CS801986A2 - Method of substituted imidazopyrrole,-pyridine and-azepine derivatives production - Google Patents

Method of substituted imidazopyrrole,-pyridine and-azepine derivatives production

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Publication number
CS801986A2
CS801986A2 CS868019A CS801986A CS801986A2 CS 801986 A2 CS801986 A2 CS 801986A2 CS 868019 A CS868019 A CS 868019A CS 801986 A CS801986 A CS 801986A CS 801986 A2 CS801986 A2 CS 801986A2
Authority
CS
Czechoslovakia
Prior art keywords
opt
alkyl
substd
alkoxy
etherified
Prior art date
Application number
CS868019A
Other languages
Czech (cs)
Other versions
CS268685B2 (en
Inventor
Leslie J Dr Browne
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/622,421 external-priority patent/US4617307A/en
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Priority to CS868019A priority Critical patent/CS268685B2/en
Publication of CS801986A2 publication Critical patent/CS801986A2/en
Publication of CS268685B2 publication Critical patent/CS268685B2/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

(A) Bicyclic imidazole derivs. of formula (Ia)-(Ic) and their salts are new. R1=H; alkyl opt. substd. by alkanoyl, NH2, mono- or dialkylamino, SO3H, COOH, alkoxycarbonyl, CONH2 or CN; 2-7C alkyl substd. by OH, alkoxy, halogen or alkanoyloxy; NO2, alkoxy, alkanoyl alkanoyloxy, phenylsulphonyloxy, alkylsulphonyloxy, alkylthio, alkylsulphinyl, alkylsulphonyl, alkanoylthio, NH2, mono- or dialkylamino, alkylenamino, morpholino, thiomorpholino, 1-piperazinyl, 4-alkyl-1-piperazinyl, trialkylammonio, SO3H, alkoxy sulphonyl, SO2NH2, mono- or dialkylsulphamoyl; iminomethyl opt. N-substd. by OH, alkoxy, alkanoyloxy, alkyl, phenyl or NH2; 2-7C alkanoyl or benzoyl; R2=H, alkyl, phenylalkyl, carboxyalkyl, alkoxycarbonylalkyl, halogen, OH, alkoxy, alkanoyloxy, SH, alkylthio, phenylalkylthio, phenylthio, alkanoylthio, COOH, alkoxycarbonyl or alkanoyl; R'1=R1, CH2OH, alkoxymethyl, halomethyl, alkanoyloxymethyl, halogen, OH, SH, CHO, COOH, alkoxycarbonyl, CONH2, mono- or dialkylcarbamoyl, CN, 5-tetrazolyl, 4,5-dihydro-2-oxazolyl (opt. substd. by alkyl) or CONHOH, n=0-4; R''1 =R1 or may be R'1 when n=0, 1, 3 or 4 or when n=2 and R2=phenyl alkyl, carboxyalkyl, alkoxycarbonylalkyl, alkanoyloxy, SH, alkylthio, phenylalkylthio, phenylthio, alkanoylthio, COOH, alkoxycarbonyl or alkanoyl; all alkyl, alkoxy and alkanoyl gps. are 'lower' unless otherwise stated; all phenyl gps. are opt. substd. by alkyl, alkoxy or halogen. - (B) The use of cpds. (Ia, R1=R, R2=R') (Ib: R'1=R, R2=R') and (Ic; R''1=R1, R2=R') for prepn. of medicaments for treating diseases responding to aromatase inhibition is claimed, where: R= H, opt. substd. alkyl, NO2, halogen, opt. etherified or esterified OH, opt. etherified, oxidised-etherified or esterified SH, NH2, mono- or disubstd. amino, ammonio, opt. functionally modified SO3H, COOH or CHO or 2-20C acyl; R'=H, opt. substd. alkyl, halogen, opt. etherified or esterified OH, opt. etherified, oxidised-etherified or esterified SH, opt. functionally modi
CS868019A 1984-06-20 1986-11-05 Method of substituted imidazopyrrole,-pyridine and-azepine derivatives production CS268685B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CS868019A CS268685B2 (en) 1984-06-20 1986-11-05 Method of substituted imidazopyrrole,-pyridine and-azepine derivatives production

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US06/622,421 US4617307A (en) 1984-06-20 1984-06-20 Substituted imidazo[1,5-A]pyridine derivatives as aromatase inhibitors
CS854449A CS268672B2 (en) 1984-06-20 1985-06-18 Method of substituted imidazo-(1,5-a)pyridine derivatives production
CS868019A CS268685B2 (en) 1984-06-20 1986-11-05 Method of substituted imidazopyrrole,-pyridine and-azepine derivatives production

Publications (2)

Publication Number Publication Date
CS801986A2 true CS801986A2 (en) 1989-07-12
CS268685B2 CS268685B2 (en) 1990-04-11

Family

ID=25745999

Family Applications (3)

Application Number Title Priority Date Filing Date
CS868018A CS268684B2 (en) 1984-06-20 1986-11-05 Method of substituted imidazopyrrole,-pyridine and-azepine derivatives production
CS868019A CS268685B2 (en) 1984-06-20 1986-11-05 Method of substituted imidazopyrrole,-pyridine and-azepine derivatives production
CS868021A CS268687B2 (en) 1984-06-20 1986-11-05 Method of substituted imidazopyridine derivatives production

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CS868018A CS268684B2 (en) 1984-06-20 1986-11-05 Method of substituted imidazopyrrole,-pyridine and-azepine derivatives production

Family Applications After (1)

Application Number Title Priority Date Filing Date
CS868021A CS268687B2 (en) 1984-06-20 1986-11-05 Method of substituted imidazopyridine derivatives production

Country Status (1)

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CS (3) CS268684B2 (en)

Also Published As

Publication number Publication date
CS268684B2 (en) 1990-04-11
CS802186A2 (en) 1989-07-12
CS801886A2 (en) 1989-07-12
CS268687B2 (en) 1990-04-11
CS268685B2 (en) 1990-04-11

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MK4A Patent expired

Effective date: 20000618