JP4219794B2 - Antiperspirant / deodorant composition - Google Patents
Antiperspirant / deodorant composition Download PDFInfo
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- JP4219794B2 JP4219794B2 JP2003401130A JP2003401130A JP4219794B2 JP 4219794 B2 JP4219794 B2 JP 4219794B2 JP 2003401130 A JP2003401130 A JP 2003401130A JP 2003401130 A JP2003401130 A JP 2003401130A JP 4219794 B2 JP4219794 B2 JP 4219794B2
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- aluminum
- antiperspirant
- deodorant composition
- odor
- glyceryl
- Prior art date
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- 230000001166 anti-perspirative effect Effects 0.000 title claims description 27
- 239000003213 antiperspirant Substances 0.000 title claims description 27
- 239000002781 deodorant agent Substances 0.000 title claims description 18
- 239000000203 mixture Substances 0.000 title claims description 17
- -1 chlorohydroxyaluminum Chemical compound 0.000 claims description 17
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 10
- 229910052782 aluminium Inorganic materials 0.000 claims description 10
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 6
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 6
- 239000004480 active ingredient Substances 0.000 claims description 6
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims description 6
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 claims description 6
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims description 3
- 239000004471 Glycine Substances 0.000 claims description 3
- 229960000458 allantoin Drugs 0.000 claims description 3
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 claims description 3
- DIZPMCHEQGEION-UHFFFAOYSA-H aluminium sulfate (anhydrous) Chemical compound [Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O DIZPMCHEQGEION-UHFFFAOYSA-H 0.000 claims description 3
- 229940046892 lead acetate Drugs 0.000 claims description 3
- ADGFKRMKSIAMAI-UHFFFAOYSA-L oxygen(2-);zirconium(4+);chloride;hydroxide Chemical compound [OH-].[O-2].[Cl-].[Zr+4] ADGFKRMKSIAMAI-UHFFFAOYSA-L 0.000 claims description 3
- GRLPQNLYRHEGIJ-UHFFFAOYSA-J potassium aluminium sulfate Chemical compound [Al+3].[K+].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O GRLPQNLYRHEGIJ-UHFFFAOYSA-J 0.000 claims description 3
- 229960001922 sodium perborate Drugs 0.000 claims description 3
- YKLJGMBLPUQQOI-UHFFFAOYSA-M sodium;oxidooxy(oxo)borane Chemical compound [Na+].[O-]OB=O YKLJGMBLPUQQOI-UHFFFAOYSA-M 0.000 claims description 3
- 239000011787 zinc oxide Substances 0.000 claims description 3
- 229960001296 zinc oxide Drugs 0.000 claims description 3
- ZUGAOYSWHHGDJY-UHFFFAOYSA-K 5-hydroxy-2,8,9-trioxa-1-aluminabicyclo[3.3.2]decane-3,7,10-trione Chemical compound [Al+3].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O ZUGAOYSWHHGDJY-UHFFFAOYSA-K 0.000 claims description 2
- 229940044652 phenolsulfonate Drugs 0.000 claims description 2
- 239000007762 w/o emulsion Substances 0.000 claims description 2
- ZNVKGUVDRSSWHV-UHFFFAOYSA-L zinc;4-hydroxybenzenesulfonate Chemical compound [Zn+2].OC1=CC=C(S([O-])(=O)=O)C=C1.OC1=CC=C(S([O-])(=O)=O)C=C1 ZNVKGUVDRSSWHV-UHFFFAOYSA-L 0.000 claims description 2
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 claims 1
- 235000019645 odor Nutrition 0.000 description 15
- 230000000844 anti-bacterial effect Effects 0.000 description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 210000004243 sweat Anatomy 0.000 description 5
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 4
