JP2003286176A - Calcium hydroxide based root canal filling material - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain a new calcium hydroxide based root canal-filling material that has excellent operability due to its excellent fluidity, but can be readily removed from the root canals when necessary. <P>SOLUTION: This root canal filling material comprises 10-30 wt.% of at least one selected from the group consisting of ester gum, polyisoprene, a polyisoprene copolymer and carnauba wax, 27-55 wt.% of calcium hydroxide, 30-60 wt.% of water and 3-15 wt.% of a thickener. In a preferred embodiment, 5-25 pts.wt. of at least one selected from the group consisting of barium sulfate, zirconium oxide, bismuth subnitrite, bismuth trioxide and bismuth carbonate as an X-ray contrast medium, is added to 100 pts.wt. of the initial filling material. <P>COPYRIGHT: (C)2004,JPO

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention provides a final root canal filling material such as gutta percha in a root canal prepared in a form that facilitates root canal filling after removing pulp tissue when performing root canal treatment of teeth. The present invention relates to a calcium hydroxide-based root canal filling material for temporarily sterilizing the inside of a root canal as a pre-filling step.

[0002]

2. Description of the Related Art In dental treatment, in order to treat dental pulp disease and apical periodontal disease of teeth, first, debris such as necrotic tissue pieces and food pieces in the root canal and contaminated root canal inner wall are removed. After the root canal is prepared in a form that facilitates root canal filling using a cutting device such as a reamer or a file, a material that is stable in material, such as gutta-percha, is filled into the formed root canal. Then, measures are taken to prevent the invasion of pathogenic bacteria from the outside of the root canal into the root canal. This series of treatments is called root canal treatment.

To perform this root canal treatment, first, the pulp is removed, then the dentin on the contaminated inner wall of the root canal is removed, and a device such as a reamer or a file is used to expand the root canal. Root canal formation is performed, and then root canal cleaning is performed by chemically cleaning the root canal after formation of the root canal with a drug. However, the shape of the root canal is complicated, and the number of root canals is different from single root canal, two root canals, three root canals, and four root canals per tooth depending on the part where the teeth are present, and the shape is also linear or flat. , It is not possible to completely remove the bacteria in the root canal even if such treatment is performed because it varies depending on individual teeth such as curved shape, so even if the treatment is continued as it is, infection due to residual bacteria causes toothache and gums. Swelling may occur. In such a case, it becomes necessary to repeat the series of root canal treatments.

Therefore, root canal disinfection is performed as a measure against such fears. For root canal disinfection, a method is used in which a calcium hydroxide-based root canal filling material containing calcium hydroxide is temporarily filled in the root canal and sterilized by utilizing the strong alkalinity of calcium hydroxide. Then, after the treatment of this root canal disinfection (after filling the root canal with calcium hydroxide, this filling may be repeated at intervals of about 5 days to 1 week), the root canal is washed with water, It is customary to remove the water and then fill the root canal with a final root canal filling material such as gutta-percha.

The calcium hydroxide-based root canal filling material has a soft effect rather than a transient strong bactericidal effect, and at the same time, carbon dioxide from the living body or the like turns calcium hydroxide into calcium carbonate to form a root canal. By adhering to the wall, hard tissue formation can be promoted and biological closure of the apical foramen can be expected, which is a feature that is not found in other preparations that is biofriendly. However, it is a very difficult and time-consuming treatment to remove the calcium hydroxide-based root canal filling material from the inside of the root canal having a complicated shape by a mechanical cutting method such as a reamer or a file as described above.

Further, in recent years, calcium hydroxide-based root canal filling with a viscosity-imparting agent such as polypropylene glycol for the purpose of improving operability and spreading the calcium hydroxide-based root canal filling material to the details of the root canal. Wood is used. By using such a calcium hydroxide-based root canal filling material, the disinfection effect can be extended to every corner of the root canal. However, the calcium hydroxide-based root canal filling material has a complicated shape. The work of removing it from the inside further causes great pain to the operator and the patient.

[0007]

SUMMARY OF THE INVENTION Therefore, the present invention is a novel calcium hydroxide-based root canal filling material which has excellent operability due to its fluidity and can be easily removed from the root canal when necessary. The challenge is to provide.

[0008]

Means for Solving the Problems As a result of intensive studies to solve the above problems, the present inventors have found that calcium hydroxide-based root canal fillers containing a viscosity-imparting agent are mixed with ester gum, polyisoprene, and polyisoprene. When at least one selected from the group consisting of polymers and carnauba wax is blended in an appropriate amount, the above-mentioned components are dissolved when a solvent such as limonene or eucalyptus oil is used when removal is required while having the conventional excellent characteristics. The present invention has been completed by finding that the calcium hydroxide-based root canal filler softens and can be easily removed from the root canal.

