CS224966B1 - The production of loose agents with the high content of biologically active oils - Google Patents

Description

BACKGROUND OF THE INVENTION The present invention relates to a process for the manufacture of free-flowing, high-biologically-active oil formulations which are understood to mean an oil phase which is sparingly soluble in water, such as vitamin S, vitamin 1 concentrate, vitamin D oil solution or mixtures thereof. For the purposes of this invention, a high biologically active oil content is at least 25% by weight or more, based on the dry weight of the formulation.

Loose preparations with high content of biologically active oils are mainly intended as part of vitamin concentrates and feed supplements for livestock nutrition ·

The production of free-flowing, high bioactive oils (hereafter referred to as oil) mainly pursues two goals, to allow convenient and accurate dosing and to increase the stability of the active ingredients sensitive to the active ingredients of the atmosphere, while maintaining good bioavailability.

This problem is usually solved by dispersing the oil in a hydrophilic base (hereinafter the base), i.e. in an aqueous solution containing excipients such as gelatin, carbohydrates, or high-carbohydrate technical products, for example milk whey, polysaoharides, e.g. types of dextrins with varying amounts of residual starch, starch derivatives, cellulose derivatives, polyvinyl alcohol and the like; and in addition stabilizers with antioxidant and chelating properties, after which the dispersion is dried, conveniently in a fluid drier.

224 966

In addition to the process mode, the result of the described process is dependent upon the properties of the base after drying and the degree of oil dispersion therein. Both of these factors also determine the capacity of the base for the oil.

It was found that rapid release of loose formulations in lukewarm water to form a homogeneous emulsion is a prerequisite to guarantee good bioavailability of the active ingredient. * A test was performed to monitor the release kinetics of oil from the formulation into a lipophilic solvent. differences in a larger number of samples of commercial preparations containing oils in the capacity, dispersion and stability of the active ingredients * Based on the results of studies of these tests, a new rational solution of the formulation of these preparations was used, which was used in this invention ·

The invention relates to a process for the production of free-flowing, high-bioavailable oils, in particular oil solutions of vitamins A, B and D, mixtures thereof or oil concentrates thereof, and the addition of stabilizers, antioxidant and chelating agents by fluid drying. based on water-soluble polysaccharides or its derivatives, for example dextrin * The essence of this process is that, prior to fluidic drying, a silica dispersion containing 0.1-0.8% silica based on the dry weight of the preparation is formed by adding aqueous sodium silicate solution ·

If desired, the base can be further modified by the action of a plasticizer, in particular a milk protein, preferably casein, in an amount of 5 to 20% by weight, based on dry weight, optionally also modified by addition of a calcium salt, preferably calcium gluconate. 2.0% by weight and / or aliphatic aldehyde, preferably formaldehyde, in an amount of 0.1 to 1.0% by weight, based on the casein content.

The process of the present invention was based on a dextrin-predominant base, which mainly focused on improving the oil phase dispersion and optimizing plastic properties as a prerequisite for high oil capacity.

224 966

Among the many test substances, the fine silicic dispersion (sol to gel), formed by adding a sodium silicate solution to a slightly acidic or slightly acidified base, has proven to be the most suitable. Protein substances such as gelatin, but preferably casein whose properties can be further favorably modified by the addition of other substances which react with casein, such as aliphatic aldehydes, for example formaldehyde, calcium salts, for example calcium gluconate, have proved to be a plasticizing component. a base having a high oil capacity (e.g., content) was formed. .

% by weight to 30 to 35 wt. The bulk formulations made with the concentrate of this base were able to withstand long-term stability experiments compared to conventional commercial formulations.

Naturally, the proportions of the ingredients in the preparation may vary within certain limits depending on the oil used.

Further details of the process according to the invention are apparent from the examples.

Example 1

For the preparation of 1000 g of loose form, the quantity of vitamin A acetate or its concentrate is weighed equal to 350,000 IU. Weigh 50 g of ethoxine, 3 g of ethylenediaminetetraootic acid sodium salt, 15 g of commercial water glass solution, 25 g of 16 $ polyvinyl alcohol. , measure 5 drops of n-octyl alcohol and weigh enough dextrin to make up the dry weight to 1000 g.

Bextrin is dissolved in water to a 50% solution with stirring and heating at 60 ° C. Add water glass and soda-lime ethylenediaminetetraootic acid ·

Y, vitamin A acetate or a concentrate thereof, and, with gentle gentle heating, dissolve etoxichine and add the solution to the dextrin base. Then n-octyl alcohol and polyvinyl alcohol are added. After mixing, the mixture is homogenized in a high pressure homogenizer and then dried in a spray drier.

^Z /

Example 2

224 966

To prepare 1000 g of the loose form, weigh as much as 350,000 IU of vitamin A acetate. Also weigh 50 g of etoxichine, 3 g of soda-lime ethylenediaminetetraacetic acid, 15 g of water glass, 25 g of 16 # polyvinyl alcohol, 5 drops are measured. n-octyl alcohol and weigh dextrin and kaaine at a weight ratio of 5 s 1 in such a quantity as to make up the mass of the dry matter up to 1 000 g.

*

Dextrin dissolves in water to 50 # solution, sodium ethylenediaminetetraacetic acid and water glass are added ·

Casein is dissolved in water to a 15 # solution by adding a minimum of 20 # sodium hydroxide solution, octyl alcohol is added ·

With careful gentle heating, the vitamin A acetate is mixed with etoxichine. The dextrin dispersion is added with stirring to the aqueous casein solution and after mixing the vitamin A acetate with etoxichine is added. After thorough mixing, the mixture is homogenized in a high pressure homogenizer and then dried in a spray drier.

Example 3

The procedure was as in Example 2 except that 4 g of 36% formaldehyde solution was added to the dispersion after addition of the vitamin A concentrate.

Example 4

The procedure is as in Example 2 except that 30 g of calcium gluconate is added to the dispersion after the addition of the vitamin A concentrate.

Example 5 "" "

224 986

For the preparation of a loose form containing 25% by weight of vitamin se, the procedure is as described in Examples 1 to 4, but instead of the vitamin A acetate concentrate, vitamin koncent concentrate is used in an amount corresponding to 25% by weight of vitamin 5. bulk forms.

Claims (2)

The BD BD HAS THE INVENTION 1. A process for the production of free-flowing, high-biologically-active oils, in particular oil solutions of vitamins A, BAL, mixtures thereof or oil concentrates thereof, with the addition of stabilizers, antioxidant and chelating agents, by fluid drying the dispersion of these oils in hydrophilic basis, water-soluble polysaoharides or derivatives thereof, for example dextrin, characterized in that, prior to fluidized-bed drying, a silica dispersion containing from 0.1 to 0.8 silica, based on the dry matter of the composition, is formed by the addition of an aqueous solution of sodium silicate. Process according to claim 1, characterized in that the base is modified by the action of a plasticizer, in particular a milk protein, and preferably casein, in an amount of 5 to 20% by weight, based on dry matter, optionally also modified with calcium salt, preferably calcium gluconate. , in an amount of 0.2 to 2.0% by weight of a / nobo aliphatic aldehyde, preferably formaldehyde, in an amount of 0.1 to 1.0% by weight, based on the casein content.