CY1117674T1 - Χρηση παραγωγων των orvinol και thevinol ως θεραπευτικη αγωγη στην καταχρηση αλκοολ και φαρμακων - Google Patents
Χρηση παραγωγων των orvinol και thevinol ως θεραπευτικη αγωγη στην καταχρηση αλκοολ και φαρμακωνInfo
- Publication number
- CY1117674T1 CY1117674T1 CY20161100558T CY161100558T CY1117674T1 CY 1117674 T1 CY1117674 T1 CY 1117674T1 CY 20161100558 T CY20161100558 T CY 20161100558T CY 161100558 T CY161100558 T CY 161100558T CY 1117674 T1 CY1117674 T1 CY 1117674T1
- Authority
- CY
- Cyprus
- Prior art keywords
- thevinol
- orvinol
- alcohol
- producers
- therapeutic treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
- C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
- C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4748—Quinolines; Isoquinolines forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
- C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Addiction (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1111775.1A GB201111775D0 (en) | 2011-07-08 | 2011-07-08 | Compounds and uses thereof |
| PCT/GB2012/051575 WO2013007986A1 (en) | 2011-07-08 | 2012-07-05 | Orvinol and thevinol derivatives useful in the treatment of drug and alcohol abuse |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1117674T1 true CY1117674T1 (el) | 2017-05-17 |
Family
ID=44544490
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20161100558T CY1117674T1 (el) | 2011-07-08 | 2016-06-21 | Χρηση παραγωγων των orvinol και thevinol ως θεραπευτικη αγωγη στην καταχρηση αλκοολ και φαρμακων |
Country Status (15)
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201111775D0 (en) | 2011-07-08 | 2011-08-24 | Univ Bath | Compounds and uses thereof |
| WO2013050748A2 (en) | 2011-10-03 | 2013-04-11 | Johnson Matthey Plc | An improved method of preparing buprenorphine |
| EP3087078B1 (en) * | 2013-12-26 | 2019-05-15 | Purdue Pharma LP | 7-beta-alkyl analogs of orvinols |
| TW201607923A (zh) | 2014-07-15 | 2016-03-01 | 歌林達有限公司 | 被取代之氮螺環（４．５）癸烷衍生物 |
| GB201716830D0 (en) | 2017-10-13 | 2017-11-29 | Cambrex Charles City Inc | New Process |
| CN110117288A (zh) * | 2018-02-07 | 2019-08-13 | 复旦大学 | 7β-甲基-奈培酮衍生物及其制备方法和用途 |
| CN114195798B (zh) * | 2021-12-31 | 2023-07-28 | 复旦大学 | 7α-甲基稠环吗啡类衍生物及其制备方法和用途 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1136214A (en) | 1965-06-15 | 1968-12-11 | Reckitt & Sons Ltd | Thebaine and oripavine derivatives |
| GB937214A (en) | 1961-06-02 | 1963-09-18 | J F Macfarlan & Company Ltd | Oripavine derivatives |
| US3474101A (en) | 1960-09-05 | 1969-10-21 | Reckitt & Sons Ltd | Thebaine and oripavine derivatives |
| GB925723A (en) | 1960-09-05 | 1963-05-08 | J F Macfarlan & Company Ltd | Novel thebaine derivatives |
| GB902659A (en) | 1961-02-02 | 1962-08-09 | J F Macfarlan & Company Ltd | A process for the production of a derivative of thebaine |
| NL289751A (cg-RX-API-DMAC10.html) | 1962-03-02 | |||
| DE1493696A1 (de) | 1965-02-17 | 1969-12-18 | Hoechst Ag | Verfahren zur Herstellung klarfluessiger,leicht mit Wasser verduennbarer Fettsaeurekondensationsprodukte |
| WO2004078178A1 (en) | 2003-03-03 | 2004-09-16 | Markus Heilig | Buprenorphine compounds for treatment of alcohol dependence and excessive alcohol use |
| GB201111775D0 (en) * | 2011-07-08 | 2011-08-24 | Univ Bath | Compounds and uses thereof |
| JP6314571B2 (ja) * | 2013-12-16 | 2018-04-25 | ヤマハ株式会社 | 反力発生装置 |
-
2011
- 2011-07-08 GB GBGB1111775.1A patent/GB201111775D0/en not_active Ceased
-
2012
- 2012-07-05 CA CA2841169A patent/CA2841169C/en active Active
- 2012-07-05 ES ES12735607T patent/ES2572508T3/es active Active
- 2012-07-05 DK DK12735607.9T patent/DK2729469T3/en active
- 2012-07-05 HR HRP20160389TT patent/HRP20160389T1/hr unknown
- 2012-07-05 EP EP12735607.9A patent/EP2729469B1/en active Active
- 2012-07-05 RS RS20160426A patent/RS54830B1/sr unknown
- 2012-07-05 HU HUE12735607A patent/HUE028785T2/en unknown
