DE10015547C2 - Verfahren zur Detektion von Molekülen mittels Impedanzspektroskopie und Vorrichtung zur Durchführung dieser Verfahren - Google Patents

Verfahren zur Detektion von Molekülen mittels Impedanzspektroskopie und Vorrichtung zur Durchführung dieser Verfahren

Info

Publication number
DE10015547C2
DE10015547C2 DE2000115547 DE10015547A DE10015547C2 DE 10015547 C2 DE10015547 C2 DE 10015547C2 DE 2000115547 DE2000115547 DE 2000115547 DE 10015547 A DE10015547 A DE 10015547A DE 10015547 C2 DE10015547 C2 DE 10015547C2
Authority
DE
Germany
Prior art keywords
carrier
molecules
layers
electrodes
membrane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE2000115547
Other languages
German (de)
English (en)
Other versions
DE10015547A1 (de
Inventor
Claus Escher
Norbert Windhab
Jochen Muth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nanogen Inc
Original Assignee
Aventis Research and Technologies GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Research and Technologies GmbH and Co KG filed Critical Aventis Research and Technologies GmbH and Co KG
Priority to DE2000115547 priority Critical patent/DE10015547C2/de
Priority to EP01929349A priority patent/EP1272851A1/fr
Priority to PCT/EP2001/001899 priority patent/WO2001075445A1/fr
Publication of DE10015547A1 publication Critical patent/DE10015547A1/de
Application granted granted Critical
Publication of DE10015547C2 publication Critical patent/DE10015547C2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/002—Electrode membranes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
DE2000115547 2000-03-30 2000-03-30 Verfahren zur Detektion von Molekülen mittels Impedanzspektroskopie und Vorrichtung zur Durchführung dieser Verfahren Expired - Lifetime DE10015547C2 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
DE2000115547 DE10015547C2 (de) 2000-03-30 2000-03-30 Verfahren zur Detektion von Molekülen mittels Impedanzspektroskopie und Vorrichtung zur Durchführung dieser Verfahren
EP01929349A EP1272851A1 (fr) 2000-03-30 2001-02-20 Procede et dispositif de detection de molecules par spectroscopie d'impedance
PCT/EP2001/001899 WO2001075445A1 (fr) 2000-03-30 2001-02-20 Procede et dispositif de detection de molecules par spectroscopie d'impedance

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2000115547 DE10015547C2 (de) 2000-03-30 2000-03-30 Verfahren zur Detektion von Molekülen mittels Impedanzspektroskopie und Vorrichtung zur Durchführung dieser Verfahren

Publications (2)

Publication Number Publication Date
DE10015547A1 DE10015547A1 (de) 2001-10-31
DE10015547C2 true DE10015547C2 (de) 2002-02-14

Family

ID=7636795

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2000115547 Expired - Lifetime DE10015547C2 (de) 2000-03-30 2000-03-30 Verfahren zur Detektion von Molekülen mittels Impedanzspektroskopie und Vorrichtung zur Durchführung dieser Verfahren

Country Status (3)

Country Link
EP (1) EP1272851A1 (fr)
DE (1) DE10015547C2 (fr)
WO (1) WO2001075445A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10211358B4 (de) * 2002-03-14 2006-10-26 Siemens Ag Vertikal-Impedanz-Sensor-Anordnung und Verfahren zum Herstellen einer Vertikal-Impedanz-Sensor-Anordnung
DE102007009131B4 (de) * 2007-02-24 2008-12-04 Forschungszentrum Karlsruhe Gmbh Verfahren zum hochempfindlichen Nachweis des Vorhandenseins von Makromolekülen in einem wässrigen Medium

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4787963A (en) * 1987-05-04 1988-11-29 Syntro Corporation Method and means for annealing complementary nucleic acid molecules at an accelerated rate
WO1988009499A1 (fr) * 1987-05-18 1988-12-01 The Johns Hopkins University Detecteur capacitif optimise pour des analyses et des mesures chimiques
EP0543550A1 (fr) * 1991-11-19 1993-05-26 Houston Advanced Research Center Méthode et appareil pour la détection de molécules
WO1996001836A1 (fr) * 1994-07-07 1996-01-25 Nanogen, Inc. Systemes et dispositifs microelectroniques a auto-adressage et auto-assemblage destines a des analyses et diagnostics de biologie moleculaire
WO1997021094A1 (fr) * 1995-12-01 1997-06-12 Innogenetics N.V. Systeme de detection par mesure de l'impedance et procede pour le fabriquer
US5653939A (en) * 1991-11-19 1997-08-05 Massachusetts Institute Of Technology Optical and electrical methods and apparatus for molecule detection
WO1997034140A1 (fr) * 1996-03-14 1997-09-18 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Detection de molecules et complexes moleculaires

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2107833T3 (es) * 1993-05-29 1997-12-01 Cambridge Life Sciences Sensores basados en transformacion de polimeros.
US5567301A (en) * 1995-03-01 1996-10-22 Illinois Institute Of Technology Antibody covalently bound film immunobiosensor
AU734086B2 (en) * 1996-05-22 2001-05-31 Australian Membrane And Biotechnology Research Institute Nucleic acid sensor
GB9622304D0 (en) * 1996-10-26 1996-12-18 Univ Manchester Sensor
FR2757949B1 (fr) * 1996-12-30 1999-01-22 Commissariat Energie Atomique Microsysteme pour analyses biologiques et son procede de fabrication

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4787963A (en) * 1987-05-04 1988-11-29 Syntro Corporation Method and means for annealing complementary nucleic acid molecules at an accelerated rate
WO1988009499A1 (fr) * 1987-05-18 1988-12-01 The Johns Hopkins University Detecteur capacitif optimise pour des analyses et des mesures chimiques
EP0543550A1 (fr) * 1991-11-19 1993-05-26 Houston Advanced Research Center Méthode et appareil pour la détection de molécules
US5653939A (en) * 1991-11-19 1997-08-05 Massachusetts Institute Of Technology Optical and electrical methods and apparatus for molecule detection
WO1996001836A1 (fr) * 1994-07-07 1996-01-25 Nanogen, Inc. Systemes et dispositifs microelectroniques a auto-adressage et auto-assemblage destines a des analyses et diagnostics de biologie moleculaire
WO1997021094A1 (fr) * 1995-12-01 1997-06-12 Innogenetics N.V. Systeme de detection par mesure de l'impedance et procede pour le fabriquer
WO1997034140A1 (fr) * 1996-03-14 1997-09-18 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Detection de molecules et complexes moleculaires

Also Published As

Publication number Publication date
EP1272851A1 (fr) 2003-01-08
WO2001075445A1 (fr) 2001-10-11
DE10015547A1 (de) 2001-10-31

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Legal Events

Date Code Title Description
OP8 Request for examination as to paragraph 44 patent law
D2 Grant after examination
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: NANOGEN, INC., SAN DIEGO, CALIF., US

8328 Change in the person/name/address of the agent

Representative=s name: ACKERMANN, J., DIPL.-CHEM. DR.RER.NAT., PAT.-ANW.,

8330 Complete disclaimer