CS261853B2 - Method of aminoglycoside antibiotic's selectively acylated n-protected derivative production - Google Patents

Method of aminoglycoside antibiotic's selectively acylated n-protected derivative production Download PDF

Info

Publication number
CS261853B2
CS261853B2 CS797711A CS771179A CS261853B2 CS 261853 B2 CS261853 B2 CS 261853B2 CS 797711 A CS797711 A CS 797711A CS 771179 A CS771179 A CS 771179A CS 261853 B2 CS261853 B2 CS 261853B2
Authority
CS
Czechoslovakia
Prior art keywords
amino
hydrogen
formula
zinc
hydroxy
Prior art date
Application number
CS797711A
Other languages
Czech (cs)
English (en)
Other versions
CS771179A2 (en
Inventor
Hamao Umezawa
Sumio Umezawa
Tsutomu Tsuchiya
Yasushi Takagi
Tomo Jikihara
Original Assignee
Microbial Chem Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chem Res Found filed Critical Microbial Chem Res Found
Priority to CS829399A priority Critical patent/CS261859B2/cs
Publication of CS771179A2 publication Critical patent/CS771179A2/cs
Publication of CS261853B2 publication Critical patent/CS261853B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
CS797711A 1978-11-11 1979-11-12 Method of aminoglycoside antibiotic's selectively acylated n-protected derivative production CS261853B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CS829399A CS261859B2 (cs) 1978-11-11 1982-12-20 Způsob přípravy selektivně chráněného N-acylovaného derivátu aminoglykosidového antibiotika

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13840278A JPS5564598A (en) 1978-11-11 1978-11-11 Preparation of aminoglycoside antibiotic having selectively protected amino group

Publications (2)

Publication Number Publication Date
CS771179A2 CS771179A2 (en) 1988-06-15
CS261853B2 true CS261853B2 (en) 1989-02-10

Family

ID=15221109

Family Applications (1)

Application Number Title Priority Date Filing Date
CS797711A CS261853B2 (en) 1978-11-11 1979-11-12 Method of aminoglycoside antibiotic's selectively acylated n-protected derivative production

Country Status (5)

Country Link
JP (1) JPS5564598A (fr)
BE (1) BE879925A (fr)
CS (1) CS261853B2 (fr)
HU (1) HU183050B (fr)
ZA (1) ZA795691B (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4136254A (en) * 1976-06-17 1979-01-23 Schering Corporation Process of selectively blocking amino functions in aminoglycosides using transition metal salts and intermediates used thereby
ATE111917T1 (de) * 1990-03-08 1994-10-15 Opos Biochimica Srl Verfahren zur herstellung von amikacin- vorläufern.
KR100450607B1 (ko) * 2002-07-11 2004-09-30 경동제약 주식회사 가라민 유도체의 제조방법

Also Published As

Publication number Publication date
JPS5564598A (en) 1980-05-15
JPS631319B2 (fr) 1988-01-12
BE879925A (fr) 1980-03-03
CS771179A2 (en) 1988-06-15
ZA795691B (en) 1980-11-26
HU183050B (en) 1984-04-28

Similar Documents

Publication Publication Date Title
US4297485A (en) Production of a selectively protected N-acylated derivative of an aminoglycosidic antibiotic
IE45734B1 (en) Process of selectively blocking amino groups
CS202570B2 (en) Process for preparing aminoglycsidic antibiotics
CS261853B2 (en) Method of aminoglycoside antibiotic's selectively acylated n-protected derivative production
KR840001622B1 (ko) 3-0-데메틸 이스타마이신 b의 제조방법
US4547492A (en) 1-N-(ω-Amino-α-hydroxyalkanoyl-2',3'-dideoxykanamycin A and pharmaceutical composition containing same
US3872080A (en) Process for the preparation of garamine and intermediates produced thereby
US4298727A (en) 3',4'-Dideoxykanamycin A and 1-N-(S)-α-hydroxy-ω-aminoalkanoyl) derivatives thereof
JPS631954B2 (fr)
EP0546179B1 (fr) Derive de 4-0-(aminoglycosyl)-or4,6-di-0-(aminoglycosyl)-2,5 didesoxy-5,5-difluorostreptamine et production de ce derive
KR830001613B1 (ko) 아미노기를 선택적으로 보호한 아미노글리코사이드 항생물질의 제조방법
JPS6332799B2 (fr)
CA1152063A (fr) 3',4'-DIDESOXYKANAMYCINE A ET SES DERIVES 1-N-((S-.alpha.-HYDROXY-.omega.-AMINOALCANOYL)
EP0259014A2 (fr) Dérivés de la 5-déoxy-5-fluorokanamycine B et leurs procédés de préparation
CA1131628A (fr) Obtention d'un derive n-acyle protege selectivement, a partir d'un antibiotique aminoglycosidique
JP3215732B2 (ja) 耐性菌に有効なジベカシン誘導体またはアルベカシン誘導体とそれらの製造法
GB1567560A (en) Kanamycin c derivatives active against various drug-resistant bacteria
CA1175816A (fr) DERIVES 1-N-(.alpha.-HYDROXY-.omega.-AMINOALKANOYL) DES 5,3',4-TRIDESOXY-OU 5,3',4'-TRIDESOXY-6'-N-METHYL- OU 5,3',4',6"-TETRADESOXY-KANAMYCINE B ET PROCEDE DE PRODUCTION
JPS6312079B2 (fr)
GB2075010A (en) Process for the Production of 3'- Deoxykanamycin A
IE48973B1 (en) The production of a selectively protected n-acylated derivative of an aminoglycosidic antibiotic
JPS631953B2 (fr)
JPH0631296B2 (ja) ２′，３′−ジデオキシ−２′−フルオロカナマイシンａ誘導体、およびその製造法
JPS631951B2 (fr)
JPS6310959B2 (fr)