DD286113A5 - METHOD AND DEVICE FOR STERIL FILTRATION OF FERMENTATION DRAIN - Google Patents

Abstract

The invention relates to a method and a device for sterile filtration of fermentation air from fermentations with complex media in the industrial Maszstab. The method is characterized in that the exhaust air filter systems consisting of one or more coarse separators and membrane filters are conditioned as Feinabscheidern in the sterile area by supplying controlled heat energy, wherein the inlet temperature of the exhaust air at the filter is higher or at least equal to the outlet temperature of the exhaust air to the fermenter to avoid a dew point in the exhaust air filter system. The device is characterized in that the exhaust pipe 2 is provided with a double jacket 3 or with a half-pipe coil 3 a. {Conditioning; exhaust; Filter; heat transfer; Temperature measurement; Inlet temperature; Outlet temperature; Exhaust pipe; Jacketed; Halfcoil}

Description

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Field of application of the invention

The invention relates to the field of sterile filtration of fermentation exhaust air from fermentations with complex media on an industrial scale.

The invention can preferably be used in the branches of the chemical industry in which fermentations are carried out with complex media and sterile filtration of the exhaust air is necessary. The invention is also applicable in all other industrial sectors in which exhaust air must be sterile filtered.

Characteristic of the known state of the art

For the filtration of fermentation exhaust air, a variety of technical solutions is known. Storile filtration of fermentation exhaust air from fermentations with complex media takes place as far as possible via membrane filters. For the separation of liquid droplets and solids content from the exhaust air and to improve the degree of separation on the membrane filter Behä.tereinbauten that work according to different principles, upstream of this filter (DD-WP 207338, DD-WP 233 078 Al).

Also known container installations for the separation of liquid droplets, the m. Packings, knitted or similar are provided (DE-OS 2 215 678). The remaining portion of the liquid droplets after this pre-separation is enriched again by condensation, caused by the cooling of the exhaust air. This proportion of water in the form of liquid droplets blocks the hydrophobic filter membrane surface shortly after.

The exhaust air must then be passed by a bypass until the end of the fermentation on filters. This leads to Unsterilitfiten by Rückkontarnination and non-filtration of the exhaust air. After drying the membrane filter elements, they are again permeable.

Object of the invention

The invention has the aim to eliminate the disadvantages of known filtration systems in membrane filtration, to significantly increase the service life of the filter systems and thus to avoid recontamination in sterile processes to reduce maintenance and upkeep and thus increase the efficiency dor overall system.

Explanation of the essence of the invention

It is the task to solve, a simple process for exhaust filtration from fermentations mti with complex media to develop that at high variability of the exhaust air flow with respect to throughput, dew point and temperature load over the longest possible period, but at least one fermentation cycle, a sterile exhaust guaranteed and sterile Fermentation processes a return contamination is avoided.

The object is achieved in that exhaust air filter systems consisting of one or more coarse separators (for example, demisters or prefilters) and membrane filters are conditioned as fine separators in the sterile area by supplying controlled heat energy, the inlet temperature of the exhaust air at the filter height ar or at least qleich df 4ustrittemperatur Exhaust air must be at the fermenter to .jrmeiden a dew point below in the exhaust air filtration system.

The conditioning of the gas to be cleaned takes place by a heat transfer to the exhaust air line in the flow direction in front of the filter and / or on the filter housing. According to the invention, the supply of heat energy via a control in dependence on the enforced exhaust air quantity, the air velocity and the temperature gradient. Preferably used for thermal energy supply resulting heat energy, which is recovered from the condensate of Sterilabschlüsse.

The Voi. Lung according to Figures 1 and 2 is characterized in that the exhaust pipe 2 'with a Doppelmante'. 3 or a half pipe coil 3a, which is divided into several segments. The individual segments can be switched on depending on the requirement of heat transfer.

In function flows through the exhaust air from the fermenter 1 in the fermentation of z. B. penicillin the exhaust pipe 2 and enters the exhaust filter 4 a. About the temperature controller 5, the temperature of the exhaust air is measured upon entry into the exhaust filter, and via the control valve 6, the heat energy supply takes place in the double jacket 3 of FIG. 1 and the half-pipe coil 3 a of FIG. 2. At a Temperbtiirdifferenz the exhaust between 1 and 10 ° C above the outlet temperature from the fermenter is closed by the temperature controller 5, the control valve 6 and the heat energy supply into the double jacket 3 is interrupted. After dropping the exhaust air temperature to temperature equality between fermenter outlet and filter inlet, the control valve 6 is controlled and opened via the temperature controller 5. Again, there is a supply of heat energy in the double jacket 3 until the set upper temperature limit of the exhaust air when entering the exhaust filter 4. This regulation serves to improve the Rnergleökonomie. It can also be a steady supply of energy.

This system of conditioning the exhaust air to be cleaned is applicable to all complex media fermentation systems.

Autfuhrungsbelsplele The invention will be explained in more detail by the following embodiments. example 1

In the fermentation of penicillin, the exhaust air from the fermenter 1 flows through the exhaust pipe 2 and enters the exhaust filter 4. About the temperature controller 6, the temperature of the exhaust air is measured when entering the exhaust filter and via the control valve β is dio heat energy supply in the double jacket 3 of FIG. 1. At a temperature difference of the exhaust air between 1 and 1O ⁰ C above the outlet temperature from don fermenter closed via the temperature controller 5, the control valve 6 and the heat energy supply in the double jacket 3 interrupted. After dropping the exhaust air temperature to temperature equality between fermenter outlet and filter inlet dps control valve 6 is controlled via the temperature controller 5 and opened. Again, there is a supply of heat energy in the double jacket 3 until the set upper temperature limit of the exhaust air when entering the exhaust filter 4. This regulation serves to improve the energy economy. It can also be a steady supply of energy.

This system of conditioning the exhaust air to be cleaned is applicable to all complex media fermentation systems.

example The reaction is carried out as in Example 1. Instead of the double jacket 3 is on the exhaust pipe 2 a Half pipe coil 3a grown.

Claims (7)

1. A process for the sterile filtration of fermentation exhaust air, characterized in that exhaust air filter systems consisting of one or more coarse separators and membrane filters are conditioned as Feinabscheider in the sterile area by supplying controlled heat energy, wherein the inlet temperature of the exhaust air at the filter higher or at least equal to the outlet temperature of the exhaust air to the fermenter is to avoid a dew point in the exhaust air filter system. 2. The method according to claim 1, characterized in that the conditioning of the gas to be cleaned by a heat transfer to the exhaust duct in the flow direction in front of the filter and / or on the filter housing. 3. The method according to claim 1 and 2, characterized in that the supply of heat energy via a control function of the enforced exhaust air quantity, air velocity and the temperature gradient takes place. 4. The method according to claim 1 to 3, characterized in that the supply of heat energy from energy recovery preferably takes place from accumulating condensate of Sterilabschlüsse. 5. The method according to claim 1 to 4, characterized in that the control of the supply of heat energy takes place manually or automatically by measuring the temperature in the exhaust air stream. 6. Apparatus for sterile filtration of fermentation exhaust air, characterized in that the exhaust pipe (2) is provided with a double jacket (3). 7. Apparatus for sterile filtration of fermentation exhaust air according to claim 6, characterized in that the exhaust pipe (2) with a half-pipe coil (3a) is provided.