SI2729469T1 - Derivati orvinola in tevinola uporabni pri zdravljenju zlorabe mamil in alkohola - Google Patents
Derivati orvinola in tevinola uporabni pri zdravljenju zlorabe mamil in alkoholaInfo
- Publication number
- SI2729469T1 SI2729469T1 SI201230514A SI201230514A SI2729469T1 SI 2729469 T1 SI2729469 T1 SI 2729469T1 SI 201230514 A SI201230514 A SI 201230514A SI 201230514 A SI201230514 A SI 201230514A SI 2729469 T1 SI2729469 T1 SI 2729469T1
- Authority
- SI
- Slovenia
- Prior art keywords
- thevinol
- orvinol
- drug
- treatment
- derivatives useful
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
- C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
- C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4748—Quinolines; Isoquinolines forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
- C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Addiction (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1111775.1A GB201111775D0 (en) | 2011-07-08 | 2011-07-08 | Compounds and uses thereof |
PCT/GB2012/051575 WO2013007986A1 (en) | 2011-07-08 | 2012-07-05 | Orvinol and thevinol derivatives useful in the treatment of drug and alcohol abuse |
EP12735607.9A EP2729469B1 (en) | 2011-07-08 | 2012-07-05 | Orvinol and thevinol derivatives useful in the treatment of drug and alcohol abuse |
Publications (1)
Publication Number | Publication Date |
---|---|
SI2729469T1 true SI2729469T1 (sl) | 2016-07-29 |
Family
ID=44544490
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI201230514A SI2729469T1 (sl) | 2011-07-08 | 2012-07-05 | Derivati orvinola in tevinola uporabni pri zdravljenju zlorabe mamil in alkohola |
Country Status (16)
Country | Link |
---|---|
US (5) | US9051334B2 (sl) |
EP (1) | EP2729469B1 (sl) |
JP (2) | JP6117780B2 (sl) |
CA (1) | CA2841169C (sl) |
CY (1) | CY1117674T1 (sl) |
DK (1) | DK2729469T3 (sl) |
ES (1) | ES2572508T3 (sl) |
GB (1) | GB201111775D0 (sl) |
HK (1) | HK1198031A1 (sl) |
HR (1) | HRP20160389T1 (sl) |
HU (1) | HUE028785T2 (sl) |
PL (1) | PL2729469T3 (sl) |
RS (1) | RS54830B1 (sl) |
SI (1) | SI2729469T1 (sl) |
SM (1) | SMT201600154B (sl) |
WO (1) | WO2013007986A1 (sl) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201111775D0 (en) | 2011-07-08 | 2011-08-24 | Univ Bath | Compounds and uses thereof |
PT3321269T (pt) | 2011-10-03 | 2020-07-24 | Johnson Matthey Plc | Processo para preparar intermediários de buprenorfina |
WO2015097548A1 (en) * | 2013-12-26 | 2015-07-02 | Purdue Pharma L.P. | 7-beta-alkyl analogs of orvinols |
TW201607923A (zh) | 2014-07-15 | 2016-03-01 | 歌林達有限公司 | 被取代之氮螺環(4.5)癸烷衍生物 |
GB201716830D0 (en) | 2017-10-13 | 2017-11-29 | Cambrex Charles City Inc | New Process |
CN110117288A (zh) * | 2018-02-07 | 2019-08-13 | 复旦大学 | 7β-甲基-奈培酮衍生物及其制备方法和用途 |
CN114195798B (zh) * | 2021-12-31 | 2023-07-28 | 复旦大学 | 7α-甲基稠环吗啡类衍生物及其制备方法和用途 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3474101A (en) | 1960-09-05 | 1969-10-21 | Reckitt & Sons Ltd | Thebaine and oripavine derivatives |
GB1136214A (en) | 1965-06-15 | 1968-12-11 | Reckitt & Sons Ltd | Thebaine and oripavine derivatives |
GB937214A (en) | 1961-06-02 | 1963-09-18 | J F Macfarlan & Company Ltd | Oripavine derivatives |
