CS260571B1 - Liquid emulsion base of "oil-in-water"-type - Google Patents

Abstract

a liquid type emulsion base is milled oil in water, intended for cosmetic and / or pharmaceutical purposes, which besides hydrophobic and hydrophilic components formed for example higher fatty esters and glyoerides acids, liquid paraffin and cetyl stearyl alcohol, resp. propylene glycol, ethanol and water, including emulsifier, contains in addition, 0.4 to 0.6% phytosterol wt. as a co-emulsifier and stabilizer consistency. One or more ingredients are possible more active substances and / or preservatives and / or colorants and / or perfumes.

Description

The invention relates to an oil-in-water liquid emulsion base for cosmetic and / or pharmaceutical purposes.

As is known, cosmetic and / or pharmaceutical formulations formulated with the aid of an oil-in-water liquid emulsion base (hereinafter, for brevity o / v), commonly called milk or lotions, are popular and mass produced for their properties. Their popularity is based on properties such as good spreadability, good absorbability of fat and active substances through the skin and good water washability. After application of these preparations the user does not have an unpleasant greasy or sticky feeling on the skin. The skin has a fresh, matte appearance, does not shine.

A large number of papers dealing with liquid preparations based on O / W emulsions can be found in the literature, not only in terms of recipes and various physicochemical properties, but also in terms of suitable raw materials and components, technological processes and production equipment / T. Goldschmidt, Guide-Line Formulation, pp. 12, 1983; N.A. Harb, Cosmet.-Perfum, 89, No. 4, pp. 60-70 (1974); B. Glas et al., Zbl. Pharm. 113 (8), 871 (1974); W. Heers, SOeFW 101/3/71, 1975; S. Tsukiyama et al., J. Pharm. Soc. (Japan) 94, 471 (1974); čs. Certificate No. 179 079 /.

Although in most cases the prior art O / W emulsion formulations meet the intended purposes, there is also an attempt in the art to optimize all parameters, especially physical, especially homogeneity and stability.

Systematic research aimed at reconciling the physicochemical properties of the O / W liquid emulsions, in particular stability, yiscosity, penetration, etc., with the desired physiological properties such as resorption, tolerance, irritability, etc., has found a beneficial combination of known ingredients with the newer component, yet less used, with phytosterol / NSR pat. No. 2,623,927]. It has been found and verified that the presence of this substance positively affects the physical properties of the emulsion formed, in particular viscosity and stability, and, at the same time, surprisingly synergists with other ingredients in favor of optimum physiological skin condition.

The present invention provides an oil-in-water liquid emulsion base for cosmetic and / or pharmaceutical purposes, based on a hydrophobic component such as esters and glycerides of higher fatty acids, liquid paraffin and cetylatearyl alcohol, and hydrophilic components such as propylene glycol, ethanol and water, including emulsifier and phytosterol as co-emulsifier and consistency stabilizer, optionally with the addition of one or more active ingredients and / or preservatives and / or coloring agent and / or perfume, comprising essentially 0.4 to 0.6 wt. % ethyl ester of linoleic acid and linolenic acid, 6-8 wt. % liquid paraffin, 1.3 to 1.5 wt. % molecularly distilled monoglyceride of higher fatty acids, 1.3 to 1.7 wt. % cetyl stearyl alcohol, 4.5 to 5.5 wt. % propylene glycol, 4-6 wt. % ethanol, 1.5 to 2.0 wt. % of ethylene oxide higher fatty alcohols with 30 moles of ethylene oxide, 0.18 to 0.22 wt. % carboxyvinyl polymer neutralized with triethanolamine and 0.4 to 0.6 wt. % of phytosterol, the remainder being up to 100 wt. it comprises water and optionally a perfume additive.

Preferably, the liquid emulsion base comprises propylene glycol and phytosterol in a weight ratio of 10: 1.

Phytosterol is a mixture of refined plant sterols, isolated. most commonly from edible soybean oil, containing predominantly sitosterol (56 to 61% w / w), followed by campesterol (28 to 32% w / w) and minor amounts of stigmasterol (4 to 7% w / w). It is a yellowish waxy substance having a hydroxyl value of 110-147 and a melting point of 135-141 ° C; it is orally non-toxic and does not irritate the skin or eyes. Thus, phytosterol constitutes an important part of the liquid emulsion o / w base of the invention. A relatively small amount (about 0.5% w / w) of this component is sufficient to achieve a satisfactory stabilization of the emulsion consistency and homogeneity.

As experimentally verified, the maximum practically usable amount of phytosterol in the emulsion base of the invention is about 1.5% by weight. Higher amounts are not expedient either economically or technically, since the resulting emulsion no longer becomes stable and homogeneous.

The other components of the liquid emulsion base according to the invention are commercially available commercial products known under different trade names (the exact chemical composition is not usually mentioned by the manufacturers) used in the industrial manufacture of cosmetic and / or pharmaceutical preparations whose physiological harmlessness has been verified 3 and / or relevant standards.

Long-term tests have shown good compatibility and non-irritability of the liquid emulsion base according to the invention on human skin, as well as a good cosmetic or therapeutic effect.

Also the stability and accelerated aging tests of the emulsion base samples of the invention at temperatures of 5, 20, 35 and 40 ° C and at a relative humidity of 90% confirmed the results of selective screening tests.

The liquid emulsion base according to the invention can be applied as such, i.e. in the form of a so-called milk, for example to cleanse the skin or, according to another intended purpose, it can form an essential part of a therapeutic, medical-cosmetic or cosmetic composition.

