DD276809B3 - PROCESS FOR PREPARING ANTIPUTRIDE ACTIVE FOOD - Google Patents

Description

Field of application of the invention

The invention relates to a method for the production of anti-nutrient foods based on milk, milk products or other animal and / or vegetable protein, fats, carbohydrates, minerals and vitamins. It is particularly applicable to the production of antiperspirant baby food or to the production of antiputrid diet food for the treatment of hepatic and renal insufficiency.

Characteristic of the known technical solutions

Dia nutrition of the human infant with breast milk causes a typical biochemical-microbiological environment in distal intestinal sections. This is characterized by a pH of around 5.5, a positive oxidation-reduction potential and an acidophilic intestinal flora in which putrefactive germs are either completely absent or at least greatly suppressed. This environment is of great importance for the general resistance of the macroorganism.

In disorders of the liver, both in infants and adults, attempts to relieve the liver by suppression of the entire microbial metabolism by antibiotics or by milieu change by means of lactulose syrup to achieve.

There are numerous known methods of producing cow's milk analogous to cow's milk based infant formula.

A variety of methods uses the physiological properties of bifidobacteria. The intestinal flora of a breast-fed infant consists almost entirely of a pure culture of breast-specific bifidura strains capable of suppressing putrefactive bacteria, inhibiting the formation of toxic amines, promoting digestion of the casein of the breast milk by the action of phosphorous phosphatase, and especially growth pathogenic bacteria in conjunction with the lowering of the pH of the intestinal tract by cleavage of lactose in lactic acid and acetic acid.

Due to the relatively strong acidification of the intestinal contents, the adaptation of the originally sterile intestine to the environment rich in alien germs is only possible.

CH-PS 638660, CH-PS 627349 and CH-PS 627348 describe methods according to which bifidobacteria are grown in a milk medium and this is added to the food in liquid or dry form. The disadvantage of this method is a high technological effort and time. To grow a strain intended for baby food, a zeix of 72 hours is given. Thereafter, this milk medium is centrifuged, suspended and, depending on the application, evaporated to dryness, freeze-dried or m liquid form and then added to the whole milk powder. Another disadvantage is, dc. ^ the viability of the bacteria in storage decreases greatly, the shelf life of the baby food is consequently limited.

In DE-PS 2057906 a similar process is described. Milk is pre-acidified to pH 5.5 ... 6.2 using bifidobacteria. Then the milk is gently dried immediately. The viability of Bifiduskeime should be preserved in this way for up to one year.

According to DE-PS 3 242 372 cow's milk is modified as a primary substance by addition of demineralized milk serum, vegetable oils, lactosa and mother milk-specific nucleotides in order to improve their biological value and their digestibility. The addition of the nucleotides contained in breast milk is intended to stimulate the development of bifidobacteria in the gut of the newborn and thus act in the manner described above.

According to the method according to DD-PS 83295 an acidophilic, rot-inhibiting environment in distal intestinal sections is to be achieved in that the majority of lactose is used in the form of ß-anomer, which is cleaved more slowly than the a-anomers in lactic acid and acetic acid.

The disadvantage of a product obtained by this method is that the food can be prepared only immediately before feeding and heating is to be avoided, otherwise already before feeding due to Mutarotation the

Conversion of β- into α-lactose to equilibrium occurs, so that the effect is lost. This also prohibits a one-time reconstitution of the required amount of milk for the whole day.

In DD-PS 104707 a method is shown in which substances that accelerate the anomeric conversion of lactose, z. As the anions of weak acids, are reduced in the aqueous phase or in protein binding by the process management and at the same time a minimum content of lactose is maintained in the anomeric equilibrium. A disadvantage of this method is in particular the high technological cost of ion exchange. According to the method according to DD-PS 228951 a product is obtained, which is optimally adapted in its composition of the woman's milk. In particular, by the women's milk adapted low concentration of active ingredients that accelerate the mutarotation of lactose, it should be ensured that ß-lactose enters the rectum, where it serves as a substrate for lactobacilli and bifidobacteria and thus produces an acidic pH in the rectum. The disadvantage of the method is that compliance with the drug concentration can be ensured only in a relatively complicated manner and beyond uncertainty, whether the proportion of ß-lactose in any case is sufficient to create an optimal acidic environment for ßifidobakterien.

Object of the invention

The aim of the invention is to demonstrate economic process conditions for the production of antiperspirant diets, which cause an inhibition of intestinal decay processes and are suitable for all cases of immature or disturbed detoxification function of the macroorganism, especially in infants.

Essence of the invention

The invention has for its object to provide a method that allows the production of such food with little technical and technological effort and time, in which it is ensured that in the course of the digestive process in distal intestinal sections suitable for the propagation of bifidobacteria acidophilic environment established.

According to the invention, the object is achieved in such a way that for the production of antiperspirant acting food, especially baby food, based on milk, dairy or other animal and / or vegetable protein, fats, carbohydrates, minerals and vitamins in the course of the manufacturing process, especially during mixing the starting components, substances are added which partially block the receptors of lactase in the brush border of the small intestinal mucosa. Such substances may be alcoholic extracts of glycoprotein hydrolysates, for example D-gluconic acid-δ-lactose, β-methyl lactoside, acarbose, D-xylose, L-sorbose, D-sorbitol and D-fructose-1-barium phosphate and synthetically produced or from natural substances obtained oligosaccharides and sugar analogues, such as raffinose, L-arabinose or L-rhamnose, inositol, fucitol, sorbic acid or D-glucosamine hydrochloride, but also Maillard products, such as 4-0-.beta.-D-galactopyranosyl-D-fructose, also as lactulose or 6-phthalimido-6-deoxy-D-galactosdiethylmercaptal. The cleavage of these substances by lactase occurs in comparison to the natural substrate lactose greatly delayed. This lactase inhibition reduces the capacity of small intestinal lactase to completely break down lactose. When adding such lactase inhibitors to diets de: o. G. Consequently, composition prevents the complete cleavage of lactose in the small intestine, leading to partial malabsorption. In this way, the lactose can pass through the small intestine and enter the rectum.

