic or dermatological preparations according to the invention preferably contain from 0.001 to 10% by weight, particularly preferably from 0.01 to 1% by weight, of isoflavones, based on the total composition of the preparations.

When using the active ingredients used in the invention or cosmetic or topical dermatological preparations with an effective content of fiction, according to the active ingredients used in a surprising treatment is effective treatment, but also a prophylaxis of

• - changes in normal lipid peroxidation,
• - deficient, sensitive or hypoactive skin conditions or deficient, sensitive or hypoactive states of skin appendages,
• - inflammatory skin conditions,
• - atopic eczema, polymorphic photodermatosis, psoriasis, vitiligo
• - sensitive, itchy or irritated skin,  
• Changing the ceramide, lipid and energy metabolism of healthy skin,
• Change in physiological transepidermal water loss,
• Reduction of skin hydration and decrease of moisture content of Skin,
• - Change in Natural Moisturizing Factor content,
• - reduction of cell-cell communication,
• Deficiency symptoms of intracellular DNA synthesis,
• DNA damage and reduction of endogenous DNA repair mechanism men,
• Activation of metalloproteinases and / or other proteases or inhibition the corresponding endogenous inhibitors of these enzymes,
• - Deviations from the normal post-translational modifications of Bindege websbestandteilen,
• Changes in the normal hyaluronic acid and glycosaminoglycans content of healthy skin,
• - dandruff of the hair,
• - skin brittleness and skin fatigue,
• Increase in normal keratinocyte proliferation,
• - reduction of natural regeneration and structure of hair,
• - environmental (through smoking, smog, reactive oxygen species, free radicals caused) negative changes of the skin and the skin appendages

possible.

It is particularly advantageous according to the invention, ver according to the invention used active substance or cosmetic or topical dermatological preparations an effective content of the active ingredient used according to the invention for the cosmetic or dermatological treatment or prophylaxis of undesirable skin conditions use.

According to the invention, preparations containing the active compound com contain common antioxidants.

Advantageously, the antioxidants are selected from the group consisting of amino acids (eg, glycine, histidine, tyrosine, tryptophan) and their derivatives, imidazoles (eg, urocanic acid) and derivatives thereof, peptides such as D, L-carnosine, D Carnosine, L-carnosine and their derivatives (eg anserine), carotenoids, carotenes (eg α-carotene, β-carotene, lycopene) and their derivatives, lipoic acid and derivatives thereof (eg dihydrolipoic acid) , Aurothio glucose, propylthiouracil and other thiols (eg thioredoxin, glutathione, cysteine, cystine, cystamine and their glycosyl, N-acetyl, methyl, ethyl, propyl, amyl, butyl and lauryl, Palmitoyl, oleyl, γ-linoleyl, cholesteryl and glyceryl esters) and their salts, dilauryl thiodipropionate, distearyl thiodipropionate, thiodipropionic acid and derivatives thereof (esters, ethers, peptides, lipids, nucleotides, nucleosides and salts) and sulfoximine compounds (e.g. Buthionine sulfoximines, Homocysteinsulfoximin, Buthioninsul fone, penta-, hexa-, heptathionine sulfoximine) in very low tolerated dosages (eg. Pmol to μmol / kg), furthermore (metal) chelators (for example α-hydroxyfatty acids, palmitic acid, phytic acid, lactoferrin), α-hydroxy acids (for example citric acid, lactic acid, rocker acid), humic acid, Bile acids, bile extracts, bilirubin, biliverdin, EDTA, EGTA and their derivatives, unsaturated fatty acids and their derivatives (eg γ-linolenic acid, linoleic acid, oleic acid), folic acid and its derivatives, alaninediacetic acid, flavonoids, polyphenols, catechins, vitamin C and derivatives (e.g., ascorbyl palmitate, Mg-ascorbyl phosphate, ascorbyl acetate), tocopherols and derivatives (e.g., vitamin E acetate), and benzoic acid coniferyl benzoate, rutinic acid and derivatives thereof, ferulic acid and its derivatives, butylhydroxytoluene, butylated hydroxyanisole , Nordihydroguaiacetic acid, nordihydroguaiaretic acid, trihydroxybutyrophenone, uric acid and its derivatives, mannose and its derivatives, zinc and its derivatives (eg ZnO, ZnSO ₄ ) selenium and its derivatives (eg selenomethionine), stilbenes and their derivatives (for example stilbene oxide, trans-stilbene oxide) and the derivatives suitable for this purpose (salts, esters, ethers, sugars, nucleotides, nucleosides, peptides and lipids) of these active substances mentioned.

