CY1116164T1 - Προδρομη 4-σουλφαταση ν-ακετυλογαλακτο σαμινης, μεθοδοι θεραπευτικης αγωγης που χρησιμοποιουν το εν λογω ενζυμο και μεθοδοι για παραγωγη και καθαρισμο του εν λογω ενζυμου - Google Patents
Προδρομη 4-σουλφαταση ν-ακετυλογαλακτο σαμινης, μεθοδοι θεραπευτικης αγωγης που χρησιμοποιουν το εν λογω ενζυμο και μεθοδοι για παραγωγη και καθαρισμο του εν λογω ενζυμουInfo
- Publication number
- CY1116164T1 CY1116164T1 CY20151100321T CY151100321T CY1116164T1 CY 1116164 T1 CY1116164 T1 CY 1116164T1 CY 20151100321 T CY20151100321 T CY 20151100321T CY 151100321 T CY151100321 T CY 151100321T CY 1116164 T1 CY1116164 T1 CY 1116164T1
- Authority
- CY
- Cyprus
- Prior art keywords
- methods
- sulfathata
- saminis
- acetylgalactin
- know
- Prior art date
Links
- 102000004190 Enzymes Human genes 0.000 title abstract 2
- 108090000790 Enzymes Proteins 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title 1
- 239000002243 precursor Substances 0.000 abstract 3
- 101000923070 Homo sapiens Arylsulfatase B Proteins 0.000 abstract 2
- OVRNDRQMDRJTHS-CBQIKETKSA-N N-Acetyl-D-Galactosamine Chemical compound CC(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@H](O)[C@@H]1O OVRNDRQMDRJTHS-CBQIKETKSA-N 0.000 abstract 1
- MBLBDJOUHNCFQT-UHFFFAOYSA-N N-acetyl-D-galactosamine Natural products CC(=O)NC(C=O)C(O)C(O)C(O)CO MBLBDJOUHNCFQT-UHFFFAOYSA-N 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 208000000690 mucopolysaccharidosis VI Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
- B01D15/3804—Affinity chromatography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/32—Bonded phase chromatography
- B01D15/325—Reversed phase
- B01D15/327—Reversed phase with hydrophobic interaction
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
- B01D15/3804—Affinity chromatography
- B01D15/3828—Ligand exchange chromatography, e.g. complexation, chelation or metal interaction chromatography
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/06—Sulfuric ester hydrolases (3.1.6)
- C12Y301/06012—N-Acetylgalactosamine-4-sulfatase (3.1.6.12)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Otolaryngology (AREA)
- Ophthalmology & Optometry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/290,908 US6866844B2 (en) | 2002-11-07 | 2002-11-07 | Precursor N-acetylgalactosamine-4-sulfatase, methods of treatment using said enzyme and methods for producing and purifying said enzyme |
| EP10011421.4A EP2327414B1 (en) | 2002-11-07 | 2003-11-07 | Precursor N-acetylgalactosamine-4-sulfatase, methods of treatment using said enzyme and methods for producing and purifying said enzyme |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1116164T1 true CY1116164T1 (el) | 2017-02-08 |
Family
ID=32312121
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20151100321T CY1116164T1 (el) | 2002-11-07 | 2015-04-03 | Προδρομη 4-σουλφαταση ν-ακετυλογαλακτο σαμινης, μεθοδοι θεραπευτικης αγωγης που χρησιμοποιουν το εν λογω ενζυμο και μεθοδοι για παραγωγη και καθαρισμο του εν λογω ενζυμου |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6866844B2 (enExample) |
| EP (2) | EP2327414B1 (enExample) |
| JP (1) | JP4459059B2 (enExample) |
| CN (1) | CN100374157C (enExample) |
| AR (1) | AR042019A1 (enExample) |
| AU (1) | AU2003290642B2 (enExample) |
| BR (1) | BRPI0316039B1 (enExample) |
| CA (1) | CA2502928C (enExample) |
| CY (1) | CY1116164T1 (enExample) |
| DK (1) | DK2327414T3 (enExample) |
| ES (2) | ES2533770T3 (enExample) |
| IL (1) | IL168435A (enExample) |
| MX (1) | MXPA05004880A (enExample) |
| PT (2) | PT1565209E (enExample) |
| SI (1) | SI2327414T1 (enExample) |
| TW (1) | TWI327919B (enExample) |
| WO (1) | WO2004043373A2 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6972124B2 (en) * | 2000-05-01 | 2005-12-06 | Biomarin Pharmaceuticals Inc. | Precursor of N-acetylgalactosamine-4-sulfatase, methods of treatment using said enzyme and methods for producing and purifying said enzyme |
