CY1123720T1 - Συνθεσεις ενος πολυορθοεστερα και ενος εκδοχου οργανικου οξεος - Google Patents

Συνθεσεις ενος πολυορθοεστερα και ενος εκδοχου οργανικου οξεος

Info

Publication number
CY1123720T1
CY1123720T1 CY20201101190T CY201101190T CY1123720T1 CY 1123720 T1 CY1123720 T1 CY 1123720T1 CY 20201101190 T CY20201101190 T CY 20201101190T CY 201101190 T CY201101190 T CY 201101190T CY 1123720 T1 CY1123720 T1 CY 1123720T1
Authority
CY
Cyprus
Prior art keywords
compositions
organic acid
polyorthoester
acid acceptor
along
Prior art date
Application number
CY20201101190T
Other languages
English (en)
Inventor
Thomas B. Ottoboni
Lee Ann Lynn Girotti
Original Assignee
Heron Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heron Therapeutics, Inc. filed Critical Heron Therapeutics, Inc.
Publication of CY1123720T1 publication Critical patent/CY1123720T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Anesthesiology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Περιγράφονται συστήματα χορήγησης και συνθέσεις που αποτελούνται από ένα βιοαποικοδομήσιμο πολυμερές πολυορθοεστέρα, ένα έκδοχο οργανικού οξέος και ένα βασικό φάρμακο, μαζί με σχετικές μεθόδους.
CY20201101190T 2014-04-21 2020-12-15 Συνθεσεις ενος πολυορθοεστερα και ενος εκδοχου οργανικου οξεος CY1123720T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461982300P 2014-04-21 2014-04-21
PCT/US2015/026720 WO2015164283A1 (en) 2014-04-21 2015-04-20 Compositions of a polyorthoester and an organic acid excipient

Publications (1)

Publication Number Publication Date
CY1123720T1 true CY1123720T1 (el) 2022-03-24

Family

ID=53039640

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20201101190T CY1123720T1 (el) 2014-04-21 2020-12-15 Συνθεσεις ενος πολυορθοεστερα και ενος εκδοχου οργανικου οξεος

Country Status (14)

Country Link
US (2) US10980886B2 (el)
EP (2) EP3134070B1 (el)
JP (4) JP6723162B2 (el)
CY (1) CY1123720T1 (el)
DK (1) DK3134070T3 (el)
ES (1) ES2837149T3 (el)
HR (1) HRP20202010T1 (el)
HU (1) HUE052224T2 (el)
LT (1) LT3134070T (el)
PL (1) PL3134070T3 (el)
PT (1) PT3134070T (el)
RS (1) RS61202B1 (el)
SI (1) SI3134070T1 (el)
WO (1) WO2015164283A1 (el)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
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US9801945B2 (en) 2014-04-21 2017-10-31 Heron Therapeutics, Inc. Long-acting polymeric delivery systems
EP3509601A1 (en) 2014-04-21 2019-07-17 Heron Therapeutics, Inc. A pharmaceutical composition comprising a delivery system, an amide-type local anesthetic, and meloxicam
HUE052224T2 (hu) 2014-04-21 2021-04-28 Heron Therapeutics Inc Poliortoészterbõl és szerves sav segédanyagból álló készítmények
CN106535886A (zh) 2014-04-21 2017-03-22 赫伦治疗有限公司 长效聚合物输送系统
WO2017193066A1 (en) * 2016-05-05 2017-11-09 Liquidia Technologies, Inc. Precision controlled load and release particles for post-operative pain
US11000487B2 (en) * 2016-12-26 2021-05-11 Cellix Bio Private Limited Compositions and methods for the treatment of chronic pain

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HUE052224T2 (hu) 2014-04-21 2021-04-28 Heron Therapeutics Inc Poliortoészterbõl és szerves sav segédanyagból álló készítmények
EP3509601A1 (en) 2014-04-21 2019-07-17 Heron Therapeutics, Inc. A pharmaceutical composition comprising a delivery system, an amide-type local anesthetic, and meloxicam

Also Published As

Publication number Publication date
US10980886B2 (en) 2021-04-20
RS61202B1 (sr) 2021-01-29
US20210205458A1 (en) 2021-07-08
HUE052224T2 (hu) 2021-04-28
PT3134070T (pt) 2020-12-21
HRP20202010T1 (hr) 2021-03-05
PL3134070T3 (pl) 2021-07-05
JP2019194267A (ja) 2019-11-07
JP2017513872A (ja) 2017-06-01
JP6977003B2 (ja) 2021-12-08
DK3134070T3 (da) 2020-12-21
EP3134070B1 (en) 2020-09-23
ES2837149T3 (es) 2021-06-29
WO2015164283A1 (en) 2015-10-29
JP2022082776A (ja) 2022-06-02
SI3134070T1 (sl) 2021-03-31
JP6723162B2 (ja) 2020-07-15
US20150297730A1 (en) 2015-10-22
LT3134070T (lt) 2020-12-28
EP3785700A1 (en) 2021-03-03
EP3134070A1 (en) 2017-03-01
US11844837B2 (en) 2023-12-19
JP2021059598A (ja) 2021-04-15

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