FR2081378A1 - 6-isothiocyanato-penicillanic acid - Google Patents

6-isothiocyanato-penicillanic acid

Info

Publication number
FR2081378A1
FR2081378A1 FR7045660A FR7045660A FR2081378A1 FR 2081378 A1 FR2081378 A1 FR 2081378A1 FR 7045660 A FR7045660 A FR 7045660A FR 7045660 A FR7045660 A FR 7045660A FR 2081378 A1 FR2081378 A1 FR 2081378A1
Authority
FR
France
Prior art keywords
isothiocyanato
penicillanic acid
group
ester
readily
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7045660A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM Delft BV
Original Assignee
Koninklijke Nederlandsche Gist en Spiritusfabriek BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninklijke Nederlandsche Gist en Spiritusfabriek BV filed Critical Koninklijke Nederlandsche Gist en Spiritusfabriek BV
Publication of FR2081378A1 publication Critical patent/FR2081378A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

6-Isothiocyanato-penicillanic acid Title compd. and its readily cleavable esters and amine, ammonium and alkali (ne earth) salts are prepd. by reacting a penicillin of formula (I) (where E' is a readily removable ester group such as a silyl, phenacyl or benz(hydr)yl group and W is H or E') with CSCl2 and optionally converting the product into the free acid or an ester or salt thereof. The products are intermediates for a wide variety of new and known therapeutically active thio-penicillins, many of which are claimed.
FR7045660A 1969-12-18 1970-12-17 6-isothiocyanato-penicillanic acid Withdrawn FR2081378A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB6184069 1969-12-18

Publications (1)

Publication Number Publication Date
FR2081378A1 true FR2081378A1 (en) 1971-12-03

Family

ID=10487530

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7045660A Withdrawn FR2081378A1 (en) 1969-12-18 1970-12-17 6-isothiocyanato-penicillanic acid

Country Status (3)

Country Link
DE (1) DE2062297A1 (en)
FR (1) FR2081378A1 (en)
NL (1) NL7018386A (en)

Also Published As

Publication number Publication date
NL7018386A (en) 1971-06-22
DE2062297A1 (en) 1971-06-24

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Legal Events

Date Code Title Description
ST Notification of lapse