CY1107137T1 - Αντιμικροβιακες αμινοξικες αλληλουχιες προερχομενες απο την αλφα-μελανοκυτταροτροπο ορμονη - Google Patents

Αντιμικροβιακες αμινοξικες αλληλουχιες προερχομενες απο την αλφα-μελανοκυτταροτροπο ορμονη

Info

Publication number
CY1107137T1
CY1107137T1 CY20081100049T CY081100049T CY1107137T1 CY 1107137 T1 CY1107137 T1 CY 1107137T1 CY 20081100049 T CY20081100049 T CY 20081100049T CY 081100049 T CY081100049 T CY 081100049T CY 1107137 T1 CY1107137 T1 CY 1107137T1
Authority
CY
Cyprus
Prior art keywords
polypeptides
amino acid
seq
uro
another preferred
Prior art date
Application number
CY20081100049T
Other languages
English (en)
Inventor
Anna Pia Catania
James M Lipton
Original Assignee
Zengen, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zengen, Inc. filed Critical Zengen, Inc.
Publication of CY1107137T1 publication Critical patent/CY1107137T1/el

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • A61K38/34—Melanocyte stimulating hormone [MSH], e.g. alpha- or beta-melanotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicinal Preparation (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • Prostheses (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Το πεπτίδιο α-μελανοκυτταροτρόπος ορμόνη (α-MSH) απαντάται σε όργανα-φραγμούς, όπως το έντερο και το δέρμα. Οι αντιφλεγμονώδεις ιδιότητες του πεπτιδίου, το καθιστούν χρήσιμο στην αντιμετώπιση της φλεγμονής σε ανθρώπινες και κτηνιατρικές παθήσεις. Έχει βρεθεί ότι αυτό το πεπτίδιο, και άλλα πεπτίδια που προκύπτουν από την a-MSH, διαθέτουν αντιμικροβιακή δραστικότητα κατά του Staphylococcus aureus και του Candida albicans. Αυτά τα α-MSH πεπτίδια παρουσίασαν αντιμικροβιακή δράση σε μεγάλο εύρος συγκεντρώσεων, στις οποίες περιλαμβάνεται και το φυσιολογικό εύρος (τάξης picomolar). Ιδιαίτερο ενδιαφέρον παρουσιάζουν εκείνα τα πεπτίδια που περιλαμβάνουν την αμινοξική αλληλουχία KPV, ή εκείνα που περιλαμβάνουν την αλληλουχία MEHFRWG. Τα πεπτίδια με την ισχυρότερη αντιμικροβιακή δρστικότητα φέρουν την C-αμινοξιτελική αλληλουχία της α-MSH. Αντιφλεγμονώδεις παράγοντες με βάση a-MSH πεπτίδια, με ενισχυμένη αντιμικροβιακή δραστικότητα, θα ελαχιστοποιούσαν τον κίνδυνο περαιτέρω μόλυνσης, που συνήθως συνοδεύει αγωγές με κορτικοστεροειδή ή άλλα μη στεροειδή αντιφλεγμονώδη φάρμακα.
CY20081100049T 1999-03-24 2008-01-14 Αντιμικροβιακες αμινοξικες αλληλουχιες προερχομενες απο την αλφα-μελανοκυτταροτροπο ορμονη CY1107137T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12623399P 1999-03-24 1999-03-24
EP00914980A EP1191939B1 (en) 1999-03-24 2000-03-17 Antimicrobial amino acid sequences derived from alpha-melanocyte-stimulating hormone

Publications (1)

Publication Number Publication Date
CY1107137T1 true CY1107137T1 (el) 2012-10-24

Family

ID=22423735

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20081100049T CY1107137T1 (el) 1999-03-24 2008-01-14 Αντιμικροβιακες αμινοξικες αλληλουχιες προερχομενες απο την αλφα-μελανοκυτταροτροπο ορμονη

Country Status (14)