The amount of antioxidants (one or more compounds) in the preparations is preferably 0.001 to 30 wt .-%, particularly preferably 0.05 to 20 wt .-%, in particular 1 to 10 wt .-%, based on the total weight of the preparation.

Furthermore, it may be advantageous to encapsulate the active compounds according to the invention, for. B. as so-called solid lipid nanoparts with the help of melted waxes, the un Others, but not exclusively, may be selected from the group of esters waxes, triglyceride waxes or hydrocarbon waxes. Furthermore it can by  Be advantageous to encapsulate the active compounds of the invention in polymers, eg. B. in Parti based on highly crosslinked polymethacrylates and / or cellulose triacetates and / or as Core / shell particles with a shell of poly (oxymethylurea), nylon, polyamides, poly urethane, polyester, gelatin and polyolefins.

The prophylaxis or the cosmetic or dermatological treatment with the inventions used according to the active ingredient or with the cosmetic or topical derma use tological preparations with an effective content of the invention Active ingredient is carried out in the usual way, in such a way that the erfindungsge the active ingredient used or the cosmetic or topical dermatological additives preparations with an effective content of active ingredient used in the invention is applied to the affected skin areas.

Advantageously, the active ingredient used in the invention can be incorporated in üb Liche cosmetic and dermatological preparations, which in various For may be present. So they can z. As a solution, an emulsion of the type What ser-in-oil (W / O) or oil-in-water (O / W), or multiple emulsions For example, the type of water-in-oil-in-water (W / O / W) or oil-in-water-in-oil (O / W / O), a hydrodispersion or lipodispersion, a gel, a Pickering emulsion, represent a solid pin or an aerosol.

According to the invention emulsions, z. B. in the form of a Cream, a lotion, a cosmetic milk are advantageous and contain z. Fats, Oils, waxes and / or other fatty substances, as well as water and one or more emul gators, as commonly used for such a type of formulation the.

It is also possible and advantageous within the meaning of the present invention, the inventions used according to the invention in aqueous systems or surfactant preparations for To cleanse the skin and hair.

Of course, it is known to those skilled in the art that sophisticated cosmetic compositions usually not without the usual auxiliaries and additives are conceivable. Dar include, for example, bodying agents, fillers, perfume, dyes, emulsifiers,  additional active ingredients such as vitamins or proteins, light stabilizers, stabilizers, Insect repellents, alcohol, water, salts, antimicrobial, proteolytic or keratoly table effective substances etc.

Mutatis mutandis, corresponding requirements apply to the formulation medical shear preparations.

Medical topical compositions according to the present invention ent usually keep one or more drugs in effective concentration. The For the sake of simplicity, a clear distinction between cosmetic and medi application and corresponding products to the legal requirements referred to in the Federal Republic of Germany (eg Cosmetics Regulation, Lebens Central and Drug Law).

It is also advantageous to use the active ingredient according to the invention as to give preparations which already have other active substances for other purposes contain.

Accordingly, cosmetic or topical dermatological compositions according to the present invention, depending on their structure, for example ver to be used as a skin protection cream, cleansing milk, sunscreen lotion, nutrient Cream, day or night cream, etc. It may be possible and advantageous to the Compositions of the invention as a basis for pharmaceutical Formu lierungen to use.

It is also advantageous in the context of the present invention, cosmetic and dermatolo to prepare gische preparations whose main purpose is not to protect against Sunlight is, but still contain a content of UV-protective substances. So be z. As in day creams or makeup products usually UV-A or UV-B-Fil tersubstanzen incorporated. Also, UV protectants, as well as antioxidants dants and, if desired, preservatives, effective protection of Preparations themselves against spoilage are also favorable cosmetic and dermatolo gische preparations, which are in the form of a sunscreen.  

Accordingly, the preparations according to the present invention contain preferably in addition to one or more active ingredients used in the invention additionally at least one further UV-A and / or UV-B filter substance. The formula although not necessary, may also include one or more orga contain nische and / or inorganic pigments as UV filter substances, which in the water and / or the oil phase may be present.

Preferred inorganic pigments are metal oxides and / or other water-insoluble or insoluble metal compounds, in particular oxides of titanium (TiO ₂ ), zinc (ZnO), iron (eg Fe ₂ O ₃ ), zirconium (ZrO ₂ ), silicon ( SiO ₂ ), manganese (for example MnO), aluminum (Al ₂ O ₃ ), cerium (for example Ce ₂ O ₃ ), mixed oxides of the corresponding metals and mixtures of such oxides.

