CY1105454T1 - Αντοχολοστατικη δραστικοτητα λουτεολινης, apigenin και naringenin - Google Patents
Αντοχολοστατικη δραστικοτητα λουτεολινης, apigenin και naringeninInfo
- Publication number
- CY1105454T1 CY1105454T1 CY20051101156T CY051101156T CY1105454T1 CY 1105454 T1 CY1105454 T1 CY 1105454T1 CY 20051101156 T CY20051101156 T CY 20051101156T CY 051101156 T CY051101156 T CY 051101156T CY 1105454 T1 CY1105454 T1 CY 1105454T1
- Authority
- CY
- Cyprus
- Prior art keywords
- cholostatic
- naringenin
- apigenin
- luteolin
- activity
- Prior art date
Links
- FTVWIRXFELQLPI-ZDUSSCGKSA-N (S)-naringenin Chemical compound C1=CC(O)=CC=C1[C@H]1OC2=CC(O)=CC(O)=C2C(=O)C1 FTVWIRXFELQLPI-ZDUSSCGKSA-N 0.000 title 1
- XADJWCRESPGUTB-UHFFFAOYSA-N apigenin Natural products C1=CC(O)=CC=C1C1=CC(=O)C2=CC(O)=C(O)C=C2O1 XADJWCRESPGUTB-UHFFFAOYSA-N 0.000 title 1
- 235000008714 apigenin Nutrition 0.000 title 1
- KZNIFHPLKGYRTM-UHFFFAOYSA-N apigenin Chemical compound C1=CC(O)=CC=C1C1=CC(=O)C2=C(O)C=C(O)C=C2O1 KZNIFHPLKGYRTM-UHFFFAOYSA-N 0.000 title 1
- 229940117893 apigenin Drugs 0.000 title 1
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 title 1
- LRDGATPGVJTWLJ-UHFFFAOYSA-N luteolin Natural products OC1=CC(O)=CC(C=2OC3=CC(O)=CC(O)=C3C(=O)C=2)=C1 LRDGATPGVJTWLJ-UHFFFAOYSA-N 0.000 title 1
- 235000009498 luteolin Nutrition 0.000 title 1
- IQPNAANSBPBGFQ-UHFFFAOYSA-N luteolin Chemical compound C=1C(O)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=C(O)C(O)=C1 IQPNAANSBPBGFQ-UHFFFAOYSA-N 0.000 title 1
- 229940117954 naringenin Drugs 0.000 title 1
- WGEYAGZBLYNDFV-UHFFFAOYSA-N naringenin Natural products C1(=O)C2=C(O)C=C(O)C=C2OC(C1)C1=CC=C(CC1)O WGEYAGZBLYNDFV-UHFFFAOYSA-N 0.000 title 1
- 235000007625 naringenin Nutrition 0.000 title 1
- 125000002861 (C1-C4) alkanoyl group Chemical group 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 208000001024 intrahepatic cholestasis Diseases 0.000 abstract 1
- 230000007872 intrahepatic cholestasis Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pyrane Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Seasonings (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Η εφεύρεση αφορά ένα φάρμακο για τη θεραπεία ή πρόληψη μιας ενδοηπατιτικής χολόστασης, το οποίο χαρακτηρίζεται από ένα περιεχόμενο σε τουλάχιστον μία ένωση του γενικού τύπου I όπου R, R1 και R2 ανεξάρτητα μεταξύ τους σημαίνουν η κάθε μία = Η, C1-2-αλκύλιο ή C1-3-ακύλιο, R3 = Η ή OR4 και R4 = Η, C1-2-αλκύλιο ή C1-4-ακύλιο και μεταξύ των θέσεων 2 και 3 υπάρχει ένας απλός ή διπλός δεσμός, ή σε ένα φυσιολογικά αποδεκτό άλας της σαν δραστική ουσία.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19902773A DE19902773A1 (de) | 1999-01-25 | 1999-01-25 | Anticholestatische Wirksamkeit von Luteolin |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1105454T1 true CY1105454T1 (el) | 2010-04-28 |
Family
ID=7895269
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20051101156T CY1105454T1 (el) | 1999-01-25 | 2005-09-21 | Αντοχολοστατικη δραστικοτητα λουτεολινης, apigenin και naringenin |
Country Status (8)
Country | Link |
---|---|
US (1) | US6248778B1 (el) |
EP (1) | EP1022024B1 (el) |
AT (1) | ATE299702T1 (el) |
CY (1) | CY1105454T1 (el) |
DE (2) | DE19902773A1 (el) |
DK (1) | DK1022024T3 (el) |
ES (1) | ES2242557T3 (el) |
PT (1) | PT1022024E (el) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10029047B4 (de) * | 2000-06-13 | 2010-12-30 | Divapharma Chur Ag | Verwendung von Luteolin-7-O-glucuronid als Wirkstoff in einem anticholestatischen Arzneimittel |
CN107397743A (zh) * | 2016-05-19 | 2017-11-28 | 苏州凯祥生物科技有限公司 | 二氢黄酮类化合物在制备法尼醇x受体激动剂中的应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2159219A1 (en) * | 1993-03-31 | 1994-10-13 | Minoru Maeda | Cholestasis ameliorant |
EP0807435A3 (de) * | 1996-05-17 | 1999-02-24 | Sertürner Arzneimittel GmbH | Indirekter HMG-CoA-Reduktase-Hemmer |
KR100447918B1 (ko) * | 1996-07-25 | 2005-09-28 | 동아제약주식회사 | 대장을포함한위장관보호작용을갖는플라본및플라바논화합물 |
ATE295176T1 (de) * | 1997-05-19 | 2005-05-15 | Repligen Corp | Verfahren zur unterstützung der differentialdiagnostik und behandlung von autistischen syndromen |
DE19755504A1 (de) * | 1997-12-13 | 1999-06-17 | Beiersdorf Ag | Verwendung von Flavonen und Flavonoiden gegen die UV-induzierte Zersetzung von Dibenzoylmethan und dessen Derivaten |
-
1999
- 1999-01-25 DE DE19902773A patent/DE19902773A1/de not_active Withdrawn
-
2000
- 2000-01-25 PT PT00101455T patent/PT1022024E/pt unknown
- 2000-01-25 EP EP00101455A patent/EP1022024B1/de not_active Expired - Lifetime
- 2000-01-25 AT AT00101455T patent/ATE299702T1/de not_active IP Right Cessation
- 2000-01-25 ES ES00101455T patent/ES2242557T3/es not_active Expired - Lifetime
- 2000-01-25 DK DK00101455T patent/DK1022024T3/da active
- 2000-01-25 DE DE50010724T patent/DE50010724D1/de not_active Expired - Lifetime
- 2000-01-27 US US09/492,004 patent/US6248778B1/en not_active Expired - Fee Related
-
2005
- 2005-09-21 CY CY20051101156T patent/CY1105454T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
US6248778B1 (en) | 2001-06-19 |
ES2242557T3 (es) | 2005-11-16 |
DE19902773A1 (de) | 2000-07-27 |
PT1022024E (pt) | 2005-11-30 |
EP1022024A2 (de) | 2000-07-26 |
DE50010724D1 (de) | 2005-08-25 |
DK1022024T3 (da) | 2005-11-21 |
EP1022024B1 (de) | 2005-07-20 |
EP1022024A3 (de) | 2003-05-28 |
ATE299702T1 (de) | 2005-08-15 |
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