CY1121824T1 - Μεθοδοι και συνθεσεις για προληψη και ανακουφιση μυικων κραμπων και για αποκατασταση απο νευρομυικη ευερεθιστικοτητα και κοπωση μετα απο ασκηση - Google Patents

Μεθοδοι και συνθεσεις για προληψη και ανακουφιση μυικων κραμπων και για αποκατασταση απο νευρομυικη ευερεθιστικοτητα και κοπωση μετα απο ασκηση

Info

Publication number
CY1121824T1
CY1121824T1 CY20171101225T CY171101225T CY1121824T1 CY 1121824 T1 CY1121824 T1 CY 1121824T1 CY 20171101225 T CY20171101225 T CY 20171101225T CY 171101225 T CY171101225 T CY 171101225T CY 1121824 T1 CY1121824 T1 CY 1121824T1
Authority
CY
Cyprus
Prior art keywords
compositions
methods
neuromusical
irritisability
exercise
Prior art date
Application number
CY20171101225T
Other languages
English (en)
Inventor
Bruce P. Bean
Donald Mackinnon
Roderick Mackinnon
Original Assignee
Flex Pharma, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Flex Pharma, Inc. filed Critical Flex Pharma, Inc.
Publication of CY1121824T1 publication Critical patent/CY1121824T1/el

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52—Adding ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/42—Phosphorus; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/67—Piperaceae (Pepper family), e.g. Jamaican pepper or kava
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Nutrition Science (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Organic Chemistry (AREA)
  • Physiology (AREA)
  • Pain & Pain Management (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Οι μέθοδοι και συνθέσεις της παρούσας εφεύρεσης εστιάζονται στην αγωγή ή καλυτέρευση μυικών κραμπών χρησιμοποιώντας σύνθεση η οποία περιλαμβάνει έναν ή περισσότερους ενεργοποιητές διαύλου TRPV1, και/η έναν ή περισσότερους ενεργοποιητές διαύλου TRPA1, και/ή έναν ή περισσότερους ενεργοποιητές διαύλου ASIC.
CY20171101225T 2010-07-27 2017-11-22 Μεθοδοι και συνθεσεις για προληψη και ανακουφιση μυικων κραμπων και για αποκατασταση απο νευρομυικη ευερεθιστικοτητα και κοπωση μετα απο ασκηση CY1121824T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36805910P 2010-07-27 2010-07-27
PCT/US2011/045480 WO2012015882A1 (en) 2010-07-27 2011-07-27 Methods and compositions for preventing and relieving muscle cramps and for recovery from neuromuscular irritability and fatigue following exercise

Publications (1)

Publication Number Publication Date
CY1121824T1 true CY1121824T1 (el) 2020-07-31

Family

ID=45526958

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20171101225T CY1121824T1 (el) 2010-07-27 2017-11-22 Μεθοδοι και συνθεσεις για προληψη και ανακουφιση μυικων κραμπων και για αποκατασταση απο νευρομυικη ευερεθιστικοτητα και κοπωση μετα απο ασκηση

Country Status (11)