Such pigments may advantageously be superficial in the sense of the present invention be treated ("coated"), wherein, for example, an amphiphilic or hydrophobic Character should be formed or preserved. This surface treatment may consist in that the pigments according to known methods with a thin hydrophobic layer can be provided.

According to the invention are advantageous z. As titanium dioxide pigments which are coated with octylsilanol be. Suitable titanium dioxide particles are available under the trade name T805 from Degussa. Also particularly advantageous are aluminum stearate coated with TiO ₂ pigments, z. As those available under the trade name MT 100 T from TAYCA.

Another advantageous coating of the inorganic pigments consists of dime thylpolysiloxane (also: dimethicone), a mixture of fully methylated, linear siloxane poly monomers which are terminally blocked with trimethylsiloxy units. Especially advantageous For the purposes of the present invention are zinc oxide pigments, be in this way be be layered.

Furthermore, a coating of the inorganic pigments with a mixture is advantageous of dimethylpolysiloxane, in particular dimethylpolysiloxane with an average Chain length of 200 to 350 dimethylsiloxane units, and silica gel, which is also known as  Simethicone is called. It is particularly advantageous if the inorganic Pigments additionally with aluminum hydroxide or alumina hydrate (also: alumina, CAS No .: 1333-84-2). Titanium dioxides which are particularly advantageous are Simethicone and alumina are coated, the coating also ent can hold. An example of this is the under the trade name Eusolex T2000 at The company Merck available titanium dioxide.

Advantageous organic pigment in the context of the present invention is the 2,2'-Me thylenebis (6- (2H-benzotriazol-2-yl) -4- (1,1,3,3-tetramethylbutyl) -phenol) [INCI: bisoctyl triazole], which is marketed under the trade name Tinosorb® M in CIBA chemicals GmbH is available.

Advantageously, preparations according to the invention contain substances which are UV radiation absorb in the UV-A and / or UV-B range, the total amount of the filtersub punching z. B. 0.1 wt .-% to 30 wt .-%, preferably 0.5 to 20 wt .-%, insbesonde 1.0 to 15.0% by weight, based on the total weight of the preparations, of to provide cosmetic preparations which pre-coat the hair or the skin protect the entire range of ultraviolet radiation. You can also as Son protect the hair or skin.

Advantageous UV-A filter substances for the purposes of the present invention are dibenzoyl methane derivatives, in particular 4- (tert-butyl) -4'-methoxydibenzoylmethane (CAS no. 70356-09-1), which was sold by Givaudan under the trademark Parsol® 1789 and Merck under the trade name Eusolex® 9020 is sold.

Further advantageous UV-A filter substances are the phenylene-1,4-bis (2-benzimidazyl) - 3,3'-5,5'-tetrasulfonic acid and its salts, especially the corresponding sodium, potassium or triethanolammonium salts, in particular the phenylene-1,4-bis (2-benzimi dazyl) -3,3'-5,5'-tetrasulfonic acid bis-sodium salt with the INCI name Bisimidazy late, which, for example, under the trade name Neo Heliopan AP at Haarmann & Reimer is available.

Also advantageous are 1,4-di (2-oxo-10-sulfo-3-bomylidenemethyl) benzene and its Salts (especially the entprechenden 10-sulfato compounds, in particular the corresponding  Sodium, potassium or triethanolammonium salt), which is also known as benzene 1,4-di (2-oxo-3-bornylidenemethyl-10-sulfonic acid).

Advantageous UV filter substances in the context of the present invention are also soge called broadband filter, d. H. Filter substances containing both UV-A and UV-B radiation absorb.

Advantageous broadband filters or UV-B filter substances are, for example, bis-resorci nyltriazinderivate. Particularly preferred are the 2,4-bis - {[4- (2-ethyl-hexyloxy) -2-hy droxy] -phenyl} -6- (4-methoxyphenyl) -1,3,5-triazine (INCI: aniso triazine), which is available under the Trade name Tinosorb® S is available from CIBA-Chemikalien GmbH.

Particularly advantageous preparations in the context of the present invention, which characterized by a high or very high UV-A protection, preferably contain several UV-A and / or broadband filters, in particular Dibenzoylmethanderivate [in For example, the 4- (tert-butyl) -4'-methoxydibenzoylmethan], benzotriazole derivatives [at For example, the 2,2'-methylenebis (6- (2H-benzotriazol-2-yl) -4- (1,1,3,3-tetramethylbutyl) - phenol)], phenylene-1,4-bis (2-benzimidazyl) -3,3'-5,5'-tetrasulfonic acid and / or their Salts, the 1,4-di (2-oxo-10-sulfo-3-bomylidenmethyl) benzene and / or its salts and / or the 2,4-bis - {[4- (2-ethyl-hexyloxy) -2-hydroxy] -phenyl} 6- (4-methoxyphenyl) - 1,3,5-triazine, each individually or in any combination with each other.

