CS80392A3 - Mixed diamides of pyridine-2,4- and -2,5-dicarboxylic acids, process oftheir preparation, their use as well as medicaments based thereon - Google Patents

Mixed diamides of pyridine-2,4- and -2,5-dicarboxylic acids, process oftheir preparation, their use as well as medicaments based thereon

Info

Publication number
CS80392A3
CS80392A3 CS92803A CS80392A CS80392A3 CS 80392 A3 CS80392 A3 CS 80392A3 CS 92803 A CS92803 A CS 92803A CS 80392 A CS80392 A CS 80392A CS 80392 A3 CS80392 A3 CS 80392A3
Authority
CS
Czechoslovakia
Prior art keywords
pyridine
oftheir
preparation
well
dicarboxylic acids
Prior art date
Application number
CS92803A
Other languages
Czech (cs)
Inventor
Ekkehard Dr Baader
Martin Dr Bickel
Volkmar Dr Gunzler-Pukall
Manfred Dr Volz
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of CS80392A3 publication Critical patent/CS80392A3/en
Publication of CZ282298B6 publication Critical patent/CZ282298B6/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Hydrogenated Pyridines (AREA)
  • Indole Compounds (AREA)

Abstract

The invention relates to mixed pyridine-2,4- and -2,5-dicarboxylic acid diamides, the carboxylic acid amide group in position 2 being a primary acid amide. The said compounds are suitable for the inhibition of proline hydroxylase and lysine hydroxylase and are used as fibrosuppressants and immunosuppressants.
CS92803A 1991-03-18 1992-03-17 Diamides of pyridine-2,4- and -2,5-dicarboxylic acids, process of their preparation and pharmaceutical composition based thereon CZ282298B6 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4108824 1991-03-18

Publications (2)

Publication Number Publication Date
CS80392A3 true CS80392A3 (en) 1992-10-14
CZ282298B6 CZ282298B6 (en) 1997-06-11

Family

ID=6427597

Country Status (22)

Country Link
EP (1) EP0504799B1 (en)
JP (1) JP3121428B2 (en)
KR (1) KR100243959B1 (en)
AT (1) ATE154929T1 (en)
AU (1) AU645668B2 (en)
CA (1) CA2063177A1 (en)
CZ (1) CZ282298B6 (en)
DE (1) DE59208651D1 (en)
DK (1) DK0504799T3 (en)
ES (1) ES2104758T3 (en)
FI (1) FI101701B (en)
GR (1) GR3024309T3 (en)
HR (1) HRP940835A2 (en)
HU (1) HU217809B (en)
IE (1) IE920843A1 (en)
IL (1) IL101257A (en)
MX (1) MX9201156A (en)
NO (1) NO178859C (en)
NZ (1) NZ241968A (en)
TW (1) TW199147B (en)
YU (1) YU48156B (en)
ZA (1) ZA921945B (en)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3703959A1 (en) * 1987-02-10 1988-08-18 Hoechst Ag PYRIDINE-2,4- AND 2,5-DICARBONIC ACID AMIDES, METHOD FOR THE PRODUCTION THEREOF, USE OF THE SAME AND MEDICINAL PRODUCTS BASED ON THESE COMPOUNDS
ATE113036T1 (en) * 1988-08-04 1994-11-15 Hoechst Ag IMPROVED PROCESS FOR THE PRODUCTION OF N,N-BIS(ALKOXYALKYL)-PYRIDINE-2,4-DICARBONIC DIAMIDES.
DE3924093A1 (en) * 1989-07-20 1991-02-07 Hoechst Ag N, N'-BIS (ALKOXY-ALKYL) -PYRIDINE-2,4-DICARBONESAUREDIAMIDES, METHOD FOR THE PRODUCTION AND USE THEREOF
DE3928144A1 (en) * 1989-08-25 1991-02-28 Hoechst Ag CYCLIC PYRIDINE-2,4- AND -2,5-DICARBONIC ACIDEDIAMIDES, METHOD FOR THE PRODUCTION AND USE THEREOF
DE3938805A1 (en) * 1989-11-23 1991-05-29 Hoechst Ag PYRIDINE-2,4- AND 2,5-DICARBONIC ACID DIAMOND, METHOD FOR THE PRODUCTION AND USE THEREOF
DE4030999A1 (en) * 1990-10-01 1992-04-09 Hoechst Ag 4- OR 5-SUBSTITUTED PYRIDINE-2-CARBONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A MEDICINAL PRODUCT

Also Published As

Publication number Publication date
JP3121428B2 (en) 2000-12-25
DK0504799T3 (en) 1998-02-02
KR920018051A (en) 1992-10-21
IE920843A1 (en) 1992-09-23
CA2063177A1 (en) 1992-09-19
EP0504799A1 (en) 1992-09-23
NO921025L (en) 1992-09-21
AU645668B2 (en) 1994-01-20
FI921119L (en) 1992-09-19
IL101257A (en) 1998-03-10
HU217809B (en) 2000-04-28
HU9200891D0 (en) 1992-05-28
FI921119A0 (en) 1992-03-16
YU24692A (en) 1994-06-24
JPH0586032A (en) 1993-04-06
MX9201156A (en) 1992-10-01
CZ282298B6 (en) 1997-06-11
NO178859B (en) 1996-03-11
TW199147B (en) 1993-02-01
HRP940835A2 (en) 1997-06-30
FI101701B1 (en) 1998-08-14
HUT62565A (en) 1993-05-28
ATE154929T1 (en) 1997-07-15
DE59208651D1 (en) 1997-08-07
ES2104758T3 (en) 1997-10-16
YU48156B (en) 1997-05-28
EP0504799B1 (en) 1997-07-02
IL101257A0 (en) 1992-11-15
NZ241968A (en) 1994-04-27
GR3024309T3 (en) 1997-10-31
FI101701B (en) 1998-08-14
KR100243959B1 (en) 2000-03-02
NO921025D0 (en) 1992-03-17
ZA921945B (en) 1992-11-25
AU1296792A (en) 1992-09-24
NO178859C (en) 1996-06-19

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Legal Events

Date Code Title Description
IF00 In force as of 2000-06-30 in czech republic