This provides the conditions for the formation of an acidophilic intestinal milieu by lactose-splitting bacteria, preferably bifidus bacteria. To achieve this effect, both a selected lactase inhibitor, but it can also be added in the mixture of food in powder form or liquid several substances.

Essential to the essence of the invention is the ratio lactose / lactase inhibitor. 0.0003 ... 0.01 g of lactase inhibitor are added to 1 g of lactose in the diet, bearing in mind that the efficacy of the individual inhibitors varies, so it must be taken into account in the application. Since Maillard products in the o. G. Act way by partially occupy the receptors of the lactase in the brush border of the small intestinal mucosa, a variant of the invention is to use in the production of diet food proteins, which contain such products due to their pretreatment. For example, unrefined casein or whey protein acid hydrolyzate can be used. The pretreatment of the proteins is carried out by subjecting them to an acid treatment at a temperature of 80 ° C. and then drying them, resulting in the preservation of Maillard products.

The essence of the invention is therefore that in the production of antiperspirant food on the basis of milk, dairy or other animal and / or vegetable protein, fats, carbohydrates, minerals, vitamins and optionally other additives lactase inhibitors or lactase inhibitors containing starting materials in one Concentration of 0.0003 ... 0.01 wt .-%, based on the lactose content of the diet, be added liquid and / or powdered, wherein as lactase inhibitors in particular alcoholic extracts of Glykoproteinhydrolysaten, synthetically produced or derived from natural oligosaccharides and sugar analogues and Maillard products can be used, followed by homogenization and the food dried or left in the liquid phase. An essential advantage of the process is the possibility of a well controllable stabilization of the antipridogenic, bifidogenic effect of infant formulas based on cows milk, but also the antiprid effect of diet foods. For patients with hepatic or renal insufficiency, the benefits of such diets are the reduction in ammonia reabsorption from the colon and thus a reduction in urea synthesis.

The product of the invention is characterized by a stability of its micro-ecological effect, which is independent of the duration of storage of the product. Another advantage of the invention is the simple and straightforward procedure compared to conventional methods for the production of antiputroid diets. To achieve the antiperspid effect no special technical and technological effort is required.

-3- 276 809 Execution Boisplele

example 1

Preparation of a part adapted to Kuhmilchproteirv milk / whey protein base to the preparation of 50kg granules are in a heatable mixer homogenizer, a mixture of 4 kg and 2.7 kg of casein whey protein ι pit 0.18 nlHCI adjusted to pH 1.5 and 1 h at 8O ⁰ C heated with stirring. Thereafter, it is neutralized with NaOH, KOH and Ca (OH) ₂ to pH 6.51, the ratio KOH, NaOH, Ca (OH) ₂ chosen so that the cationic pattern of mother's milk is reached. Thereafter, 130 g of NaHjPO, 7.5 kg of corn starch, 35 kg of lactose, 7 kg of butter and 12 kg of sunflower oil are added, mixed for 10 min and homogenized after addition of 200 g of D-glucosamine hydrochloride for 10 min.

Thereafter, it is dried by spraying.

Example 2

Making a diet food

For the production of 101 liquid diet food for sufferers from renal failure in a heatable mixer homogenizer 100g casein with 0.18 nHCI be added to the pH 1.5 and 1 h of stirring at 8O ⁰ C untei hydrolyzed. It is then neutralized with NaOH, KOH and Ca (OH) ₂ in a defined ratio to pH 6.5. Furthermore, 500 g of lactose, 0.15 g of L-fucitol and 150 g of starch are added with the setting of a defined mineral and vitamin content, made up to 101 with water, mixed for 10 minutes, homogenized for 10 minutes and then sterilized.

Example 3

Production of partially adapted milk based on whey protein

The preparation is analogous to Example 1, as Laktasehemrnstoff 120 g of D-fructose-1-barium phosphate are added, then mixed, homogenized and dried as Example 1.

Example 4

Production of diet food for rehabilitants

The preparation is analogous to Example 1, as Laktasehemmstoff 160 g of L-sorbose are used, then the procedure is as Example 1.

Claims (3)

1. A process for the preparation of antiperspirant acting food on the basis of milk, milk products odor other animal and / or vegetable protein, fats, carbohydrates, especially lactose, minerals ^, vitamins and optionally other additives, characterized in that lactase inhibitors and / or lactase inhibitors containing Starting materials, in a concentration of 0,00ü3 ... 0,0l wt .-% lactase inhibitor, based on the La'ctosegehalt of the diet, liquid and / or powdered added, then homogenized and the food dried or left in the liquid phase becomes. 2. The method according to claim 1, characterized in that as lactase inhibitors alcoholic extracts of Glykoproteinhydrolysaten as D-Gkikonsäure-Ö-lactose, ß-methyl lactoside, acarbose, D-xylose, L-sorbose, D-sorbitol and D-fructose-1 barium phosphate or synthetically produced or derived from natural substances oligosaccharides and sugar analogues such as raffinose, L-arabinose, L-rhamnose, inositol, fucitol, sorbic acid or D-Glucrsaminhydrochlorid be used 3. The method according to claim 1, characterized in that as lactase inhibitors containing starting materials proteins such as unrefined caseinates, whey proteins and whey protein hydrolysates or Maillardprodukte such as ^ O-ß-D-galactopyranosyl-D-fructose or e-phthalimido-e-deoxy-D-galactosdiethylmercaptal be used.