CY1106504T1 - Υβριδιακες πρωτεϊνες του τοξοειδους του τετανου που μετακινουνται παλινδρομικα και διασυναπτικα στο κνς - Google Patents

Υβριδιακες πρωτεϊνες του τοξοειδους του τετανου που μετακινουνται παλινδρομικα και διασυναπτικα στο κνς

Info

Publication number
CY1106504T1
CY1106504T1 CY20071100505T CY071100505T CY1106504T1 CY 1106504 T1 CY1106504 T1 CY 1106504T1 CY 20071100505 T CY20071100505 T CY 20071100505T CY 071100505 T CY071100505 T CY 071100505T CY 1106504 T1 CY1106504 T1 CY 1106504T1
Authority
CY
Cyprus
Prior art keywords
ttc
neurons
palindromically
transsynaptically
cns
Prior art date
Application number
CY20071100505T
Other languages
English (en)
Inventor
Laurent Coen
Rosario Osta Pinzolas
Philippe Brulet
Original Assignee
Institut Pasteur
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut Pasteur filed Critical Institut Pasteur
Publication of CY1106504T1 publication Critical patent/CY1106504T1/el

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

To μη τοξικό πρωτεολυτικό τμήμα C της τοξίνης του τετάνου (TTC πεπτίδιο) έχει την ίδια ικανότητα πρόσδεσης στα νευρικά κύτταρα και μεταφέρεται παλινδρομικά μέσω μίας σύναψης όμοια με την ενδογενή τοξίνη. Μία υβριδιακή πρωτεΐνη που κωδικοποιείται από την γονιδιακή σύντηξη lacZ- TTC διατηρεί τις βιολογικές λειτουργίες και των δύο πρωτεϊνών in vivo δηλ., την παλίνδρομη διασυναπτική μεταφορά του τμήματος TTC και την ενζυματική δραστικότητα β-gal. Μετά από ενδομυϊκή ένεση, η ενζυματική δραστικότητα μπορεί να ανιχνευθεί στους κινητικούς νευρώνες και στους συνδεδεμένους νευρώνες των περιοχών του στελέχους του εγκεφάλου. Η στρατηγική αυτή είναι χρήσιμη για την διανομή μιας βιολογικής δραστικότητας στους νευρώνες από την περιφέρεια προς το κεντρικό νευρικό σύστημα. Μία τέτοιου τύπου υβριδιακή πρωτεΐνη μπορεί επίσης να χρησιμοποιηθεί για την χαρτογράφηση συνοπτικών συνδέσεων μεταξύ νευρικών κυττάρων.
CY20071100505T 1997-08-14 2007-04-12 Υβριδιακες πρωτεϊνες του τοξοειδους του τετανου που μετακινουνται παλινδρομικα και διασυναπτικα στο κνς CY1106504T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5561597P 1997-08-14 1997-08-14
US6523697P 1997-11-13 1997-11-13
PCT/EP1998/005113 WO1999009057A2 (en) 1997-08-14 1998-08-12 Hybrid tetanus toxoid proteins that migrate retrogradely and transynaptically into the cns

Publications (1)

Publication Number Publication Date
CY1106504T1 true CY1106504T1 (el) 2012-01-25

Family

ID=26734425

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20071100505T CY1106504T1 (el) 1997-08-14 2007-04-12 Υβριδιακες πρωτεϊνες του τοξοειδους του τετανου που μετακινουνται παλινδρομικα και διασυναπτικα στο κνς

Country Status (9)

Country Link
US (4) US7435792B2 (el)
EP (2) EP1049712B1 (el)
AT (1) ATE352558T1 (el)
CY (1) CY1106504T1 (el)
DE (1) DE69836982T2 (el)
DK (1) DK1049712T3 (el)
ES (1) ES2281135T3 (el)
PT (1) PT1049712E (el)
WO (1) WO1999009057A2 (el)

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WO1995016774A1 (en) * 1993-12-17 1995-06-22 Spinal Cord Society Method for inducing dna synthesis in neurons
DE69836982T2 (de) * 1997-08-14 2007-10-31 Institut Pasteur Hybride Tetanustoxinproteine die retrograd und transsynaptisch ins ZNS migrieren
US7923015B2 (en) 1997-08-14 2011-04-12 Institut Pasteur Methods for direct visualization of active synapses
US7923216B2 (en) 1997-08-14 2011-04-12 Institut Pasteur In vivo modulation of neuronal transport
US7368532B2 (en) 1999-12-02 2008-05-06 Syntaxin Limited Constructs for delivery of therapeutic agents to neuronal cells
ES2216996T3 (es) * 1999-12-02 2004-11-01 Health Protection Agency Construcciones para suministrar agentes terapeuticos a celulas neuronales.
WO2004021992A2 (en) * 2002-09-06 2004-03-18 The General Hospital Corporation Delivery of therapeutics to the brain and spinal cord
DE10303974A1 (de) 2003-01-31 2004-08-05 Abbott Gmbh & Co. Kg Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung
WO2006070290A2 (en) * 2004-06-23 2006-07-06 Ferguson Ian A Agents and methods for early diagnosis and monitoring of alzheimer's disease and other neurological disorders
KR101667623B1 (ko) 2005-11-30 2016-10-19 애브비 인코포레이티드 아밀로이드 베타 단백질에 대한 모노클로날 항체 및 이의 용도
PL1954718T3 (pl) 2005-11-30 2015-04-30 Abbvie Inc Przeciwciała skierowane przeciwko A globulomerowi, ich reszty wiążące antygeny, odpowiednie hybrydomy, kwasy nukleinowe, wektory, komórki gospodarze, sposoby wytwarzania tych przeciwciał, kompozycje zawierające te przeciwciała, zastosowania tych przeciwciał i sposoby stosowania tych przeciwciał
CA2656104A1 (en) * 2006-06-30 2008-01-10 Board Of Regents, The University Of Texas System Tetanus toxin fragment c based imaging agents and methods, and confocal microscopy dataset processes
US8455626B2 (en) 2006-11-30 2013-06-04 Abbott Laboratories Aβ conformer selective anti-aβ globulomer monoclonal antibodies
EP2124952A2 (en) 2007-02-27 2009-12-02 Abbott GmbH & Co. KG Method for the treatment of amyloidoses
ES2332628B1 (es) * 2007-10-05 2011-01-24 Universidad De Zaragoza Uso de la secuencia codificante del dominio carboxilo terminal de la cadena pesada de la toxina tetanica como medicamento.
US8173768B2 (en) * 2009-07-13 2012-05-08 Centre National De La Recherche Scientifique Peptides having antimicrobial and neurotrophic activity and uses thereof
MX336196B (es) 2010-04-15 2016-01-11 Abbvie Inc Proteinas de union a amiloide beta.
WO2011143557A2 (en) 2010-05-14 2011-11-17 The Children's Hospital Of Philadelphia Humanized ttc and methods of use thereof
MX358739B (es) 2010-08-14 2018-09-03 Abbvie Inc Star Proteinas de union a amiloide beta.
EP3164149A1 (en) 2014-07-02 2017-05-10 Spherium Biomed S.L. Methods of increasing muscle mass using non-toxic tetanus toxin c fragment (ttc)

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FR2498192A2 (fr) * 1981-01-22 1982-07-23 Pasteur Institut Nouveau compose polypeptidique thiole provenant d'un fragment de la toxine tetanique, son procede d'obtention et ses applications
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US5004683A (en) * 1986-07-31 1991-04-02 The Research Foundation Of State University Of New York Means for detecting and analyzing neuroanatomy
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US5650148A (en) * 1988-12-15 1997-07-22 The Regents Of The University Of California Method of grafting genetically modified cells to treat defects, disease or damage of the central nervous system
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Also Published As

Publication number Publication date
US20030004121A1 (en) 2003-01-02
DE69836982D1 (de) 2007-03-15
WO1999009057A3 (en) 1999-07-08
PT1049712E (pt) 2007-04-30
US7435792B2 (en) 2008-10-14
US20100239534A1 (en) 2010-09-23
EP1681300A1 (en) 2006-07-19
EP1049712A2 (en) 2000-11-08
US20110002914A1 (en) 2011-01-06
US20090226468A1 (en) 2009-09-10
ATE352558T1 (de) 2007-02-15
DE69836982T2 (de) 2007-10-31
ES2281135T3 (es) 2007-09-16
WO1999009057A2 (en) 1999-02-25
DK1049712T3 (da) 2007-05-29
EP1049712B1 (en) 2007-01-24

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