[0009]

BEST MODE FOR CARRYING OUT THE INVENTION That is, the calcium hydroxide-based root canal filling material according to the present invention comprises ester gum, polyisoprene,
10 to 30% by weight of at least one selected from the group consisting of polyisoprene copolymer and carnauba wax, 27 to 55% by weight of calcium hydroxide, and 30 to 60% by weight of water.
And 3 to 15% by weight of a viscosity imparting agent, which is a calcium hydroxide-based root canal filling material. X is further added to 100 parts by weight of this calcium hydroxide-based root canal filling material. It is preferable to contain 5 to 20 parts by weight of at least one selected from the group consisting of barium sulfate, zirconium oxide, bismuth subnitrate, bismuth trioxide, and bismuth carbonate, which are line contrast agents.

At least one selected from the group consisting of ester gum, polyisoprene, polyisoprene copolymer and carnauba wax used in the present invention is soluble in a solvent such as chloroform, eucalyptus oil, limonene, xylene and ethanol. However, when these solvents are used, the calcium hydroxide-based root canal filling material is softened and can be easily removed from the root canal. In particular, ester gum is preferable not only because it has high biocompatibility itself, but also because it has excellent solubility in terpene oil such as limonene, which has the highest biocompatibility among solvents.

At least one selected from the group consisting of ester gum, polyisoprene, polyisoprene copolymer and carnauba wax is blended in an amount of 10 to 30% by weight based on the calcium hydroxide-based root canal filling material. If it is less than 10% by weight, the effect of softening the calcium hydroxide-based root canal filling material is small, and it is not possible to exert a remarkable advantage in removing the calcium hydroxide-based root canal filling material from the inside of the root canal. When the content exceeds%, the operability of the calcium hydroxide-based root canal filling material deteriorates and it is impossible to spread the calcium hydroxide-based root canal filling material to every corner of the root canal. It becomes impossible to expect a sufficient bactericidal effect in the root canal. These substances may be in a powder form or a liquid form as long as they are stable in the root canal, but in the case of a powder form, a powder having a particle size of 0.1 to 30 μm, which is the particle size of the filler generally used in dentistry. It is preferably in the form of a shape.

The calcium hydroxide and water used in the present invention are the main components of the calcium hydroxide-based root canal filling material, and have the function of disinfecting the inside of the root canal. The compounding amounts of calcium hydroxide and water are 27 to 55% by weight and 30 to 60% by weight, respectively, and if calcium hydroxide is less than 27% by weight, the disinfecting effect in the root canal cannot be expected, and 55% by weight is required. If it exceeds the limit, the operability of the calcium hydroxide-based root canal filling material deteriorates. In addition, the content of water is less than 30% by weight or 60% by weight
If it exceeds, the operability of the calcium hydroxide-based root canal filler deteriorates.

Examples of the viscosity-imparting agent used in the calcium hydroxide-based root canal filling material according to the present invention include sodium multifibrin glucose, sodium alginate, propylene glycol alginate, polyethylene glycol,
A viscosity-imparting agent composed of synthetic additives such as polypropylene glycol, sodium carboxymethyl cellulose, calcium carboxymethyl cellulose, sodium starch glycolate, sodium starch phosphate, sodium polyacrylate, methyl cellulose, hydroxypropyl cell sauce, and polyvinylpyrrolidone,
Guar gum, cajib bean gum, tara gum, tamarind seed gum, gum arabic, tragacanth gum, karaya gum, alginic acid, carrageenan, xanthan gum, dielan gum, curdlan, chitin, chitosan, chitosamine, and other natural thickeners, calcium carbonate, calcium silicate, fumed Examples thereof include inorganic viscosity imparting agents such as silica, amorphous hydrous silicic acid, and hydrophobic silica. These viscosity-imparting agents are used in the same manner as in the case of the conventional calcium hydroxide-based root canal filling material, and the compounding amount is 3 to 15% by weight of the total amount of the calcium hydroxide-based root canal filling material. If it is less than 3% by weight, the effect of imparting viscosity cannot be obtained and the operability and fluidity are deteriorated, and if it exceeds 15% by weight, the inherent characteristics of the calcium hydroxide-based root canal filling material such as blocking ability cannot be obtained.

Further, in the calcium hydroxide-based root canal filling material according to the present invention, X-ray contrast agents such as barium sulfate, zirconium oxide, bismuth subnitrate, bismuth trioxide, and bismuth carbonate are used as X-ray contrast agents. It is also possible to add at least one selected from the group consisting of: The amount of addition is 10 to 30% by weight of at least one selected from the group consisting of ester gum, polyisoprene, polyisoprene copolymer, and carnauba wax, calcium hydroxide 27 to 55% by weight, and water 30 to 60% by weight. %, And 5 to 20 parts by weight with respect to 100 parts by weight of a calcium hydroxide-based root canal filler containing 3% to 15% by weight of a viscosity imparting agent. If the content of the X-ray contrast agent is less than 5 parts by weight, it tends to be difficult to effectively obtain the X-ray contrast effect.
If added in excess of parts by weight, the advantages of other ingredients cannot be exhibited, and calcium hydroxide-based roots containing at least one selected from the group consisting of ester gum, polyisoprene, polyisoprene copolymer, and carnauba wax The original properties of the tube filler are impaired.

