CS258579B1 - (2R,SS,10aS,10bS)-5-Benzyl-3,6-dioxo-10b-hydroxy-2-karboxy-8-methoxy-2-methyl-2,3,5,6,9,10,10a,10b-oktahydro-8H-oxazolo/3,2-a/- pyrrolo/2,1-c/pyrazin a způsob jeho výroby - Google Patents

(2R,SS,10aS,10bS)-5-Benzyl-3,6-dioxo-10b-hydroxy-2-karboxy-8-methoxy-2-methyl-2,3,5,6,9,10,10a,10b-oktahydro-8H-oxazolo/3,2-a/- pyrrolo/2,1-c/pyrazin a způsob jeho výroby Download PDF

Info

Publication number
CS258579B1
CS258579B1 CS8610030A CS1003086A CS258579B1 CS 258579 B1 CS258579 B1 CS 258579B1 CS 8610030 A CS8610030 A CS 8610030A CS 1003086 A CS1003086 A CS 1003086A CS 258579 B1 CS258579 B1 CS 258579B1
Authority
CS
Czechoslovakia
Prior art keywords
benzyl
dioxo
pyrazine
hydroxy
methoxy
Prior art date
Application number
CS8610030A
Other languages
Czech (cs)
English (en)
Other versions
CS1003086A1 (en
Inventor
Jan Benes
Antonin Cerny
Original Assignee
Jan Benes
Antonin Cerny
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jan Benes, Antonin Cerny filed Critical Jan Benes
Priority to CS8610030A priority Critical patent/CS258579B1/sk
Publication of CS1003086A1 publication Critical patent/CS1003086A1/cs
Publication of CS258579B1 publication Critical patent/CS258579B1/sk

Links

Landscapes

  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Řešení se týká (2R,5S,10aS,10bS)- -5-benzyl-3,6-dioxo-10b-hydroxy-2-karboxy- -8-methoxy-2-methyl-2,3,5,6,9,10,10a,10b- -oktahydro-8H-oxazolo/3,2-a/pyrrolo/2,1-c/- pyrazinu a způsobu jeho výroby, vyznačujícího se tím, že se do reakce uvede (3S,8aS)- -3-benzyl-6-hydroxy-l,4-dioxo-l,2,3,4,6,- 7,8,8a-oktahydropyrrolo/1,2-a/pyrazin a methanol za přítomnosti katalytického množství kyseliny, načež se vzniklý 6-methoxyderivát uvede do reakce s ethylesterchloridem kyseliny (S)-2-benzyloxy- -2-methylmalonové a nestálý meziprodukt se katalytickou debenzylací a basickou hydrolysou převede na produkt. Připravená sloučenina je syntetickým prekursorem farmaceuticky využitelných látek.
CS8610030A 1986-12-28 1986-12-28 (2R,SS,10aS,10bS)-5-Benzyl-3,6-dioxo-10b-hydroxy-2-karboxy-8-methoxy-2-methyl-2,3,5,6,9,10,10a,10b-oktahydro-8H-oxazolo/3,2-a/- pyrrolo/2,1-c/pyrazin a způsob jeho výroby CS258579B1 (sk)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CS8610030A CS258579B1 (sk) 1986-12-28 1986-12-28 (2R,SS,10aS,10bS)-5-Benzyl-3,6-dioxo-10b-hydroxy-2-karboxy-8-methoxy-2-methyl-2,3,5,6,9,10,10a,10b-oktahydro-8H-oxazolo/3,2-a/- pyrrolo/2,1-c/pyrazin a způsob jeho výroby

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CS8610030A CS258579B1 (sk) 1986-12-28 1986-12-28 (2R,SS,10aS,10bS)-5-Benzyl-3,6-dioxo-10b-hydroxy-2-karboxy-8-methoxy-2-methyl-2,3,5,6,9,10,10a,10b-oktahydro-8H-oxazolo/3,2-a/- pyrrolo/2,1-c/pyrazin a způsob jeho výroby

Publications (2)

Publication Number Publication Date
CS1003086A1 CS1003086A1 (en) 1987-12-17
CS258579B1 true CS258579B1 (sk) 1988-08-16

Family

ID=5447656

Family Applications (1)

