CY1110790T1 - Παραγωγο φθοριωμενης κινολιν-2(1η)-ονης, η διαδικασια παρασκευης του και η χρηση του ως ενδιαμεσου συνθεσης - Google Patents

Παραγωγο φθοριωμενης κινολιν-2(1η)-ονης, η διαδικασια παρασκευης του και η χρηση του ως ενδιαμεσου συνθεσης

Info

Publication number
CY1110790T1
CY1110790T1 CY20101100848T CY101100848T CY1110790T1 CY 1110790 T1 CY1110790 T1 CY 1110790T1 CY 20101100848 T CY20101100848 T CY 20101100848T CY 101100848 T CY101100848 T CY 101100848T CY 1110790 T1 CY1110790 T1 CY 1110790T1
Authority
CY
Cyprus
Prior art keywords
fluorinated
kinolin
producer
procedure
intermediate composition
Prior art date
Application number
CY20101100848T
Other languages
English (en)
Inventor
Didier Legroux
Véronique MORAGUES
José Ruiz-Montes
Laurent Salle
Original Assignee
Sanofi-Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38318660&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1110790(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi-Aventis filed Critical Sanofi-Aventis
Publication of CY1110790T1 publication Critical patent/CY1110790T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Η εφεύρεση αφορά σε ένα φθοριωμένο παράγωγο κινολιν-2(1Η)-όνης, (I), στην διαδικασία παρασκευής του και στη χρήση του ως ενδιάμεσου στη σύνθεση του 7-φθορο-2-οξο-4-[2-[4-[θειενο[3,2-c]πυριδιν-4-υλ]πιπεραζιν-1-υλ]αιθυλ]-1,2-διϋδροκινολεϊν-1-ακεταμιδίου (I), καθώς και στα φαρμακευτικά αποδεκτά του άλατα.
CY20101100848T 2006-12-12 2010-09-22 Παραγωγο φθοριωμενης κινολιν-2(1η)-ονης, η διαδικασια παρασκευης του και η χρηση του ως ενδιαμεσου συνθεσης CY1110790T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0610802A FR2909670B1 (fr) 2006-12-12 2006-12-12 Derive fluore de quinoleine-2(1h)-one,son procede de preparation et son utilisation comme intermediaire de synthese
EP07871822A EP2102216B1 (fr) 2006-12-12 2007-12-10 Derive fluore de ouinoleine-2(1h)-one, son procede de preparation et son utilisation comme intermediaire de synthese

Publications (1)

Publication Number Publication Date
CY1110790T1 true CY1110790T1 (el) 2015-06-10

Family

ID=38318660

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20101100848T CY1110790T1 (el) 2006-12-12 2010-09-22 Παραγωγο φθοριωμενης κινολιν-2(1η)-ονης, η διαδικασια παρασκευης του και η χρηση του ως ενδιαμεσου συνθεσης

Country Status (20)

Country Link
US (1) US7943769B2 (el)
EP (1) EP2102216B1 (el)
JP (1) JP2010512373A (el)
AR (1) AR064210A1 (el)
AT (1) ATE474841T1 (el)
CL (1) CL2007003602A1 (el)
CY (1) CY1110790T1 (el)
DE (1) DE602007007988D1 (el)
DK (1) DK2102216T3 (el)
ES (1) ES2348822T3 (el)
FR (1) FR2909670B1 (el)
HR (1) HRP20100571T1 (el)
PE (1) PE20081405A1 (el)
PL (1) PL2102216T3 (el)
PT (1) PT2102216E (el)
RS (1) RS51439B (el)
SI (1) SI2102216T1 (el)
TW (1) TW200829592A (el)
UY (1) UY30784A1 (el)
WO (1) WO2008087277A1 (el)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2692264B1 (fr) * 1992-06-12 1994-08-05 Adir Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant.
FR2738823B1 (fr) * 1995-09-15 1997-10-31 Synthelabo Derives de 3-(omega-(4-(thieno(3,2-c)pyridin-4-yl)piperazin- 1-yl)alkyl)-3,4-dihydroquinolein-2(1h)-one,leur preparation et leur application en therapeutique
US5958924A (en) * 1995-09-15 1999-09-28 Synthelabo Quinolein-2 (1H)-one derivatives as serotonin antagonists
FR2797874B1 (fr) * 1999-08-27 2002-03-29 Adir Nouveaux derives de la pyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
ES2348822T3 (es) 2010-12-15
EP2102216A1 (fr) 2009-09-23
ATE474841T1 (de) 2010-08-15
FR2909670A1 (fr) 2008-06-13
TW200829592A (en) 2008-07-16
US20100094005A1 (en) 2010-04-15
WO2008087277A1 (fr) 2008-07-24
EP2102216B1 (fr) 2010-07-21
UY30784A1 (es) 2008-07-31
CL2007003602A1 (es) 2009-03-27
HRP20100571T1 (hr) 2010-11-30
DK2102216T3 (da) 2010-11-15
PL2102216T3 (pl) 2010-12-31
SI2102216T1 (sl) 2010-11-30
RS51439B (en) 2011-04-30
FR2909670B1 (fr) 2010-07-30
AR064210A1 (es) 2009-03-18
PE20081405A1 (es) 2008-11-14
DE602007007988D1 (de) 2010-09-02
JP2010512373A (ja) 2010-04-22
US7943769B2 (en) 2011-05-17
PT2102216E (pt) 2010-10-04