It is needless to say that the calcium hydroxide-based root canal filling material according to the present invention may be added with general coloring agents, antibacterial agents, etc. within a range not impairing its performance.

Hereinafter, the calcium hydroxide-based root canal filling material according to the present invention will be specifically described with reference to examples, but the present invention is not limited thereto.

[0017]

[Example 1] 14% by weight of ester gum, 46% by weight of calcium hydroxide, 35% by weight of water, and 5% by weight of polyethylene glycol as a viscosity-imparting agent were added,
Mix well to make a paste. The following tests were performed on the obtained calcium hydroxide-based root canal filling material.

<Evaluation of operability of filling root canal> The obtained calcium hydroxide-based root canal filling material was loaded into an injection cylinder, and a 25 gauge needle (inner diameter: 0.26 mm) was attached to the tip of the injection cylinder to make it easy. Is good when it can be pushed out, and bad when it is difficult
It was evaluated.

<Evaluation of operability for removal from the root canal> A standard human maxillary lateral incisor stored in a 10% formalin solution after tooth extraction was used as a sample, and the incision was cut to open the medullary chamber, followed by normal operation. Root canal formation was performed by root canal expansion operation. The calcium hydroxide-based root canal filling material (colored blue for distinguishing from the root canal wall) of Examples and Comparative Examples was directly filled from the syringe into the root canal. After leaving the sample in an atmosphere of 37 ° C constant temperature and 100% humidity for 7 days,
The calcium hydroxide-based root canal filling material was removed, taking care not to carefully expand the root canal using the file. After that, while applying Limonene (trade name: QP Solvent, manufactured by Nippon Dental Co., Ltd.) to the file (trade name: Tuck End File, manufactured by GC), the calcium hydroxide-based root canal filling material remaining in the root canal is applied. After removing the softened / melted and removed sample, the sample washed with water is cut and the inside of the root canal is visually observed. From the state inside the root canal after removing the calcium hydroxide-based root canal filling material, from the inside of the root canal The removal operability was evaluated in the following three grades from A to C. Further, the removal of the calcium hydroxide-based root canal filling material using only the file was set as Comparative Example 1. A: The calcium hydroxide-based root canal filling material has been removed from the root canal wall. B: A small amount of calcium hydroxide-based root canal filling material remains on the root canal wall. C: Calcium hydroxide-based root canal filling material remains in the root canal

<Examples 2 to 6> Experiments were performed in the same manner as in Example 1 except that the formulation was changed as shown in Table 1. The results are summarized in Table 1.

[0021]

[Table 1]

As is clear from Examples 1 to 6, the calcium hydroxide-based root canal filling material according to the present invention has the same filling operability as that of the conventional calcium hydroxide-based root canal filling material, and the final stage. With a solvent such as limonene, it is possible to soften and dissolve the calcium hydroxide-based root canal filling material remaining in the root canal and easily remove the details from the root canal easily with a reamer file. I was able to confirm that. On the other hand, Comparative Example 1, which is similar to the conventional calcium hydroxide-based root canal filling material, has poor operability for removal from the inside of the root canal, and thus ester gum,
Comparative Example 2 containing a large amount of at least one selected from the group consisting of polyisoprene, polyisoprene copolymer, and carnauba wax, and Comparative Example 3 containing a large amount of a viscosity imparting agent.
Was confirmed to be inferior in filling operability from the root canal.

[0023]

As described above in detail, the calcium hydroxide-based root canal filling material according to the present invention maintains the operability due to the excellent fluidity of the calcium hydroxide-based root canal filling material to which the viscosity-imparting agent is added. However, it can be easily removed from the root canal when necessary, and its value that contributes to dental care is extremely large.

─────────────────────────────────────────────────── ─── Continuation of front page (51) Int.Cl. ⁷ Identification code FI theme code (reference) A61L 2/16 A61L 2/16 Z A61P 1/02 A61P 1/02 31/04 31/04 (72) Invention Person Masao Angi 76-1 Hasunuma-cho, Itabashi-ku, Tokyo G-C F-Term Co., Ltd. (reference) 4C052 AA16 AA17 4C058 AA28 BB07 JJ07 JJ21 4C076 BB22 CC31 EE01 EE04 EE53 EE56 FF17 4C085 HH05 KB02 KB07 KB86 AKBAKB4A4 HA23 MA03 MA05 MA57 NA06 ZA67 ZB35

Claims (2)

[Claims] 1. At least one kind selected from the group consisting of ester gum, polyisoprene, polyisoprene copolymer and carnauba wax, 10 to 30% by weight, calcium hydroxide 27 to 55% by weight, and water 30 to 60% by weight. % And a viscosity-imparting agent of 3 to 15% by weight, a calcium hydroxide-based root canal filling material. 2. A 100-part by weight calcium hydroxide-based root canal filling material according to claim 1, further comprising X-ray contrast agents barium sulfate, zirconium oxide, bismuth subnitrate, bismuth trioxide, and bismuth carbonate. A calcium hydroxide-based root canal filling material containing 5 to 20 parts by weight of at least one selected from the group consisting of: