CY1122145T1 - Ανοσογονικη συνθεση για clostridium difficile - Google Patents
Ανοσογονικη συνθεση για clostridium difficileInfo
- Publication number
- CY1122145T1 CY1122145T1 CY20191101061T CY191101061T CY1122145T1 CY 1122145 T1 CY1122145 T1 CY 1122145T1 CY 20191101061 T CY20191101061 T CY 20191101061T CY 191101061 T CY191101061 T CY 191101061T CY 1122145 T1 CY1122145 T1 CY 1122145T1
- Authority
- CY
- Cyprus
- Prior art keywords
- clostridium difficile
- protein
- cdtb
- modify
- binding domain
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- 241000193163 Clostridioides difficile Species 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 108010010925 Clostridium actin-specific ADP-ribosyltransferase Proteins 0.000 abstract 2
- 230000002163 immunogen Effects 0.000 abstract 2
- 108010076504 Protein Sorting Signals Proteins 0.000 abstract 1
- 102000037865 fusion proteins Human genes 0.000 abstract 1
- 108020001507 fusion proteins Proteins 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/08—Clostridium, e.g. Clostridium tetani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Mycology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Η παρούσα εφεύρεση αφορά σε ανοσογονικές συνθέσεις που περιλαμβάνουν απομονωμένη Clostridium difficile CDTb. Συγκεκριμένα, η απομονωθείσα Clostridium difficile CDTb πρωτεΐνη έχει υποστεί μετάλλαξη για τροποποίηση της ικανότητας σχηματισμού πόρου, τροποποίηση της ικανότητας επταμερισμού ή είναι ακρωτηριασμένη CDTb πρωτεΐνη με το πεπτίδιο-σήματος και το προπεδίο απομακρυνθέντα και επίσης το πεδίο σύνδεσης υποδοχέα απομακρυνθέν ή/και το πεδίο σύνδεσης CDTa απομακρυνθέν. Η εφεύρεση επίσης αφορά σε πρωτεΐνες σύντηξης που περιλαμβάνουν πρωτεΐνη CDTa και πρωτεΐνη CDTb. Εμβόλια που περιλαμβάνουν τέτοιες ανοσογονικές συνθέσεις και θεραπευτικές χρήσεις των ιδίων επίσης αποτελούν μέρος της εφεύρεσης.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1411306.2A GB201411306D0 (en) | 2014-06-25 | 2014-06-25 | Immunogenic composition |
GB201411371A GB201411371D0 (en) | 2014-06-26 | 2014-06-26 | Immunogenic composition |
PCT/EP2015/064324 WO2015197737A1 (en) | 2014-06-25 | 2015-06-25 | Clostridium difficile immunogenic composition |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1122145T1 true CY1122145T1 (el) | 2020-11-25 |
Family
ID=53498986
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20191101061T CY1122145T1 (el) | 2014-06-25 | 2019-10-09 | Ανοσογονικη συνθεση για clostridium difficile |
Country Status (18)
Country | Link |
---|---|
US (1) | US20170218031A1 (el) |
EP (2) | EP3160500B1 (el) |
JP (2) | JP6688233B2 (el) |
CN (1) | CN106536544B (el) |
BE (1) | BE1022949B1 (el) |
BR (1) | BR112016030096B1 (el) |
CA (1) | CA2952118A1 (el) |
CY (1) | CY1122145T1 (el) |
DK (1) | DK3160500T3 (el) |
ES (1) | ES2749701T3 (el) |
HR (1) | HRP20191864T1 (el) |
HU (1) | HUE045936T2 (el) |
LT (1) | LT3160500T (el) |
MX (1) | MX2016017094A (el) |
PL (1) | PL3160500T3 (el) |
PT (1) | PT3160500T (el) |
SI (1) | SI3160500T1 (el) |
WO (1) | WO2015197737A1 (el) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3595709A4 (en) * | 2017-03-15 | 2020-12-23 | Novavax, Inc. | METHODS AND COMPOSITIONS FOR INDUCING IMMUNE RESPONSES TO CLOSTRIDIUM DIFFICILE |
CN112703006A (zh) | 2018-06-19 | 2021-04-23 | 葛兰素史密丝克莱恩生物有限公司 | 免疫原性组合物 |
GB202205833D0 (en) | 2022-04-21 | 2022-06-08 | Glaxosmithkline Biologicals Sa | Bacteriophage |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4235877A (en) | 1979-06-27 | 1980-11-25 | Merck & Co., Inc. | Liposome particle containing viral or bacterial antigenic subunit |
US4866034A (en) | 1982-05-26 | 1989-09-12 | Ribi Immunochem Research Inc. | Refined detoxified endotoxin |
US4436727A (en) | 1982-05-26 | 1984-03-13 | Ribi Immunochem Research, Inc. | Refined detoxified endotoxin product |
US4751180A (en) | 1985-03-28 | 1988-06-14 | Chiron Corporation | Expression using fused genes providing for protein product |
US4935233A (en) | 1985-12-02 | 1990-06-19 | G. D. Searle And Company | Covalently linked polypeptide cell modulators |
US4877611A (en) | 1986-04-15 | 1989-10-31 | Ribi Immunochem Research Inc. | Vaccine containing tumor antigens and adjuvants |
