CY1108988T1 - Διαμορφωτες υποδοχεα βιταμινης d - Google Patents

Διαμορφωτες υποδοχεα βιταμινης d

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Publication number
CY1108988T1
CY1108988T1 CY20091100445T CY091100445T CY1108988T1 CY 1108988 T1 CY1108988 T1 CY 1108988T1 CY 20091100445 T CY20091100445 T CY 20091100445T CY 091100445 T CY091100445 T CY 091100445T CY 1108988 T1 CY1108988 T1 CY 1108988T1
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CY
Cyprus
Prior art keywords
vitamin
containers
compounds
secosteroidal
vdr
Prior art date
Application number
CY20091100445T
Other languages
English (en)
Inventor
Emilio Enrique Bunel
Robert Peter Gajewski
Charles David Jones
Jianliang Lu
Tianwei Ma
Sunil Nagpal
Ying Kwong Yee
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of CY1108988T1 publication Critical patent/CY1108988T1/el

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P17/06—Antipsoriatics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
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    • C07C317/28—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
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    • C07C59/40—Unsaturated compounds
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    • C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
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    • C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
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    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

Η παρούσα εφεύρεση αναφέρεται σε νέες, μη σεκοστεροειδείς, διαρυλο ενώσεις με διαμορφωτική υποδοχέα βιταμίνης D (VDR) δραστικότητα που είναι λιγότερο υπερασβεστιαιμικές από ό,τι η 1a,25 διυδροξυ βιταμίνη D3. Αυτές οι ενώσεις είναι χρήσιμες για τη θεραπεία οστικής νόσου και της ψωρίασης.
CY20091100445T 2002-11-22 2009-04-14 Διαμορφωτες υποδοχεα βιταμινης d CY1108988T1 (el)

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Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2184281A1 (en) 2002-05-29 2010-05-12 Eli Lilly & Company Phenyl-thiophene type vitamin D receptor modulators
JP4594099B2 (ja) * 2002-11-22 2010-12-08 イーライ リリー アンド カンパニー ビタミンｄレセプターモジュレーター
EP1675812B1 (en) * 2003-10-14 2010-01-20 X-Ceptor Therapeutics, Inc. Bridged ring structures as pharmaceutical agents
CA2544501A1 (en) * 2003-11-20 2005-06-09 Eli Lilly And Company Vitamin d receptor modulators
US7750184B2 (en) * 2003-11-20 2010-07-06 Eli Lilly And Company Vitamin D receptor modulators
ES2291981T3 (es) 2003-11-20 2008-03-01 Eli Lilly And Company Moduladores del receptor de la vitamina d.
WO2005051938A1 (en) 2003-11-20 2005-06-09 Eli Lilly And Company Vitamin d receptor modulators
TW200600494A (en) * 2004-03-08 2006-01-01 Chugai Pharmaceutical Co Ltd Bisphenyl compounds useful as vitamin d3 receptor agonists
US7825265B2 (en) 2004-05-04 2010-11-02 Acadia Pharmaceuticals Inc. Compounds with activity at estrogen receptors
JP5209963B2 (ja) * 2004-07-02 2013-06-12 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 噴霧剤としてｔｇ２２７ｅａ又はｔｇ１３４ａを含有するエアロゾル懸濁製剤
EP1836151B1 (en) 2004-12-21 2009-04-01 Eli Lilly And Company Vitamin d receptor modulators
KR100931777B1 (ko) * 2004-12-21 2009-12-14 일라이 릴리 앤드 캄파니 비타민 ｄ 수용체 조절제
TW200716536A (en) 2005-06-09 2007-05-01 Chugai Pharmaceutical Co Ltd Vitamin D compounds
AU2007326395B2 (en) * 2006-12-01 2012-10-11 Msd K.K. Novel phenyl-isoxazol-3-ol derivative
JP2010208997A (ja) * 2009-03-11 2010-09-24 Okayama Univ 置換ジフェニルメタン酸誘導体を含有する医薬組成物
CN101906443B (zh) * 2010-06-25 2012-07-25 绍兴文理学院 (2S)-[2-(t-叔丁基)二甲基硅氧基]-2-环丙基-1-乙基-三苯基膦的合成方法
CN103193695B (zh) * 2013-04-22 2015-08-05 中国药科大学 3-苯基-3-吡咯基戊烷类衍生物及其医药用途
CN104030913A (zh) * 2014-06-26 2014-09-10 江南大学 一种四溴双酚a类似物四溴双酚a己酸的合成方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6218430B1 (en) * 1998-08-24 2001-04-17 Ligand Pharmaceuticals Incorporated Vitamin D3 mimics
EP2184281A1 (en) 2002-05-29 2010-05-12 Eli Lilly & Company Phenyl-thiophene type vitamin D receptor modulators
JP4594099B2 (ja) * 2002-11-22 2010-12-08 イーライ リリー アンド カンパニー ビタミンｄレセプターモジュレーター
WO2004063348A2 (en) 2003-01-10 2004-07-29 Eli Lilly And Company Vesicant treatment with phenyl-thiophene type vitamin d receptor modulators
WO2004063345A2 (en) 2003-01-10 2004-07-29 Eli Lilly And Company Vesicant treatment with phenyl-phenyl type vitamin d receptor modulators
WO2005051936A1 (en) 2003-11-20 2005-06-09 Eli Lilly And Company Phenyl-furan compounds as vitamin d receptor modulators
ES2291981T3 (es) 2003-11-20 2008-03-01 Eli Lilly And Company Moduladores del receptor de la vitamina d.
WO2005051938A1 (en) 2003-11-20 2005-06-09 Eli Lilly And Company Vitamin d receptor modulators
CA2544501A1 (en) * 2003-11-20 2005-06-09 Eli Lilly And Company Vitamin d receptor modulators
US7750184B2 (en) 2003-11-20 2010-07-06 Eli Lilly And Company Vitamin D receptor modulators
KR100931777B1 (ko) 2004-12-21 2009-12-14 일라이 릴리 앤드 캄파니 비타민 ｄ 수용체 조절제
EP1836151B1 (en) 2004-12-21 2009-04-01 Eli Lilly And Company Vitamin d receptor modulators

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WO2004048309A1 (en) 2004-06-10
CN1714070A (zh) 2005-12-28
SI1565422T1 (sl) 2009-08-31
ATE422197T1 (de) 2009-02-15
US20090227604A1 (en) 2009-09-10
DE60326082D1 (de) 2009-03-19
AU2003287500A1 (en) 2004-06-18
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US7566803B2 (en) 2009-07-28
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CA2506891A1 (en) 2004-06-10
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MXPA05005439A (es) 2005-08-03
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