CZ27752U1 - Dried probiotic preparation with moistening effect for special applications - Google Patents

Description

Probiotic preparation dried with moisturizing effect for special applications

Technical field

The technical solution concerns a probiotic preparation with a moisturizing effect for special applications on the mucous membranes of the nose and nasopharynx.

BACKGROUND OF THE INVENTION

Lactobacilli have significant effects on human health. The application of probiotics in the prevention and treatment of dysmicrobia is considered beneficial and the results indicate a good response from the human body. Of particular importance are the immunomodulatory properties of lactobacilli, which may contribute to the prevention and treatment of diseases by initiating a proper immune response.

Probiotic microorganisms lactobacilli and bifidobacteria are microorganisms that are commonly used in the dairy industry in the manufacture of cheeses, curds and fermented dairy products. High-quality dairy products containing probiotic microflora at a high density are a reliable source of microorganisms that promote human health.

Nutritional supplements in the form of tablets and capsules are another possible way of applying the probiotic microflora to prevent and treat the disease.

For applications of microorganisms with probiotic effect per os it is always necessary to verify the properties of these species and individual strains in terms of passage through the digestive tract, to verify resistance to critical low pH values and bile content.

When administered orally, it is essential that microorganisms enter the gastrointestinal tract at a high density and have the ability to maintain and be positively involved in the prevention and treatment of diseases.

Probiotic microorganisms are also applied in inflammations of the upper respiratory tract and their complications, in the form of inflammations of the middle ear and sinuses, which pose a number of problems for children and adults.

A probiotic preparation containing lactobacilli and intended for intranasal administration is currently being tested. The probiotic preparation for intranasal administration is a preparation without secondary effects on other organs, it has a form for intranasal administration which is carried out directly on the mucosa of the nose and nasopharynx. In this way, the probiotic reaches the mucosa directly, washes the mucosa and can settle the surface at the application site. A drawback of the product for intranasal application is the fact that direct application of the preparation to the mucous membrane of the nose causes discomfort on the mucous membrane after drying of the preparation, ie dryness of the mucosa, increased sensitivity, occasionally probiotic components.

The essence of the technical solution

This drawback completely removes the probiotic preparation having a wetting effect for special applications, according to this technical solution, which consists in that it contains a probiotic premix from the Lbe strains. acidophilus and Lbe. helveticus in a balanced ratio at a density of 10 ⁶ to 10 ⁹ per gram of product in a dairy based matrix containing 30 to 60 wt% fat. The probiotic preparation further comprises other species of Lactobacillus and bifidobacteria in a density of 10 ⁶ to 10 ⁸ per gram of product. The probiotic formulation further comprises soya lecithin 0.1 to 6 wt. per gram of product. The probiotic composition further comprises an omega 3 polyunsaturated fatty acid of 0.1 to 2 wt. per gram of product. The probiotic composition further comprises evening primrose oil 0.1 to 4 wt. per gram of product. The probiotic composition further comprises borage oil 0.1 to 4 wt. per gram of product. The probiotic composition further comprises peanut oil 0.1 to 4 wt. per gram of product. The probiotic preparation further comprises rapeseed oil 0.1 to 4 wt. per gram of product. The probiotic composition further comprises sunflower oil 0.1 to 4 wt. per gram of product. The composition further comprises soybean oil 0.1 to 4 wt.%. per gram of product. The probiotic composition further comprises olive oil 0.1 to 4 wt. per gram of product. The probiotic composition further comprises sweet whey 0.1 to 5 wt. per gram of product. The probiotic composition further comprises a whey protein concentrate of 0.1 to 5 wt. per gram of product. The probiotic composition further comprises an aroma of 0.01 to 1 wt. per gram of product. The probiotic composition further comprises the antioxidants vitamin A, vitamin E and vitamin C in a mixture comprising 0.001 to 1 wt. per gram of product.

The advantage of the probiotic preparation with moisturizing effect for special applications, according to this technical solution lies in the combination of special substances having proven moisturizing effect on the skin and mucosa. They are completely natural substances, without preservatives and for lactobacilli, preferably components, as an optimal medium for growth and long-term protection of their vitality.

The milk-based substrate contains fat-soluble vitamins - A, D, E, K. The fat component contains a proportion of significant mono and polyunsaturated fatty acids. Further, the substrate contains a number of other bioactive components such as phospholipids, sphingomyelin, immunoglobulins, lysozyme, and bifidogenic glycomacropeptides.

