TR201905664T4 - Nicotine formulation. - Google Patents
Nicotine formulation. Download PDFInfo
- Publication number
- TR201905664T4 TR201905664T4 TR2019/05664T TR201905664T TR201905664T4 TR 201905664 T4 TR201905664 T4 TR 201905664T4 TR 2019/05664 T TR2019/05664 T TR 2019/05664T TR 201905664 T TR201905664 T TR 201905664T TR 201905664 T4 TR201905664 T4 TR 201905664T4
- Authority
- TR
- Turkey
- Prior art keywords
- film
- solution
- nicotine
- mol
- weight
- Prior art date
Links
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 title abstract 4
- 229960002715 nicotine Drugs 0.000 title abstract 3
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 2
- 238000009472 formulation Methods 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 abstract 3
- 239000000243 solution Substances 0.000 abstract 3
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical class O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 2
- 150000001768 cations Chemical class 0.000 abstract 2
- 230000003232 mucoadhesive effect Effects 0.000 abstract 2
- AEMOLEFTQBMNLQ-BZINKQHNSA-N D-Guluronic Acid Chemical compound OC1O[C@H](C(O)=O)[C@H](O)[C@@H](O)[C@H]1O AEMOLEFTQBMNLQ-BZINKQHNSA-N 0.000 abstract 1
- AEMOLEFTQBMNLQ-VANFPWTGSA-N D-mannopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@@H]1O AEMOLEFTQBMNLQ-VANFPWTGSA-N 0.000 abstract 1
- 239000002313 adhesive film Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
9.5 ila 13 arasında bir pH'ta bir sulu çözeltinin hazırlanmasıyla, bir nikotin-barındıran muko yapışkan filmin imal edilmesine yönelik bir yöntem olup, söz konusu çözelti, (i) bir nikotin tuzu, (ii) bir alkalin pH-düzenleyici ajan, ve (iii) tek değerli katyonun bir aljinat tuzunu veya tek değerli katyonların aljinat tuzlarının bir karışımını içeren bir film-oluşturma ajanı içermektedir, film-oluşturma ajanı, ağırlık cinsinden %50 ila 85 arasında bir ortalama guluronat (G) içeriğine, ağırlık cinsinden %15 ila 50 arasında bir ortalama mannuronat (M) içeriğine, 30,000 g/mol ila 90,000 g/mol arasında bir ortalama moleküler ağırlığa sahiptir ve 20°C'lik bir sıcaklıkta bunun %10'luk bir sulu çözeltisinin, bir 2 Numaralı spindle içeren bir Brookfield viskozimetre kullanılarak 20 rpm'lik bir kayma hızında ölçüldüğü üzere, 100-1000 mPas'lik bir viskoziteye sahiptir; çözeltinin bir söz konusu yüzeyin üzerine dağıtılması; ve çözeltinin söz konusu yüzey üzerinde kurumasına imkân tanınması ile imal edilmesine yönelik bir yöntemdir. Bir nikotin-barındıran muko yapışkan film.A method of manufacturing a nicotine-containing mucoadhesive film by preparing an aqueous solution at a pH between 9.5 and 13, said solution being (i) a nicotine salt, (ii) an alkaline pH-regulating agent, and ( iii) a film-forming agent containing an alginate salt of monovalent cation or a mixture of alginate salts of monovalent cations, the film-forming agent having an average guluronate (G) content of 50 to 85% by weight, 15 to 50% by weight It has an average mannuronate (M) content of between 30,000 g / mol and 90,000 g / mol and a 10% aqueous solution thereof at a temperature of 20 ° C using a Brookfield viscometer containing a Number 2 spindle It has a viscosity of 100-1000 mPas as measured at a shear rate of 20 rpm; distributing the solution over a said surface; and allowing the solution to dry on said surface. A nicotine-containing muco adhesive film.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261615997P | 2012-03-27 | 2012-03-27 | |
EP12161483 | 2012-03-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR201905664T4 true TR201905664T4 (en) | 2019-05-21 |