EP0362278A4 (en) | 1987-06-05 | 1990-05-14 | Us Health | FACTORS OF AUTOCRINE MOTILITY IN THE DIAGNOSIS AND TREATMENT OF CANCER. |
US4912094B1 (en) | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
ATE115862T1 (de) | 1989-02-04 | 1995-01-15 | Akzo Nobel Nv | Tocole als impfstoffadjuvans. |
PL170980B1 (pl) | 1992-06-25 | 1997-02-28 | Smithkline Beecham Biolog | Szczepionka PL PL PL PL PL PL PL |
ES2162139T5 (es) | 1993-03-23 | 2008-05-16 | Smithkline Beecham Biologicals S.A. | Composiciones de vacuna que contienen monofosforil-lipido a 3-o-desacilado. |
NZ295998A (en) | 1994-10-24 | 1999-10-28 | Ophidian Pharm Inc | Neutralizing antitoxins against clostridium difficile and clostidium botulinum toxins |
UA56132C2 (uk) | 1995-04-25 | 2003-05-15 | Смітклайн Бічем Байолоджікалс С.А. | Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини |
EP0832282A1 (en) | 1995-06-02 | 1998-04-01 | Incyte Pharmaceuticals, Inc. | IMPROVED METHOD FOR OBTAINING FULL-LENGTH cDNA SEQUENCES |
JP2002542169A (ja) * | 1999-04-09 | 2002-12-10 | テクラブ, インコーポレイテッド | Clostridiumdifficileに対する、組換え毒素A/毒素Bワクチン |
US20020065396A1 (en) | 2000-03-28 | 2002-05-30 | Fei Yang | Compositions and methods of diagnosing, monitoring, staging, imaging and treating colon cancer |
WO2005004791A2 (en) * | 2002-11-08 | 2005-01-20 | President And Fellows Of Harvard College | Compounds and methods for the treatment and prevention of bacterial infection |
AU2012349753A1 (en) * | 2011-12-08 | 2014-06-19 | Novartis Ag | Clostridium difficile toxin-based vaccine |
AR089797A1 (es) | 2012-01-27 | 2014-09-17 | Merck Sharp & Dohme | Vacunas contra clostridum difficile que comprenden toxinas recombinantes |
SI2928489T1 (sl) * | 2012-12-05 | 2019-05-31 | Glaxosmithkline Biologicals S.A. | Imunogeni sestavek |
GB201223342D0 (en) * | 2012-12-23 | 2013-02-06 | Glaxosmithkline Biolog Sa | Immunogenic composition |
-
2015
- 2015-06-25 CN CN201580039744.7A patent/CN106536544B/zh active Active
- 2015-06-25 ES ES15733404T patent/ES2749701T3/es active Active
- 2015-06-25 JP JP2016575190A patent/JP6688233B2/ja active Active
- 2015-06-25 HU HUE15733404A patent/HUE045936T2/hu unknown
- 2015-06-25 EP EP15733404.6A patent/EP3160500B1/en active Active
- 2015-06-25 LT LT15733404T patent/LT3160500T/lt unknown
- 2015-06-25 EP EP19192151.9A patent/EP3636278A3/en not_active Withdrawn
- 2015-06-25 BE BE2015/5390A patent/BE1022949B1/fr active
- 2015-06-25 BR BR112016030096-3A patent/BR112016030096B1/pt active IP Right Grant
- 2015-06-25 WO PCT/EP2015/064324 patent/WO2015197737A1/en active Application Filing
- 2015-06-25 US US15/320,190 patent/US20170218031A1/en not_active Abandoned
- 2015-06-25 SI SI201530954T patent/SI3160500T1/sl unknown
- 2015-06-25 MX MX2016017094A patent/MX2016017094A/es active IP Right Grant
- 2015-06-25 PT PT157334046T patent/PT3160500T/pt unknown
- 2015-06-25 DK DK15733404T patent/DK3160500T3/da active
- 2015-06-25 PL PL15733404T patent/PL3160500T3/pl unknown
- 2015-06-25 CA CA2952118A patent/CA2952118A1/en active Pending
-
2019
- 2019-10-09 CY CY20191101061T patent/CY1122145T1/el unknown
- 2019-10-15 HR HRP20191864TT patent/HRP20191864T1/hr unknown
-
2020
- 2020-01-17 JP JP2020005532A patent/JP2020100625A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
BE1022949B1 (fr) | 2016-10-21 |
JP6688233B2 (ja) | 2020-04-28 |
CA2952118A1 (en) | 2015-12-30 |
PL3160500T3 (pl) | 2020-02-28 |
EP3160500A1 (en) | 2017-05-03 |
BE1022949A1 (fr) | 2016-10-21 |
ES2749701T3 (es) | 2020-03-23 |
BR112016030096A2 (pt) | 2017-08-22 |
EP3636278A2 (en) | 2020-04-15 |
EP3160500B1 (en) | 2019-08-21 |
MX2016017094A (es) | 2017-05-03 |
WO2015197737A1 (en) | 2015-12-30 |
US20170218031A1 (en) | 2017-08-03 |
LT3160500T (lt) | 2019-10-25 |
HRP20191864T1 (hr) | 2020-01-10 |
JP2020100625A (ja) | 2020-07-02 |
PT3160500T (pt) | 2019-11-11 |
CN106536544A (zh) | 2017-03-22 |
CN106536544B (zh) | 2020-04-07 |
JP2017520573A (ja) | 2017-07-27 |
BR112016030096A8 (pt) | 2021-07-06 |
EP3636278A3 (en) | 2020-07-15 |
DK3160500T3 (da) | 2019-11-11 |
HUE045936T2 (hu) | 2020-01-28 |
SI3160500T1 (sl) | 2019-11-29 |
BR112016030096B1 (pt) | 2023-10-03 |
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