Other UV filter substances, which are the structural motif

are advantageous UV filter substances in the context of the present invention, for example, those described in European Published Patent Application EP 570 838 A1 nen s-triazine derivatives, their chemical structure by the generic formula

is reproduced, wherein
R is a branched or unbranched C ₁ -C ₁₈ -alkyl radical, a C ₅ -C ₁₂ -cycloalkyl radical, optionally substituted by one or more C ₁ -C ₄ -alkyl groups,
X represents an oxygen atom or an NH group,
R _{1 is} a branched or unbranched C ₁ -C ₁₈ -alkyl radical, a C ₅ -C ₁₂ -cycloalkyl radical, optionally substituted by one or more C ₁ -C ₄ -alkyl groups, or a hydrogen atom, an alkali metal atom, an ammonium group or a group the formula

means in which
A is a branched or unbranched C ₁ -C ₁₈ -alkyl radical, a C ₅ -C ₁₂ -cycloalkyl or aryl radical, optionally substituted by one or more C ₁ -C ₄ -alkyl groups,
R _{3 represents} a hydrogen atom or a methyl group,
n represents a number from 1 to 10,
R _{2 represents} a branched or unbranched C ₁ -C ₁₈ alkyl radical, a C ₅ -C ₁₂ cycloalkyl radical optionally substituted by one or more C ₁ -C ₄ alkyl groups, when X represents the NH group, and
a branched or unbranched C ₁ -C ₁₈ -alkyl radical, a C ₅ -C ₁₂ -cycloalkyl radical, optionally substituted by one or more C ₁ -C ₄ -alkyl groups, or a hydrogen atom, an alkali metal atom, an ammonium group or a group of the formula

means in which
A is a branched or unbranched C ₁ -C ₁₈ -alkyl radical, a C ₅ -C ₁₂ -cycloalkyl or aryl radical, optionally substituted by one or more C ₁ -C ₄ -alkyl groups,
R _{3 represents} a hydrogen atom or a methyl group,
n represents a number from 1 to 10,
when X represents an oxygen atom.

Particularly preferred UV filter substance in the context of the present invention is also an unsymmetrically substituted s-triazine whose chemical structure is represented by the formula

which is also referred to below as dioctylbutylamidotriazone (INCI: Dioctylbutamidotriazone) and is sold under the trade name UVA- SORB HEB is available from Sigma 3V.

Advantageous in the context of the present invention is also a symmetrically substituted s-triazine containing 4,4 ', 4 "- (1,3,5-triazine-2,4,6-triyltriimino) -tris-benzoic acid tris (2-ethylhexyl ester), synonymous: 2,4,6-tris [anilino- (p-carbo-2'-ethyl-1'-hexyloxy)] - 1,3,5-triazine (INCI: Octyl Triazone), which is marketed by BASF Aktiengesellschaft under the trade name UVINUL® T 150 is sold.

Also in the European Patent Application 775,698 de preferred to use de bis-Resorcinyltriazinderivate described their chemical structure by the gene genetic formula

is reproduced, wherein R ₁ , R ₂ and A _{1 represent a} wide variety of organic radicals animals.

Advantageous in the context of the present invention are also the 2,4-bis - {[4- (3-sulfonato) - 2-hydroxy-propyloxy) -2-hydroxy] -phenyl} -6- (4-methoxyphenyl) -1,3,5-triazine sodium salt, the 2,4-bis - {[4- (3- (2-propyloxy) -2-hydroxy-propyloxy) -2-hydroxy] -phenyl} -6- (4-methoxy phenyl) -1,3,5-triazine which is 2,4-bis - {[4- (2-ethyl-hexyloxy) -2-hydroxy] -phenyl) -6- [4- (2-meth oxyethyl-carboxyl) -phenylamino] -1,3,5-triazine which is 2,4-bis - {[4- (3- (2-propyloxy) -2-hy droxy-propyloxy) -2-hydroxy] phenyl} -6- [4- (2-ethyl-carboxyl) -phenylamino] -1,3,5-triazine, 2,4-bis - {[4- (2-ethyl-hexyloxy) -2-hydroxy] -phenyl} -6- (1-methylpyrrol-2-yl) -1,3,5-tri azine, the 2,4-bis - {[4-tris (trimethylsiloxy-silylpropyloxy) -2-hydroxy] -phenyl} -6- (4-methoxy phenyl) -1,3,5-triazine which is 2,4-bis - {[4- (2 "-methylpropenyloxy) -2-hydroxy-phenyl} -6- (4-me thoxyphenyl) -1,3,5-triazine and the 2,4-bis - {[4- (1 ', 1', 1 ', 3', 5 ', 5', 5'-heptamethylsiloxy-2 "- methyl-propyloxy) -2-hydroxy] phenyl} -6- (4-methoxyphenyl) -1,3,5-triazine.

