CZ302808B6 - Vakcína proti sexuálne prenosným nemocem - Google Patents
Vakcína proti sexuálne prenosným nemocem Download PDFInfo
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- CZ302808B6 CZ302808B6 CZ20010887A CZ2001887A CZ302808B6 CZ 302808 B6 CZ302808 B6 CZ 302808B6 CZ 20010887 A CZ20010887 A CZ 20010887A CZ 2001887 A CZ2001887 A CZ 2001887A CZ 302808 B6 CZ302808 B6 CZ 302808B6
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16634—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9819898A GB9819898D0 (en) | 1998-09-11 | 1998-09-11 | New vaccine and method of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CZ2001887A3 CZ2001887A3 (cs) | 2001-10-17 |
| CZ302808B6 true CZ302808B6 (cs) | 2011-11-23 |
Family
ID=10838766
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CZ20010887A CZ302808B6 (cs) | 1998-09-11 | 1999-09-08 | Vakcína proti sexuálne prenosným nemocem |
Country Status (28)
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|---|---|
| EP (1) | EP1109574B1 (https=) |
| JP (1) | JP2002524532A (https=) |
| KR (1) | KR100777896B1 (https=) |
| CN (2) | CN1325311A (https=) |
| AR (1) | AR021798A1 (https=) |
| AT (1) | ATE392214T1 (https=) |
| AU (1) | AU744989B2 (https=) |
| BR (1) | BR9913630A (https=) |
| CA (1) | CA2343399C (https=) |
| CO (1) | CO5090882A1 (https=) |
| CY (1) | CY1108147T1 (https=) |
| CZ (1) | CZ302808B6 (https=) |
| DE (1) | DE69938555T2 (https=) |
| DK (1) | DK1109574T3 (https=) |
| ES (1) | ES2304068T3 (https=) |
| GB (1) | GB9819898D0 (https=) |
| HU (1) | HUP0104297A3 (https=) |
| IL (1) | IL141843A0 (https=) |
| MY (1) | MY122216A (https=) |
| NO (1) | NO329522B1 (https=) |
| NZ (1) | NZ510425A (https=) |
| PL (1) | PL199545B1 (https=) |
| PT (1) | PT1109574E (https=) |
| SI (1) | SI1109574T1 (https=) |
| TR (1) | TR200100948T2 (https=) |
| TW (1) | TWI225790B (https=) |
| WO (1) | WO2000015255A1 (https=) |
| ZA (1) | ZA200101987B (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100629028B1 (ko) | 1998-10-16 | 2006-09-26 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 애쥬번트 시스템 및 백신 |
| GB9921146D0 (en) | 1999-09-07 | 1999-11-10 | Smithkline Beecham Biolog | Novel composition |
| WO2006115509A2 (en) | 2004-06-24 | 2006-11-02 | Novartis Vaccines And Diagnostics Inc. | Small molecule immunopotentiators and assays for their detection |
| ES2514316T3 (es) | 2005-11-22 | 2014-10-28 | Novartis Vaccines And Diagnostics, Inc. | Partículas similares a virus (VLPs) de Norovirus y Sapovirus |
| AU2007281934B2 (en) | 2006-01-18 | 2012-11-15 | University Of Chicago | Compositions and methods related to Staphylococcal bacterium proteins |
| KR101621837B1 (ko) | 2007-09-12 | 2016-05-17 | 노파르티스 아게 | Ｇａｓ57 돌연변이 항원 및 ｇａｓ57 항체 |
| GB0818453D0 (en) | 2008-10-08 | 2008-11-12 | Novartis Ag | Fermentation processes for cultivating streptococci and purification processes for obtaining cps therefrom |
| WO2011008400A2 (en) | 2009-06-16 | 2011-01-20 | Novartis Ag | High-throughput complement-mediated antibody-dependent and opsonic bactericidal assays |
| WO2011026111A1 (en) | 2009-08-31 | 2011-03-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Oral delivery of a vaccine to the large intestine to induce mucosal immunity |
| EP2556377B1 (en) | 2010-04-08 | 2017-07-12 | University of Pittsburgh - Of the Commonwealth System of Higher Education | B-cell antigen presenting cell assay |
| KR20130121699A (ko) | 2010-05-28 | 2013-11-06 | 테트리스 온라인, 인코포레이티드 | 상호작용 혼성 비동기 컴퓨터 게임 기반구조 |
| EP2726097A4 (en) * | 2011-07-01 | 2015-03-11 | Univ California | HERPES VIRUS VACCINE AND METHOD OF USE |
| AU2015287994B2 (en) * | 2014-07-07 | 2020-03-12 | Prophylaxis, Llc | Viral prophylaxis treatment methods and pre-exposure prophylaxis kits |
| US11071745B2 (en) | 2014-07-07 | 2021-07-27 | Elian Llc | Viral prophylaxis treatment methods and pre-exposure prophylaxis kits |
