CY1121920T1 - Παραγωγα 4-οξο-ν-(4-υδροξυφαινυλ)ρητιναμιδιου ως θεραπευτικοι παραγοντες για την αγωγη του καρκινου - Google Patents
Παραγωγα 4-οξο-ν-(4-υδροξυφαινυλ)ρητιναμιδιου ως θεραπευτικοι παραγοντες για την αγωγη του καρκινουInfo
- Publication number
- CY1121920T1 CY1121920T1 CY20181100888T CY181100888T CY1121920T1 CY 1121920 T1 CY1121920 T1 CY 1121920T1 CY 20181100888 T CY20181100888 T CY 20181100888T CY 181100888 T CY181100888 T CY 181100888T CY 1121920 T1 CY1121920 T1 CY 1121920T1
- Authority
- CY
- Cyprus
- Prior art keywords
- hydroxyphenyl
- oxo
- cancer
- treatment
- therapeutic agents
- Prior art date
Links
- NZVOGZATHCUFRC-KFJFTADJSA-N (2e,4e,6e,8e)-n-(4-hydroxyphenyl)-3,7-dimethyl-9-(2,6,6-trimethyl-3-oxocyclohexen-1-yl)nona-2,4,6,8-tetraenamide Chemical class C=1C=C(O)C=CC=1NC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)C(=O)CCC1(C)C NZVOGZATHCUFRC-KFJFTADJSA-N 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 229940124597 therapeutic agent Drugs 0.000 title 1
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 2
- 125000006832 (C1-C10) alkylene group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000004067 bulking agent Substances 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/32—Oximes
- C07C251/50—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals
- C07C251/60—Oximes having oxygen atoms of oxyimino groups bound to carbon atoms of substituted hydrocarbon radicals of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
- C07C403/20—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by carboxyl groups or halides, anhydrides, or (thio)esters thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Η παρούσα εφεύρεση αφορά μία ένωση η οποία έχει τον τύπο (I) κατωτέρω ή ένα φαρμακευτικά αποδεκτό άλας αυτής: όπου το Χ είναι -COOH ή NH2· το R είναι μία ευθεία ή διακλαδισμένη C1-C10 αλκυλενική αλυσίδα· και το R1 είναι Η, ευθείας ή διακλαδισμένης αλυσίδας C1-C10 αλκύλιο, αρύλιο, ή R2CO- όπου το R2 είναι ευθείας ή διακλαδισμένης αλυσίδας C1-C10 αλκύλιο, για χρήση ως παράγοντα έναντι όγκου.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI20141603 | 2014-09-17 | ||
| PCT/EP2015/071178 WO2016042010A1 (en) | 2014-09-17 | 2015-09-16 | 4-oxo-n-(4-hydroxyphenyl)retinamide derivatives as therapeutic agents for the treatment of cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1121920T1 true CY1121920T1 (el) | 2020-07-31 |
Family
ID=51799184
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20181100888T CY1121920T1 (el) | 2014-09-17 | 2018-08-27 | Παραγωγα 4-οξο-ν-(4-υδροξυφαινυλ)ρητιναμιδιου ως θεραπευτικοι παραγοντες για την αγωγη του καρκινου |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US10093621B2 (el) |
| EP (1) | EP3194360B1 (el) |
| JP (1) | JP6654771B2 (el) |
| KR (1) | KR102547925B1 (el) |
| CN (1) | CN107001258B (el) |
| AU (1) | AU2015316886B2 (el) |
| CA (1) | CA2961275C (el) |
| CY (1) | CY1121920T1 (el) |
| DK (1) | DK3194360T3 (el) |
| ES (1) | ES2686733T3 (el) |
| HR (1) | HRP20181460T1 (el) |
| HU (1) | HUE039947T2 (el) |
| PL (1) | PL3194360T3 (el) |
| PT (1) | PT3194360T (el) |
| RS (1) | RS57443B1 (el) |
| SI (1) | SI3194360T1 (el) |
| WO (1) | WO2016042010A1 (el) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5399757A (en) * | 1993-07-20 | 1995-03-21 | Ortho Pharmaceutical Corporation | Process for the preparation of N-(4-hydroxyphenyl)-retinamide |
| US20030232820A1 (en) | 2001-08-29 | 2003-12-18 | Saul Wolfe | Method for synthesizing oxazinones |
| JP4689660B2 (ja) * | 2004-03-18 | 2011-05-25 | ファンダツィオーネ ィルックス インスティチュート ナツィオナレ デイ ツモリ | がんに対する予防薬および治療薬として単独投与およびフェンレチニドと併用される４−オキソ−フェンレチニド |
| EP2521541A2 (en) * | 2009-10-28 | 2012-11-14 | ReVision Therapeutics, Inc. | Prophylaxis of skin cancer with retinamides |
-
2015
- 2015-09-16 HU HUE15775638A patent/HUE039947T2/hu unknown
- 2015-09-16 KR KR1020177006984A patent/KR102547925B1/ko active IP Right Grant
- 2015-09-16 AU AU2015316886A patent/AU2015316886B2/en active Active
- 2015-09-16 PL PL15775638T patent/PL3194360T3/pl unknown
- 2015-09-16 ES ES15775638.8T patent/ES2686733T3/es active Active
- 2015-09-16 WO PCT/EP2015/071178 patent/WO2016042010A1/en active Application Filing
- 2015-09-16 PT PT15775638T patent/PT3194360T/pt unknown
- 2015-09-16 SI SI201530348T patent/SI3194360T1/sl unknown
- 2015-09-16 US US15/510,798 patent/US10093621B2/en active Active
- 2015-09-16 EP EP15775638.8A patent/EP3194360B1/en active Active
- 2015-09-16 CA CA2961275A patent/CA2961275C/en active Active
- 2015-09-16 RS RS20180828A patent/RS57443B1/sr unknown
- 2015-09-16 CN CN201580049384.9A patent/CN107001258B/zh active Active
- 2015-09-16 DK DK15775638.8T patent/DK3194360T3/en active
- 2015-09-16 JP JP2017515241A patent/JP6654771B2/ja active Active
-
2018
- 2018-08-27 CY CY20181100888T patent/CY1121920T1/el unknown
- 2018-09-12 HR HRP20181460TT patent/HRP20181460T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3194360A1 (en) | 2017-07-26 |
| DK3194360T3 (en) | 2018-09-03 |
| HUE039947T2 (hu) | 2019-02-28 |
| CN107001258B (zh) | 2019-03-19 |
| US10093621B2 (en) | 2018-10-09 |
| US20170253560A1 (en) | 2017-09-07 |
| KR102547925B1 (ko) | 2023-06-26 |
| EP3194360B1 (en) | 2018-06-27 |
| SI3194360T1 (sl) | 2018-09-28 |
| KR20170076649A (ko) | 2017-07-04 |
| PT3194360T (pt) | 2018-10-18 |
| AU2015316886B2 (en) | 2019-02-21 |
| JP2017533185A (ja) | 2017-11-09 |
| AU2015316886A1 (en) | 2017-04-06 |
| RS57443B1 (sr) | 2018-09-28 |
| PL3194360T3 (pl) | 2018-11-30 |
| JP6654771B2 (ja) | 2020-02-26 |
| ES2686733T3 (es) | 2018-10-19 |
| HRP20181460T1 (hr) | 2018-11-02 |
| WO2016042010A1 (en) | 2016-03-24 |
| CN107001258A (zh) | 2017-08-01 |
| CA2961275A1 (en) | 2016-03-24 |
| CA2961275C (en) | 2023-10-03 |
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