Country Link
US (5) US20120027693A1 (el)
EP (2) EP3295794A1 (el)
CY (1) CY1121824T1 (el)
DK (1) DK2629610T3 (el)
ES (1) ES2647087T3 (el)
HR (1) HRP20171744T1 (el)
HU (1) HUE035134T2 (el)
NO (1) NO2629610T3 (el)
PL (1) PL2629610T3 (el)
PT (1) PT2629610T (el)
WO (1) WO2012015882A1 (el)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2647087T3 (es) 2010-07-27 2017-12-19 Flex Pharma, Inc. Métodos y composiciones para prevenir y aliviar los calambres musculares y para la recuperación de la irritabilidad neuromuscular y de la fatiga después del ejercicio
US9713543B2 (en) 2011-02-16 2017-07-25 Charlie C. Koo Methods of and devices for chemical and threshold-gated electrical neuro-immuno-stimulation that triggers the stem cell growth to restore bodily functions
US20130052234A1 (en) * 2011-08-25 2013-02-28 Purebrands LLC Edible strips
WO2014124219A1 (en) 2013-02-08 2014-08-14 General Mills, Inc. Reduced sodium food product
US9319916B2 (en) * 2013-03-15 2016-04-19 Isco International, Llc Method and appartus for signal interference processing
GB2514417A (en) * 2013-05-24 2014-11-26 Susan Jane Branch Topical composition
GB2523578A (en) * 2014-02-28 2015-09-02 Daniel Nelson A nutritional supplement
BR112016024034A2 (pt) * 2014-04-14 2017-12-26 Flex Pharma Inc ativadores de canal iônico e métodos de uso
WO2015160842A1 (en) * 2014-04-14 2015-10-22 Flex Pharma, Inc. Methods and formulatiions of capsaicinoids and capsinoids
JP2015231964A (ja) * 2014-06-09 2015-12-24 花王株式会社 運動神経活性化用皮膚塗布剤
WO2016137478A1 (en) * 2015-02-26 2016-09-01 Koo Charles C Methods of and devices for chemical and threshold-gated electrical neuro-immuno-stimulation that triggers the stem cell growth to restore bodily functions
US10034831B2 (en) 2015-03-10 2018-07-31 CrampsAWAY Inc. Neuromuscular aid
WO2017020125A1 (en) 2015-07-31 2017-02-09 Delivra Inc. Transdermal formulations for delivery of capsaicinoids
SG11201802785XA (en) * 2015-10-06 2018-05-30 Flex Pharma Inc Methods and compositions for unwanted or abnormal muscle contractions
WO2017160156A1 (en) * 2016-03-18 2017-09-21 Axichem Ab Synthetic capasaicin analogs as trpv1 agonists
ES2971121T3 (es) 2016-08-30 2024-06-03 Omniactive Health Tech Ltd Métodos para mejorar el rendimiento físico y composiciones de guindilla utilizadas para ello
US20180084827A1 (en) 2016-09-23 2018-03-29 Sentiens, Llc Agents and methods for modulating the sensory impact of tobacco or herbal smoke
WO2018136943A1 (en) 2017-01-23 2018-07-26 Flex Pharma, Inc. Compositions and methods affecting exercise performance
US20180360750A1 (en) * 2017-06-16 2018-12-20 Lillian Johnson Composition for reducing muscle cramps
CN107638473A (zh) * 2017-09-28 2018-01-30 苟稳 一种用于腓肠肌痉挛的中药药酒
CN112292041A (zh) * 2018-05-09 2021-01-29 多马利纳股份有限公司Atf多马利纳单位信托 一种用于健康成分的可食用凝胶递送方法
US11730187B2 (en) 2019-05-08 2023-08-22 Gamot Global Pte. Ltd. Use of isothiocyanate in smokeless tobacco products
PL242445B1 (pl) * 2020-03-15 2023-02-20 Anwipharma Spolka Z Ograniczona Odpowiedzialnoscia Sposób otrzymywania preparatu i preparat zawierający elektrolity dla zwierząt kopytnych, zwłaszcza koni
WO2024074839A1 (en) * 2022-10-07 2024-04-11 Nicoventures Trading Limited Oral product