Family
ID=66248907
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2019/05664T TR201905664T4 (en) | 2012-03-27 | 2013-03-15 | Nicotine formulation. |
Country Status (10)
Country | Link |
---|---|
CY (1) | CY1121570T1 (en) |
DK (1) | DK2830589T3 (en) |
ES (1) | ES2720488T3 (en) |
HR (1) | HRP20190598T1 (en) |
HU (1) | HUE043009T2 (en) |
IL (1) | IL234771B (en) |
LT (1) | LT2830589T (en) |
ME (1) | ME03456B (en) |
PT (1) | PT2830589T (en) |
TR (1) | TR201905664T4 (en) |
-
2013
- 2013-03-15 HU HUE13712730A patent/HUE043009T2/en unknown
- 2013-03-15 TR TR2019/05664T patent/TR201905664T4/en unknown
- 2013-03-15 DK DK13712730.4T patent/DK2830589T3/en active
- 2013-03-15 LT LTEP13712730.4T patent/LT2830589T/en unknown
- 2013-03-15 PT PT13712730T patent/PT2830589T/en unknown
- 2013-03-15 ES ES13712730T patent/ES2720488T3/en active Active
- 2013-03-15 ME MEP-2019-104A patent/ME03456B/en unknown
-
2014
- 2014-09-22 IL IL23477114A patent/IL234771B/en active IP Right Grant
-
2019
- 2019-03-27 HR HRP20190598TT patent/HRP20190598T1/en unknown
- 2019-04-16 CY CY20191100419T patent/CY1121570T1/en unknown
Also Published As
Publication number | Publication date |
---|---|
HRP20190598T1 (en) | 2019-06-14 |
LT2830589T (en) | 2019-05-27 |
CY1121570T1 (en) | 2020-05-29 |
PT2830589T (en) | 2019-05-20 |
ES2720488T3 (en) | 2019-07-22 |
IL234771A0 (en) | 2014-11-30 |
IL234771B (en) | 2019-10-31 |
ME03456B (en) | 2020-01-20 |
DK2830589T3 (en) | 2019-04-29 |
HUE043009T2 (en) | 2019-07-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SE0502900L (en) | Composition and method | |
MY183216A (en) | Nicotine formulation | |
MX337891B (en) | Antimicrobial tissue paper and process to manufacture same. | |
JP2012082199A5 (en) | ||
CY1113863T1 (en) | POLYMER SALT SYSTEM FOR STORAGE AND TRANSPORT OF THERMAL ENERGY | |
MX355921B (en) | A stain-proof oral care composition. | |
MX2013002153A (en) | Compositions and methods for improving the compatibility of water soluble herbicide salts. | |
WO2010141099A3 (en) | Methods and compositions for viscosifying heavy aqueous brines | |
NZ597968A (en) | Coated dehydrated microorganisms with enhanced stability and viability | |
AR072580A1 (en) | PROCEDURE FOR OBTAINING ESTERES OF PIRAZOLCARBOXILIC ACID DISPOSED IN 1.3 | |
MX2018006567A (en) | Stable dry compositions having no or little sugars. | |
CN104497210A (en) | Super absorbent resin used for paper diaper and production method thereof | |
MX336777B (en) | Films and compositions comprising the same. | |
GB201020191D0 (en) | Glucan gels | |
JP2015514120A5 (en) | ||
RU2016129169A (en) | GEL WIPES FOR PERSONAL HYGIENE AND FOR APPLICATION IN HOUSEHOLD CONDITIONS | |
CN104146880A (en) | Solid spray and preparation method thereof | |
PH12014501981A1 (en) | Method for producing enteric alginate microcapsules via ionic gelation containing diclofenac or one of the salts thereof and multiparticled pharmaceutical composition containing them | |
MX2023003010A (en) | Compositions for small molecule therapeutic agent compounds. | |
WO2012063199A3 (en) | Formate salts for increased stability of polyacrylamide fluids | |
AR061301A1 (en) | ACID SALTS 6-METOXI -8- [4- (1- (5- FLUORO) -QUINOLIN -8-IL-PIPERIDIN -4-IL) -PIPERAZIN -1-IL] -CHLORINE HYDROCHLININE | |
TR201905664T4 (en) | Nicotine formulation. | |
MY160461A (en) | Process for producing granules comprising one or more complexing agent salts | |
JP2016020462A5 (en) | ||
BR112015013068A2 (en) | compositions and methods of use |