Country Link
EP (3) EP1191939B1 (el)
JP (2) JP4767418B2 (el)
KR (1) KR20020000791A (el)
CN (4) CN101249258A (el)
AT (3) ATE375801T1 (el)
AU (3) AU3629300A (el)
CA (2) CA2368387A1 (el)
CY (1) CY1107137T1 (el)
DE (3) DE60036800T2 (el)
DK (3) DK1191939T3 (el)
ES (3) ES2295016T3 (el)
HK (2) HK1040496B (el)
PT (2) PT1191939E (el)
WO (2) WO2000059527A1 (el)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7402559B2 (en) 1999-03-24 2008-07-22 Msh Pharma, Incorporated Composition and method of treatment for urogenital conditions
US6887846B2 (en) 1999-03-24 2005-05-03 Zengen, Inc. Antimicrobial amino acid sequences derived from alpha-melanocyte-stimulating hormone
US6800291B1 (en) 1999-03-24 2004-10-05 Zengen, Inc. Uro-genital condition treatment system
EP1294740A2 (en) 2000-06-16 2003-03-26 Hercules Incorporated Chemically-modified antimicrobial peptides, compositions and methods of production and use
US6780838B2 (en) * 2001-01-29 2004-08-24 Zengen, Inc. Compounds for treating fungal pathologies of the oral cavity
US6894028B2 (en) 2001-04-06 2005-05-17 Zengen, Inc. Use of KPV tripeptide for dermatological disorders
US7115574B2 (en) 2001-12-10 2006-10-03 Zengen, Inc. System and method for support legacy operating system booting in a legacy-free system
US6939846B2 (en) 2001-12-17 2005-09-06 Zengen, Inc. Use of a polypeptide for treatment of pruritis in animals
US7135548B2 (en) * 2002-11-14 2006-11-14 Zengen, Inc. Modified α-MSH peptides and derivatives thereof
WO2004058804A1 (en) * 2002-12-24 2004-07-15 Walter And Eliza Hall Institute Of Medical Research Peptides and therapeutic uses thereof
US20090232866A1 (en) * 2003-10-07 2009-09-17 Mariann Pavone-Gyongyosi Oligopeptides as coating material for medical products
US7674771B2 (en) 2003-10-29 2010-03-09 Toagosei Co., Ltd Antimicrobial peptides and utilization of the same
CN100390194C (zh) * 2004-02-27 2008-05-28 沛进生物科技股份有限公司 低溶血性的抗菌胜肽及其使用方法
JP4507080B2 (ja) 2004-07-30 2010-07-21 東亞合成株式会社 抗菌ペプチド及びその利用
JP4730584B2 (ja) 2004-12-06 2011-07-20 東亞合成株式会社 抗菌ペプチド及びその利用
WO2006071822A1 (en) * 2004-12-23 2006-07-06 Regents Of The University Of Minnesota Exotoxin inhibitory factor
EP1849474B1 (en) 2005-02-15 2016-09-07 Toagosei Co., Ltd. Antimicrobial peptide and use thereof
US8552042B2 (en) * 2006-05-12 2013-10-08 Christian Noe Use of combination preparations comprising antifungal agents
US20110171195A1 (en) * 2007-06-15 2011-07-14 Duke University Methods and compositions for treating urinary tract infections using agents that mimic or elevate cyclic amp
AU2008303922A1 (en) * 2007-09-11 2009-04-02 Mondobiotech Laboratories Ag Use of the peptide His-Ser-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro-Asp-Lys-Phe alone or in combination with the peptide Gly-Ard-Gly-Asp-Asn-Pro-OH as a therapeutic agent
WO2009033812A2 (en) * 2007-09-11 2009-03-19 Mondobiotech Laboratories Ag Use of a combination of neuropeptide-ff and alpha-msh as a therapeutic agent
JP5491396B2 (ja) * 2007-09-11 2014-05-14 モンドバイオテック ラボラトリーズ アクチエンゲゼルシャフト 治療剤としてのデフェンシンペプチドの使用
EP2508198B1 (en) 2011-04-07 2014-08-27 Fresenius Medical Care Deutschland GmbH Peptides for suppressing inflammation reactions in hemodialysis
SE539566C2 (en) * 2014-09-03 2017-10-10 Danell Nils Device for the detection of gaseous amines from disease in the human urogential system
US10828015B2 (en) * 2018-07-12 2020-11-10 Prima-Temp, Inc. Vaginal temperature sensing apparatus and methods