After easy application by spraying or spreading on the mucosa, the milk-fat-based substrate containing the probiotic microflora exerts a soothing effect with the potential to retain the aqueous component in the form of an emulsion. The components further contained in the preparation act favorably on the mucosa. At the same time, the complete milk fat substrate has a protective effect on the probiotic bacteria present.

A probiotic preparation with a humectant effect for special applications according to the present invention has the further advantage that the preparation acts at the application site, i.e. on the mucosa, without the need for oral administration. The fatty carrier prevents the mucous membranes from drying out and at the same time has a protective effect on living probiotic microorganisms.

Examples of technical solutions

1. A moistening effect-dried probiotic formulation for special applications comprises a probiotic component consisting of Lbe strains. acidophilus at a density of 10 ⁷ and Lbe. % of helveticus at a density of 10 ⁷ per gram of product and further comprising 30 wt. homogenized milk fat.

2. The wetted effect probiotic preparation for special applications comprises a probiotic component consisting of Lbe strains. acidophilus at a density of 10 ⁷ and the Lbe strain. helveticus at a density of 10 ⁷ in 1 gram of the product, further containing the Lbe strain. rhamnosus at a density of 10 ⁶ and Bifidobacterium sp. at a density of 10 ⁶ and the Lbe strain. casei at a density of 10 ⁷ and the Lbe strain. % plantarum at a density of 10 ⁷ per gram of product and further comprising 40 wt. homogenized milk fat.

3. The wetted effect probiotic preparation for special applications comprises a probiotic component consisting of Lbe strains. acidophilus at a density of 10 ⁷ and Lbe. % of helveticus at a density of 10 ⁷ per gram of product, and further comprising 50 wt. % homogenized milk fat and 0.5 wt. soya lecithin per gram of product.

4. The wetted effect probiotic preparation for special applications comprises a probiotic component consisting of Lbe strains. acidophilus at a density of 10 ⁸ and the Lbe strain. % of helveticus at a density of 10 ⁸ per gram of product and further comprising 30 wt. % homogenized milk fat and 1 wt. omega 3 polyunsaturated fatty acids.

5. The wetted effect probiotic formulation for special applications comprises a probiotic component consisting of Lbe strains. acidophilus at a density of 10 ⁷ and Lbe. % of helveticus at a density of 10 ⁷ per gram of product and further comprising 30 wt. % homogenized milk fat and 3 wt. evening primrose oil.

6. The wetted effect probiotic preparation for special applications comprises a probiotic component consisting of Lbe strains. acidophilus at a density of 10 ⁷ and Lbe. % of helveticus at a density of 10 ⁷ per gram of product and further comprising 30 wt. % homogenized milk fat and 1.5 wt. borage oil.

CZ 27752 Ul

7. The wetted effect probiotic formulation for special applications comprises a probiotic component consisting of Lbe strains. acidophilus at a density of 10 ⁷ and Lbe. % of helveticus at a density of 10 ⁷ per gram of product and further comprising 30 wt. % homogenized milk fat and 1.5 wt. peanut oil.

8. The wetted effect probiotic preparation for special applications comprises a probiotic component consisting of Lbe strains. acidophilus at a density of 10 ⁷ and Lbe. % of helveticus at a density of 10 ⁷ per gram of product and further comprising 30 wt. % homogenized milk fat and 0.5 wt. of rapeseed oil.

9. The wetted effect probiotic formulation for special applications comprises a probiotic component consisting of Lbe strains. acidophilus at a density of 10 ⁷ and Lbe. % of helveticus at a density of 10 ⁷ per gram of product and further comprising 30 wt. % homogenized milk fat and 0.5 wt. sunflower oil.

10. The wetted effect probiotic formulation for special applications comprises a probiotic component consisting of Lbe strains. acidophilus at a density of 10 ⁷ and Lbe. % of helveticus at a density of 10 ⁷ per gram of product and further comprising 30 wt. % homogenized milk fat and 0.5 wt. soybean oil.

11. The wetted effect probiotic formulation for special applications comprises a probiotic component consisting of Lbe strains. acidophilus at a density of 10 ⁷ and Lbe. % of helveticus at a density of 10 ⁷ per gram of product and further comprising 30 wt. % homogenized milk fat and 4 wt. of olive oil.

12. The wetted effect probiotic formulation for special applications comprises a probiotic component consisting of Lbe strains. acidophilus at a density of 10 ⁷ and Lbe. % of helveticus at a density of 10 ⁷ per gram of product and further comprising 40 wt. % homogenized milk fat and 2 wt. sweet whey.

13. The wetted effect probiotic formulation for special applications comprises a probiotic component consisting of Lbe strains. acidophilus at a density of 10 ⁷ and Lbe. % of helveticus at a density of 10 ⁷ per gram of product and further comprising 30 wt. % homogenized milk fat and 4 wt. whey protein concentrate.

14. The wetted effect probiotic formulation for special applications comprises a probiotic component consisting of Lbe strains. acidophilus at a density of 10 ⁷ and Lbe. % of helveticus at a density of 10 ⁷ per gram of product and further comprising 30 wt. % homogenized milk fat and 0.05 wt. % vanilla and 0.05 wt. strawberry aroma.

15. The wetted effect probiotic formulation for special applications comprises a probiotic component consisting of Lbe strains. acidophilus at a density of 10 ⁷ and Lbe. % of helveticus at a density of 10 ⁷ per gram of product and further comprising 30 wt. % homogenized milk fat and a mixture of antioxidants 0.1 wt.

The probiotic premix is prepared from strains of Lactobacillus acidophilus and Lactobacillus helveticus in a balanced ratio. The premix is bound to a milk fat matrix and other biologically active substances and technologically necessary substances and lyophilized.

The prepared composition is dosed into suitable containers.

The probiotic humectant preparation for special applications can be applied directly by smearing or transferred to an aqueous solution (10% by weight) which can be applied by rinsing or spraying prior to application.

The probiotic preparation tested was tested to be dried with a moisturizing effect for special applications on the nasal mucosa where it did not show adverse side effects. The problems with rapid mucosal drying, increased mucosal sensitivity and nasal bleeding have been eliminated, while preserving the protective and therapeutic effects of the formulation. Moisturizing components favorably influenced the vitality of the probiotic component and thereby prolonged the minimum shelf life of the preparation.

Claims (15)

PROTECTION REQUIREMENTS What is claimed is: 1. A probiotic preparation having a moisturizing effect for special applications, characterized in that it comprises a probiotic premix from the Lbe strains. acidophilus and Lbe. helveticus in a balanced ratio at a density of 10 ⁶ to 10 ⁹ per gram of product in a dairy based matrix containing 30 to 60 wt. fat. The special purpose wetting agent according to claim 1, further comprising other Lactobacillus species at a density of 10 ⁶ to 10 ⁸ , and / or bifidobacteria at a density of 10 ⁶ to 10 ⁸ per gram of product. The special purpose wetting-effect probiotic composition according to claim 1, characterized in that it further comprises soya lecithin 0.1 to 6% by weight. per gram of product. The special purpose wetting effect composition of claim 1, further comprising an omega 3 polyunsaturated fatty acid of 0.1 to 2 wt. per gram of product. The special purpose wetting effect probiotic composition of claim 1, further comprising evening primrose oil 0.1 to 4 wt. per gram of product. 6. A special purpose wetting-effect probiotic composition according to claim 1, further comprising borage oil 0.1 to 4% by weight. per gram of product. 7. A special purpose wetting effect probiotic composition according to claim 1, further comprising peanut oil 0.1 to 4% by weight. per gram of product. The special purpose wetting-effect probiotic composition according to claim 1, further comprising rapeseed oil 0.1 to 4% by weight. per gram of product. The special purpose wetting-effect probiotic composition according to claim 1, further comprising sunflower oil 0.1 to 4 wt.%. per gram of product. The special purpose wetting-effect probiotic formulation according to claim 1, further comprising soybean oil 0.1 to 4 wt. per gram of product. 11. The special purpose wetting effect composition of claim 1, further comprising olive oil of from about 0.1% to about 4% by weight. per gram of product. 12. A special purpose wetting effect antibiotic composition according to claim 1, further comprising sweet whey 0.1 to 5% by weight. per gram of product. 13. The special purpose wetting effect composition of claim 1, further comprising a whey protein concentrate of from about 0.1% to about 5% by weight. per gram of product 14. A special purpose wetting effect antibiotic composition according to claim 1, further comprising an aroma of 0.01 to 1% by weight. per gram of product. CZ 27752 Ul 15. The special purpose wetting effect composition of claim 1, further comprising vitamin A, vitamin E, and vitamin C antioxidants in a composition comprising from about 0.001% to about 1% by weight. per gram of product.