Similar Documents

Publication Publication Date Title
ECSP056194A (es) Derivados de pirazolo-quinazolina, procedimiento para su preparacion y su uso como inhibidores de quinasa
EA201001769A1 (ru) Производные хинолинов и хиноксалинов в качестве ингибиторов протеинтирозинкиназы
CY1117667T1 (el) 3,4-διαρυλπυραζολια ως αναστολεις κινασης πρωτεϊνης
MEP23808A (en) Pyridine[3,4-b]pyrazinones
EA200970611A1 (ru) Замещенные пиразолохиназолиновые производные, способ их получения и их применение в качестве ингибиторов киназы
UY29246A1 (es) Nuevos compuestos
MX2009003958A (es) Nuevos derivados de 1,4-benzotiepina-1,1-dioxido sustituidos con radicales bencilo, metodo para su preparacion, productos farmaceuticos que comprenden estos compuestos y su uso.
SE0402735D0 (sv) Novel compounds
MX2009000531A (es) Derivados heterociclicos fusionados y metodos de uso.
NO20084752L (no) Konjugater av aziridinayl-epotilonanaloger og farmasoytiske sammensetninger som inneholder disse
MX2010006799A (es) Benzofuropirimidinonas como inhibidores de la proteina cinasa.
EA201001017A1 (ru) 3h-[1,2,3]триазоло[4,5-d]пиримидиновые соединения, их применение в качестве ингибиторов киназы mtor и киназы pi3 и их синтезы
MX2007009372A (es) Nuevos compuestos ii derivados de 2-piridina como inhibidores de elastasa neutrofila.
MX2009000169A (es) Derivados de purinona como agonistas de hm74a.
NO20083708L (no) 4-Fenyl-tiazol-5-karboksylsyre og 4-fenyl-tiazol-5-karboksylmider som PLK1-inhibitorer
ATE466842T1 (de) 3-substituierte pyridinderivate als h3- antagonisten
ECSP088971A (es) Ligandos 101 de los receptores nicotínicos de acetilcolina
EA200870302A1 (ru) 1,3-диоксанкарбоновые кислоты
EA200970851A1 (ru) Еженедельное введение ингибиторов дипептидилпептидазы
IL188942A0 (en) Benzimidazole derivatives and pharmaceutical compositions containing the same
NO20080033L (no) Kinolinderivater som NK3-antagonister
ATE460396T1 (de) N-carbamoylmethyl-4-(r)-phenyl-2-pyrrolidinon, verfahren zu dessen herstellung und pharmazeutische verwendung
ATE496918T1 (de) Als a2b-adenosinrezeptorantagonisten geeignete 5- phenyl-6-pyridin-4-yl-1,3-dihydro-2h-imidazoä4, - büpyridin-2-onderivate
UA107353C2 (en) Salts of bicyclo-substituted pyrazolon azo derivatives, preparation method and use thereof
DE602006020864D1 (de) 2, 6-di-(hetero-)aryl-4-amido-pyrimidine als adenosin-rezeptor-antagonisten