The following examples illustrate the typical composition of the emulsion base according to the invention and illustrate several possibilities of assembling different formulations using this base without, however, limiting in any way a possible broader product range.

In all examples, the amounts of the individual components are given in percent by weight. Always use demineralized or distilled water, which is sterilized. Also, the fat components (liquid paraffin, cetyl stearyl alcohol and the like) were pre-sterilized for 1 hour at 120 ° C.

Example 1

Liquid emulsion base

Ethyl ester of linoleic and linolenic acid 0.50 Liquid paraffin 7.00 Propylene glycol 5.00 Ethanol 5.00 Ethylene oxidized higher fatty alcohols with 30 moles of ethylene oxide 1.80 Cetylstearyl alcohol 1.50 Higher fatty acid monoglyceride molecularly distilled 1.40 Carboxyvinylpolymer 0.20 Triethanolamine 0.26 Phytosterol 0.50 Perfume 0.50 Water 7.6.34

Workflow? the fat fractions with phytosterol are emulsified into the aqueous suspension of the carboxyvinyl polymer at 70 ° C and the emulsion is neutralized with a solution of triethanolamine in propylene glycol. The mixture is cooled while stirring, an ethanolic perfume solution is added at a temperature of about 40 ° C and cooled to storage temperature (below 20 ° C) with stirring.

Example 2

Regenerating lotion

Linoleic and linolenic acid ethyl ester 0,50 Pregnenolone 0,05 Paraffin liquid 7,00 Propylene glycol 5,00 Ethanol 5,00 Ethylene oxide higher fatty alcohols 1,80 with 30 mol ethylene oxide

Cetyl Stearyl Alcohol 1.50 High Fatty Acid Monoglyceride Molecular Distilled 1.40 Carboxyvinylpolymer 0.20 Triethanolamine 0.26 Phytosterol 0.50 Perfume 0.50 Water 76.29

Procedure: As in Example 1, pregnenolone is added with phytosterol and fat fractions.

Example 3

PleE milk with camomile

Linoleic and linolenic acid ethyl ester 0.40 alpha-Bisabolol 0.20 Chamomile oil 0.60 Liquid paraffin 7.00 Propylene glycol 5.00 Ethanol * 5.00 Ethylene oxide high fatty alcohols with 30 moles ethylene oxide 1.80 Chloro-stearyl alcohol 1.50 Higher monoglyceride fatty acids molecularly distilled 1.40 Carboxyvinylpolymer 0.20 Triethanolamine 0.26 Phytosterol 0.50 Water 76.14

Working procedure: as in Example 1, wherein a solution of bisabolol in ethanol is added to the emulsion at a temperature of about 40 ° C and cooled to storage temperature with stirring.

He attaches

Baby skin lotion

Ethyl ester of linoleic and linolenic acid 0,45 alpha-Bisabolol 0,15 Allantoin 0,20 Liquid paraffin 7,00 Propylene glycol 5,00 Ethanol 5,00 Ethylene oxidized higher fatty alcohols with 30 moles of ethylene oxide 1.80 Cetylstearyl alcohol 1.50 Higher fatty acid monoglyceride molecularly distilled 1.40

Carboxyvinylpolymer 0.20 Triethanolamine 0.26 Phytosterol 0.50 Perfume 0.40 Water 76.14

Workflow: as in Example 2; a solution of allantoin in water is added to the starting aqueous suspension of the carboxyvinyl polymer.

Example 5

Milk after sunbathing

Ethyl ester of linoleic and linolenic acids

Arnica extract

Witch hazel extract

Liquid paraffin

Propylene glycol

Ethanol

Ethylene oxide higher fatty alcohols with 30 moles of ethylene oxide Cetyl stearyl alcohol

Higher fatty acid monoglyceride molecularly distilled

Xarboxyviny lpolymer

Triethanolamine

Phytosterol

Perfume

Water

0.45

3.00

2.00

7.00

5.00

5.00

1.80

1.50

1.40

0.20 *

0.26

0.50

0.40

71.39

Workflow: as in Example 1; Arnica and witch hazel extract are dissolved in liquid paraffin and added to the starting aqueous suspension of the carboxyvinyl polymer.

Claims (2)

OBJECT OF THE INVENTION An oil-in-water liquid emulsion base for cosmetic and / or pharmaceutical purposes, based on a hydrophobic component, such as esters and glycerides of higher fatty acids, liquid paraffin and cetylstearyl alcohol, and hydrophilic components, such as propylene glycol, ethanol and water, including an emulsifier and phytosterol as a co-emulsifier and a consistency stabilizer, optionally with the addition of one or more active substances and / or preservatives and / or a colorant and / or a perfume, characterized in that it contains 0.4 to 0.6 wt. % ethyl ester of linoleic acid and linolenic acid, 6-8 wt. % liquid paraffin, 1.3 to 1.5 wt. % molecularly distilled higher fatty acid monoglyceride, 1.3 to 1.7 wt. % cetyl stearyl alcohol, 4.5 to 5.5 wt. % propylene glycol, 4-6 wt. % ethanol, 1.5 to 2.0 wt. % of ethylene oxide higher fatty alcohols with 30 moles of ethylene oxide, 0.18 to 0.22 wt. % carboxyvinyl polymer neutralized with triethanolamine and 0.4 to 0.6 wt. phytosterol, the remainder being up to 100 wt. it comprises water and optionally a perfume additive. 2. A liquid emulsion base as claimed in claim 1 comprising propylene glycol and phytosterol in a weight ratio of 10: 1.