CS382491A3 - N-oxides of alpha, alpha-diaryl-4-aryl-4-hydroxy-1-piepridinebutaneamides, process of their preparation and pharmaceuticals based thereon - Google Patents

N-oxides of alpha, alpha-diaryl-4-aryl-4-hydroxy-1-piepridinebutaneamides, process of their preparation and pharmaceuticals based thereon

Info

Publication number
CS382491A3
CS382491A3 CS913824A CS382491A CS382491A3 CS 382491 A3 CS382491 A3 CS 382491A3 CS 913824 A CS913824 A CS 913824A CS 382491 A CS382491 A CS 382491A CS 382491 A3 CS382491 A3 CS 382491A3
Authority
CS
Czechoslovakia
Prior art keywords
alpha
piepridinebutaneamides
diaryl
oxides
aryl
Prior art date
Application number
CS913824A
Other languages
English (en)
Inventor
Lourens Wals
Ludwig P Cooymans
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of CS382491A3 publication Critical patent/CS382491A3/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/94—Oxygen atom, e.g. piperidine N-oxide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
CS913824A 1985-10-11 1991-12-16 N-oxides of alpha, alpha-diaryl-4-aryl-4-hydroxy-1-piepridinebutaneamides, process of their preparation and pharmaceuticals based thereon CS382491A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78656685A 1985-10-11 1985-10-11
US06/888,606 US4824853A (en) 1985-10-11 1986-07-23 α,α-diaryl-4-aryl-4-hydroxy-1-piperidinebutanamide, N-oxides and method of treating diarrhea

Publications (1)

Publication Number Publication Date
CS382491A3 true CS382491A3 (en) 1992-04-15

Family

ID=27120554

Family Applications (1)

Application Number Title Priority Date Filing Date
CS913824A CS382491A3 (en) 1985-10-11 1991-12-16 N-oxides of alpha, alpha-diaryl-4-aryl-4-hydroxy-1-piepridinebutaneamides, process of their preparation and pharmaceuticals based thereon

Country Status (2)

Country Link
US (2) US4824853A (cs)
CS (1) CS382491A3 (cs)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2711759B2 (ja) * 1990-10-24 1998-02-10 エスエス製薬 株式会社 止瀉剤組成物
US5962477A (en) * 1994-04-12 1999-10-05 Adolor Corporation Screening methods for cytokine inhibitors
US6190691B1 (en) 1994-04-12 2001-02-20 Adolor Corporation Methods for treating inflammatory conditions
US6573282B1 (en) 1995-09-12 2003-06-03 Adolor Corporation Peripherally active anti-hyperalgesic opiates
US5849761A (en) * 1995-09-12 1998-12-15 Regents Of The University Of California Peripherally active anti-hyperalgesic opiates
US6353004B1 (en) * 1997-07-14 2002-03-05 Adolor Coporation Peripherally acting anti-pruritic opiates
US5849762A (en) * 1997-07-14 1998-12-15 Adolor Corporation Peripherally acting anti-pruritic opiates
US20030158220A1 (en) * 1997-11-03 2003-08-21 Foss Joseph F. Use of methylnaltrexone and related compounds to treat chronic opioid use side effects
CA2811272C (en) 2003-04-08 2016-12-20 Progenics Pharmaceuticals, Inc. Pharmaceutical formulations containing methylnaltrexone
US20050040310A1 (en) * 2003-08-18 2005-02-24 Beard George Andrew Highly absorbent durable coaster
AR057325A1 (es) 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
AR057035A1 (es) 2005-05-25 2007-11-14 Progenics Pharm Inc SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
EP1749528A1 (en) 2005-08-05 2007-02-07 Pharma C S.A. Pharmaceutical combinations containing a mu opioid agonist and an inhibitor of NO production
TWI489984B (zh) 2006-08-04 2015-07-01 Wyeth Corp 用於非經腸道傳輸化合物之配方及其用途
TW200817048A (en) * 2006-09-08 2008-04-16 Wyeth Corp Dry powder compound formulations and uses thereof
JP2010522756A (ja) * 2007-03-29 2010-07-08 プロジェニックス ファーマシューティカルズ，インコーポレーテッド 結晶形およびその使用
EP2565195B1 (en) * 2007-03-29 2015-05-06 Wyeth LLC Peripheral opioid receptor and antagonists and uses thereof
PL2137191T3 (pl) * 2007-03-29 2016-12-30 Antagoniści obwodowego receptora opioidowego i ich zastosowania
AU2008349873B2 (en) 2008-02-06 2014-02-13 Progenics Pharmaceuticals, Inc. Preparation and use of (R),(R)-2,2'-bis-methylnaltrexone
CN102123624B (zh) * 2008-07-06 2014-04-02 阿什尔·鲍姆 在衣物产品上提供可变化设计项目的方法及系统
CA2676881C (en) 2008-09-30 2017-04-25 Wyeth Peripheral opioid receptor antagonists and uses thereof
US20100144657A1 (en) * 2008-12-09 2010-06-10 Auspex Pharmaceuticals, Inc. PHENYLPIPERIDINE MODULATORS OF mu-OPIOID RECEPTORS

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1356118A (en) * 1970-12-16 1974-06-12 Searle & Co 1-3-cyano-3,3-diphenylpropyl-4-phenylpiperidine-4-carboxylic acid derivatives
US3714159A (en) * 1971-03-30 1973-01-30 Janssen Pharmaceutica Nv 2,2-diaryl-4-(4'-aryl-4'-hydroxy-piper-idino)-butyramides
US3892776A (en) * 1974-03-08 1975-07-01 Richardson Merrell Inc N-oxides of bis-basic tricyclic ethers
US4086345A (en) * 1976-03-31 1978-04-25 Istituto Chemioterapico Italiano Product and method for combatting swine dysentery
US4277605A (en) * 1980-03-07 1981-07-07 Bristol-Myers Company Chemical compounds
US4306069A (en) * 1980-06-19 1981-12-15 Mead Johnson & Company Encainide N-oxide

Also Published As

Publication number Publication date
US4898873A (en) 1990-02-06
US4824853A (en) 1989-04-25

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Legal Events

Date Code Title Description
PD00 Pending as of 2000-06-30 in czech republic