CY1122089T1 - Νουκλεοτιδιο dimso-150 για χρηση στη θεραπεια της χρονιας ενεργου ελκωδους κολιτιδας - Google Patents
Νουκλεοτιδιο dimso-150 για χρηση στη θεραπεια της χρονιας ενεργου ελκωδους κολιτιδαςInfo
- Publication number
- CY1122089T1 CY1122089T1 CY20191101013T CY191101013T CY1122089T1 CY 1122089 T1 CY1122089 T1 CY 1122089T1 CY 20191101013 T CY20191101013 T CY 20191101013T CY 191101013 T CY191101013 T CY 191101013T CY 1122089 T1 CY1122089 T1 CY 1122089T1
- Authority
- CY
- Cyprus
- Prior art keywords
- treatment
- ulcerative colitis
- dimso
- nucleotide
- chronic active
- Prior art date
Links
- 206010009900 Colitis ulcerative Diseases 0.000 title abstract 3
- 201000006704 Ulcerative Colitis Diseases 0.000 title abstract 3
- 230000001684 chronic effect Effects 0.000 title 1
- 239000002773 nucleotide Substances 0.000 title 1
- 108091034117 Oligonucleotide Proteins 0.000 abstract 2
- 208000011231 Crohn disease Diseases 0.000 abstract 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 abstract 1
- 238000011861 anti-inflammatory therapy Methods 0.000 abstract 1
- 238000012321 colectomy Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/17—Immunomodulatory nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/31—Combination therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Mycology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11190826.5A EP2596806A1 (en) | 2011-11-25 | 2011-11-25 | Method for prevention of colectomy |
| US201261595230P | 2012-02-06 | 2012-02-06 | |
| PCT/EP2012/073501 WO2013076262A1 (en) | 2011-11-25 | 2012-11-23 | Method for prevention of colectomy |
| EP12790904.2A EP2782602B1 (en) | 2011-11-25 | 2012-11-23 | Nucleotide DIMS0-150 for use in the treatment of chronic active ulcerative colitis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1122089T1 true CY1122089T1 (el) | 2020-11-25 |
Family
ID=45094516
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20191101013T CY1122089T1 (el) | 2011-11-25 | 2019-09-26 | Νουκλεοτιδιο dimso-150 για χρηση στη θεραπεια της χρονιας ενεργου ελκωδους κολιτιδας |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US9492516B2 (cg-RX-API-DMAC7.html) |
| EP (3) | EP2596806A1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP6193248B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2892203C (cg-RX-API-DMAC7.html) |
| CY (1) | CY1122089T1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK2782602T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2745677T3 (cg-RX-API-DMAC7.html) |
| HR (1) | HRP20191723T1 (cg-RX-API-DMAC7.html) |
| HU (1) | HUE046154T2 (cg-RX-API-DMAC7.html) |
| LT (1) | LT2782602T (cg-RX-API-DMAC7.html) |
| PL (1) | PL2782602T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT2782602T (cg-RX-API-DMAC7.html) |
| RS (1) | RS59358B1 (cg-RX-API-DMAC7.html) |
| SI (1) | SI2782602T1 (cg-RX-API-DMAC7.html) |
| SM (1) | SMT201900527T1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2013076262A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2881808C (en) * | 2013-07-05 | 2021-08-17 | Sony Corporation | Transmission apparatus, transmission method, reception apparatus, and reception method |
| JP2019535839A (ja) | 2016-11-29 | 2019-12-12 | ピュアテック ヘルス エルエルシー | 治療剤の送達のためのエクソソーム |
| BR112019021520A2 (pt) | 2017-04-14 | 2020-08-04 | Tollnine, Inc. | oligonucleotídeo, composto, polinucleotídeo imunomodulador, composição, conjugado, método para modular um receptor, método de tratamento de um tumor, método de tratamento de câncer, método para tratar um tumor, método de prevenção de câncer, método para induzir uma resposta imune |
| GB201707501D0 (en) * | 2017-05-10 | 2017-06-21 | Index Pharmaceuticals Ab | New therapy 2 |
| GB201707503D0 (en) * | 2017-05-10 | 2017-06-21 | Index Pharmaceuticals Ab | New Therapy 3 |
| GB201807312D0 (en) * | 2018-05-03 | 2018-06-20 | Index Pharmaceuticals Ab | Formulation |
| GB201818579D0 (en) * | 2018-11-14 | 2018-12-26 | Index Pharmaceuticals Ab | New therapy |
| GB201912191D0 (en) * | 2019-08-24 | 2019-10-09 | Index Pharmaceuticals Ab | New therapy |
| EP4147688A1 (en) * | 2021-09-09 | 2023-03-15 | InDex Pharmaceuticals AB | Enema formulation |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5149797A (en) | 1990-02-15 | 1992-09-22 | The Worcester Foundation For Experimental Biology | Method of site-specific alteration of rna and production of encoded polypeptides |
