CU24288B1 - Vacuna polivalente de proteína de fusión contra la influenza - Google Patents

Vacuna polivalente de proteína de fusión contra la influenza

Info

Publication number
CU24288B1
CU24288B1 CUP2015000083A CU20150083A CU24288B1 CU 24288 B1 CU24288 B1 CU 24288B1 CU P2015000083 A CUP2015000083 A CU P2015000083A CU 20150083 A CU20150083 A CU 20150083A CU 24288 B1 CU24288 B1 CU 24288B1
Authority
CU
Cuba
Prior art keywords
influenza
fusion protein
against influenza
vaccine
polivalent
Prior art date
Application number
CUP2015000083A
Other languages
English (en)
Other versions
CU20150083A7 (es
Inventor
Ilya Vladimirovich Dukhovlinov
Oleg Ivanovich Kiselev
Anton Iosifovich Orlov
Ljudmila Markovna Tsybalova
Original Assignee
Universal Biosystems Ltd Company (Ubs Ltd)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universal Biosystems Ltd Company (Ubs Ltd) filed Critical Universal Biosystems Ltd Company (Ubs Ltd)
Publication of CU20150083A7 publication Critical patent/CU20150083A7/es
Publication of CU24288B1 publication Critical patent/CU24288B1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55544—Bacterial toxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16211—Influenzavirus B, i.e. influenza B virus
    • C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

<p>El problema a resolver es la ausencia de una vacuna universal eficiente y segura contra la influenza. Se proporciona la vacuna basada en la proteína de fusión que consiste en determinantes antígénicos de hemaglutininas de los virus de influenza A y B y fragmentos de flagelina que funcionan como adyuvante seguro (sec. con núm. de ident.: 1) unidos por medio de bisagras flexibles la que puede usarse para la profilaxis de la influenza causada por cepas de influenza A y B existentes así como también por posibles recombinantes. Se ha demostrado la seguridad, la eficacia, la polivalencia y el efecto preventivo. El uso de la presente vacuna permitirá proporcionar protección universal contra la influenza.</p>
CUP2015000083A 2013-02-15 2014-02-14 Vacuna polivalente de proteína de fusión contra la influenza CU24288B1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2013107777/10A RU2531235C2 (ru) 2013-02-15 2013-02-15 Поливалентная вакцина против гриппа на основе гибридного белка
PCT/RU2014/000096 WO2014126510A2 (en) 2013-02-15 2014-02-14 Polyvalent fusion protein vaccine against influenza

Publications (2)

Publication Number Publication Date
CU20150083A7 CU20150083A7 (es) 2016-07-29
CU24288B1 true CU24288B1 (es) 2017-12-08

Family

ID=51354649

Family Applications (1)

Application Number Title Priority Date Filing Date
CUP2015000083A CU24288B1 (es) 2013-02-15 2014-02-14 Vacuna polivalente de proteína de fusión contra la influenza

Country Status (11)

Country Link
US (1) US9480737B2 (es)
EP (1) EP2956168B8 (es)
CN (1) CN104994871B (es)
CU (1) CU24288B1 (es)
EA (1) EA027463B1 (es)
HK (1) HK1216499A1 (es)
MX (1) MX362420B (es)
NI (1) NI201500109A (es)
RU (1) RU2531235C2 (es)
UA (1) UA115895C2 (es)
WO (1) WO2014126510A2 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2757013C2 (ru) * 2017-12-19 2021-10-08 Федеральное государственное бюджетное учреждение "Научно-исследовательский институт гриппа имени А.А. Смородинцева" Министерства здравоохранения Российской Федерации Рекомбинантная противогриппозная вакцина с широким спектром защиты и способ ее получения
IL305911B1 (en) 2018-03-19 2024-09-01 Novavax Inc Multifunctional nanoparticle vaccines for influenza

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL127331A0 (en) * 1998-11-30 1999-09-22 Yeda Res & Dev Peptide-based vaccine for influenza
CN101394864A (zh) * 2006-03-07 2009-03-25 法克斯因内特公司 包含血细胞凝集素的组合物、制造其的方法与使用其的方法
JP2009540801A (ja) 2006-06-16 2009-11-26 ダウ・アグロサイエンス・エル・エル・シー トリインフルエンザ赤血球凝集素の新規なｄｎａ配列、ベクターおよびタンパク質
RU2358981C2 (ru) * 2007-08-07 2009-06-20 Центр "Биоинженерия" Российской Академии Наук Универсальная вакцина против вируса гриппа птиц
RU2008139004A (ru) 2008-10-01 2010-04-10 Биологический факультет Московского государственного университета им. М.В. Ломоносова (RU) Ген вакцинного искусственного белка, продуцирующий в растениях рекомбинантную мультиэпитопную вакцину на базе гемагглютинина вируса гриппа птиц
CN101450209B (zh) 2008-12-31 2012-01-25 中国人民解放军军事医学科学院微生物流行病研究所 透皮免疫流感多价疫苗的制备及其方法
JP2009102416A (ja) 2009-02-04 2009-05-14 Protein Sciences インフルエンザ血球凝集素多価ワクチンの製造方法
CN101524538A (zh) 2009-03-26 2009-09-09 成都康华生物制品有限公司 一种流感-大流行流感二价联合疫苗及其制备方法
JP2012521786A (ja) * 2009-03-30 2012-09-20 モウント シナイ スクール オフ メディシネ インフルエンザウイルスワクチン及びその使用
CN101732711A (zh) 2009-12-31 2010-06-16 中国人民解放军军事医学科学院微生物流行病研究所 一种喷鼻免疫流感五价或多价灭活疫苗的制备及其应用
US8513006B2 (en) * 2010-09-14 2013-08-20 University of Pittsburgh—of the Commonwealth System of Higher Education Tetravalent influenza vaccine and use thereof

Also Published As

Publication number Publication date
CN104994871A (zh) 2015-10-21
MX362420B (es) 2019-01-14
HK1216499A1 (zh) 2016-11-18
NI201500109A (es) 2015-10-27
EP2956168A2 (en) 2015-12-23
CU20150083A7 (es) 2016-07-29
US9480737B2 (en) 2016-11-01
MX2015010623A (es) 2015-12-15
WO2014126510A3 (en) 2014-10-16
US20150374814A1 (en) 2015-12-31
RU2531235C2 (ru) 2014-10-20
WO2014126510A2 (en) 2014-08-21
EP2956168A4 (en) 2016-09-14
EA201500770A1 (ru) 2015-12-30
CN104994871B (zh) 2018-01-26
RU2013107777A (ru) 2014-08-20
EA027463B1 (ru) 2017-07-31
EP2956168B1 (en) 2018-07-25
EP2956168B8 (en) 2019-01-23
UA115895C2 (uk) 2018-01-10

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