Application Number Title Priority Date Filing Date
CS8610030A CS258579B1 (sk) 1986-12-28 1986-12-28 (2R,SS,10aS,10bS)-5-Benzyl-3,6-dioxo-10b-hydroxy-2-karboxy-8-methoxy-2-methyl-2,3,5,6,9,10,10a,10b-oktahydro-8H-oxazolo/3,2-a/- pyrrolo/2,1-c/pyrazin a způsob jeho výroby

Country Status (1)

Country Link
CS (1) CS258579B1 (sk)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108467398A (zh) * 2018-05-29 2018-08-31 中国科学院烟台海岸带研究所 一种二酮哌嗪类化合物及其制备和应用

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108467398A (zh) * 2018-05-29 2018-08-31 中国科学院烟台海岸带研究所 一种二酮哌嗪类化合物及其制备和应用
CN108467398B (zh) * 2018-05-29 2020-06-23 中国科学院烟台海岸带研究所 一种二酮哌嗪类化合物及其制备和应用

Also Published As

Publication number Publication date
CS1003086A1 (en) 1987-12-17

Similar Documents

Publication Publication Date Title
SU776557A3 (ru) Способ получени оптически активных антрациклинонов
EP0109047A1 (en) Total synthesis of antitumor antibiotics
EP1280771B1 (de) Neue prodrugs von 6-hydroxy-2,3-dihydro-1h-indolen, 5-hydroxy-1,2-dihydro-3h-pyrrolo 3,2-e]indolen und 5-hydroxy-1,2-dihydro-3h-benzo e]indolen sowie von 6-hydroxy-1,2,3,4-tetrahydro-benzo f]chinolin-derivaten für eine selektive krebstherapie
EP0340064B1 (fr) Benzodiazépines, leur procédé et intermédiaires de préparation et leurs applications en thérapeutique
Tietze et al. A novel approach in drug discovery: synthesis of estrone–talaromycin natural product hybrids
US4977144A (en) Imidazo[4,5-b]pyridine derivatives as cardiovascular agents
MC1969A1 (fr) Procedes pour preparer des composes antitumoraux,formulation pharmaceutique contenant ces composes,leurs utilisations en medecine et pharmacie,et composes intermediaires pour leur preparation
US3652569A (en) Ergonine ergoptine and the 1-methyl and 9 10-dihydro derivatives thereof
SU910118A3 (ru) Способ получени N @ -глюкофуранозид-6-ил-N @ -нитрозомочевины
EP1042326B1 (fr) Nouveaux derives de l'acronycine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
Tadano et al. Synthesis of (-)-8a-epi-swainsonine,(1S, 2R, 8R, 8aS)-octahydro-1, 2, 8-indolizinetriol.
JPS63303991A (ja) エピポドフイロトキシングルコシドの窒素含有誘導体
CN112441982A (zh) 一种盐酸咪达唑仑糖浆杂质a和杂质b及其用途
Maekawa et al. meta-Substituent effects on the photocyclization of aryl-substituted N-acyl-α-dehydroalanine derivatives
Rao et al. A new route to annelated dihydrofurofurans. Synthesis of 6, 8-dideoxyversicolorin A
KR820000419B1 (ko) 니트로소-우레아 유도체의 제조방법
KR20000010893A (ko) 마피아 포에티다(mappia foetida)에서 분리한캄토테신골격화합물 및 이들의 신규한 치료제 및 의약품기질로서의 용도
GB2036744A (en) Eburnane derivatives
US4474967A (en) 8-Deutero and 8-tritio-substituted derivatives of D-4S-6-fluoro-spiro-[chroman-4,4'-imidazolidine]-2',5'-dione
Jung et al. Synthesis of fully functionalized intermediates for the bottom half of the 4-acyloxymethyl milbemycin antibiotics (1)
Kalaus et al. Synthesis of Vinca alkaloids and related compounds. 37. Some new reactions of (.+-.)-C-norquebrachamine and its derivatives
Marquez et al. 1, 3-Diazepinones. 1. Synthesis of 5-hydroxyperhydro-1, 3-diazepin-2-one
US6458792B1 (en) Compounds
US4895854A (en) Antitumor alkaloids
CA2220995C (fr) Nouveaux derives 7,12-dioxa-benzo¬a|anthraceniques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent