CZ201629A3 - Krystalické modifikace solí (3R)-3-cyklopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propannitrilu a způsoby jejich přípravy - Google Patents

Krystalické modifikace solí (3R)-3-cyklopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propannitrilu a způsoby jejich přípravy Download PDF

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Publication number
CZ201629A3
CZ201629A3 CZ2016-29A CZ201629A CZ201629A3 CZ 201629 A3 CZ201629 A3 CZ 201629A3 CZ 201629 A CZ201629 A CZ 201629A CZ 201629 A3 CZ201629 A3 CZ 201629A3
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CZ
Czechia
Prior art keywords
salt
acid
crystalline
ruxolitinib
crystalline modification
Prior art date
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CZ2016-29A
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Czech (cs)
English (en)
Inventor
Eszter Tieger
Hana Tožičková
Marcela Tkadlecová
Ondřej Dammer
Tomáš Gurgut
Original Assignee
Zentiva, K.S.
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Publication date
Application filed by Zentiva, K.S. filed Critical Zentiva, K.S.
Priority to CZ2016-29A priority Critical patent/CZ201629A3/cs
Priority to PCT/CZ2016/000133 priority patent/WO2017125097A1/fr
Publication of CZ201629A3 publication Critical patent/CZ201629A3/cs

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CZ2016-29A 2016-01-22 2016-01-22 Krystalické modifikace solí (3R)-3-cyklopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propannitrilu a způsoby jejich přípravy CZ201629A3 (cs)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CZ2016-29A CZ201629A3 (cs) 2016-01-22 2016-01-22 Krystalické modifikace solí (3R)-3-cyklopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propannitrilu a způsoby jejich přípravy
PCT/CZ2016/000133 WO2017125097A1 (fr) 2016-01-22 2016-12-22 Formes cristallines de sels de (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile et préparation correspondante

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CZ2016-29A CZ201629A3 (cs) 2016-01-22 2016-01-22 Krystalické modifikace solí (3R)-3-cyklopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propannitrilu a způsoby jejich přípravy

Publications (1)

Publication Number Publication Date
CZ201629A3 true CZ201629A3 (cs) 2017-08-02

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CZ2016-29A CZ201629A3 (cs) 2016-01-22 2016-01-22 Krystalické modifikace solí (3R)-3-cyklopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propannitrilu a způsoby jejich přípravy

Country Status (2)

Country Link
CZ (1) CZ201629A3 (fr)
WO (1) WO2017125097A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7120505B2 (ja) 2017-06-07 2022-08-17 シチュアン ケルン－バイオテック バイオファーマシューティカル カンパニー リミテッド アゼチジン誘導体の固体形態並びにその調製方法及びその使用
WO2020072870A1 (fr) * 2018-10-05 2020-04-09 Johnson Matthey Public Limited Company Formes co-cristallines du baricitinib
PE20231308A1 (es) 2020-08-18 2023-08-24 Incyte Corp Proceso e intermedios para preparar un inhibidor de jak1
IL300555A (en) 2020-08-18 2023-04-01 Incyte Corp Process and intermediates for preparing a JAK inhibitor
EP4370504A1 (fr) 2021-07-12 2024-05-22 Incyte Corporation Procédé et intermédiaires pour la préparation de baricitinib
WO2023121574A1 (fr) * 2021-12-23 2023-06-29 Deva Holding Anonim Sirketi Nouveau polymorphe d'hémifumarate de ruxolitinib et son procédé de préparation
WO2024028193A1 (fr) 2022-08-03 2024-02-08 Medichem, S.A. Formulation pharmaceutique orale stable contenant de l'hémifumarate de ruxolitinib
WO2024172778A1 (fr) * 2023-02-16 2024-08-22 Deva Holding Nouveau polymorphe d'hémifumarate de ruxolitinib et procédé de préparation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA116187C2 (uk) 2005-12-13 2018-02-26 Інсайт Холдінгс Корпорейшн ГЕТЕРОАРИЛЗАМІЩЕНІ ПІРОЛО[2,3-b]ПІРИДИНИ Й ПІРОЛО[2,3-b]ПІРИМІДИНИ ЯК ІНГІБІТОРИ ЯНУС-КІНАЗИ
ES2714092T3 (es) 2007-06-13 2019-05-27 Incyte Holdings Corp Uso de sales del inhibidor de quinasas Janus (R)-3-(4-(7H-pirrolo[2,3-d]pirimidin-4-il)-1H-pirazol-1-il)-3-ciclopentilpropanonitrilo
JOP20190231A1 (ar) 2009-01-15 2017-06-16 Incyte Corp طرق لاصلاح مثبطات انزيم jak و المركبات الوسيطة المتعلقة به
PE20130216A1 (es) * 2010-05-21 2013-02-27 Incyte Corp Formulacion topica para un inhibidor de jak
WO2016063294A2 (fr) * 2014-10-20 2016-04-28 Msn Laboratories Private Limited Procédé de préparation de phosphate de (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile et de ses polymorphes

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WO2017125097A1 (fr) 2017-07-27

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