An advantageous broadband filter in the context of the present invention is the 2,2'-methyl lenbis (6- (2H-benzotriazol-2-yl) -4- (1,1,3,3-tetramethylbutyl) -phenol), which is available under the Trade name Tinosorb® M is available from CIBA-Chemikalien GmbH.

Advantageous broadband filter according to the present invention, the 2- (2H- benzotriazol-2-yl) -4-methyl-6- [2-methyl-3- [1,3,3,3-tetramethyl-1 - [(trimethylsilyl) oxy] di siloxanyl] propyl] phenol (CAS No .: 155633-54-8) with the INCI name Drometrizole Trisiloxane.

The UV-B and / or broadband filters may be oil-soluble or water-soluble. Advantage is oil-soluble UV-B and / or broadband filter substances are z. B .:

• 3-benzylidene camphor derivatives, preferably 3- (4-methylbenzylidene) camphor, 3 benzylidenecamphor;
• 4-aminobenzoic acid derivatives, preferably 4- (dimethylamino) benzoic acid (2- ethylhexyl) ester, 4- (dimethylamino) benzoic acid amyl ester;
• - 2,4,6-trianilino- (p-carbo-2'-ethyl-1'-hexyloxy) -1,3,5-triazine;
• Esters of benzalmalonic acid, preferably 4-methoxybenzalmalonic acid di (2-ethyl hexyl ester);  
• Esters of cinnamic acid, preferably 4-methoxycinnamic acid (2-ethylhexyl) ester, 4-meth oxyzimtsäureisopentylester;
• Derivatives of benzophenone, preferably 2-hydroxy-4-methoxybenzophenone, 2- Hydroxy-4-methoxy-4'-methylbenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone
• - As well as bound to polymers UV filters.

Advantageous water-soluble UV-B and / or broadband filter substances are z. B .:

• Salts of 2-phenylbenzimidazole-5-sulfonic acid, such as its sodium, potassium or tri ethanolammonium salt, as well as the sulfonic acid itself;
• - Sulfonic acid derivatives of 3-Benzylidencamphers, such as. B. 4- (2-oxo-3-bomylidene methyl) benzenesulfonic acid, 2-methyl-5- (2-oxo-3-bomylidenemethyl) sulfonic acid and their salts.

A further light stabilizer filter substance to be advantageously used according to the invention is ethylhexyl 2-cyano-3,3-diphenylacrylate (octocrylene), available from BASF under the Designation Uvinul® N 539 is available.

It can also be of considerable advantage, polymer-bound or polymeric UV filters to use substances in preparations according to the present invention, esp especially those as described in WO-A-92/20690.

Furthermore, it may be advantageous, according to the invention, to obtain further UVA and / or UV-B filter incorporated into cosmetic or dermatological preparations example, certain salicylic acid derivatives such as 4-Isopropylbenzylsalicylat, 2- Ethyl hexyl salicylate (= octyl salicylate), homomenthyl salicylate.

The list of said UV filters used in the context of the present invention of course, should not be limiting.

The preparations according to the invention advantageously contain the substances which Absorb radiation in the UV-A and / or UV-B range, in a total of z. 0.1% to 30% by weight, preferably 0.5 to 20% by weight, especially 1.0 to 15.0% by weight, in each case based on the total weight of the preparations, of cosmetic  To provide preparations that the hair or skin before ge protect the entire area of ultraviolet radiation. They can also be called suns protect the hair or skin.

The cosmetic and dermatological preparations according to the invention can contain cosmetic active ingredients, auxiliaries and / or additives, as commonly used in sol chen preparations are used, for. Anti-oxidants, preservatives, Bactericides, perfumes, anti-foaming agents, dyes, Pig pigments which have a coloring effect, thickeners, surface-active substances, Emulsifiers, softening, moisturizing and / or moisturizing substances, Fet te, oils, waxes or other common ingredients of a cosmetic or dermato logical formulation such as alcohols, polyols, polymers, foam stabilizers, elec trolytes, organic solvents or silicone derivatives.

