CS801886A2 - Method of substituted imidazopyrrole,-pyridine and-azepine derivatives production - Google Patents
Method of substituted imidazopyrrole,-pyridine and-azepine derivatives productionInfo
- Publication number
- CS801886A2 CS801886A2 CS868018A CS801886A CS801886A2 CS 801886 A2 CS801886 A2 CS 801886A2 CS 868018 A CS868018 A CS 868018A CS 801886 A CS801886 A CS 801886A CS 801886 A2 CS801886 A2 CS 801886A2
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- opt
- alkyl
- substd
- alkoxy
- etherified
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
(A) Bicyclic imidazole derivs. of formula (Ia)-(Ic) and their salts are new. R1=H; alkyl opt. substd. by alkanoyl, NH2, mono- or dialkylamino, SO3H, COOH, alkoxycarbonyl, CONH2 or CN; 2-7C alkyl substd. by OH, alkoxy, halogen or alkanoyloxy; NO2, alkoxy, alkanoyl alkanoyloxy, phenylsulphonyloxy, alkylsulphonyloxy, alkylthio, alkylsulphinyl, alkylsulphonyl, alkanoylthio, NH2, mono- or dialkylamino, alkylenamino, morpholino, thiomorpholino, 1-piperazinyl, 4-alkyl-1-piperazinyl, trialkylammonio, SO3H, alkoxy sulphonyl, SO2NH2, mono- or dialkylsulphamoyl; iminomethyl opt. N-substd. by OH, alkoxy, alkanoyloxy, alkyl, phenyl or NH2; 2-7C alkanoyl or benzoyl; R2=H, alkyl, phenylalkyl, carboxyalkyl, alkoxycarbonylalkyl, halogen, OH, alkoxy, alkanoyloxy, SH, alkylthio, phenylalkylthio, phenylthio, alkanoylthio, COOH, alkoxycarbonyl or alkanoyl; R'1=R1, CH2OH, alkoxymethyl, halomethyl, alkanoyloxymethyl, halogen, OH, SH, CHO, COOH, alkoxycarbonyl, CONH2, mono- or dialkylcarbamoyl, CN, 5-tetrazolyl, 4,5-dihydro-2-oxazolyl (opt. substd. by alkyl) or CONHOH, n=0-4; R''1 =R1 or may be R'1 when n=0, 1, 3 or 4 or when n=2 and R2=phenyl alkyl, carboxyalkyl, alkoxycarbonylalkyl, alkanoyloxy, SH, alkylthio, phenylalkylthio, phenylthio, alkanoylthio, COOH, alkoxycarbonyl or alkanoyl; all alkyl, alkoxy and alkanoyl gps. are 'lower' unless otherwise stated; all phenyl gps. are opt. substd. by alkyl, alkoxy or halogen. - (B) The use of cpds. (Ia, R1=R, R2=R') (Ib: R'1=R, R2=R') and (Ic; R''1=R1, R2=R') for prepn. of medicaments for treating diseases responding to aromatase inhibition is claimed, where: R= H, opt. substd. alkyl, NO2, halogen, opt. etherified or esterified OH, opt. etherified, oxidised-etherified or esterified SH, NH2, mono- or disubstd. amino, ammonio, opt. functionally modified SO3H, COOH or CHO or 2-20C acyl; R'=H, opt. substd. alkyl, halogen, opt. etherified or esterified OH, opt. etherified, oxidised-etherified or esterified SH, opt. functionally modi
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CS868018A CS268684B2 (en) | 1984-06-20 | 1986-11-05 | Method of substituted imidazopyrrole,-pyridine and-azepine derivatives production |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/622,421 US4617307A (en) | 1984-06-20 | 1984-06-20 | Substituted imidazo[1,5-A]pyridine derivatives as aromatase inhibitors |
CS854449A CS268672B2 (en) | 1984-06-20 | 1985-06-18 | Method of substituted imidazo-(1,5-a)pyridine derivatives production |
CS868018A CS268684B2 (en) | 1984-06-20 | 1986-11-05 | Method of substituted imidazopyrrole,-pyridine and-azepine derivatives production |
Publications (2)
Publication Number | Publication Date |
---|---|
CS801886A2 true CS801886A2 (en) | 1989-07-12 |
CS268684B2 CS268684B2 (en) | 1990-04-11 |
Family
ID=25745999
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CS868018A CS268684B2 (en) | 1984-06-20 | 1986-11-05 | Method of substituted imidazopyrrole,-pyridine and-azepine derivatives production |
CS868019A CS268685B2 (en) | 1984-06-20 | 1986-11-05 | Method of substituted imidazopyrrole,-pyridine and-azepine derivatives production |
CS868021A CS268687B2 (en) | 1984-06-20 | 1986-11-05 | Method of substituted imidazopyridine derivatives production |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CS868019A CS268685B2 (en) | 1984-06-20 | 1986-11-05 | Method of substituted imidazopyrrole,-pyridine and-azepine derivatives production |
CS868021A CS268687B2 (en) | 1984-06-20 | 1986-11-05 | Method of substituted imidazopyridine derivatives production |
Country Status (1)
Country | Link |
---|---|
CS (3) | CS268684B2 (en) |
-
1986
- 1986-11-05 CS CS868018A patent/CS268684B2/en not_active IP Right Cessation
- 1986-11-05 CS CS868019A patent/CS268685B2/en not_active IP Right Cessation
- 1986-11-05 CS CS868021A patent/CS268687B2/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CS268687B2 (en) | 1990-04-11 |
CS802186A2 (en) | 1989-07-12 |
CS801986A2 (en) | 1989-07-12 |
CS268685B2 (en) | 1990-04-11 |
CS268684B2 (en) | 1990-04-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK4A | Patent expired |
Effective date: 20000618 |