CY1122145T1 - Ανοσογονικη συνθεση για clostridium difficile - Google Patents
Ανοσογονικη συνθεση για clostridium difficileInfo
- Publication number
- CY1122145T1 CY1122145T1 CY20191101061T CY191101061T CY1122145T1 CY 1122145 T1 CY1122145 T1 CY 1122145T1 CY 20191101061 T CY20191101061 T CY 20191101061T CY 191101061 T CY191101061 T CY 191101061T CY 1122145 T1 CY1122145 T1 CY 1122145T1
- Authority
- CY
- Cyprus
- Prior art keywords
- clostridium difficile
- protein
- cdtb
- modify
- binding domain
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- 241000193163 Clostridioides difficile Species 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 108010010925 Clostridium actin-specific ADP-ribosyltransferase Proteins 0.000 abstract 2
- 230000002163 immunogen Effects 0.000 abstract 2
- 108010076504 Protein Sorting Signals Proteins 0.000 abstract 1
- 102000037865 fusion proteins Human genes 0.000 abstract 1
- 108020001507 fusion proteins Proteins 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/08—Clostridium, e.g. Clostridium tetani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Η παρούσα εφεύρεση αφορά σε ανοσογονικές συνθέσεις που περιλαμβάνουν απομονωμένη Clostridium difficile CDTb. Συγκεκριμένα, η απομονωθείσα Clostridium difficile CDTb πρωτεΐνη έχει υποστεί μετάλλαξη για τροποποίηση της ικανότητας σχηματισμού πόρου, τροποποίηση της ικανότητας επταμερισμού ή είναι ακρωτηριασμένη CDTb πρωτεΐνη με το πεπτίδιο-σήματος και το προπεδίο απομακρυνθέντα και επίσης το πεδίο σύνδεσης υποδοχέα απομακρυνθέν ή/και το πεδίο σύνδεσης CDTa απομακρυνθέν. Η εφεύρεση επίσης αφορά σε πρωτεΐνες σύντηξης που περιλαμβάνουν πρωτεΐνη CDTa και πρωτεΐνη CDTb. Εμβόλια που περιλαμβάνουν τέτοιες ανοσογονικές συνθέσεις και θεραπευτικές χρήσεις των ιδίων επίσης αποτελούν μέρος της εφεύρεσης.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1411306.2A GB201411306D0 (en) | 2014-06-25 | 2014-06-25 | Immunogenic composition |
GB201411371A GB201411371D0 (en) | 2014-06-26 | 2014-06-26 | Immunogenic composition |
PCT/EP2015/064324 WO2015197737A1 (en) | 2014-06-25 | 2015-06-25 | Clostridium difficile immunogenic composition |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1122145T1 true CY1122145T1 (el) | 2020-11-25 |
Family
ID=53498986
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20191101061T CY1122145T1 (el) | 2014-06-25 | 2019-10-09 | Ανοσογονικη συνθεση για clostridium difficile |
Country Status (18)
Country | Link |
---|---|
US (1) | US20170218031A1 (el) |
EP (2) | EP3160500B1 (el) |
JP (2) | JP6688233B2 (el) |
CN (1) | CN106536544B (el) |
BE (1) | BE1022949B1 (el) |
BR (1) | BR112016030096B1 (el) |
CA (1) | CA2952118A1 (el) |
CY (1) | CY1122145T1 (el) |
DK (1) | DK3160500T3 (el) |
ES (1) | ES2749701T3 (el) |
HR (1) | HRP20191864T1 (el) |
HU (1) | HUE045936T2 (el) |
LT (1) | LT3160500T (el) |
MX (1) | MX2016017094A (el) |
PL (1) | PL3160500T3 (el) |
PT (1) | PT3160500T (el) |
SI (1) | SI3160500T1 (el) |
WO (1) | WO2015197737A1 (el) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP7149285B2 (ja) | 2017-03-15 | 2022-10-06 | ノババックス,インコーポレイテッド | Clostridium difficileに対する免疫応答を誘導するための方法および組成物 |
MX2020013623A (es) | 2018-06-19 | 2021-03-25 | Glaxosmithkline Biologicals Sa | Composicion inmunogenica. |
GB202205833D0 (en) | 2022-04-21 | 2022-06-08 | Glaxosmithkline Biologicals Sa | Bacteriophage |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4235877A (en) | 1979-06-27 | 1980-11-25 | Merck & Co., Inc. | Liposome particle containing viral or bacterial antigenic subunit |