- 239000008213 purified water Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 239000002552 dosage form Substances 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- 229940058015 1,3-butylene glycol Drugs 0.000 description 2
- JWAZRIHNYRIHIV-UHFFFAOYSA-N 2-naphthol Chemical compound C1=CC=CC2=CC(O)=CC=C21 JWAZRIHNYRIHIV-UHFFFAOYSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 206010040880 Skin irritation Diseases 0.000 description 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000000022 bacteriostatic agent Substances 0.000 description 2
- 235000019437 butane-1,3-diol Nutrition 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 230000001877 deodorizing effect Effects 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- 239000006210 lotion Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 230000036556 skin irritation Effects 0.000 description 2
- 231100000475 skin irritation Toxicity 0.000 description 2
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 description 1
- WHOZNOZYMBRCBL-OUKQBFOZSA-N (2E)-2-Tetradecenal Chemical compound CCCCCCCCCCC\C=C\C=O WHOZNOZYMBRCBL-OUKQBFOZSA-N 0.000 description 1
- GBXRUYNQDDTQQS-UHFFFAOYSA-N 1-O-dodecylglycerol Chemical compound CCCCCCCCCCCCOCC(O)CO GBXRUYNQDDTQQS-UHFFFAOYSA-N 0.000 description 1
- DIZBQMTZXOUFTD-UHFFFAOYSA-N 2-(furan-2-yl)-3h-benzimidazole-5-carboxylic acid Chemical compound N1C2=CC(C(=O)O)=CC=C2N=C1C1=CC=CO1 DIZBQMTZXOUFTD-UHFFFAOYSA-N 0.000 description 1
- SHQRLYGZJPBYGJ-UHFFFAOYSA-N 3-decoxypropane-1,2-diol Chemical compound CCCCCCCCCCOCC(O)CO SHQRLYGZJPBYGJ-UHFFFAOYSA-N 0.000 description 1
- LUCBXPCLWJFUFS-UHFFFAOYSA-N 3-heptoxypropane-1,2-diol Chemical compound CCCCCCCOCC(O)CO LUCBXPCLWJFUFS-UHFFFAOYSA-N 0.000 description 1
- GUPXYSSGJWIURR-UHFFFAOYSA-N 3-octoxypropane-1,2-diol Chemical compound CCCCCCCCOCC(O)CO GUPXYSSGJWIURR-UHFFFAOYSA-N 0.000 description 1
- 241000186216 Corynebacterium Species 0.000 description 1
- GZIFEOYASATJEH-UHFFFAOYSA-N D-delta tocopherol Natural products OC1=CC(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 GZIFEOYASATJEH-UHFFFAOYSA-N 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 208000030961 allergic reaction Diseases 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- OGQYPPBGSLZBEG-UHFFFAOYSA-N dimethyl(dioctadecyl)azanium Chemical compound CCCCCCCCCCCCCCCCCC[N+](C)(C)CCCCCCCCCCCCCCCCCC OGQYPPBGSLZBEG-UHFFFAOYSA-N 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 1
- KWLMIXQRALPRBC-UHFFFAOYSA-L hectorite Chemical compound [Li+].[OH-].[OH-].[Na+].[Mg+2].O1[Si]2([O-])O[Si]1([O-])O[Si]([O-])(O1)O[Si]1([O-])O2 KWLMIXQRALPRBC-UHFFFAOYSA-L 0.000 description 1
- 229910000271 hectorite Inorganic materials 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 230000000873 masking effect Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 229940044654 phenolsulfonic acid Drugs 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 244000005714 skin microbiome Species 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000009747 swallowing Effects 0.000 description 1
- 210000000106 sweat gland Anatomy 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- GZIFEOYASATJEH-VHFRWLAGSA-N δ-tocopherol Chemical compound OC1=CC(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 GZIFEOYASATJEH-VHFRWLAGSA-N 0.000 description 1
Description
この発明は、汗の臭いを防ぐ効果が高く、且つ長時間にわたり持続力のある制汗・防臭剤組成物に関する。 The present invention relates to an antiperspirant / deodorant composition that is highly effective in preventing sweat odor and has a long-lasting ability.