- 2012-07-05 SI SI201230514A patent/SI2729469T1/sl unknown
- 2012-07-05 WO PCT/GB2012/051575 patent/WO2013007986A1/en not_active Ceased
- 2012-07-05 PL PL12735607.9T patent/PL2729469T3/pl unknown
- 2012-07-05 JP JP2014519623A patent/JP6117780B2/ja active Active
- 2012-07-05 US US14/131,361 patent/US9051334B2/en active Active
-
2015
- 2015-03-31 US US14/674,578 patent/US9259422B2/en active Active
- 2015-07-06 JP JP2015135460A patent/JP6117862B2/ja active Active
-
2016
- 2016-01-20 US US15/001,553 patent/US9480684B2/en active Active
- 2016-05-31 SM SM201600154T patent/SMT201600154B/it unknown
- 2016-06-21 CY CY20161100558T patent/CY1117674T1/el unknown
- 2016-10-27 US US15/336,193 patent/US9890170B2/en active Active
-
2017
- 2017-10-03 US US15/723,871 patent/US10030031B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20170044173A1 (en) | 2017-02-16 |
| EP2729469B1 (en) | 2016-03-30 |
| DK2729469T3 (en) | 2016-07-18 |
| RS54830B1 (sr) | 2016-10-31 |
| SMT201600154B (it) | 2016-08-31 |
| CA2841169A1 (en) | 2013-01-17 |
| ES2572508T3 (es) | 2016-05-31 |
| US10030031B2 (en) | 2018-07-24 |
| CA2841169C (en) | 2019-08-27 |
| US9259422B2 (en) | 2016-02-16 |
| US9480684B2 (en) | 2016-11-01 |
| JP2015172089A (ja) | 2015-10-01 |
| US20140213603A1 (en) | 2014-07-31 |
| WO2013007986A1 (en) | 2013-01-17 |
| SI2729469T1 (sl) | 2016-07-29 |
| JP6117862B2 (ja) | 2017-04-19 |
| HUE028785T2 (en) | 2017-01-30 |
| US9051334B2 (en) | 2015-06-09 |
| US20150202200A1 (en) | 2015-07-23 |
| US9890170B2 (en) | 2018-02-13 |
| EP2729469A1 (en) | 2014-05-14 |
| PL2729469T3 (pl) | 2016-09-30 |
| US20160136151A1 (en) | 2016-05-19 |
| JP6117780B2 (ja) | 2017-04-19 |
| GB201111775D0 (en) | 2011-08-24 |
| HK1198031A1 (zh) | 2015-03-06 |
| US20180030062A1 (en) | 2018-02-01 |
| HRP20160389T1 (hr) | 2016-07-01 |
| JP2014522854A (ja) | 2014-09-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1124407T1 (el) | Ενωσεις αναστολεα αυτοταξινης | |
| CY1124729T1 (el) | Φαρμακοτεχνικες μορφες του ενζαλουταμιδιου | |
| CY1124959T1 (el) | Αναστολεις λυσινης ειδικης απομεθυλασης-1 | |
| CY1124298T1 (el) | Φενφλουραμινη για χρηση στην θεραπευτικη αντιμετωπιση του συνδρομου dravet | |
| CY1122671T1 (el) | Θεραπευτικως δραστικες ενωσεις και οι μεθοδοι χρησεις αυτων | |
| CY1124144T1 (el) | Συνθεσεις και μεθοδοι για θεραπεια εγκεφαλικου επεισοδιου σε ενα υποκειμενο επι ταυτοχρονης θεραπειας στατινης | |
| CY1123633T1 (el) | Ετεροκυκλικες ενωσεις και οι χρησεις αυτων | |
| CY1120318T1 (el) | Υποκατεστημενες βενζυλινδαζολες για χρηση ως αναστολεις κινασης bub1 στη θεραπευτικη αντιμετωπιση υπερπολλαπλασιαστικων ασθενειων | |
| CY1121695T1 (el) | Ενωσεις και συνθεσεις ως αναστολεις κινασης c-kit | |
| CY1122101T1 (el) | Τροποποιημενα πολυπεπτιδια ρελαξινης και χρησεις αυτων | |
| CY1119709T1 (el) | Αντιμυκητιασικοι παραγοντες και χρησεις αυτων | |
| CY1121907T1 (el) | Συζευγματα antidll3-antiσωmatoς-pbd και χρησεις αυτων | |
| CY1121511T1 (el) | Ενωσεις και μεθοδοι για διαμορφωση κινασων και ενδειξεις αυτων | |
| CY1122358T1 (el) | C-τελικοι hsp90 αναστολεις | |
| CY1121742T1 (el) | Αντισωματα s100a4 και θεραπευτικες χρησεις αυτων | |
| CY1120246T1 (el) | Ενωσεις αναστολεων μεταλλοενζυμου | |
| CY1120556T1 (el) | Δικυκλικα ετεροκυκλα ως αναστολεις fgfr | |
| CY1120297T1 (el) | Ρυθμιστες υποδοχεα ανδρογονου και χρησεις αυτων | |
| CY1119974T1 (el) | Στερεες μορφες 3-(5-αμινο-2-μεθυλ-4-οξο-4η-κιναζολιν-3-υλ)-πιπεριδινο-2,6-διονης και φαρμακευτικες συνθεσεις και χρησεις αυτης | |
| UA110470C2 (ru) | Антидот антикоагулянта | |
| CY1119518T1 (el) | Τροποποιημενα αντιγονα φυματιωσης | |
| CY1124331T1 (el) | Αυξημενη βιοδιαθεσιμοτητα δραστικης ουσιας σε θεραπεια ναλτρεξονης | |
| CY1120881T1 (el) | Ανταγωνιστες υποδοχεα 5-ητ3 | |
| CY1115871T1 (el) | Μεθοδοι για την αντιμετωπιση ουρικης αρθριτιδας | |
| EA201270722A1 (ru) | Формы рифаксимина и их применение |