| ES2366059T3 (es) * | 2006-03-17 | 2011-10-14 | Biomarin Pharmaceutical Inc. | Ensayos para la detección de anticuerpos anti-enzimas lisosómicas. |
| CN101539550B (zh) * | 2009-04-28 | 2012-05-23 | 李绍平 | 用于多糖的定性与定量分析方法 |
| MX382443B (es) | 2010-06-25 | 2025-03-11 | Shire Human Genetic Therapies | Una formulación estable para usarse en el tratamiento de la enfermedad por leucodistrofia metacromática (mld). |
| PE20130589A1 (es) * | 2010-06-25 | 2013-05-19 | Shire Human Genetic Therapies | Composiciones y metodos para suministro al sistema nervioso central de arilsulfatasa a |
| CN103068999A (zh) * | 2010-08-20 | 2013-04-24 | 贝林格尔.英格海姆国际有限公司 | 通过在获自细胞培养物的液体中改变ph灭活蛋白酶的方法 |
| US9896715B2 (en) | 2011-12-20 | 2018-02-20 | Jcr Pharmaceuticals Co., Ltd. | Method for analyzing formyl glycine residue |
| WO2013096899A2 (en) | 2011-12-23 | 2013-06-27 | Shire Human Genetic Therapies, Inc. | Stable formulations for cns delivery of arylsulfatase a |
| CN105848746B (zh) * | 2013-09-05 | 2019-07-09 | 豪夫迈·罗氏有限公司 | 用于层析重复利用的方法 |
| FR3011468B1 (fr) * | 2013-10-04 | 2015-12-04 | Inventiva | Utilisation de l'odiparcil dans le traitement d'une mucopolysaccharidose |
| US11584777B2 (en) | 2017-08-31 | 2023-02-21 | Green Cross Corporation | Method for purifying a sulfatase protein |
| TWI870412B (zh) * | 2019-06-05 | 2025-01-21 | 美商建南德克公司 | 過載層析管柱之再生方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL281225A (enExample) | 1961-07-20 | |||
| US3472931A (en) | 1969-01-17 | 1969-10-14 | Foster Milburn Co | Percutaneous absorption with lower alkyl amides |
| US3891757A (en) | 1971-11-11 | 1975-06-24 | Alza Corp | Anaesthetic topical and percutaneous administration with selected promoters |
| SE387536B (sv) | 1973-03-13 | 1976-09-13 | Astra Laekemedel Ab | Forfarande for framstellning av en lokalanestetisk beredning |
| AU5577101A (en) | 2000-05-01 | 2001-11-12 | Biomarin Pharmaceuticals | Enzymes useful for treating and methods for treating mps-vi and cells lines for producing such enzymes recombinantly |
-
2002
- 2002-11-07 US US10/290,908 patent/US6866844B2/en not_active Expired - Lifetime
-
2003
- 2003-11-07 MX MXPA05004880A patent/MXPA05004880A/es active IP Right Grant
- 2003-11-07 AU AU2003290642A patent/AU2003290642B2/en not_active Expired
- 2003-11-07 DK DK10011421.4T patent/DK2327414T3/en active
- 2003-11-07 CN CNB2003801059229A patent/CN100374157C/zh not_active Expired - Lifetime
- 2003-11-07 EP EP10011421.4A patent/EP2327414B1/en not_active Expired - Lifetime
- 2003-11-07 ES ES10011421.4T patent/ES2533770T3/es not_active Expired - Lifetime
- 2003-11-07 AR ARP030104118A patent/AR042019A1/es not_active Application Discontinuation
- 2003-11-07 CA CA2502928A patent/CA2502928C/en not_active Expired - Lifetime
- 2003-11-07 EP EP03783223.5A patent/EP1565209B1/en not_active Expired - Lifetime
- 2003-11-07 SI SI200332419T patent/SI2327414T1/sl unknown
- 2003-11-07 PT PT37832235T patent/PT1565209E/pt unknown
- 2003-11-07 ES ES03783223.5T patent/ES2445028T3/es not_active Expired - Lifetime
- 2003-11-07 TW TW092131341A patent/TWI327919B/zh not_active IP Right Cessation
- 2003-11-07 JP JP2004551853A patent/JP4459059B2/ja not_active Expired - Lifetime
- 2003-11-07 WO PCT/US2003/035510 patent/WO2004043373A2/en not_active Ceased
- 2003-11-07 BR BRPI0316039-4A patent/BRPI0316039B1/pt not_active IP Right Cessation
- 2003-11-07 PT PT100114214T patent/PT2327414E/pt unknown
-
2005
- 2005-05-05 IL IL168435A patent/IL168435A/en active IP Right Grant
-
2015
- 2015-04-03 CY CY20151100321T patent/CY1116164T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2327414B1 (en) | 2015-01-07 |
| BR0316039A (pt) | 2005-09-13 |