一般に、汗の臭いは、汗腺などの皮膚分泌腺を通して生じた皮膚分泌物が、皮膚常在菌により分解され、低級脂肪酸、ケトン、アンモニア、アルデヒドなどの成分に変化し発生する。これら臭いを抑えるためには、汗や皮膚分泌物を抑制する方法、皮膚常在菌を殺菌、滅菌あるいは制菌する方法、発生した臭い成分を吸着消臭する方法、または、香料などによりマスキングする方法などが一般的に知られており、従来より、制汗デオドラント剤には、これらの方法が併用される場合が多い。 In general, the smell of sweat is generated when skin secretions generated through skin secretory glands such as sweat glands are decomposed by skin resident bacteria and changed into components such as lower fatty acids, ketones, ammonia and aldehydes. In order to suppress these odors, a method of suppressing sweat and skin secretions, a method of sterilizing, sterilizing or sterilizing resident skin bacteria, a method of adsorbing and deodorizing generated odor components, or masking with a fragrance, etc. Methods are generally known, and conventionally, these methods are often used in combination with antiperspirant deodorant agents.
しかしながら、従来のデオドラント化粧料では、制汗剤、殺菌剤、消臭剤が配合されているものの、皮膚刺激性や薬事上の規制などの点から配合できる量には限界があり、安全性，有効性の両面を兼ね備えた制汗・防臭剤組成物は未だ得られていないのが現状である。 However, although conventional deodorant cosmetics contain antiperspirants, bactericides, and deodorants, there are limits to the amount that can be added in terms of skin irritation and regulatory regulations, The present condition is that the antiperspirant and deodorant composition which has both sides of effectiveness has not been obtained yet.
なお、グリセリルモノアルキルエーテルは、ノニオン性界面活性剤として知られており（非特許文献１参照）、その化粧料への配合，抗菌作用等についても研究されている（特許文献１〜特許文献５参照）。 Glyceryl monoalkyl ether is known as a nonionic surfactant (see Non-Patent Document 1), and its formulation into cosmetics, antibacterial action, and the like have also been studied (Patent Documents 1 to 5). reference).
本発明においては、上記のような問題点を解決し、人体への安全性が高く、高い制汗・防臭効果を発揮する制汗・防臭剤組成物を提供することにある。 In the present invention, an object of the present invention is to provide an antiperspirant / deodorant composition that solves the above-described problems, has high safety to the human body, and exhibits a high antiperspirant / deodorant effect.
上記の課題を解決するにあたり、種々検討を行ったところ、静菌剤としてグリセリルモノアルキルエーテルを使用し、さらに特定の制汗有効成分を併用して制汗防臭剤組成物に配合することにより、人体への安全性が高く、高い制汗・防臭効果を発揮することを見いだし、本発明を完成するにいたった。 In order to solve the above-mentioned problems, various studies were conducted, and by using glyceryl monoalkyl ether as a bacteriostatic agent, and further using a specific antiperspirant active ingredient in combination with the antiperspirant deodorant composition, It has been found that the safety to the human body is high and high antiperspirant and deodorizing effects are exhibited, and the present invention has been completed.
制汗・防臭剤組成物に、クロルヒドロキシアルミニウム、塩化アルミニウム、アラントイン・アルミニウム誘導体、硫酸アルミニウム、硫酸アルミニウムカリウム、アルミニウム・ジルコニウムクロロハイドレート・グリシンコンプレックス、クエン酸アルミニウム、フェノールスルホン酸アルミニウム、β−ナフトールジスルホン酸アルミニウム、ｐ−フェノールスルホン酸亜鉛、酸化亜鉛、酢酸鉛、過ホウ酸ナトリウムから選択される１種又は２種以上の制汗有効成分と、静菌剤であるグリセリルモノアルキルエーテルを併用することにより、人体への安全性が高く、高い制汗・防臭効果を発揮する。 Antiperspirant / deodorant composition, chlorohydroxyaluminum, aluminum chloride, allantoin / aluminum derivative, aluminum sulfate, aluminum sulfate potassium, aluminum / zirconium chlorohydrate / glycine complex, aluminum citrate, phenol sulfonate aluminum, β-naphthol Use one or more active antiperspirant ingredients selected from aluminum disulfonate, zinc p-phenolsulfonate, zinc oxide, lead acetate, sodium perborate, and glyceryl monoalkyl ether as a bacteriostatic agent Therefore, it is highly safe for the human body and exhibits high antiperspirant and deodorant effects.
