DE10019753A1 - Use of glucoside residue-containing polysiloxanes in topical deodorant preparations to stem growth of sweat-decomposing microbes without destroying them - Google Patents

Abstract

Use is claimed of glucoside residue-containing polysiloxanes, which stem the growth of sweat-decomposing microbes, as deodorant in topical preparations for suppressing body odors.

Description

The invention relates to the use of polysiloxanes containing glycosides as deodorant active ingredients that inhibit the growth of sweat-decomposing germs in typi preparations for suppressing body odor.

The annoying smell that accompanies human perspiration becomes mainly through the bacterial decomposition of the initially odorless sweat on the skin and in of clothing. One therefore has to suppress body odor either antiperspirant preparations or substances used to support growth or life impair the function of the sweat-decomposing germs.

Attempts have also been made to mask the body odor with fragrances or with Ab bind sorbents, but such measures have generally not been sufficient proven. Strongly antimicrobial substances in turn have the disadvantage that they Permanently disturb the skin's bacterial flora or are not sufficiently compatible with the skin and in this way lead to irritation and intolerance.

There is therefore a constant need for substances that are suitable for use as deodo dermatologically safe, well tolerated active ingredients for the suppression of Body odor.

It is known that sweat decomposition on the skin is preferred by gram-positive bacteria me, especially by so-called., Coryneform bacteria, e.g. B. the Corynebacterium xerosis, is caused. It has now been found that polysiloxanes containing glucoside residues  Effectively inhibit the growth of these germs without causing a radical killing of the Germ comes. It is therefore believed that the skin flora does not damage the However, the sweat-decomposing effect of the skin flora is already considerably reduced.

The invention therefore relates to the use of poly having glucoside residues siloxanes as a deodorant, growth-inhibiting germ-inhibiting effect substances in topical preparations for suppressing body odor.

Polysiloxanes with glucosides bound directly or via glycol ether groups are litera known, e.g. B. from AT 393 509; US 5,428,142 A; WO 98/49998 A2; WO 98/50006 A1, WO 99/00400 and EP 0 612 759 A1. Products of this type are already on the market, e.g. B. under the name Belsil® SPG 121 VP (Wacker Chemie GmbH). The invent Polysiloxanes which contain suitable glucoside residues are water-soluble compounds bindings with surface-active properties, e.g. B. with a good emulsifying power. However, there are also known lipophilic polysiloxanes containing glucoside residues. B. still contain one or more pendant alkyl groups with 6-18 carbon atoms or whose glucoside residues are alkyl substituted.

Suitable active substances are in particular the products of the formula I.

R ¹ [Si (CH ₃ ) ₂ O] _x - [SiCH ₃ R ² O] _y - [Si (CH ₃ ) ₂ O] _z -Si (CH ₃ ) ₂ R ³ (I)

in which at least one of the groups R ¹ , R ² or R ^{3 is} a group of the formula (G) _n - (R ⁴ O) _p - R ⁵ - and the other are methyl groups, R ⁴ and R ^{5 are} alkylene groups with 2-4 C atoms, x, y, z and p are each O or numbers from 1-20, where (x + y + z) is at least 2 and (G) _{n is} an oligoglycoside residue with a degree of oligomerization n of 1-4. The product Belsil® SPG121 VP is one of these preferred suitable polysiloxanes containing glucoside residues. In these preferably suitable compounds of the formula I, R ¹ and R ^{3 are} hydrogen and (G) _{n is} a glucoside residue with an average degree of oligomerization n of 1-2.

The polysiloxanes containing glucoside residues to be used according to the invention are described in the deodorant cosmetic preparations are preferred as the sole antimicrobial deodorant component used.  

Another object of the invention is a deodorant cosmetic preparation for topical application in an aqueous, emulsion-like, aqueous-alcoholic or anhydrous carrier as a deodorant component 0.1-10% by weight of a glucoside contain polysiloxane.

In order to take advantage of the particular benefits of these active ingredients, the inventive should Preparations should preferably be free of other antimicrobial substances. On the other hand, can a content of other deodorant components, e.g. B. esterase inhibiting agents, ad sorptive or antioxidant components, fragrances or antiperspirant the protein coagulating salts further increase the deodorising effect.

The aqueous, emulsion or anhydrous carriers suitable as carriers can be be liquid, pasty or solid. It can be liquid lotions or low viscosity Emulsions act out of pump atomizers or with the help of aerosol propellants the skin to be brought. But it can also be thickened lotions or emulsions act that are applied from roll-on donation containers. After all, he can Preparations according to the invention also as deodorant ointments or creams, as deodorant pen preparations or deodorising soaps.