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH422813A (de) * 1960-11-17 1966-10-31 Ciba Geigy Verfahren zur Herstellung neuer Polypeptide
CH444178A (de) * 1963-05-20 1967-09-30 Ciba Geigy Verfahren zur Herstellung von B-MSH
US5028592A (en) 1986-08-08 1991-07-02 Lipton James M Antipyretic and anti-inflammatory peptides
US5157023A (en) 1984-08-21 1992-10-20 Lipton James M Antipyretic and anti-inflammatory lys pro val compositions and method of use
AU597630B2 (en) * 1986-02-03 1990-06-07 University Patents Inc. Method of stimulating melanocytes by topical application of analogs of alpha-msh, and compositions for use in same
JP2633369B2 (ja) * 1988-03-28 1997-07-23 ブリティッシュ・テクノロジー・グループ・リミテッド ペプチド
FR2733421B1 (fr) * 1995-04-28 1997-06-06 Oreal Utilisation de derives de l'hormone stimulatrice des melanocytes de type alpha pour stimuler ou induire la pousse des cheveux et/ou stopper leur chute

Also Published As

Publication number Publication date
DK1165120T3 (da) 2006-03-06
HK1040496B (zh) 2006-05-12
EP1433485A3 (en) 2004-09-22
CN1359300A (zh) 2002-07-17
WO2000056353A3 (en) 2000-12-28
WO2000056353A2 (en) 2000-09-28
ATE375801T1 (de) 2007-11-15
CN1544461A (zh) 2004-11-10
EP1191939A1 (en) 2002-04-03
AU3772500A (en) 2000-10-09
HK1040496A1 (en) 2002-06-14
CA2368387A1 (en) 2000-10-12
CN100371019C (zh) 2008-02-27
CN101240017A (zh) 2008-08-13
ES2295016T3 (es) 2008-04-16
ATE308338T1 (de) 2005-11-15
PT1433485E (pt) 2010-02-03
AU2004242451A1 (en) 2005-01-20
DE60043358D1 (de) 2009-12-31
WO2000059527A1 (en) 2000-10-12
EP1433485B1 (en) 2009-11-18
JP2002541118A (ja) 2002-12-03
DE60023667T2 (de) 2006-08-10
HK1044287A1 (zh) 2002-10-18
JP2002542158A (ja) 2002-12-10
ES2251982T3 (es) 2006-05-16
AU776804B2 (en) 2004-09-23
ES2336661T3 (es) 2010-04-15
CN101249258A (zh) 2008-08-27
PT1191939E (pt) 2008-01-04
CA2367118A1 (en) 2000-09-28
DE60036800T2 (de) 2008-07-24
DK1433485T3 (da) 2010-03-29
EP1191939A4 (en) 2004-03-24
ATE448790T1 (de) 2009-12-15
EP1165120A2 (en) 2002-01-02
DK1191939T3 (da) 2008-02-11
JP4057787B2 (ja) 2008-03-05
AU776804C (en) 2005-06-23
KR20020000791A (ko) 2002-01-05
AU3629300A (en) 2000-10-23
EP1191939B1 (en) 2007-10-17
DE60023667D1 (de) 2005-12-08
EP1165120B1 (en) 2005-11-02
JP4767418B2 (ja) 2011-09-07
EP1433485A2 (en) 2004-06-30
DE60036800D1 (de) 2007-11-29

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