If the cosmetic or dermatological preparation in the sense of the present invention is a solution or emulsion or dispersion, it is possible to use as solvents:

• - water or aqueous solutions
• - Oils, such as triglycerides of capric or caprylic acid, but preferably Rizi nusöl;
• - Fats, waxes and other natural and synthetic fats, preferably Esters of fatty acids with lower C-number alcohols, e.g. B. with isopropanol, propy glycol or glycerol, or esters of fatty alcohols with lower alkanoic acids. Number or with fatty acids;
• - Alcohols, diols or polyols low C number, and their ethers, preferably Ethanol, isopropanol, propylene glycol, glycerol, ethylene glycol, ethylene glycol mono ethyl or monobutyl ether, propylene glycol monomethyl, monoethyl or mono butyl ether, diethylene glycol monomethyl or monoethyl ether and analogous Pro -products.

In particular, mixtures of the abovementioned solvents are used. For alcoholic solvents, water can be another ingredient.

The oil phase of the emulsions, oleogels or hydrodispersions or lipodispersions  For the purposes of the present invention is advantageously selected from the group of esters from saturated and / or unsaturated, branched and / or unbranched Alkancar bonsäuren a chain length of 3 to 30 carbon atoms and saturated and / or unsatd saturated, branched and / or unbranched alcohols of a chain length of 3 to 30 C Atoms, from the group of esters of aromatic carboxylic acids and saturated and / or unsaturated, branched and / or unbranched alcohols of a chain length of 3 to 30 carbon atoms. Such ester oils can then be chosen advantageously from the group isopropyl myristate, isopropyl palmitate, isopropyl stearate, isopropyl oleate, n- Butyl stearate, n-hexyl laurate, n-decyl oleate, isooctyl stearate, isononyl stearate, isononyl iso nonanoate, 2-ethylhexyl palmitate, 2-ethylhexyl laurate, 2-hexyldecyl stearate, 2-octyldodecyl palmitate, oleyl oleate, oleyl erucate, erucyl oleate, erucyl erucate, and synthetic, semysin thetic and natural mixtures of such esters, e.g. B. jojoba oil.

Furthermore, the oil phase can be advantageously selected from the group of branched and unbranched hydrocarbons and waxes, the silicone oils, the dialkyl ethers, the group of saturated or unsaturated, branched or unbranched alcohols le, as well as the fatty acid triglycerides, namely the triglycerol esters of saturated and / or unsaturated, branched and / or unbranched alkanecarboxylic acids of a chain length ge from 8 to 24, in particular 12-18 C-atoms. The fatty acid triglycerides may be included For example, be advantageously selected from the group of synthetic, semisyntheti and natural oils, eg. Olive oil, sunflower oil, soybean oil, peanut oil, rapeseed oil, Almond oil, palm oil, coconut oil, palm kernel oil, and the like.

Any mixtures of such oil and wax components are advantageous in Use of the present invention. It may also be advantageous if necessary waxes, for example cetyl palmitate, as the sole lipid component of the oil phase use.

Advantageously, the oil phase is selected from the group consisting of 2-ethylhexyl isostearate, octyldodanol, isotridecyl isononanoate, isoeicosane, 2-ethylhexyl cocoate, C _12-15 alkyl benzoate, caprylic capric acid triglyceride, dicaprylyl ether.

Particularly advantageous are mixtures of C _12-15 -alkyl benzoate and 2-Ethylhexylisostea rat, mixtures of C _12-15 -alkyl benzoate and Isotridecylisononanoat and mixtures of C _12-15 -alkyl benzoate, 2-Ethylhexylisostearat and Isotridecylisononanoat.

Of the hydrocarbons, paraffin oil, squalane and squalene are advantageous in the sense to use the present invention.

Advantageously, the oil phase may further contain cyclic or linear silicone oils or consist entirely of such oils, although it is preferred that in addition to the silicone oil or the silicone oils an additional content of other oil phase vertical components to use.

Advantageously, cyclomethicone (octamethylcyclotetrasiloxane) is used as the invention used silicone oil. But other silicone oils are beneficial in Sin ne of the present invention, for example hexamethylcyclotrisiloxane, Polydimethylsiloxane, poly (methylphenylsiloxane).

Also particularly advantageous are mixtures of cyclomethicone and isotridecylisono nanoate, from cyclomethicone and 2-ethylhexyl isostearate.

