CY1105531T1 - Ρυθμιστες πολυσακχαριδιων και χρησεις αυτων - Google Patents
Ρυθμιστες πολυσακχαριδιων και χρησεις αυτωνInfo
- Publication number
- CY1105531T1 CY1105531T1 CY20061101185T CY061101185T CY1105531T1 CY 1105531 T1 CY1105531 T1 CY 1105531T1 CY 20061101185 T CY20061101185 T CY 20061101185T CY 061101185 T CY061101185 T CY 061101185T CY 1105531 T1 CY1105531 T1 CY 1105531T1
- Authority
- CY
- Cyprus
- Prior art keywords
- glycosaminoglycan
- peptides
- sulfate
- chondroitin
- chitosan
- Prior art date
Links
- 150000004676 glycans Chemical class 0.000 title 1
- 229920001282 polysaccharide Polymers 0.000 title 1
- 239000005017 polysaccharide Substances 0.000 title 1
- 229920002683 Glycosaminoglycan Polymers 0.000 abstract 5
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 5
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 5
- 229920001661 Chitosan Polymers 0.000 abstract 2
- KXCLCNHUUKTANI-RBIYJLQWSA-N keratan Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@H](COS(O)(=O)=O)O[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@H](O[C@@H](O[C@H]3[C@H]([C@@H](COS(O)(=O)=O)O[C@@H](O)[C@@H]3O)O)[C@H](NC(C)=O)[C@H]2O)COS(O)(=O)=O)O[C@H](COS(O)(=O)=O)[C@@H]1O KXCLCNHUUKTANI-RBIYJLQWSA-N 0.000 abstract 2
- 230000001404 mediated effect Effects 0.000 abstract 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 abstract 1
- 229920002101 Chitin Polymers 0.000 abstract 1
- 229920002567 Chondroitin Polymers 0.000 abstract 1
- 229920000045 Dermatan sulfate Polymers 0.000 abstract 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 229920000288 Keratan sulfate Polymers 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
- AVJBPWGFOQAPRH-MMPMEFKSSA-N beta-D-GlcpA-(1->3)-beta-D-GalpNAc4S Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS(O)(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O1 AVJBPWGFOQAPRH-MMPMEFKSSA-N 0.000 abstract 1
- 230000008827 biological function Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- DLGJWSVWTWEWBJ-HGGSSLSASA-N chondroitin Chemical compound CC(O)=N[C@@H]1[C@H](O)O[C@H](CO)[C@H](O)[C@@H]1OC1[C@H](O)[C@H](O)C=C(C(O)=O)O1 DLGJWSVWTWEWBJ-HGGSSLSASA-N 0.000 abstract 1
- AVJBPWGFOQAPRH-FWMKGIEWSA-L dermatan sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C([O-])=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-L 0.000 abstract 1
- 229940051593 dermatan sulfate Drugs 0.000 abstract 1
- 230000006806 disease prevention Effects 0.000 abstract 1
- 239000003623 enhancer Substances 0.000 abstract 1
- 230000006870 function Effects 0.000 abstract 1
- 229920000669 heparin Polymers 0.000 abstract 1
- 229960002897 heparin Drugs 0.000 abstract 1
- 229920002674 hyaluronan Polymers 0.000 abstract 1
- 229960003160 hyaluronic acid Drugs 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000003068 molecular probe Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Transplantation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polyesters Or Polycarbonates (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicinal Preparation (AREA)
Abstract
Η παρούσα εφεύρεση παρέχει πεπτίδια με ειδική συνάφεια για μόρια γλυκοζαμινογλυκάνης. Αυτά τα πεπτίδια μπορεί να έχουν οποιοδήποτε αριθμό λειτουργιών, που συμπεριλαμβάνουν, αλλά δεν περιορίζονται σε αυτά, χρήση σαν αναστολείς προκαλουμένων από γλυκοζαμινογλυκάνη-διεργασιών, αυξητές προκαλουμένων από γλυκοζαμινογλυκάνη-διεργασιών και σαν μοριακοί διερευνητές για να πιστοποιείται η παρουσία μιας ειδικής γλυκοζαμινογλυκάνης. Πεπτίδια της εφεύρεσης μπορεί να κατευθύνονται έναντι οποιασδήποτε γλυκοζαμινογλυκάνης, συμπεριλαμβανομένου υαλουρονικού οξέος, θειικής χονδροϊτίνης Α, θειικής χονδροϊτίνης C, θειικής δερματάνης, ηπαρίνης, θειικής κερατάνης, κερατοθειϊκού, χιτίνης, χιτοζάνης 1 και χιτοζάνης 2. Αυτά τα απομονωθέντα πεπτίδια μπορεί να έχουν θεραπευτικές χρήσεις στη θεραπεία ή πρόληψη ασθενειών όπου ενέχεται φλεγμονή, φλεγμονωδών ασθενειών, καρκίνου, λοιμώξεων, κ.λ.π. Τα πεπτίδια μπορεί επίσης να έχουν άλλες βιολογικές λειτουργίες όπως αντισύλληψη.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12647599P | 1999-03-26 | 1999-03-26 | |