本発明の制汗・防臭剤組成物に配合する制汗有効成分としては、クロルヒドロキシアルミニウム、塩化アルミニウム、アラントイン・アルミニウム誘導体、硫酸アルミニウム、硫酸アルミニウムカリウム、アルミニウム・ジルコニウムクロロハイドレート・グリシンコンプレックス、クエン酸アルミニウム、フェノールスルホン酸アルミニウム、β−ナフトールジスルホン酸アルミニウム、ｐ−フェノールスルホン酸亜鉛、酸化亜鉛、酢酸鉛、過ホウ酸ナトリウムから選択される１種又は２種以上を用いる。かかる制汗剤は制汗・防臭剤組成物中に０．０１〜３０重量％、特に０．１〜１５．０重量％含有するのが好ましい。 Antiperspirant active ingredients to be incorporated into the antiperspirant / deodorant composition of the present invention include chlorohydroxyaluminum, aluminum chloride, allantoin / aluminum derivatives, aluminum sulfate, potassium aluminum sulfate, aluminum / zirconium chlorohydrate / glycine complex, 1 type (s) or 2 or more types selected from aluminum acid aluminum, phenolsulfonic acid aluminum, (beta) -naphthol disulfonic acid aluminum, p-phenolsulfonic acid zinc, zinc oxide, lead acetate, and sodium perborate are used. Such an antiperspirant is preferably contained in the antiperspirant / deodorant composition in an amount of 0.01 to 30% by weight, particularly 0.1 to 15.0% by weight.
一般的に使用されるグリセリルモノアルキルエーテルは、下記の化学式（１）を有する。
Ｒ-Ｏ-ＣＨ2-ＣＨＯＨ-ＣＨ2ＯＨ （１）
上記式中、Ｒは直鎖状もしくは分枝状で、炭素原子が３〜１４、特に５〜１２、好ましくは７〜１２の飽和もしくは不飽和のアルキル基を表す。
A commonly used glyceryl monoalkyl ether has the following chemical formula (1).
R—O—CH 2 —CHOH—CH 2 OH (1)
In the above formula, R represents a straight-chain or branched alkyl group having 3 to 14, particularly 5 to 12, preferably 7 to 12 carbon atoms, which is saturated or unsaturated.
これらの化合物の中では、特に、１−ヘプチルグリセリルエーテル、１−（２−エチルヘキシル）グリセリルエーテル、１−オクチルグリセリルエーテル、１−デシルグリセリルエーテル及び１−ドデシルグリセリルエーテルを挙げることができる。これらの中では、１−（２−エチルヘキシル）グリセリルエーテルを使用することが好ましい。 Among these compounds, mention may in particular be made of 1-heptyl glyceryl ether, 1- (2-ethylhexyl) glyceryl ether, 1-octyl glyceryl ether, 1-decyl glyceryl ether and 1-dodecyl glyceryl ether. In these, it is preferable to use 1- (2-ethylhexyl) glyceryl ether.
グリセリルモノアルキルエーテルは、エタノールに溶解して用いることもできるが、油性成分に溶解して用いると、その抗菌作用を損なうことなく皮膚刺激性が低減され、好ましい。 Glyceryl monoalkyl ether can be used by dissolving it in ethanol, but it is preferable to use it by dissolving it in an oily component because the skin irritation is reduced without impairing its antibacterial action.
グリセリルモノアルキルエーテルの配合量は、制汗・防臭剤組成物全量に対して、０．０５〜３０重量％が好ましく、０．１〜５重量％がさらに好ましい。 The blending amount of glyceryl monoalkyl ether is preferably 0.05 to 30% by weight, more preferably 0.1 to 5% by weight, based on the total amount of the antiperspirant / deodorant composition.
本発明においては、上述の制汗有効成分とグリセリルモノアルキルエーテルを併用して制汗・防臭剤組成物に配合する。 In the present invention, the aforementioned antiperspirant active ingredient and glyceryl monoalkyl ether are used in combination in an antiperspirant / deodorant composition.
本発明の制汗・防臭剤組成物の剤型としては、クリーム、乳液、ローション、ゲル状、溶液状、スティック状等がある。これらの剤型のなかでも、乳化組成物、特に油中水型乳化組成物の剤型をとることにより、より高い効果が得られる。また、これらには適宜の成分、例えば、油剤、保湿剤、増粘剤、防腐剤、乳化剤、顔料、pH調製剤、他の薬効成分、紫外線吸収剤、香料等など一般に用いられる各種成分を配合することもできる。 Examples of the dosage form of the antiperspirant / deodorant composition of the present invention include creams, emulsions, lotions, gels, solutions, and sticks. Among these dosage forms, higher effects can be obtained by taking the dosage form of an emulsion composition, particularly a water-in-oil emulsion composition. In addition, appropriate ingredients such as oils, moisturizers, thickeners, preservatives, emulsifiers, pigments, pH adjusters, other medicinal ingredients, ultraviolet absorbers, fragrances, etc. You can also
なお、本願発明における皮膚外用剤において、他の制汗・防臭剤有効成分を併用して用いることも可能である。 In addition, in the skin external preparation in this invention, it is also possible to use together with another antiperspirant / deodorant active ingredient.
本発明の詳細について、実施例を用いて説明する。 Details of the present invention will be described using examples.
［実施例１〜実施例４］ 腋臭防止用油中水型乳化クリーム
(１)デカメチルシクロペンタシロキサン １２．３０(重量％)
(２)トリ２−エチルヘキサン酸グリセリル １２．３０
(３)メチルポリシロキサン ５．００
(４)ポリオキシエチレン・メチルポリシロキサン共重合体 ３．００
(５)架橋型メチルポリシロキサン １．２０
(６)ｄ−δ−トコフェロール ０．０５
(７)１−（２−エチルヘキシル）グリセリルエーテル ０．３０
(８)ポリメタクリル酸メチル ５．００
(９)エタノール １０．００
(10)ジメチルジステアリルアンモニウムヘクトライト ０．７０
(11)精製水 ４０．１５
(12)１，３−ブチレングリコール ５．００
(13)表１に示した制汗有効成分 ５．００
製法：(１)〜(８)の成分を混合し、(10)を(９)で膨潤させたものを添加して混合後、(11)〜(13)を添加して乳化する。
[Examples 1 to 4] Water-in-oil emulsified cream for odor control
(1) Decamethylcyclopentasiloxane 12.30 (% by weight)
(2) Glyceryl tri-2-ethylhexanoate 12.30
(3) Methylpolysiloxane 5.00
(4) Polyoxyethylene / methylpolysiloxane copolymer 3.00
(5) Cross-linked methylpolysiloxane 1.20
(6) d-δ-tocopherol 0.05
(7) 1- (2-Ethylhexyl) glyceryl ether 0.30
(8) Polymethyl methacrylate 5.00
(9) Ethanol 10.00
(10) Dimethyl distearyl ammonium hectorite 0.70
(11) Purified water 40.15
(12) 1,3-butylene glycol 5.00
(13) Antiperspirant active ingredient shown in Table 1 5.00
Production method: The components (1) to (8) are mixed, and the mixture obtained by swelling (10) with (9) is added and mixed, and then (11) to (13) are added and emulsified.
［実施例５］ 制汗ローション
(１)エタノール ３５．００(重量％)
(２)クロルヒドロキシアルミニウム ５．００
(３)１−（２−エチルヘキシル）グリセリルエーテル ０．５０
(４)ｌ−メントール ０．０５
(５)１，３−ブチレングリコール ５．００
(６)精製水 ５４．４５
製法：(１)に(２)〜(６)の成分を順次添加，混合する。
[Example 5] Antiperspirant lotion
(1) Ethanol 35.00 (wt%)
(2) Chlorhydroxyaluminum 5.00
(3) 1- (2-ethylhexyl) glyceryl ether 0.50
(4) l-Menthol 0.05
(5) 1,3-butylene glycol 5.00
(6) Purified water 54.45
Production method: Components (2) to (6) are sequentially added to (1) and mixed.