The aqueous phase of the preparations according to the invention optionally contains partly alcohols, diols or polyols low C number, and their ethers, preferably Ethanol, isopropanol, propylene glycol, glycerol, ethylene glycol, ethylene glycol monoethyl or monobutyl ether, propylene glycol monomethyl, monoethyl or monobutyl ether, Diethylene glycol monomethyl or monoethyl ether and analogous products, further Alko get low C-number, z. As ethanol, isopropanol, 1,2-propanediol, glycerol and in particular in particular one or more thickening agents, which or which are advantageously chosen can be selected from the group silicon dioxide, aluminum silicates, polysaccharides or their derivatives, eg. Hyaluronic acid, xanthan gum, hydroxypropylmethylcellulose, be particularly advantageous from the group of polyacrylates, preferably a polyacrylate from the Group of so-called Carbopols, for example Carbopols of types 980, 981, 1382, 2984, 5984, each alone or in combination.

Gels used according to the invention usually contain alcohols of low C number, z. For example, ethanol, isopropanol, 1,2-propanediol, glycerol and water or an above called oil in the presence of a thickening agent, the oily-alcoholic gels  preferably silicon dioxide or an aluminum silicate, with aqueous-alcoholic or al koholischen gels is preferably a polyacrylate.

Fixed pins contain z. As natural or synthetic waxes, fatty alcohols or Fatty acid ester.

Usual raw materials which are suitable for use as cosmetic sticks in the sense of are suitable in the present invention, liquid oils (eg., Paraffin oils, castor oil, Iso propyl myristate), semi-solid ingredients (e.g., vaseline, lanolin), solid ingredients (e.g. Beeswax, ceresin and microcrystalline waxes or ozokerite) and Hochschmel shiny waxes (eg carnauba wax, candelilla wax)

As a propellant for sprayable from aerosol containers cosmetic and / or dermato Logical preparations in the sense of the present invention are the usual ones highly volatile, liquefied propellants, for example hydrocarbons (Pro pan, butane, isobutane) which are used alone or mixed with one another you can. Also, compressed air is advantageous to use.

Of course, the expert knows that there are nontoxic propellants per se, the reason in addition to the realization of the present invention in the form of Aerosolpräpa would be appropriate, but nevertheless due to a dubious effect on the order world or other accompanying circumstances should be waived, in particular Fluorkoh hydrocarbons and chlorofluorocarbons (CFCs).

Cosmetic preparations according to the present invention may also be used as gels present, in addition to an effective content of the active ingredient according to the invention and there for commonly used solvents, preferably water, still organic Thickener, z. Gum arabic, xanthan gum, sodium alginate, cellulose de preferably, methylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, Hydroxypropylcellulose, hydroxypropylmethylcellulose or inorganic thickening medium, z. As aluminum silicates such as bentonites, or a mixture of poly ethylene glycol and polyethylene glycol stearate or distearate. The thickening is medium in the gel z. B. in an amount between 0.1 and 30 wt .-%, preferably zwi 0.5 and 15 wt .-%, contained.  

It is particularly advantageous in the context of the present invention, when the inventions According to the cosmetic or dermatological preparations according to the invention further active ingredients contain, in particular natural agents and / or derivatives thereof, such as. Eg alpha- Lipoic acid, phytoene, D-biotin, coenzyme Q10, alpha glucosylrutin, carnitine, carnosine, Osmolyte, clover extract, hop or hop malt extract.

The content of these active ingredients (one or more compounds) is advantageously from the Range from 0.0001 to 30 wt .-% selected, based on the total weight of Zube TION.

The following examples are intended to illustrate the present invention, wherein one or more of the following substances are to be understood here in particular as "isoflavones":
Ipriflavone (7-isopropoxy-isoflavone), formononetin (7-hydroxy-4'-methoxyisoflavone), ononine (formononetin-7-O-β-D-glucopyranoside), 4'-isopropyl-isoflavone, mono-hydroxy-isoflavones, mono -hydroxy-dihydro-isoflavones, mono-hydroxy-tetrahydro-isoflavones, O-desmethylangolensin, dihydro-daidzein (dihydro-7,4-dihydroxy-isoflavone), tetrahydro-daidzein (tetrahydro-7,4'-dihydroxy-isoflavone), Dihydro-genistein (dihydro-5,7,4'-trihydroxy-isoflavone), 2-dehydro-O-desmethyl-angolensin, dehydroequol, 4-hydroxy-7-glucose isoflavone and 5-hydroxy-7,4'- dimethoxy-isoflavone

Examples

7. Examples O / W creams

continuation

2. Examples W / O Emulsions

continuation

3. Examples of hydrodispersions

4th example (gel cream)

