CY2085B1 - Ng-monomethyl-l-arginine hydrochloride derivatives and process for their preparation - Google Patents

Ng-monomethyl-l-arginine hydrochloride derivatives and process for their preparation

Info

Publication number
CY2085B1
CY2085B1 CY9902085A CY9902085A CY2085B1 CY 2085 B1 CY2085 B1 CY 2085B1 CY 9902085 A CY9902085 A CY 9902085A CY 9902085 A CY9902085 A CY 9902085A CY 2085 B1 CY2085 B1 CY 2085B1
Authority
CY
Cyprus
Prior art keywords
preparation
monomethyl
arginine hydrochloride
hydrochloride derivatives
derivatives
Prior art date
Application number
CY9902085A
Other languages
English (en)
Inventor
Harold Francis Hodson
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of CY2085B1 publication Critical patent/CY2085B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CY9902085A 1992-07-24 1999-03-05 Ng-monomethyl-l-arginine hydrochloride derivatives and process for their preparation CY2085B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929215816A GB9215816D0 (en) 1992-07-24 1992-07-24 Arginine derivatives
PCT/GB1993/001563 WO1994002453A1 (en) 1992-07-24 1993-07-23 Ng-monomethyl-l-arginine hydrochloride derivatives and their use in the treatment of septic shock

Publications (1)

Publication Number Publication Date
CY2085B1 true CY2085B1 (en) 1999-03-05

Family

ID=10719277

Family Applications (1)

Application Number Title Priority Date Filing Date
CY9902085A CY2085B1 (en) 1992-07-24 1999-03-05 Ng-monomethyl-l-arginine hydrochloride derivatives and process for their preparation

Country Status (24)

Country Link
EP (1) EP0651741B1 (xx)
JP (1) JP2878844B2 (xx)
KR (1) KR950702528A (xx)
CN (1) CN1087624A (xx)
AT (1) ATE148451T1 (xx)
CA (1) CA2140852A1 (xx)
CY (1) CY2085B1 (xx)
CZ (1) CZ8095A3 (xx)
DE (1) DE69307894T2 (xx)
DK (1) DK0651741T3 (xx)
ES (1) ES2098051T3 (xx)
GB (1) GB9215816D0 (xx)
GR (1) GR3022773T3 (xx)
HU (1) HU210876A9 (xx)
IL (1) IL106463A (xx)
MX (1) MX9304466A (xx)
NO (1) NO302360B1 (xx)
NZ (1) NZ254865A (xx)
PL (1) PL307238A1 (xx)
RU (1) RU95105249A (xx)
SG (1) SG46425A1 (xx)
SK (1) SK8295A3 (xx)
WO (1) WO1994002453A1 (xx)
ZA (1) ZA935348B (xx)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5424447A (en) * 1993-07-07 1995-06-13 The Medical College Of Wisconsin Research Foundation, Inc. Heme binding compounds and use thereof
GB9603522D0 (en) * 1996-02-20 1996-04-17 Wellcome Found Chemical process
CA2514575A1 (en) * 2003-01-31 2004-08-12 Teijin Pharma Limited Crystal of (23s)-1.alpha.-hydroxy-27-nor-25-methylenevitamin d3-26,23-lactone and process for producing the same
CN1724514B (zh) * 2004-07-19 2010-06-09 上海依福瑞实业有限公司 一种l－高精氨酸盐酸盐的制备方法
WO2007139897A1 (en) * 2006-05-23 2007-12-06 University Of Utah Research Foundation Compositions and methods for the inhibition of endothelial nitric oxide synthase activity

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5028627A (en) * 1989-09-13 1991-07-02 Cornell Research Foundation, Inc. Method of using arginine derivatives to inhibit systemic hypotension associated with nitric oxide production or endothelial derived relaxing factor

Also Published As

Publication number Publication date
IL106463A0 (en) 1993-11-15
GB9215816D0 (en) 1992-09-09
NO950248D0 (no) 1995-01-23
JP2878844B2 (ja) 1999-04-05
MX9304466A (es) 1994-04-29
SK8295A3 (en) 1995-07-11
RU95105249A (ru) 1996-10-27
DK0651741T3 (da) 1997-05-12
AU669557B2 (en) 1996-06-13
CZ8095A3 (en) 1995-10-18
CN1087624A (zh) 1994-06-08
NO950248L (no) 1995-01-23
KR950702528A (ko) 1995-07-29
DE69307894T2 (de) 1997-06-12
DE69307894D1 (de) 1997-03-13
NO302360B1 (no) 1998-02-23
WO1994002453A1 (en) 1994-02-03
NZ254865A (en) 1996-10-28
ZA935348B (en) 1995-01-23
EP0651741A1 (en) 1995-05-10
PL307238A1 (en) 1995-05-15
GR3022773T3 (en) 1997-06-30
HU210876A9 (en) 1995-09-28
IL106463A (en) 1998-08-16
ES2098051T3 (es) 1997-04-16
CA2140852A1 (en) 1994-02-03
SG46425A1 (en) 1998-02-20
EP0651741B1 (en) 1997-01-29
ATE148451T1 (de) 1997-02-15
AU4715793A (en) 1994-02-14
JPH07509239A (ja) 1995-10-12

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