The poly containing glucoside residues to be used according to the invention are preferred siloxanes in combination with antiperspirant, astringent salts in the preparation used. In a preferred embodiment, the deodorie according to the invention contains astringent, antiperspirant salts in an amount of 1-40 % By weight of the composition. Suitable antiperspirant salts are e.g. B. aluminum chloride, aluminum chlorohydrate, aluminum dichlorohydrate, aluminum sesquichlorohydrate and their complexes with 1,2-propylene glycol, aluminum hydroxyallantoinate, aluminum Zirconium tri or tetrachlorohydrate, aluminum zirconium pentachlorohydrate and their Complex compounds with amino acids, e.g. B. with glycine.

In anhydrous compositions, the astringent, antiperspirant Sal ze preferably in the form of fine particles with an average particle size of less than 100 μm, the poly containing 0.05 to 10 wt .-% (of the composition) of the glucoside residues  siloxane impregnated or coated. In watery, watery-alcoholic and emulsion-like compositions, the glycoside residues are incorporated send polysiloxanes by dissolving in the aqueous phase. Less hydrophilic, glycosidre Polysiloxanes containing ste can also in alcohols, glycols, glycol ethers, polyols or polyalkylene glycols can be dissolved and thus incorporated into the preparation. Very lipo phile polysiloxanes are mixed with the emulsifiers or the oil components and incorporated.

In addition, the deodorant preparations according to the invention can contain all the auxiliaries and additives required for the particular application form, for. B.

• - cosmetic oils, fats, waxes, silicones
• - surfactants and emulsifiers
• - lower alcohols with 2-4 C atoms, glycols, glycol ethers and polyols with 2-6 C- Atoms
• - polyethylene glycols and other water-soluble synthetic polymers
• - Cellulose ethers, starch derivatives, vegetable gums and biopolymers
• - organophilic clays
• - Dyes and fragrances
• - complexing agent
• - antioxidants
• - Adsorbents such as B. cellus or starch powder, aerosil, talc, layered silicates (Hectorite)
• - Esterase-inhibiting agents such. B. triethyl citrate, tracetin,
• - Skin care substances such as B. plant extracts, humectants, vitamins, panthenol, Urea, allantoin

The following examples are intended to explain the subject matter of the invention in more detail:  

Examples 1. Testing bacterial growth inhibition

0.3 ml of a solution of 2% by weight Belsil SPG 121 UP (corresponding to 1% by weight silicone polyglucoside) in water was applied to a filter paper disc (d = 4.5 cm) and this was placed on a bacterial agar medium ( Brain Heart Infusion Agar with Coryne bacterium xerosis, 2.4.10 ⁴ CFU / ml agar).

After incubation, the width of the inhibition zone formed was measured; if no inhibition zone was formed, the growth under the filter paper disc was assessed:
no growth = 0
clearly inhibited growth = 1
slightly inhibited growth = 2
uninhibited growth = 3

There was no inhibition zone, but also no bacterial growth under the filter pa pier disc.

2. Examples of use

Claims (6)

1. Use of polysiloxanes containing glucoside residues as the deodorant Active ingredients inhibiting the growth of perspiration-disrupting germs in topical preparations to suppress body odor. 2. Use according to claim 1, characterized in that those of formula I as deodorant active ingredients
R ¹ [Si (CH ₃ ) ₂ O] _x - [SiCH ₃ R ² O] _y - [Si (CH ₃ ) ₂ O] _z -Si (CH ₃ ) ₂ R ³
in which at least one of the groups R ¹ , R ² or R ^{3 is} a group of the formula (G) _n - (R ⁴ O) _p R ⁵ - and the other are methyl groups, R ⁴ and R ^{5 are} alkylene groups with 2-4 C. -Atoms, x, y, z and p = 0 or numbers from 1-20, where (x + y + z) is at least 2 and (G) _{n is} an oligoglycoside residue with a degree of oligomerization n of 1-4. 3. Use according to claim 1 or 2, characterized in that R ¹ and R ³ What serstoff and (G) _{n is} a glucoside residue with an average degree of oligomerization n of 1-2. 4. Deodorant cosmetic compositions, characterized in that they in an aqueous, emulsion-like, aqueous-alcoholic or anhydrous Carrier as a deodorant component 0.1-10 wt .-% of a glucoside residue send contain polysiloxane. 5. Deodorant cosmetic compositions according to claim 4, characterized ge indicates that they contain astringent antiperspirant salts in an amount of Contain 1-40 wt .-% of the composition. 6. Deodorising cosmetic anhydrous compositions according to one of the An sayings 4 or 5, characterized in that they contain 5-40% by weight of astringent, antiperspirant salts in the form of fine particles with an average particle size of less than 100 microns, with 0.05-10 wt .-% of the glucoside residues containing poly are siloxane impregnated or coated.