Mass content (%) Acrylates / C10-30 Alkyl Acrylate Crosspolymer 0.40 Carbomer 0.20 Xanthan gum 0.10 Cetearyl alcohol 3.00 C _12-15 alkyl benzoates 4.00 Caprylic / Capric Triglycerides 3.00 cyclomethicones 5.00 dimeticones 1.00 isoflavonoids 0.20 glycerin 3.00 sodium hydroxide q. s. preservation q. s. Perfume q. s. Water, demineralized pH adjusted to 6.0 ad 100.0

Example (W / O cream)

Mass content (%) Lameform TGI 3.50 glycerin 3.00 Dehymuls PGPH 3.50 isoflavonoids 0.50 preservative q. s. Perfume q. s. magnesium sulfate 0.6 Isopropyl stearate 2.0 Caprylyl ether 8.0 Cetearyl Isononanoate 6.0 Water, demin. ad 100.0

Example (W / O / W cream)

Mass content (%) Glyceryl stearate 3.00 PEG-100 stearates 0.75 behenyl 2.00 Caprylic / Capric Triglycerides 8.0 octyldodecanol 5.00 C _12-15 alkyl benzoates 3.00 isoflavonoids 1.00 Magnesium sulphate (MgSO ₄ ) 0.80 EDTA 0.10 preservation q. s. Perfume q. s. Water, demineralized pH adjusted to 6.0 ad 100.0

Claims (5)

1. Use of substances selected from the group:
Ipriflavone (7-isopropoxy-isoflavone), formononetin (7-hydroxy-4'-methoxyisoflavone), ononine (formononetin-7-O-β-D-glucopyranoside), 4'-isopropyl-isoflavone, mono-hydroxy-isoflavones, Mono-hydroxy-dihydro-isoflavones, mono-hydroxy-tetrahydro-isoflavones, O-desmethylangolensin, dihydro-daidzein (dihydro-7,4'-dihydroxy-isoflavone), tetrahydro-daidzein (tetra-hydro-7,4'-dihydroxy) Isoflavone), dihydro-genistein (dihydro-5,7,4'-trihydroxy-isoflavone), 2-dehydro-O-desmethyl-angolensin, dehydroequol, 4-hydroxy-7-glucose isoflavone and 5-hydroy-7, 4'-dimethoxy-isoflavone
in cosmetic or dermatological preparations for the treatment, care and prophylaxis of sensitive skin and / or for the treatment and prophylaxis of the symptoms of a negative change in the physiological homeostasis of the healthy skin. 2. Use according to claim 1, wherein the skin damage and / or negative Hautzu states one or more appearances from the following group:
Changes in normal lipid peroxidation,
deficient, sensitive or hypoactive skin conditions or deficient, sensitive or hypoactive states of skin appendages,
inflammatory skin conditions,
atopic eczema, polymorphic photodermatosis, psoriasis, vitiligo,
sensitive, itchy or irritated skin,
Change in the ceramide, lipid and energy metabolism of healthy skin,
Change in physiological transepidermal water loss,
Reduction of skin hydration and decrease of the moisture content of the skin,
Change in Natural Moisturizing Factor content,
Reduction of cell-cell communication,
Deficiency symptoms of intracellular DNA synthesis,
DNA damage and reduction of endogenous DNA repair mechanisms,
Activation of metalloproteinases and / or other proteases or inhibition of the corresponding endogenous inhibitors of these enzymes,
Deviations from the normal post-translational modifications of connective tissue components,
Changes in normal hyaluronic acid and glycosaminoglycan content of healthy skin,
Dandruff of the hair,
Skin brittleness and skin fatigue,
Increase in normal keratinocyte proliferation,
Reduction of natural regeneration of hair,
environmental (caused by smoking, smog, reactive oxygen species, free Rad kale or the like) negative changes in the skin and the skin appendages. 3. Use according to claim 1, characterized in that the content of iso flavones (one or more compounds) in the cosmetic or dermato logical preparations in the range of 0.0005 to 50.0 wt .-%, esp in particular from 0.01 to 20.0 wt .-%, is selected, in each case based on the Ge total weight of the composition. 4. Use according to claim 1, characterized in that the content of iso flavones (one or more compounds) in the cosmetic or dermato logical preparations in the range of 0.02 to 10.0 wt .-%, preferably from 0.02 to 5.0% by weight, more preferably from 0.5 to 3.0% by weight is, in each case based on the total weight of the composition. 5. Use according to claim 1, wherein the cosmetic or dermatological Zu Prepare yourself by adding an additional salary to one or more of the fol natural active substances and / or their derivatives: alpha-lipone acid, phytoene, D-biotin, coenzyme Q10, alpha glucosylrutin, carnitine, carnosine, Osmolyte, clover extract, hop or hop malt extract.