DD138981A5 - Verfahren zur herstellung von 17 alpha-(3-jodbenzoyloxy)-9 alpha-chlor-4-pregnen-3.20-dionen und deren d-homo-analoga - Google Patents
Verfahren zur herstellung von 17 alpha-(3-jodbenzoyloxy)-9 alpha-chlor-4-pregnen-3.20-dionen und deren d-homo-analogaInfo
- Publication number
- DD138981A5 DD138981A5 DD78208095A DD20809578A DD138981A5 DD 138981 A5 DD138981 A5 DD 138981A5 DD 78208095 A DD78208095 A DD 78208095A DD 20809578 A DD20809578 A DD 20809578A DD 138981 A5 DD138981 A5 DD 138981A5
- Authority
- DD
- German Democratic Republic
- Prior art keywords
- alpha
- pregnen
- iodobenzoyl
- diones
- chlor
- Prior art date
Links
- -1 3-iodobenzoyl Chemical group 0.000 title 1
- 238000004770 highest occupied molecular orbital Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
- C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
- C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
- C07J7/004—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
- C07J7/0045—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa not substituted in position 16
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Pain & Pain Management (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19772748443 DE2748443A1 (de) | 1977-10-26 | 1977-10-26 | 17alpha-(3-jodbenzoyloxy)-9alpha- chlor-d-homo-4-pregnen-3.20-dione und verfahren zu ihrer herstellung |
| DE2748442A DE2748442C3 (de) | 1977-10-26 | 1977-10-26 | 17α-(3-Jodbenzoyloxy)-9α -chlor4-pregnen-3.20-dione, Zwischenprodukte und Verfahren zu ihrer Herstellung, 9α -chlor-17α, 21-dihydroxy-1,4-pregnadien-3,20-dion und dieses enthaltende Arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DD138981A5 true DD138981A5 (de) | 1979-12-05 |
Family
ID=25772982
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DD78208095A DD138981A5 (de) | 1977-10-26 | 1978-09-26 | Verfahren zur herstellung von 17 alpha-(3-jodbenzoyloxy)-9 alpha-chlor-4-pregnen-3.20-dionen und deren d-homo-analoga |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0001737B1 (enrdf_load_stackoverflow) |
| JP (1) | JPS5470253A (enrdf_load_stackoverflow) |
| BG (1) | BG28719A3 (enrdf_load_stackoverflow) |
| DD (1) | DD138981A5 (enrdf_load_stackoverflow) |
| DK (1) | DK145666C (enrdf_load_stackoverflow) |
| HU (1) | HU177759B (enrdf_load_stackoverflow) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4252729A (en) * | 1978-05-12 | 1981-02-24 | Hoffmann-La Roche Inc. | Steroids and process for their manufacture |
| US4197406A (en) * | 1978-05-12 | 1980-04-08 | Hoffmann-La Roche Inc. | D-Homosteroids |
| EP0245357B1 (en) * | 1985-10-23 | 1991-08-07 | The Upjohn Company | Angiostatic steroids |
| EP3006453A1 (en) | 2014-10-08 | 2016-04-13 | Cosmo Technologies Ltd. | 17alpha-monoesters and 17alpha,21-diesters of cortexolone for use in the treatment of tumors |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1081888B (de) * | 1956-12-31 | 1960-05-19 | Searle & Co | Verfahren zur Herstellung von ?-3-Keto-9 ª‡-halogensteroiden |
-
1978
- 1978-07-24 EP EP78100483A patent/EP0001737B1/de not_active Expired
- 1978-09-20 BG BG040913A patent/BG28719A3/xx unknown
- 1978-09-26 DD DD78208095A patent/DD138981A5/xx unknown
- 1978-10-23 JP JP12954978A patent/JPS5470253A/ja active Granted
- 1978-10-25 HU HU78SCHE657A patent/HU177759B/hu not_active IP Right Cessation
- 1978-10-26 DK DK477778A patent/DK145666C/da not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HU177759B (en) | 1981-12-28 |
| JPS5470253A (en) | 1979-06-05 |
| DK477778A (da) | 1979-04-27 |
| BG28719A3 (en) | 1980-06-16 |
| DK145666B (da) | 1983-01-17 |
| EP0001737A1 (de) | 1979-05-16 |
| DK145666C (da) | 1983-07-18 |
| EP0001737B1 (de) | 1981-01-07 |
| JPS6227076B2 (enrdf_load_stackoverflow) | 1987-06-12 |
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