US4436727A (en) | 1982-05-26 | 1984-03-13 | Ribi Immunochem Research, Inc. | Refined detoxified endotoxin product |
US4866034A (en) | 1982-05-26 | 1989-09-12 | Ribi Immunochem Research Inc. | Refined detoxified endotoxin |
US4751180A (en) | 1985-03-28 | 1988-06-14 | Chiron Corporation | Expression using fused genes providing for protein product |
US4935233A (en) | 1985-12-02 | 1990-06-19 | G. D. Searle And Company | Covalently linked polypeptide cell modulators |
US4877611A (en) | 1986-04-15 | 1989-10-31 | Ribi Immunochem Research Inc. | Vaccine containing tumor antigens and adjuvants |
JP2851288B2 (ja) | 1987-06-05 | 1999-01-27 | アメリカ合衆国 | 癌診断および管理における自己分泌運動性因子 |
US4912094B1 (en) | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
DK0382271T3 (da) | 1989-02-04 | 1995-05-01 | Akzo Nobel Nv | Tocoler som adjuvanser i vacciner |
JP3755890B2 (ja) | 1992-06-25 | 2006-03-15 | スミスクライン・ビーチャム・バイオロジカルス(ソシエテ・アノニム) | アジュバント含有ワクチン組成物 |
ATE204762T1 (de) | 1993-03-23 | 2001-09-15 | Smithkline Beecham Biolog | 3-0-deazylierte monophosphoryl lipid a enthaltende impfstoff-zusammensetzungen |
AU709586B2 (en) | 1994-10-24 | 1999-09-02 | Ophidian Pharmaceuticals, Inc. | Vaccine and antitoxin for treatment and prevention of C. difficile disease |
UA56132C2 (uk) | 1995-04-25 | 2003-05-15 | Смітклайн Бічем Байолоджікалс С.А. | Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини |
CA2220530A1 (en) | 1995-06-02 | 1996-12-05 | Incyte Pharmaceuticals, Inc. | Improved method for obtaining full-length cdna sequences |
AU781175B2 (en) * | 1999-04-09 | 2005-05-12 | Intercell Usa, Inc. | Recombinant toxin A/toxin B vaccine against Clostridium Difficile |
AU2001251013A1 (en) | 2000-03-28 | 2001-10-08 | Diadexus, Inc. | Compositions and methods of diagnosing, monitoring, staging, imaging and treating colon cancer |
AU2003304316A1 (en) * | 2002-11-08 | 2005-01-28 | President And Fellows Of Harvard College | Compounds and methods for the treatment and prevention of bacterial infection |
ES2704069T3 (es) * | 2011-12-08 | 2019-03-14 | Glaxosmithkline Biologicals Sa | Vacuna basada en toxinas de Clostridium difficile |
AR089797A1 (es) | 2012-01-27 | 2014-09-17 | Merck Sharp & Dohme | Vacunas contra clostridum difficile que comprenden toxinas recombinantes |
FI3513806T3 (fi) * | 2012-12-05 | 2023-04-26 | Glaxosmithkline Biologicals Sa | Immunogeeninen koostumus |
GB201223342D0 (en) * | 2012-12-23 | 2013-02-06 | Glaxosmithkline Biolog Sa | Immunogenic composition |
-
2015
- 2015-06-25 EP EP15733404.6A patent/EP3160500B1/en active Active
- 2015-06-25 JP JP2016575190A patent/JP6688233B2/ja active Active
- 2015-06-25 US US15/320,190 patent/US20170218031A1/en not_active Abandoned
- 2015-06-25 MX MX2016017094A patent/MX2016017094A/es active IP Right Grant
- 2015-06-25 LT LT15733404T patent/LT3160500T/lt unknown
- 2015-06-25 ES ES15733404T patent/ES2749701T3/es active Active
- 2015-06-25 BE BE2015/5390A patent/BE1022949B1/fr active
- 2015-06-25 EP EP19192151.9A patent/EP3636278A3/en not_active Withdrawn
- 2015-06-25 DK DK15733404T patent/DK3160500T3/da active
- 2015-06-25 HU HUE15733404A patent/HUE045936T2/hu unknown
- 2015-06-25 PL PL15733404T patent/PL3160500T3/pl unknown
- 2015-06-25 CN CN201580039744.7A patent/CN106536544B/zh active Active