[抗菌効果の評価]
上記実施例１〜実施例５を用いて腋臭菌（Ｃｏｒｙｎｅｂａｃｔｅｒｉｕｍ ｍｉｎｕｔｉｓｓｉｍｕｍ）に対する抗菌効果を評価した。なお、同時に実施例１〜５において１−（２−エチルヘキシル）グリセリルエーテルを精製水に代替して比較例１〜５を調製し、同時に抗菌効果を評価した。抗菌効果は、ブイヨン培地にて培養した腋臭菌を１．０×１０7ｃｆｕ／ｇなるように実施例若しくは比較例に植菌し、３，５，１５，３０分後に生菌数を確認した。結果を表２に示す。
[Evaluation of antibacterial effect]
The antibacterial effect with respect to the odorous fungus ( Corynebacterium mutissimum ) was evaluated using the said Example 1- Example 5. At the same time, Comparative Examples 1 to 5 were prepared by substituting 1- (2-ethylhexyl) glyceryl ether with purified water in Examples 1 to 5, and antibacterial effects were simultaneously evaluated. The antibacterial effect was inoculated in Example or Comparative Example so that the malodorous bacteria cultured in bouillon medium were 1.0 × 10 7 cfu / g, and the number of viable bacteria was confirmed after 3, 5, 15 and 30 minutes. . The results are shown in Table 2.
表２に示したとおり、本発明の実施例は腋臭菌に対し、高い抗菌作用を示していた．しかしながら、１−（２−エチルヘキシル）グリセリルエーテルを配合していない比較例においては、殆ど抗菌作用を示していなかった。 As shown in Table 2, the examples of the present invention showed a high antibacterial action against odor-causing bacteria. However, in the comparative example in which 1- (2-ethylhexyl) glyceryl ether was not blended, the antibacterial action was hardly exhibited.
［腋臭防止効果］
上記実施例１〜実施例４を用いて腋臭防止効果の実使用試験を行った。なお、同時に実施例１〜４において配合した制汗有効成分を精製水に代替した比較例６を調製し、実使用試験に供した。実使用試験は、腋臭を気にする成人男女２０名を一群として、実施例若しくは比較例を１日２回４週間連続して腋下に塗布させ、使用前後に（１）腋臭の程度、（２）腋下の発汗量について、アンケート調査を行った。結果は、評価点の平均値にて、表３に示した。
（１）腋臭の程度
４：強い臭いを感じる
３：かなり強い臭いを感じる
２：やや強い臭いを感じる
１：弱い臭いを感じる
０：わからない（無臭）
（２）腋下の発汗量
２：多い
１：やや多い
０：正常
[Odor control effect]
The actual use test of the odor prevention effect was conducted using Examples 1 to 4 described above. At the same time, Comparative Example 6 in which the active antiperspirant compounded in Examples 1 to 4 was replaced with purified water was prepared and subjected to an actual use test. The actual use test consisted of 20 adult men and women who worried about foul odors, and applied examples or comparative examples to the armpit twice a day for 4 weeks, before and after use. 2) A questionnaire survey was conducted on the amount of sweat under the armpit. The results are shown in Table 3 as average values of evaluation points.
(1) Degree of odor 4: Feeling strong odor 3: Feeling quite strong odor 2: Feeling slightly strong odor 1: Feeling weak odor 0: I don't know (no odor)
(2) Swallowing amount under armpit 2: High 1: Slightly high 0: Normal
表３に示したとおり、比較例使用群では腋臭の程度，腋下の発汗量ともに変化が認められなかった。しかしながら、本願発明実施例使用群においては、腋臭の程度，発汗量ともに明確な改善が認められた。 As shown in Table 3, no changes were observed in both the degree of odor and the amount of sweat under the armpit in the comparative group. However, in the use example group of the present invention, a clear improvement was observed in both the odor level and the sweating amount.
なお、上記実使用試験中に本願実施例使用者において、刺激やアレルギー反応を訴えた被験者はおらず、安全性に優れることが示された。 In addition, there was no subject who complained of irritation or allergic reaction among the users of Examples of the present application during the above-mentioned actual use test, and it was shown that the safety is excellent.
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