CS222787B1 - Gel with anti-inflammatory and antibacterial effects, especially for dental purposes - Google Patents

Abstract

Gel with anti-inflammatory and antibacterial effects, especially for dental practice, for example for the treatment of acute, acutely exacerbated chronic apical periodontitis, together with the relative indication for the treatment of teeth with chronic apical periodontitis. The gel contains as active ingredients triamcinolone acetonide, ethyltrimethylammonium bromide and chlorhexidine digluconate and its melting point is between 37 and 38 °C.

Description

The invention relates to a gel with antisense and antibacterial effects, in particular for dental purposes, for example for the treatment of acute, acutely exacerbated chronic apical periodontitis, together with a relative indication for the treatment of teeth with chronic apical periodontitis.

The treatment of acute and acutely exacerbated chronic apical periodontitis has hitherto been based on methods based on trepanation of the pulp cavity of the affected tooth associated with the release of purulent secretion from the root canal and its lavage. The affected tooth is then left without further treatment until the inflammatory manifestations have subsided. The disadvantage of this procedure is that it continually contaminates the root canal with pathogenic microorganisms present in the oral cavity. Furthermore, there is the possibility of blockage of the root canal with food debris that breaks in the cavity. content to penetrate the microorganisms and their toxins beyond the tip of the tooth and to induce an outbreak of acute inflammation. The consequence of this is, of course, an extension of the treatment time ·

The helative indication of the use of a suitable anti-inflammatory and antibecterially effective agent in the treatment of chronic apical periodontitis is due to the fact that during meohaniocular preparation of the terminal root canal section a portion of the infected material is always pushed through the tip of the tooth, especially when foramen apically tooth tip etc. Inflammatory irritation of the tissue in the area of the root nib occurs with an infected content of 2 222 787 root canal haem together with non-sterile dentin sawdust, pushed behind the foramen of apical treatment of the tooth ·

The present inventors have found that the use of a locally applied known disinfectant solution and a novel antiinflammatory and anti-bacterial active formulation of the following composition results in rapid resolution of acute inflammation and thus rapid disappearance of oitlivoati on pressure and tapping. of exogenous hippococcal apical periodontitis with the above-mentioned preparation is 3 to 4 days, as opposed to the usual treatment of teeth with the above diagnoses, which lasts on average 10 days or more.

Accordingly, the present invention provides a gel with anti-inflammatory and antibacterial effects, in particular for dental purposes, comprising: 0.09 to 0.11% by weight of triamoinolone aoetonide, 0.5 to 0.7% by weight of a higher disinfectant quaternary ammonium salts, preferably oetyltrimethylammonium bromide, 0.25 to 0.49% by weight of a 20% solution of digluconate of chlorohexidinium, 10.0 to 20.0% of a 6-propylene glycol, 24.0 to 32.0% of a polyethylene glycol 400 8.0 to 12.0% by weight of polyethylene glycol 1000, 30.0 to 34.0% by weight of polyethylene glycol 4000 and distilled or deionized water up to 100% by weight, with a flow temperature in the range of 37 to 33 ° C.

In choosing the appropriate formulation, the inventors have known from the known fact that triamoinolone azetide is one of the most effective anti-inflammatory agents when topically applied and that oetyltrimethylammonium bromide and digluconate halohexidinium are very effective antibacterial agents, the latter having an antimycotic effect.

Triamoinolone aetide is a hydrophobic substance, the remaining substances are hydrophilic in nature. The present inventors have found that by a suitable combination of three solvent components, ie distilled or deionized water, propylene glycol and polyethylene glycol 400, a solvate is obtained in which all three active substances are present in the form of a molecular dispersion. Furthermore, it has been found that the addition of a suitable amount of polyethylene glycol of molecular weight

- 1,222,787 of the weight of 1000 and 4000, the prepared solution can be adjusted to a gel consistency with a scan temperature between 37 and 38 ° C. This temperature is optimal for the desired ability of the root canal to penetrate the infected, inflammatory altered periapical plaque, so that after application the hydrogel passes into sol and therefore does not cause pain around the root tip due to mechanical irritation ·

Further details of the preparation according to the invention are apparent from the following embodiment.

Before application of the dental gel, it is necessary to carry out the pulp cavity trepanaoi, passage and mechanical extension of the root canal in the presence of a disinfectant solution, for example of the following advantageous composition (in g):

Oetyltrimethylammonium bromide 0.63

2Cl 2 solution of digluconane, chlorhexidinium 0,35 Distilled or deionized water 99,02

The prepared root canal is filled with a gel of the following composition, preferably with a disposable syringe or Miller needle, in an amount of 0.2 g per root canal.

Gel composition (g)

Triamcinolone Aetonide 0.10 Oethyl Trimethylammonium Bromide 0.63 20JL Digluconate Halohexidinium 0.35 Propylene Glycol 16.00 Polyethylene Glycol 400 28.00 Polyethylene Glycol 1000 10, OG Polyethylene Glycol 4000 32.00

Distilled or deionized water up to 100,00

Manufacturing process:

Triamoinolone o-oetonide is dissolved in sterilized propylene glycol at a temperature of 55 to 60 ° C and the solution is filtered.

- 4,222,787

Dissolve cetyltrimethylammonium bromide in distilled or deionized water, mix this solution with a 20% solution of digluconate, chlorhexidinium, and filter. The mixture of polyethylene glycols 400, 1000 and 4000 is melted, sterilized, the melt is filtered, and a solution of triamoinolone ecetonide in propylene glycol and then an aqueous solution of cetyltrimethylammonium bromide and halohexidinium digluconate are added thereto at a temperature of 55-60 ° C. The gel thus formed was homogenized by stirring under vacuum with cooling until the temperature dropped to 25 ° C. The finished gel is stored in a tightly closed container, in a cool and dark place. Under these conditions, it is physically and chemically stable, does not recrystallize from any of the active ingredients even at a reduced temperature of -10 to 5 ° C, and its antibacterial activity does not decrease even after long-term storage at room temperature.

Claims (1)

Anti-inflammatory and antibacterial gel β, in particular for dental purposes, characterized in that it contains 0.09 to 0.11% by weight of triamcinolone aoetonide, 0.5 to 0.7% by weight of a higher quaternary ammonium salt disinfectant, % of ethyl bromo trimethyl ammonium bromide, 0.25 to 0.45 wt. 20% of a chlorhexidinium digluconate solution, 10.0 to 20.0 wt. % propylene glycol, 24.0 to 32.0% by weight; of polyethylene glycol 400, 8.0 to 12.0% by weight of polyethylene glycol 1000, 30.0 to 34.0% by weight of polyethylene glycol 4000, and distilled or deionized water to 100% by weight of polyethylene glycol.