| ES2445028T3 (es) | 2014-02-27 |
| AR042019A1 (es) | 2005-06-08 |
| US20040101524A1 (en) | 2004-05-27 |
| ES2533770T3 (es) | 2015-04-15 |
| CN1726046A (zh) | 2006-01-25 |
| PT1565209E (pt) | 2014-02-13 |
| EP1565209A2 (en) | 2005-08-24 |
| PT2327414E (pt) | 2015-04-13 |
| CN100374157C (zh) | 2008-03-12 |
| HK1157215A1 (en) | 2012-06-29 |
| AU2003290642B2 (en) | 2008-07-10 |
| BRPI0316039B8 (enExample) | 2021-05-25 |
| CA2502928C (en) | 2013-07-16 |
| MXPA05004880A (es) | 2005-07-22 |
| BRPI0316039B1 (pt) | 2017-08-29 |
| CA2502928A1 (en) | 2004-05-27 |
| EP1565209A4 (en) | 2008-01-02 |
| DK2327414T3 (en) | 2015-04-13 |
| TWI327919B (en) | 2010-08-01 |
| US6866844B2 (en) | 2005-03-15 |
| WO2004043373A2 (en) | 2004-05-27 |
| WO2004043373A3 (en) | 2004-08-05 |
| TW200427459A (en) | 2004-12-16 |
| SI2327414T1 (sl) | 2015-05-29 |
| IL168435A (en) | 2014-07-31 |
| EP1565209B1 (en) | 2013-11-06 |
| JP4459059B2 (ja) | 2010-04-28 |
| AU2003290642A1 (en) | 2004-06-03 |
| EP2327414A1 (en) | 2011-06-01 |
| JP2006510356A (ja) | 2006-03-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1116164T1 (el) | Προδρομη 4-σουλφαταση ν-ακετυλογαλακτο σαμινης, μεθοδοι θεραπευτικης αγωγης που χρησιμοποιουν το εν λογω ενζυμο και μεθοδοι για παραγωγη και καθαρισμο του εν λογω ενζυμου | |
| CY1121447T1 (el) | Συνθεσεις για αυξηση δραστηριοτητας τελομερασης | |
| CY1118222T1 (el) | Συνθεσεις λυασης φαινυλαλανινης αμμωνιας προκαρυωτικων και μεθοδοι αγωγης καρκινου χρησιμοποιωντας συνθεσεις εξ' αυτης | |
| DK1309589T3 (da) | Ureaforbindelser og anvendelsesfremgangsmåder | |
| DE60332358D1 (de) | Protease-resistente modifizierte interferon alpha polypeptide | |
| EA200500782A1 (ru) | Лечение геморрагического шока | |
| CY1116464T1 (el) | Θεραπεια συνδυασμου για τη θεραπευτικη αγωγη διαταραχων ανεπαρκειας πρωτεϊνης | |
| BR0012450A (pt) | Benzimidazóis substituìdos | |
| EA200300248A1 (ru) | Бициклопиразолы, активные в качестве ингибиторов киназы, способ их получения и включающие их фармацевтические композиции | |
| EP1485381B8 (en) | Azolylaminoazine as inhibitors of protein kinases | |
| AU2003220299A1 (en) | Azinylaminoazoles as inhibitors of protein kinases | |
| DE60331871D1 (de) | Pharmazeutische Verbindung und Methoden zur Behandlungen von menschliche Karzinome mittels Arginin Entzug | |
| EA200400357A1 (ru) | Дезинтегрирующиеся в ротовой полости композиции валдекоксиба | |
| NO20060278L (no) | Piperazinderivater og fremgangsmater for anvendelse | |
| HRP20050585A2 (en) | Peptides which inhibit angiogenesis, cell migration, cell invasion and cell proliferation, compositions and uses thereof | |
| CY1110005T1 (el) | Γρανζυμο β ως ενας επαγωγεας αποπτωσης κυτταρων ογκων εξαρτωμενος απο ενα hsp70/hsp70 πεπτιδιο | |
| EA200400399A1 (ru) | Способы лечения легочных заболеваний | |
| DE60015508T2 (de) | C-16 ungesätigte fp-selektive prostaglandin analoge | |
| DE60322064D1 (de) | 4,4' -dithiobis- (3-aminobutane-1-sulfonate)-derivate und sie enthaltende zusammensetzungen | |
| PE20030236A1 (es) | Derivados de bencimidazol 1-aril-2-n,s- u o-sustituidos, obtencion de medicamentos y preparados farmaceuticos que contienen estos derivados | |
| PL1599211T3 (pl) | Zastosowanie izorhamnetyny do leczenia nastrojów i chorób depresyjnych | |
| DE60312154D1 (de) | 2-oxo-1,3,4-trihydrochinazolin derivative zur behandlung von zellproliferationskrankheiten | |
| ATE415420T1 (de) | Cxcl8-antagonisten | |
| EA200501679A2 (ru) | Фосфонатсодержащие противовоспалительные соединения (варианты), способ их получения, фармацевтическая композиция, лекарственная форма на их основе и способ подавления воспалительной активности (варианты) | |
| RU95108616A (ru) | Способ лечения верхней ретро- или микрогнатии, осложненной расщелиной твердого неба и альвеолярного отростка |