CS233421B1 - N7 (2-alkanoyloxy) atyl / * dodecyldimatyl ammonium bromides and their method of preparation - Google Patents

Abstract

The invention relates to N-/(2-alkanoyloxy)ethyl/--dodecyldlaethylaoaiuBbroides of the general formula where R is an alkyl chain and the number of carbon atoms is 2 to 12, and the method of their preparation, which consists in the reaction of (2-diethylaainoethyl)alkanoate and 1-broadodecano in a polar environment at different temperatures and the beginning of the reaction time. The organic aaonium salts prepared in this way show antimicrobial as well as surface-active properties.

Description

233421 2

The invention relates to N - ((2-alkanoyloay) ethyl-dodecyl-diethylalanine-abrasionate of the general formula CH, R - C 0 O - (CH 2) 2 --N - C 2 H 25 Br CH, (I) where R denotes an alkyl chain and carbon atoms 2 to 12 and the method of preparation. Similar to a structure-like structure and for example: CH 3 -COO-CH 2 gCH 2 CH 2 R 5 R 5, C 6 H 5 -COO- (CH 2) 2 (CH 3) 2 C 12 H 25 Br θ, (CH 3) 3 -C 6 C 4 H 4 -COO- (CH 2) ) 2 ^ (CH 3) 2 R Br ®.

The organic aonic aoll, which contains a long alkyl chain in its molecule, is a group of aldenesin and biosynthetic, antioxidant and antioxidant. For this property, nails tend to be dense, such as dense fillers, snacks in pharmaceuticals, textiles, tattoos, and the like. Also, in the organic synthesis, for example, the preparation of unsaturated alkanesin as allylphosphate catalysts et al.

The preparation is made to act and which is most closely bound by the reaction and the haloalkanes or alkylsulfates and the corresponding terealmeal; The reaction is ascertained in the form of analaric purity and purity in varlabile extracts. The reaction is carried out in water, ethanol, nitro-aethane, but also in bensene and toluene.

The process according to the invention has the advantage that the reaction is carried out in methanol or ethyl cyanide at temperatures of from 12 to 22 hours, by means of high purity and high yield products. In the examples, the Stage Adjustment Process is presented as 1 selected slds which inventes the present invention. This is characterized and the anti-cranial activity of SS1Staphylococcua aureus, Escherichia cell and Candida albicana as alnia inhibition concentrations (MIC) in µg / ml is also reported.

The anti-cellular activity of aldenesin, which in the present invention is a novel feature, is not readily available. Examples of lluatrujd, but not the scope of an engaging method. EXAMPLE 1 To 0.1 mol of (2-dimethylanyl ethyl) hexanoate roapuated in 10 .mu.l of dry ethyl acetate and laboratory temperature and 0.1 .mu.l of 1-bromododecane is added. The reaction temperature is 12 hours at 100 DEG C. After the solvent is distilled off and distilled, the crude N - [(2-hexanoyloxy) ethyl] -dodecyl-ala-lauroic acid is recrystallized to a constant temperature and dry acetone. The product was m.p. 166 at 168 ° C; electroanalysis (calculated // gold): C 60.89 / 60.55} H 10.68 / 10.57} H 3.23 / 3.06} 80% theory} MIC 3.20.5. Example 2

The working procedure is the same as in case 1, and the method is used for the preparation (2-diaethylaaino-acetonitrile, methanol was methanol, the temperature was 85 ° C and the reaction time was 18 hours. The product N - [(2-octanoyloxy) ethyl] -dodecyldiaethylaluminum bisabboldal m.p. 179.5 at 181 ° C; elenent analysis (calculated / counted): C 61.99 / 62.23} H 10.64 / 10.82; M 3.01 / 2.95} yield 91% theory, MIC 7.30.9.

Claims (2)

EXAMPLE 3 The working procedure is the same as in Example 1, using (2-diaethylaluminum ethyl) decanoate, solvent and ethyl cyanide, reacting with 22 hours, temperature 60 ° C. The product N - [(2-dodecanoyloxy) ethyl] -dodecyldaethylaconluorobenzoate m.p. 182.5 [deg.] C., eleaent analysis (calculated): C 63.34 / 63.16; H, 11.04 / 11.15; extract 84% of theory; MIC 6.80.30. The three thus prepared white crystals are white crystalline, hygroscopic compounds, soluble in polar and insoluble in non-polar solvents. The eleaent analysis of the stick Identified by spectral methods. BEFORE ET VYNA LEZU 1. N - ((2-alkanoyloxy) ethyl) -dodecyldinethylaaloneabaaaa of general formula I, CH, Br θ (I), R - C 0 O - (CH 2) 2 - N - C 12 H 25 'H 3 where R denotes an alkyl chain having from 2 to 12 carbon atoms. 2. A process for the preparation of N - [(2-alkanoyloyl) ethyl] -dodecyldiaethylaluminum bromides of general formula (I) according to claim 1, characterized in that (2-dimethylaminoethyl) alkanoate of general formula II, VR - COO - (CH2) is reacted. ) 2 - & (CH 3) 2 (II), wherein R is the same as in 1, with 1-bromoadecane in dry methanol or methyl cyanide at a temperature of 60 to 100 ° C for 12 to 22 hours.