CZ2003784A3 - Zlepšené podmíněně se replikující vektory, způsoby jejich produkce a jejich použití - Google Patents
Zlepšené podmíněně se replikující vektory, způsoby jejich produkce a jejich použití Download PDFInfo
- Publication number
- CZ2003784A3 CZ2003784A3 CZ2003784A CZ2003784A CZ2003784A3 CZ 2003784 A3 CZ2003784 A3 CZ 2003784A3 CZ 2003784 A CZ2003784 A CZ 2003784A CZ 2003784 A CZ2003784 A CZ 2003784A CZ 2003784 A3 CZ2003784 A3 CZ 2003784A3
- Authority
- CZ
- Czechia
- Prior art keywords
- vector
- hiv
- helper
- cells
- virus
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16041—Use of virus, viral particle or viral elements as a vector
- C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/108—Plasmid DNA episomal vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/40—Vector systems having a special element relevant for transcription being an insulator
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/42—Vector systems having a special element relevant for transcription being an intron or intervening sequence for splicing and/or stability of RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/48—Vector systems having a special element relevant for transcription regulating transport or export of RNA, e.g. RRE, PRE, WPRE, CTE
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/50—Vector systems having a special element relevant for transcription regulating RNA stability, not being an intron, e.g. poly A signal
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
- C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- AIDS & HIV (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biochemistry (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US66789300A | 2000-09-22 | 2000-09-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
CZ2003784A3 true CZ2003784A3 (cs) | 2003-11-12 |
Family
ID=24680093
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CZ2003784A CZ2003784A3 (cs) | 2000-09-22 | 2001-09-21 | Zlepšené podmíněně se replikující vektory, způsoby jejich produkce a jejich použití |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP1356070A2 (ru) |
JP (1) | JP2004524813A (ru) |
AU (1) | AU9307501A (ru) |
CA (1) | CA2422544A1 (ru) |
CZ (1) | CZ2003784A3 (ru) |
IL (1) | IL154987A0 (ru) |
NO (1) | NO20031293L (ru) |
NZ (1) | NZ525283A (ru) |
RU (1) | RU2301260C2 (ru) |
WO (1) | WO2002024897A2 (ru) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002059378A2 (en) | 2001-01-25 | 2002-08-01 | Virxsys | Methods and compositions for identifying gene function |
US20030026791A1 (en) * | 2001-03-27 | 2003-02-06 | Laurent Humeau | Conditionally replicating vectors for inhibiting viral infections |
CA2537953A1 (en) * | 2003-09-09 | 2005-03-17 | Virxsys Corporation | Lentivirus vector-based approaches for generating an immune response to hiv in humans |
FR2872170B1 (fr) * | 2004-06-25 | 2006-11-10 | Centre Nat Rech Scient Cnrse | Lentivirus non interactif et non replicatif, preparation et utilisations |
CN102858959B (zh) | 2009-12-10 | 2016-02-24 | 渥太华医院研究院 | 溶瘤弹状病毒 |
SG10201800873WA (en) * | 2011-04-22 | 2018-03-28 | Univ California | Adeno-associated virus virions with variant capsid and methods of use thereof |
ES2627529T3 (es) | 2011-06-08 | 2017-07-28 | Children's Hospital Of Eastern Ontario Research Institute Inc. | Composiciones para tratamiento de glioblastoma |
CA2848939A1 (en) * | 2011-10-05 | 2013-04-11 | Molmed Spa | Viral vectors purification system |
RU2488633C1 (ru) * | 2011-11-16 | 2013-07-27 | Общество с ограниченной ответственностью "Лаборатория медицинской биотехнологии" (ООО "ЛМБТ") | ЭКСПРЕССИОННЫЙ ПЛАЗМИДНЫЙ ВЕКТОР ДЛЯ ГЕТЕРОЛОГИЧНОЙ ЭКСПРЕССИИ РЕКОМБИНАНТНЫХ БЕЛКОВ, ВЫСОКОЧАСТОТНОЙ ИНТЕГРАЦИИ И УСИЛЕННОЙ АМПЛИФИКАЦИИ ЭКСПРЕССИОННОЙ КАССЕТЫ В КЛЕТКАХ МЛЕКОПИТАЮЩИХ, БИЦИСТРОННАЯ мРНК, СПОСОБ ПОЛУЧЕНИЯ СТАБИЛЬНЫХ ЛИНИЙ ПРОДУЦЕНТОВ РЕКОМБИНАНТНЫХ БЕЛКОВ С ИСПОЛЬЗОВАНИЕМ УКАЗАННОГО ВЕКТОРА, СПОСОБ ПОЛУЧЕНИЯ РЕКОМБИНАНТНЫХ БЕЛКОВ |
BR112015013669A2 (pt) * | 2012-12-12 | 2017-11-14 | Childrens Hospital Of Eastern Ontario Res Institute Inc | composições e métodos para o tratamento de cânceres cerebrais |
US10363293B2 (en) | 2013-02-21 | 2019-07-30 | Turnstone Limited Partnership | Vaccine composition |
RU2548816C1 (ru) * | 2013-12-16 | 2015-04-20 | Мамонтова Марина Васильевна | Способ выделения микрорнк из биологических жидкостей |
ES2941502T3 (es) | 2016-05-13 | 2023-05-23 | 4D Molecular Therapeutics Inc | Variantes de cápsides de virus adenoasociado y procedimientos de utilización de las mismas |
CN111491655A (zh) | 2017-08-07 | 2020-08-04 | 加利福尼亚大学董事会 | 用于生成安全细胞治疗剂的平台 |
EP4004204A1 (en) * | 2019-07-23 | 2022-06-01 | Oxford BioMedica (UK) Limited | Enhancing production of lentiviral vectors |
WO2022066937A1 (en) * | 2020-09-23 | 2022-03-31 | Regents Of The University Of Minnesota | Immortalized keratinocytes, lentivirus for keratinocyte immortalization, and methods of use |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2188802T3 (es) * | 1995-11-28 | 2003-07-01 | Univ Johns Hopkins Med | Vectores viricos de replicacion condicional y su uso. |
GB9803351D0 (en) * | 1998-02-17 | 1998-04-15 | Oxford Biomedica Ltd | Anti-viral vectors |
-
2001
- 2001-09-21 AU AU9307501A patent/AU9307501A/xx not_active Withdrawn
- 2001-09-21 JP JP2002529492A patent/JP2004524813A/ja active Pending
- 2001-09-21 CZ CZ2003784A patent/CZ2003784A3/cs unknown
- 2001-09-21 IL IL15498701A patent/IL154987A0/xx unknown
- 2001-09-21 EP EP01973503A patent/EP1356070A2/en not_active Withdrawn
- 2001-09-21 CA CA002422544A patent/CA2422544A1/en not_active Abandoned
- 2001-09-21 WO PCT/US2001/029976 patent/WO2002024897A2/en active IP Right Grant
- 2001-09-21 RU RU2003111469/13A patent/RU2301260C2/ru not_active IP Right Cessation
- 2001-09-21 NZ NZ525283A patent/NZ525283A/en not_active IP Right Cessation
-
2003
- 2003-03-20 NO NO20031293A patent/NO20031293L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
IL154987A0 (en) | 2003-10-31 |
NZ525283A (en) | 2008-06-30 |
RU2301260C2 (ru) | 2007-06-20 |
JP2004524813A (ja) | 2004-08-19 |
EP1356070A2 (en) | 2003-10-29 |
WO2002024897A2 (en) | 2002-03-28 |
NO20031293D0 (no) | 2003-03-20 |
CA2422544A1 (en) | 2002-03-28 |
AU9307501A (en) | 2002-04-02 |
NO20031293L (no) | 2003-05-14 |
WO2002024897A3 (en) | 2003-07-31 |
WO2002024897A9 (en) | 2003-03-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US6410257B1 (en) | Methods to assay gene function with viral vectors | |
JP4384146B2 (ja) | 条件付き複製ウイルスベクターおよびその用途 | |
RU2301260C2 (ru) | Вирусные векторы с зависимой от условий репликацией и их применение | |
US20040033595A1 (en) | Conditionally replicating vectors for inhibiting viral infections | |
US5885806A (en) | Methods to prepare conditionally replicating viral vectors | |
JP2007505130A5 (ru) | ||
JP2007505130A (ja) | ヒトにおいてhivに対する免疫応答を生成するための、レンチウイルスベクターベースのアプローチ | |
AU2001293075B2 (en) | Conditionally replicating viral vectors and their use | |
AU2002258639A1 (en) | Improved conditionally replicating vectors for inhibiting viral infections | |
AU2001293075A1 (en) | Conditionally replicating viral vectors and their use |