| EP0468520A3 (en) | 1990-07-27 | 1992-07-01 | Mitsui Toatsu Chemicals, Inc. | Immunostimulatory remedies containing palindromic dna sequences |
| US5849719A (en) | 1993-08-26 | 1998-12-15 | The Regents Of The University Of California | Method for treating allergic lung disease |
| EP1167378B1 (en) | 1994-07-15 | 2011-05-11 | University of Iowa Research Foundation | Immunomodulatory oligonucleotides |
| JP4359654B2 (ja) | 1996-01-30 | 2009-11-04 | ザ リージェンツ オブ ザ ユニバーシティー オブ カリフォルニア | 抗原特異的免疫応答を生起させる遺伝子発現ベクターおよびその使用方法 |
| ES2241042T3 (es) | 1996-10-11 | 2005-10-16 | The Regents Of The University Of California | Conjugados de polinucleotido inmunoestimulador/ molecula inmunomoduladora. |
| US6406705B1 (en) | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
| US6426334B1 (en) | 1997-04-30 | 2002-07-30 | Hybridon, Inc. | Oligonucleotide mediated specific cytokine induction and reduction of tumor growth in a mammal |
| US6339068B1 (en) | 1997-05-20 | 2002-01-15 | University Of Iowa Research Foundation | Vectors and methods for immunization or therapeutic protocols |
| US6809193B2 (en) * | 1997-08-13 | 2004-10-26 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotide compositions and methods for the modulation of JNK proteins |
| AU2006205571B2 (en) | 2005-01-13 | 2012-03-22 | Progenika Biopharma, S.A. | Methods and products for in vitro genotyping |
| JPWO2006132204A1 (ja) | 2005-06-06 | 2009-01-08 | アンジェスＭｇ株式会社 | 転写因子デコイ |
| EP1904077B1 (en) | 2005-07-01 | 2009-08-12 | Index Pharmaceuticals AB | Modulating responsiveness to steroids |
| ES2450593T3 (es) | 2005-07-01 | 2014-03-25 | Index Pharmaceuticals Ab | Método inmunoestimulante |
| US8637479B2 (en) | 2008-11-04 | 2014-01-28 | Index Pharmaceuticals Ab | Compounds and methods for the treatment of inflammatory diseases of the CNS |
-
2011
- 2011-11-25 EP EP11190826.5A patent/EP2596806A1/en not_active Withdrawn
-
2012
- 2012-11-23 WO PCT/EP2012/073501 patent/WO2013076262A1/en not_active Ceased
- 2012-11-23 SI SI201231671T patent/SI2782602T1/sl unknown
- 2012-11-23 HU HUE12790904A patent/HUE046154T2/hu unknown
- 2012-11-23 EP EP19173912.7A patent/EP3556403A1/en not_active Withdrawn
- 2012-11-23 US US14/359,945 patent/US9492516B2/en not_active Expired - Fee Related
- 2012-11-23 LT LTEP12790904.2T patent/LT2782602T/lt unknown
- 2012-11-23 CA CA2892203A patent/CA2892203C/en active Active
- 2012-11-23 SM SM20190527T patent/SMT201900527T1/it unknown
- 2012-11-23 HR HRP20191723 patent/HRP20191723T1/hr unknown
- 2012-11-23 PT PT127909042T patent/PT2782602T/pt unknown
- 2012-11-23 ES ES12790904T patent/ES2745677T3/es active Active
- 2012-11-23 PL PL12790904T patent/PL2782602T3/pl unknown
- 2012-11-23 RS RSP20191190 patent/RS59358B1/sr unknown
- 2012-11-23 EP EP12790904.2A patent/EP2782602B1/en active Active
- 2012-11-23 DK DK12790904.2T patent/DK2782602T3/da active
- 2012-11-23 JP JP2014542858A patent/JP6193248B2/ja not_active Expired - Fee Related
-
2016
- 2016-09-14 US US15/264,709 patent/US9795627B2/en not_active Expired - Fee Related
- 2016-11-08 JP JP2016218270A patent/JP6318221B2/ja not_active Expired - Fee Related
-
2017
- 2017-09-21 US US15/711,228 patent/US20180015117A1/en not_active Abandoned
-
2019
- 2019-09-26 CY CY20191101013T patent/CY1122089T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2017061508A (ja) | 2017-03-30 |
| CA2892203C (en) | 2021-11-16 |
| RS59358B1 (sr) | 2019-11-29 |
| SMT201900527T1 (it) | 2019-11-13 |
| PL2782602T3 (pl) | 2019-12-31 |
| LT2782602T (lt) | 2019-10-10 |
| CA2892203A1 (en) | 2013-05-30 |
| US20150004187A1 (en) | 2015-01-01 |
| JP6318221B2 (ja) | 2018-04-25 |
| HRP20191723T1 (hr) | 2019-12-13 |
| US9795627B2 (en) | 2017-10-24 |
| US9492516B2 (en) | 2016-11-15 |
| ES2745677T3 (es) | 2020-03-03 |
| WO2013076262A1 (en) | 2013-05-30 |
| US20170014442A1 (en) | 2017-01-19 |
| EP2782602B1 (en) | 2019-06-26 |
| DK2782602T3 (da) | 2019-09-30 |
| JP6193248B2 (ja) | 2017-09-06 |
| EP2596806A1 (en) | 2013-05-29 |
| SI2782602T1 (sl) | 2019-11-29 |
| HUE046154T2 (hu) | 2020-02-28 |
| JP2015504438A (ja) | 2015-02-12 |
| EP2782602A1 (en) | 2014-10-01 |
| US20180015117A1 (en) | 2018-01-18 |
| EP3556403A1 (en) | 2019-10-23 |
| PT2782602T (pt) | 2019-10-14 |
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