CY1121570T1 - NICOTINE PREPARATION - Google Patents
NICOTINE PREPARATIONInfo
- Publication number
- CY1121570T1 CY1121570T1 CY20191100419T CY191100419T CY1121570T1 CY 1121570 T1 CY1121570 T1 CY 1121570T1 CY 20191100419 T CY20191100419 T CY 20191100419T CY 191100419 T CY191100419 T CY 191100419T CY 1121570 T1 CY1121570 T1 CY 1121570T1
- Authority
- CY
- Cyprus
- Prior art keywords
- solution
- nicotine
- film
- weight
- average
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Μέθοδος βιομηχανικής κατασκευής ενός βλεννοπροσφυτικού υμενίου που περιέχει νικοτίνη, με την παρασκευή ενός υδατικού διαλύματος σε ένα pΗ από 9,5 έως 13, με το διάλυμα να περιλαμβάνει (i) ένα άλας νικοτίνης, (ii) έναν αλκαλικό παράγοντα ρύθμισης του pΗ, και (iii) έναν παράγοντα σχηματισμού υμενίου που περιλαμβάνει ένα αλγινικό άλας μονοσθενούς κατιόντος ή ένα μίγμα αλγινικών αλάτων μονοσθενών κατιόντων, με τον παράγοντα σχηματισμού υμενίου να έχει μια μέση περιεκτικότητα γουλουρονικού (G) από 50 έως 85% κατά βάρος, μια μέση περιεκτικότητα μαννουρονικού (Μ) από 15 έως 50% κατά βάρος, ένα μέσο μοριακό βάρος από 30.000 g/mol έως 90.000 g/mol και είναι τέτοιος που ένα υδατικό διάλυμα του 10% σε μια θερμοκρασία 20°C έχει ένα ιξώδες 100-1000 mPas, όπως μετριέται σε ένα ρυθμό διάτμησης 20 σαλ με τη χρήση ενός ιξωδόμετρου Brookfield με αξονίσκο No. 2, κατανέμοντας το διάλυμα επάνω σε μια στερεή επιφάνεια και επιτρέποντας στο διάλυμα να ξηρανθεί επάνω στην επιφάνεια. Βλεννοπροσφυτικό υμένιο που περιέχει νικοτίνη.Process for the manufacture of a nicotine-containing mucosal adhesive film, by preparing an aqueous solution at a pH of 9.5 to 13, wherein the solution comprises (i) a nicotine salt, (ii) an alkaline pH adjusting agent, and ( (iii) a film-forming agent comprising a monovalent cation alginate or a mixture of monovalent cation alginates, with the film-forming agent having an average guluronic acid (G) content of 50 to 85% by weight, an average mannuronic acid (M) content from 15 to 50% by weight, an average molecular weight of 30,000 g / mol to 90,000 g / mol and is such that a 10% aqueous solution at a temperature of 20 ° C has a viscosity of 100-1000 mPas, as measured in a shear rate of 20 rpm using a Brookfield viscometer with no. 2, distributing the solution on a solid surface and allowing the solution to dry on the surface. Mucosal adhesive film containing nicotine.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261615997P | 2012-03-27 | 2012-03-27 | |
| EP12161483 | 2012-03-27 | ||
| EP13712730.4A EP2830589B1 (en) | 2012-03-27 | 2013-03-15 | Nicotine formulation |
| PCT/EP2013/055456 WO2013143891A1 (en) | 2012-03-27 | 2013-03-15 | Nicotine formulation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1121570T1 true CY1121570T1 (en) | 2020-05-29 |
Family
ID=66248907
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20191100419T CY1121570T1 (en) | 2012-03-27 | 2019-04-16 | NICOTINE PREPARATION |
Country Status (10)
| Country | Link |
|---|---|
| CY (1) | CY1121570T1 (en) |
| DK (1) | DK2830589T3 (en) |
| ES (1) | ES2720488T3 (en) |
| HR (1) | HRP20190598T1 (en) |
| HU (1) | HUE043009T2 (en) |
| IL (1) | IL234771B (en) |
| LT (1) | LT2830589T (en) |
| ME (1) | ME03456B (en) |
| PT (1) | PT2830589T (en) |
| TR (1) | TR201905664T4 (en) |
-
2013
- 2013-03-15 LT LTEP13712730.4T patent/LT2830589T/en unknown
- 2013-03-15 TR TR2019/05664T patent/TR201905664T4/en unknown
- 2013-03-15 PT PT13712730T patent/PT2830589T/en unknown
- 2013-03-15 ES ES13712730T patent/ES2720488T3/en active Active
- 2013-03-15 DK DK13712730.4T patent/DK2830589T3/en active
- 2013-03-15 HU HUE13712730A patent/HUE043009T2/en unknown
- 2013-03-15 ME MEP-2019-104A patent/ME03456B/en unknown
-
2014
- 2014-09-22 IL IL23477114A patent/IL234771B/en active IP Right Grant
-
2019
- 2019-03-27 HR HRP20190598TT patent/HRP20190598T1/en unknown
- 2019-04-16 CY CY20191100419T patent/CY1121570T1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL234771B (en) | 2019-10-31 |
| TR201905664T4 (en) | 2019-05-21 |
| PT2830589T (en) | 2019-05-20 |
| ES2720488T3 (en) | 2019-07-22 |
| HUE043009T2 (en) | 2019-07-29 |
| LT2830589T (en) | 2019-05-27 |
| HRP20190598T1 (en) | 2019-06-14 |
| DK2830589T3 (en) | 2019-04-29 |
| ME03456B (en) | 2020-01-20 |
| IL234771A0 (en) | 2014-11-30 |
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