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Priority claimed from US06/039,539external-prioritypatent/US4244951A/en
Application filed by PfizerfiledCriticalPfizer
Publication of CS286680A3publicationCriticalpatent/CS286680A3/en
Publication of CS276966B6publicationCriticalpatent/CS276966B6/en
Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
Esters of formula (I) and their salts are new R is H or R1; R1 is a carboxylic acyl gp. Intermediates of formula (V) are also new. (I;R=R1) are hydrolysed in vivo to form penicillanic acid, 1,1-dioxide (II) and the corresp. penicillin (III) and (II) acts as a beta-lactamase inhibitor which potentiates the antibacterial activity of (III), e.g. against S. aureus or E. coli (depending on the nature of R1). (I; R=H) is an intermediate for (I; R = R1). (I) where R is 2-phenylacetyl, 2-phenoxyacetyl, 2-amino-2-phenylacetyl or 2-amino-2-(4-hydroxyphenyl)acetyl is specifically claimed.
CS812866A1979-05-161980-05-08Process for preparing bis-esters of methane diol with 6'-acylaminopenicillanic acid and penicillanic acid 1,1-dioxide
CS276966B6
(en)
Process for the preparation of novel therapeutically useful 8-vinyl and 8-ethynylquinolone carboxylic acid derivatives and intermediates useful in the process
INTERMEDIATES FOR THE PREPARATION OF 5R, 65-6- (1R-1-HYDROXYTHYL) -2- (1-OXO-3-THIOLANYLTIO-2-PENEM-3-CARBOXYLIC ACIDS AND PROCEDURES FOR THE PRODUCTION OF INTERMEDIATE PRODUCTS.