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4313958A (en) 1980-10-24 1982-02-02 The Procter & Gamble Company Method of producing analgesia
US4424205A (en) 1982-03-18 1984-01-03 The Procter & Gamble Company Hydroxyphenylacetamides having analgesic and anti-irritant activity
US4564633A (en) 1983-07-14 1986-01-14 The Procter & Gamble Company Compositions and methods useful for producing analgesia
US4532139A (en) 1983-07-14 1985-07-30 The Procter & Gamble Company Compounds and compositions useful for producing analgesia
US4493848A (en) 1983-07-14 1985-01-15 The Procter & Gamble Company Compositions and methods useful for producing analgesia
US4544668A (en) 1983-07-14 1985-10-01 The Procter & Gamble Company Compounds and compositions useful for producing analgesia
US4544669A (en) 1983-07-14 1985-10-01 The Procter & Gamble Company Compounds and compositions useful for producing analgesia
US4599342A (en) 1984-01-16 1986-07-08 The Procter & Gamble Company Pharmaceutical products providing enhanced analgesia
US4681897A (en) 1984-01-16 1987-07-21 The Procter & Gamble Company Pharmaceutical products providing enhanced analgesia
US4939149A (en) 1988-10-24 1990-07-03 The United States Of America As Represented By The Department Of Health And Human Services Resiniferatoxin and analogues thereof to cause sensory afferent C-fiber and thermoregulatory desensitization
US5403868A (en) 1988-12-23 1995-04-04 Sandoz Ltd. Capsaicin derivatives
US5221692A (en) 1991-08-22 1993-06-22 National Science Council Ether linked and relatively nonpungent analogues of N-nonanoyl vanillylamide
US5762963A (en) 1995-06-07 1998-06-09 Emory University Method and compositions for controlling oral and pharyngeal pain using capsaicinoids
EP1201241B8 (en) 1997-03-13 2010-10-27 James N. Campbell Compositions containing capsaicin or capsaicin analogues and an anesthetic
JP4043605B2 (ja) 1998-07-02 2008-02-06 丸善製薬株式会社 カプサイシン類縁体の製造法
EP1154989B1 (en) 1999-02-22 2005-12-14 Pacific Corporation Vanilloid analogues containing resiniferatoxin pharmacophores as potent vanilloid receptor agonists and analgesics, compositions and uses thereof
US6534086B1 (en) * 2000-03-06 2003-03-18 Metagenics, Inc. Composition and method for treatment of inflammation and pain in mammals
US6274177B1 (en) 2000-08-26 2001-08-14 National Science Council Method of preparing an extract potent in anti-inflammation and anti-platelet aggregation from Zingiber officinale and pharmaceutical compositions containing said extract
US20030104085A1 (en) 2001-12-05 2003-06-05 Yeomans David C. Methods and compositions for treating back pain
US20030180226A1 (en) * 2002-01-23 2003-09-25 Haughton Pauline A. Anti-bacterial sneeze spray
NZ542887A (en) 2003-04-08 2008-05-30 Algorx Pharmaceuticals Inc Preparation and purification of synthetic capsaicin
US20070020301A1 (en) * 2003-08-29 2007-01-25 Kao Corporation Beautification method
NO20034069L (no) 2003-09-12 2005-03-14 Aximed As Fremstilling og bruk av capsaicinderivater
ITMI20041566A1 (it) 2004-07-30 2004-10-30 Indena Spa "trpv1 agonisti, formulazioni che li contengono e loro usi"
FR2880625B1 (fr) 2005-01-07 2007-03-09 Sanofi Aventis Sa Derives de n-(heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique
WO2006116485A2 (en) 2005-04-25 2006-11-02 Neurogesx, Inc. Trpv1 agonist compounds and methods for making and using the same
CN101040720A (zh) * 2006-03-24 2007-09-26 沈华立 一种豆腐干的五香麻辣卤汤液
US7674594B2 (en) 2006-07-27 2010-03-09 Redpoint Bio Corporation Screening assay for inhibitors of TRPA1 activation by a lower alkyl phenol
US8227603B2 (en) 2006-08-01 2012-07-24 Cytokinetics, Inc. Modulating skeletal muscle
KR20090082507A (ko) 2006-11-20 2009-07-30 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 통증 및 소양증 치료용 방법, 조성물 및 키트
US8461145B2 (en) 2007-12-05 2013-06-11 Janssen Pharmaceutica Nv Dibenzoazepine and dibenzooxazepine TRPA1 agonists
KR100951656B1 (ko) * 2008-02-25 2010-04-07 고려대학교 산학협력단 프로베네시드를 포함하는 ｔｒｐｖ２ 활성제
EP2853897A1 (en) 2008-05-08 2015-04-01 University Of Utah Research Foundation Sensory receptors for chronic fatigue and pain and uses thereof
ES2647087T3 (es) 2010-07-27 2017-12-19 Flex Pharma, Inc. Métodos y composiciones para prevenir y aliviar los calambres musculares y para la recuperación de la irritabilidad neuromuscular y de la fatiga después del ejercicio

Also Published As

Publication number Publication date
EP2629610B1 (en) 2017-09-06
ES2647087T3 (es) 2017-12-19
EP2629610A4 (en) 2014-08-06
NO2629610T3 (el) 2018-02-03
WO2012015882A1 (en) 2012-02-02
DK2629610T3 (da) 2017-11-20
US20220387539A1 (en) 2022-12-08
HRP20171744T1 (hr) 2018-01-12
US20120027693A1 (en) 2012-02-02
US9937135B2 (en) 2018-04-10
PT2629610T (pt) 2017-11-24
US20200375925A1 (en) 2020-12-03
US20140343156A1 (en) 2014-11-20
HUE035134T2 (en) 2018-05-02
US20160367506A1 (en) 2016-12-22
EP2629610A1 (en) 2013-08-28
EP3295794A1 (en) 2018-03-21
PL2629610T3 (pl) 2018-02-28
US10568853B2 (en) 2020-02-25

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