- 2015-06-25 BR BR112016030096-3A patent/BR112016030096B1/pt active IP Right Grant
- 2015-06-25 PT PT157334046T patent/PT3160500T/pt unknown
- 2015-06-25 SI SI201530954T patent/SI3160500T1/sl unknown
- 2015-06-25 CA CA2952118A patent/CA2952118A1/en active Pending
- 2015-06-25 WO PCT/EP2015/064324 patent/WO2015197737A1/en active Application Filing
-
2019
- 2019-10-09 CY CY20191101061T patent/CY1122145T1/el unknown
- 2019-10-15 HR HRP20191864TT patent/HRP20191864T1/hr unknown
-
2020
- 2020-01-17 JP JP2020005532A patent/JP2020100625A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2017520573A (ja) | 2017-07-27 |
PT3160500T (pt) | 2019-11-11 |
EP3636278A2 (en) | 2020-04-15 |
SI3160500T1 (sl) | 2019-11-29 |
US20170218031A1 (en) | 2017-08-03 |
EP3160500B1 (en) | 2019-08-21 |
BE1022949A1 (fr) | 2016-10-21 |
LT3160500T (lt) | 2019-10-25 |
WO2015197737A1 (en) | 2015-12-30 |
HRP20191864T1 (hr) | 2020-01-10 |
JP6688233B2 (ja) | 2020-04-28 |
CN106536544A (zh) | 2017-03-22 |
PL3160500T3 (pl) | 2020-02-28 |
BR112016030096B1 (pt) | 2023-10-03 |
EP3636278A3 (en) | 2020-07-15 |
HUE045936T2 (hu) | 2020-01-28 |
BR112016030096A8 (pt) | 2021-07-06 |
CA2952118A1 (en) | 2015-12-30 |
DK3160500T3 (da) | 2019-11-11 |
ES2749701T3 (es) | 2020-03-23 |
JP2020100625A (ja) | 2020-07-02 |
BE1022949B1 (fr) | 2016-10-21 |
MX2016017094A (es) | 2017-05-03 |
BR112016030096A2 (pt) | 2017-08-22 |
CN106536544B (zh) | 2020-04-07 |
EP3160500A1 (en) | 2017-05-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CY1124106T1 (el) | Συνθεσεις μεταφορεα-αντισωματος και μεθοδοι παρασκευης και χρησης αυτων | |
CO2018011804A2 (es) | Receptores quiméricos de flt3 y métodos de uso de los mismos | |
CY1122898T1 (el) | Απεκκριση πολυπεπτιδιων που περιεχουν αιμη | |
DOP2021000022A (es) | Anticuerpos neutralizadores del virus de inmunodeficiencia humana | |
CY1124619T1 (el) | Αντισωματα αντι-προ/λανθανουσας μυοστατινης και χρησεις αυτων | |
CY1124131T1 (el) | Συζευγματα αντι-ρτκ7 αντισωματος-φαρμακου | |
CY1121535T1 (el) | Πρωτεϊνικα κατασκευασματα uspa2 και χρησεις αυτων | |
BR112018005779A2 (pt) | repressores de htt e usos dos mesmos | |
CL2018000042A1 (es) | Anticuerpos de unión a tau | |
CL2016002733A1 (es) | Combinación de lenalidomida y constructo de polipéptido, y sus usos | |
TR201906843T4 (tr) | Hızlı etkili insülin bileşimleri. | |
BR112016028891A2 (pt) | processos de trens de sementes e usos dos mesmos | |
BR112017011932A2 (pt) | ?anticorpos direcionados a receptor acoplado a proteína g e métodos de uso? | |
EA201790569A1 (ru) | Антитела и иммуноконъюгаты против cll-1 | |
EP3155018A4 (en) | Constant region antibody fusion proteins and compositions thereof | |
BR112016022658A2 (pt) | anticorpos anti-ox40 e métodos de uso | |
GT201700131A (es) | Composiciones y métodos para anticuerpos dirigidos a bmp6 | |
CY1122145T1 (el) | Ανοσογονικη συνθεση για clostridium difficile | |
CY1124425T1 (el) | Συνθεσεις οι οποιες περιλαμβανουν συζευγματα φαρμακου αντισωματος-δουοκαρμυκινης | |
CL2018000043A1 (es) | Anticuerpos de unión a tau | |
BR112017009297A2 (pt) | anticorpos antifator de complemento c1q humanizados e usos dos mesmos | |
MD3215187T2 (ro) | Vaccinuri HPV16 terapeutice | |
EA201891460A1 (ru) | Композиция дендритных клеток | |
DK3199179T3 (da) | Formulering af rekombinant fusionsprotein | |
CY1122644T1 (el) | Πρωτεϊνες συντηξης tatk-cdkl5, συνθεσεις, φαρμακοτεχνικες μορφες και η χρηση αυτων |