GB925723A (en) | 1960-09-05 | 1963-05-08 | J F Macfarlan & Company Ltd | Novel thebaine derivatives |
GB902659A (en) | 1961-02-02 | 1962-08-09 | J F Macfarlan & Company Ltd | A process for the production of a derivative of thebaine |
NL289751A (sl) | 1962-03-02 | |||
DE1493696A1 (de) | 1965-02-17 | 1969-12-18 | Hoechst Ag | Verfahren zur Herstellung klarfluessiger,leicht mit Wasser verduennbarer Fettsaeurekondensationsprodukte |
WO2004078178A1 (en) | 2003-03-03 | 2004-09-16 | Markus Heilig | Buprenorphine compounds for treatment of alcohol dependence and excessive alcohol use |
GB201111775D0 (en) * | 2011-07-08 | 2011-08-24 | Univ Bath | Compounds and uses thereof |
-
2011
- 2011-07-08 GB GBGB1111775.1A patent/GB201111775D0/en not_active Ceased
-
2012
- 2012-07-05 JP JP2014519623A patent/JP6117780B2/ja active Active
- 2012-07-05 ES ES12735607T patent/ES2572508T3/es active Active
- 2012-07-05 RS RS20160426A patent/RS54830B1/sr unknown
- 2012-07-05 EP EP12735607.9A patent/EP2729469B1/en active Active
- 2012-07-05 DK DK12735607.9T patent/DK2729469T3/en active
- 2012-07-05 SI SI201230514A patent/SI2729469T1/sl unknown
- 2012-07-05 CA CA2841169A patent/CA2841169C/en active Active
- 2012-07-05 US US14/131,361 patent/US9051334B2/en active Active
- 2012-07-05 HU HUE12735607A patent/HUE028785T2/en unknown
- 2012-07-05 PL PL12735607.9T patent/PL2729469T3/pl unknown
- 2012-07-05 WO PCT/GB2012/051575 patent/WO2013007986A1/en active Application Filing
-
2014
- 2014-11-14 HK HK14111535.3A patent/HK1198031A1/zh not_active IP Right Cessation
-
2015
- 2015-03-31 US US14/674,578 patent/US9259422B2/en active Active
- 2015-07-06 JP JP2015135460A patent/JP6117862B2/ja active Active
-
2016
- 2016-01-20 US US15/001,553 patent/US9480684B2/en active Active
- 2016-04-15 HR HRP20160389TT patent/HRP20160389T1/hr unknown
- 2016-05-31 SM SM201600154T patent/SMT201600154B/it unknown
- 2016-06-21 CY CY20161100558T patent/CY1117674T1/el unknown
- 2016-10-27 US US15/336,193 patent/US9890170B2/en active Active
-
2017
- 2017-10-03 US US15/723,871 patent/US10030031B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
ES2572508T3 (es) | 2016-05-31 |
US10030031B2 (en) | 2018-07-24 |
JP2015172089A (ja) | 2015-10-01 |
EP2729469B1 (en) | 2016-03-30 |
US20140213603A1 (en) | 2014-07-31 |
EP2729469A1 (en) | 2014-05-14 |
RS54830B1 (sr) | 2016-10-31 |
DK2729469T3 (en) | 2016-07-18 |
US20170044173A1 (en) | 2017-02-16 |
HUE028785T2 (en) | 2017-01-30 |
CY1117674T1 (el) | 2017-05-17 |
WO2013007986A1 (en) | 2013-01-17 |
US9480684B2 (en) | 2016-11-01 |
PL2729469T3 (pl) | 2016-09-30 |
JP2014522854A (ja) | 2014-09-08 |
GB201111775D0 (en) | 2011-08-24 |
CA2841169A1 (en) | 2013-01-17 |
US9890170B2 (en) | 2018-02-13 |
US20160136151A1 (en) | 2016-05-19 |
SMT201600154B (it) | 2016-08-31 |
JP6117862B2 (ja) | 2017-04-19 |
HK1198031A1 (zh) | 2015-03-06 |
JP6117780B2 (ja) | 2017-04-19 |
US9051334B2 (en) | 2015-06-09 |
US20150202200A1 (en) | 2015-07-23 |
US20180030062A1 (en) | 2018-02-01 |
US9259422B2 (en) | 2016-02-16 |
CA2841169C (en) | 2019-08-27 |
HRP20160389T1 (hr) | 2016-07-01 |
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