| JP7005504B2 (ja) | 2016-02-22 | 2022-01-21 | ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー | 生体分子の固定化方法 |
| WO2020086408A1 (en) | 2018-10-26 | 2020-04-30 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | A high-yield perfusion-based transient gene expression bioprocess |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995017209A1 (en) * | 1993-12-23 | 1995-06-29 | Smithkline Beecham Biologicals (S.A.) | Vaccines |
| CZ280505B6 (cs) * | 1991-03-21 | 1996-02-14 | Smithkline Beecham Biologicals (S.A.) | Vakcína proti herpes simplex, obsahující HSV glykoprotein D a 3-deacylovaný monofosforyllipid A |
| CZ313497A3 (cs) * | 1995-04-03 | 1998-03-18 | Smithkline Beecham Biologicals S. A. | Vakciny proti Chlamydiím |
| US5776468A (en) * | 1993-03-23 | 1998-07-07 | Smithkline Beecham Biologicals (S.A.) | Vaccine compositions containing 3-0 deacylated monophosphoryl lipid A |
-
1998
- 1998-09-11 GB GB9819898A patent/GB9819898D0/en not_active Ceased
-
1999
- 1999-09-08 KR KR1020017003161A patent/KR100777896B1/ko not_active Expired - Fee Related
- 1999-09-08 BR BR9913630A patent/BR9913630A/pt not_active Application Discontinuation
- 1999-09-08 HU HU0104297A patent/HUP0104297A3/hu unknown
- 1999-09-08 JP JP2000569839A patent/JP2002524532A/ja active Pending
- 1999-09-08 DK DK99969034T patent/DK1109574T3/da active
- 1999-09-08 CA CA 2343399 patent/CA2343399C/en not_active Expired - Fee Related
- 1999-09-08 AU AU59752/99A patent/AU744989B2/en not_active Ceased
- 1999-09-08 SI SI9931008T patent/SI1109574T1/sl unknown
- 1999-09-08 WO PCT/EP1999/006623 patent/WO2000015255A1/en not_active Ceased
- 1999-09-08 CN CN99813127A patent/CN1325311A/zh active Pending
- 1999-09-08 IL IL14184399A patent/IL141843A0/xx not_active IP Right Cessation
- 1999-09-08 AT AT99969034T patent/ATE392214T1/de active
- 1999-09-08 CZ CZ20010887A patent/CZ302808B6/cs not_active IP Right Cessation
- 1999-09-08 NZ NZ51042599A patent/NZ510425A/xx not_active IP Right Cessation
- 1999-09-08 PL PL346651A patent/PL199545B1/pl not_active IP Right Cessation
- 1999-09-08 TR TR200100948T patent/TR200100948T2/xx unknown
- 1999-09-08 EP EP99969034A patent/EP1109574B1/en not_active Expired - Lifetime
- 1999-09-08 PT PT99969034T patent/PT1109574E/pt unknown
- 1999-09-08 DE DE1999638555 patent/DE69938555T2/de not_active Expired - Lifetime
- 1999-09-08 CN CNA2007101469740A patent/CN101130070A/zh active Pending
- 1999-09-08 ES ES99969034T patent/ES2304068T3/es not_active Expired - Lifetime
- 1999-09-09 MY MYPI99003916A patent/MY122216A/en unknown
- 1999-09-09 AR ARP990104534 patent/AR021798A1/es unknown
- 1999-09-10 CO CO99057608A patent/CO5090882A1/es unknown
- 1999-09-14 TW TW88115828A patent/TWI225790B/zh not_active IP Right Cessation
-
2001
- 2001-03-08 NO NO20011193A patent/NO329522B1/no not_active IP Right Cessation
- 2001-03-09 ZA ZA200101987A patent/ZA200101987B/en unknown
-
2008
- 2008-06-18 CY CY081100643T patent/CY1108147T1/el unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ280505B6 (cs) * | 1991-03-21 | 1996-02-14 | Smithkline Beecham Biologicals (S.A.) | Vakcína proti herpes simplex, obsahující HSV glykoprotein D a 3-deacylovaný monofosforyllipid A |
| US5776468A (en) * | 1993-03-23 | 1998-07-07 | Smithkline Beecham Biologicals (S.A.) | Vaccine compositions containing 3-0 deacylated monophosphoryl lipid A |
| WO1995017209A1 (en) * | 1993-12-23 | 1995-06-29 | Smithkline Beecham Biologicals (S.A.) | Vaccines |
| CZ313497A3 (cs) * | 1995-04-03 | 1998-03-18 | Smithkline Beecham Biologicals S. A. | Vakciny proti Chlamydiím |
Non-Patent Citations (2)
| Title |
|---|
| Apicella M.A. et al.: Current Opinion in Infectious Diseases 1996, 9 (1), str. 52-55; abstrakt * |
| Katz S.L.: Lancet 1997, 350, 1767-70 * |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Patent lapsed due to non-payment of fee |
Effective date: 20130908 |