| PCT/US2000/007813 WO2000057896A1 (en) | 1999-03-26 | 2000-03-22 | Modulators of polysaccharides and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1105531T1 true CY1105531T1 (el) | 2010-07-28 |
Family
ID=22425031
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20061101185T CY1105531T1 (el) | 1999-03-26 | 2006-08-23 | Ρυθμιστες πολυσακχαριδιων και χρησεις αυτων |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US6653285B1 (el) |
| EP (1) | EP1165112B1 (el) |
| JP (1) | JP2002540161A (el) |
| AT (1) | ATE328603T1 (el) |
| AU (1) | AU774650B2 (el) |
| CA (1) | CA2366604A1 (el) |
| CY (1) | CY1105531T1 (el) |
| DE (1) | DE60028558T2 (el) |
| DK (1) | DK1165112T3 (el) |
| ES (1) | ES2265928T3 (el) |
| MX (1) | MXPA01009690A (el) |
| PT (1) | PT1165112E (el) |
| WO (1) | WO2000057896A1 (el) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2439409A1 (en) * | 2001-03-21 | 2002-10-03 | The University Of Texas System | Inhibitors of glycosaminoglycans |
| US20040259783A1 (en) * | 2001-11-09 | 2004-12-23 | Tony Cruz | Pharmaceutical compositions of marine sponge microciona prolifera |
| ITPD20020003A1 (it) | 2002-01-11 | 2003-07-11 | Fidia Advanced Biopolymers Srl | Biomateriali a base di acido ialuronico come terapia anti-angiogenicanella cura dei tumori. |
| US20060198800A1 (en) * | 2003-08-14 | 2006-09-07 | Natalie Dilallo | Skin care compositions including hexapeptide complexes and methods of their manufacture |
| US20050063932A1 (en) * | 2003-08-14 | 2005-03-24 | Natalie Dilallo | Skin care compositions including hexapeptide complexes and methods of their manufacture |
| EP2304033B1 (en) | 2008-06-30 | 2016-09-07 | ESBATech, an Alcon Biomedical Research Unit LLC | Functionalized polypeptides |
| CA2729766A1 (en) * | 2008-07-01 | 2010-01-07 | Zacharon Pharmaceuticals, Inc. | Heparan sulfate inhibitors |
| US9029530B2 (en) | 2009-01-02 | 2015-05-12 | Biomarin Pharmaceutical Inc. | Detection of oligosaccharides |
| US8592140B2 (en) | 2009-01-02 | 2013-11-26 | Biomarin Pharmaceutical Inc. | Detection of oligosaccharides |
| US8809009B2 (en) | 2009-01-02 | 2014-08-19 | Biomarin Pharmaceutical Inc. | Methods of diagnosing a disease and methods of monitoring treatment of a disease by quantifying a non-reducing end glycan residual compound and comparing to a second biomarker |
| US8232073B2 (en) | 2009-01-02 | 2012-07-31 | Zacharon Pharmaceuticals, Inc. | Quantification of non-reducing end glycan residual compounds |
| CN102781517B (zh) * | 2010-02-01 | 2015-11-25 | 小利兰·斯坦福大学托管委员会 | 诊断和治疗非胰岛素依赖性糖尿病的方法 |
| PL3249662T3 (pl) * | 2016-05-27 | 2020-11-16 | Hanning Elektro-Werke Gmbh & Co. Kg | Silnik elektryczny do napędu pompy |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9207949D0 (en) * | 1992-04-09 | 1992-05-27 | Univ Manitoba | Molecular cloning of a novel hyaluronan receptor that mediates tumor cell motility |
| US5981478A (en) * | 1993-11-24 | 1999-11-09 | La Jolla Cancer Research Foundation | Integrin-binding peptides |
| CA2237051A1 (en) * | 1997-12-19 | 1999-06-19 | Eva A. Turley | Enhanced affinity hyaluronan binding peptides |
| EP1324765A1 (en) * | 2000-10-05 | 2003-07-09 | Transition Therapeutics Inc. | Compositions and methods for treating cellular response to injury and other proliferating cell disorders regulated by hyaladherin and hyaluronans |
-
2000
- 2000-03-22 AU AU40255/00A patent/AU774650B2/en not_active Ceased
- 2000-03-22 MX MXPA01009690A patent/MXPA01009690A/es active IP Right Grant
- 2000-03-22 ES ES00919594T patent/ES2265928T3/es not_active Expired - Lifetime
- 2000-03-22 DE DE60028558T patent/DE60028558T2/de not_active Expired - Fee Related
- 2000-03-22 AT AT00919594T patent/ATE328603T1/de not_active IP Right Cessation
- 2000-03-22 EP EP00919594A patent/EP1165112B1/en not_active Expired - Lifetime
