CY1106004T1 - Παραγωγα αλκυλιδενοπιραζολιδινοδιονης και η χρηση τους στην θepαπευτικη αντιμετωπιση του διαβητη και της παχυσαρκιας - Google Patents

Παραγωγα αλκυλιδενοπιραζολιδινοδιονης και η χρηση τους στην θepαπευτικη αντιμετωπιση του διαβητη και της παχυσαρκιας

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Publication number
CY1106004T1
CY1106004T1 CY20071100178T CY071100178T CY1106004T1 CY 1106004 T1 CY1106004 T1 CY 1106004T1 CY 20071100178 T CY20071100178 T CY 20071100178T CY 071100178 T CY071100178 T CY 071100178T CY 1106004 T1 CY1106004 T1 CY 1106004T1
Authority
CY
Cyprus
Prior art keywords
derivatives
obesity
diabetes
alkylidenepyrazolidinedione
present
Prior art date
Application number
CY20071100178T
Other languages
English (en)
Inventor
Agnes Bombrun
Thomas Rueckle
Dominique Swinnen
Jérome Gonzalez
Dennis Church
Original Assignee
Laboratoires Serono Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Serono Sa filed Critical Laboratoires Serono Sa
Publication of CY1106004T1 publication Critical patent/CY1106004T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/28—Two oxygen or sulfur atoms
    • C07D231/30—Two oxygen or sulfur atoms attached in positions 3 and 5
    • C07D231/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Η παρούσα εφεύρεση αφορά στη χρήση παραγώγων αλκυλιδενοπιραζολιδινοδιόνης του τύπου (Ι) για τη θεραπευτική αντιμετώπιση και/ή πρόληψη του διαβήτη τύπου I και/ή II, της επιβαρυμένης πρόσληψης γλυκόζης, της ινσουλινικής αντίστασης, της υπεργλυκαιμίας, της παχυσαρκίας και του συνδρόμου πολυκυστικών ωοθηκών (PCOS). Συγκεκριμένα, η παρούσα εφεύρεση αφορά στη χρήση παραγώγων αλκυλιδενοπιραζολιδινοδιόνης του τύπου (I) με σκοπό τη ρύθμιση, δηλαδή την αναστολή, της δράσης των ΡΤΡ, ιδίως των PTPlB, TC-PTP, SHP και GLEPP-1. Η παρούσα εφεύρεση αφορά περαιτέρω σε νέα παράγωγα αλκυλιδενοπιραζολιδινοδιόνης. (Ι) τα R1 και R2 παριστάνουν ανεξάρτητα το ένα από το άλλο ένα μη υποκατεστημένο ή υποκατεστημένο αρύλιο ή ετεροαρύλιο.
CY20071100178T 2001-06-18 2007-02-09 Παραγωγα αλκυλιδενοπιραζολιδινοδιονης και η χρηση τους στην θepαπευτικη αντιμετωπιση του διαβητη και της παχυσαρκιας CY1106004T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01113633 2001-06-18
PCT/EP2002/006627 WO2002102359A2 (en) 2001-06-18 2002-06-14 Alkylidene pyrazolidinedione derivatives and use for treating diabetes and obesity
EP02735418A EP1399156B1 (en) 2001-06-18 2002-06-14 Alkylidene pirazolidinedione derivatives and their use for treating diabetes and obesity

Publications (1)

Publication Number Publication Date
CY1106004T1 true CY1106004T1 (el) 2011-04-06

Family

ID=8177642

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20071100178T CY1106004T1 (el) 2001-06-18 2007-02-09 Παραγωγα αλκυλιδενοπιραζολιδινοδιονης και η χρηση τους στην θepαπευτικη αντιμετωπιση του διαβητη και της παχυσαρκιας

Country Status (14)

Country Link
US (1) US20040220188A1 (el)
EP (1) EP1399156B1 (el)
JP (1) JP2004534072A (el)
AT (1) ATE345796T1 (el)
AU (1) AU2002310765B2 (el)
CA (1) CA2449212A1 (el)
CY (1) CY1106004T1 (el)
DE (1) DE60216279T2 (el)
DK (1) DK1399156T3 (el)
ES (1) ES2275877T3 (el)
IL (1) IL159354A0 (el)
PT (1) PT1399156E (el)
SI (1) SI1399156T1 (el)
WO (1) WO2002102359A2 (el)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003249865A1 (en) * 2003-06-24 2005-01-21 Actelion Pharmaceuticals Ltd Pyrazolidinedione derivatives and their use as platelet aggregation inhibitors
JPWO2005026127A1 (ja) * 2003-09-11 2006-11-16 株式会社医薬分子設計研究所 プラスミノゲンアクチベータインヒビター−１阻害剤
WO2007059356A2 (en) * 2005-11-19 2007-05-24 Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Furfurylidene- pyrazolidines and their use as inhibitors of ubiquitin e1
JP6016788B2 (ja) * 2011-05-16 2016-10-26 国立大学法人九州大学 ＤＯＣＫ−Ａサブファミリー分子によるＲａｃ活性化を制御する低分子化合物及びその用途
CN105254620A (zh) * 2015-11-26 2016-01-20 上海应用技术学院 吡唑类衍生物、合成方法及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8005946A (nl) * 1979-11-02 1981-06-01 Hoffmann La Roche Middelen tegen vetzucht en verhoogde vetspiegel.
US4591594A (en) * 1979-12-26 1986-05-27 Hoffmann-La Roche Inc. Thromboxane synthase inhibitors as antiobesity agents
US6211221B1 (en) * 1999-04-05 2001-04-03 Johnny W. Peterson Dietary supplement containing histidine for alleviating dysmenorrhea, endometriosis, and pre-term labor
GB9915184D0 (en) * 1999-06-29 1999-09-01 Viral As A Compounds
US20070037846A1 (en) * 2003-06-24 2007-02-15 Actelion Pharmaceuticals, Ltd. Pyrazolidinedione derivatives

Also Published As

Publication number Publication date
WO2002102359A3 (en) 2003-08-28
US20040220188A1 (en) 2004-11-04
WO2002102359A2 (en) 2002-12-27
PT1399156E (pt) 2007-02-28
EP1399156A2 (en) 2004-03-24
ATE345796T1 (de) 2006-12-15
IL159354A0 (en) 2004-06-01
AU2002310765B2 (en) 2007-10-18
EP1399156B1 (en) 2006-11-22
DE60216279D1 (de) 2007-01-04
ES2275877T3 (es) 2007-06-16
SI1399156T1 (sl) 2007-02-28
DE60216279T2 (de) 2007-05-31
CA2449212A1 (en) 2002-12-27
DK1399156T3 (da) 2007-03-05
JP2004534072A (ja) 2004-11-11

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