- 2000-03-22 WO PCT/US2000/007813 patent/WO2000057896A1/en active IP Right Grant
- 2000-03-22 DK DK00919594T patent/DK1165112T3/da active
- 2000-03-22 PT PT00919594T patent/PT1165112E/pt unknown
- 2000-03-22 US US09/532,709 patent/US6653285B1/en not_active Expired - Fee Related
- 2000-03-22 CA CA002366604A patent/CA2366604A1/en not_active Abandoned
- 2000-03-22 JP JP2000607646A patent/JP2002540161A/ja active Pending
-
2003
- 2003-10-06 US US10/680,670 patent/US6923965B2/en not_active Expired - Fee Related
-
2006
- 2006-08-23 CY CY20061101185T patent/CY1105531T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2366604A1 (en) | 2000-10-05 |
| WO2000057896A1 (en) | 2000-10-05 |
| JP2002540161A (ja) | 2002-11-26 |
| EP1165112B1 (en) | 2006-06-07 |
| MXPA01009690A (es) | 2003-06-24 |
| US6653285B1 (en) | 2003-11-25 |
| AU4025500A (en) | 2000-10-16 |
| PT1165112E (pt) | 2006-10-31 |
| AU774650B2 (en) | 2004-07-01 |
| ATE328603T1 (de) | 2006-06-15 |
| EP1165112A1 (en) | 2002-01-02 |
| ES2265928T3 (es) | 2007-03-01 |
| DE60028558T2 (de) | 2007-05-16 |
| DK1165112T3 (da) | 2006-10-09 |
| EP1165112A4 (en) | 2002-09-25 |
| US6923965B2 (en) | 2005-08-02 |
| US20040138105A1 (en) | 2004-07-15 |
| DE60028558D1 (de) | 2006-07-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1105531T1 (el) | Ρυθμιστες πολυσακχαριδιων και χρησεις αυτων | |
| CY1118363T1 (el) | Αντισωματα που ανοσοειδικως συνδεονται προς blys | |
| CY1106476T1 (el) | Υποκατεστημενες διυδροκιναζολινες με αντι-ιικες ιδιοτητες | |
| DE69928952D1 (de) | Chinolin-derivate und ihre verwendung als antibakterielle wirkstoffe | |
| CY1108722T1 (el) | Πολυκυκλικες ενωσεις και η χρηση τους ως αναστολεων των ενζυμων parp, vegfr2 και mlk3 | |
| BR0007985A (pt) | Processo para a preparação de derivados multiplamente reticulados do ácido hialurÈnico (ha), ha multiplamente reticulado, ha reticulado em um ou mais polìmeros diferentes de ha, ha reticulado em um segundo polìmero, produto, e, uso de um derivado de ha multiplamente reticulado | |
| MY155218A (en) | Small molecules useful in the treatment of inflammatory disease | |
| BR9608789A (pt) | Compostos de tetralina com atividade de mdr | |
| ATE257390T1 (de) | Verwendung eines bpi proteinproduktes als antithrombotisches mittel | |
| BR0112962A (pt) | Composições farmacêuticas para o tratamento de condições inflamatórias e ulcerativas dolorosas de maioria das superfìcies epiteliais tais como mucosite, estomatite e sìndrome de behcet | |
| BR0307508A (pt) | Composto, composição farmacêutica, e, métodos de tratamento ou prevenção de dor e inflamação e de tratamento de doença | |
| BRPI0516568A (pt) | biomateriais consistindo em ácido hialurÈnico sulfatado e gelana, bem como composição farmacêutica e uso dos mesmos | |
| ES2113891T3 (es) | Anticuerpos monoclonales de raton. | |
| ECSP055823A (es) | DERIVADOS DE [6,7-DIHIDRO-5H-IMIDAZO[1,2-a]IMIDAZOL-3-SULFONILAMINO]-PROPIONAMIDA | |
| PT1216256E (pt) | Antibioticos macrolidos e tratamento de pasteurelose | |
| BR9508323A (pt) | Uso de quitosan e um polissacarídeo imobilizado no mesmo escolhido dentre heparina sulfato de herpan e sulfato de extran e processo para impedir ou reduzir substancialmente a adesão indesejável de tecidos com relação à cicatrização de feridas | |
| DK0876346T3 (da) | Antimalariaaktive quinolinderivater | |
| DK0869965T3 (da) | Steroidnitritesterderivater anvendelige som antiinflammatoriske lægemidler | |
| BR9910860A (pt) | Uso de ciclosporinas no tratamento de doenças auto-imunes inflamatórias | |
| PT804465E (pt) | Novos inibidores da elastase | |
| DE50111415D1 (de) | Medizintechnisches produkt, verfahren zu seiner herstellung und bereitstellung für die chirurgie | |
| NO963487L (no) | Isolerte, tyrosinaseavledete peptider, samt anvendelser derav | |
| JP2004511492A5 (el) | ||
| CA2472093A1 (en) | Use of sulfated glycosaminoglycans for establishing effective labor in women | |
| PT782630E (pt) | Gene da doenca poliquistica do rim |